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IGSF1 Gene

protein-coding GIFtS: 60

GC0XM130235

immunoglobulin superfamily, member 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
IGCD1 ^¹, ²
IGDC1 ^¹, ², ³, ⁵
INHBP ^¹, ²
InhBP ^³
KIAA0364 ^¹, ², ³
MGC75490 ^¹, ²
OTTHUMP00000024029 ^²
OTTHUMP00000024030 ^²
OTTHUMP00000024031 ^²
PGSF2 ^¹, ², ³
p120 ^³

Descriptions
Immunoglobulin-like domain-containing protein 1 ^³
Inhibin-binding protein ^³
Pituitary gland specific factor 2 ^³
immunoglobulin superfamily, member 1 ^²
immunoglobulin-like domain-containing 1 ^²

External Ids
HGNC: 5948¹
Entrez Gene: 3547²
UniProtKB: Q8N6C5³
Ensembl: ENSG00000147255⁷

Search outside databases for aliases for IGSF1 gene

Previous GC identifers: GC0XM125053 GC0XM127253 GC0XM128352 GC0XM129113 GC0XM130133

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IGSF1:

Members of the immunoglobulin (Ig) superfamily (see MIM 147100), which includes IGSF1, have a

variety of functions, but all appear to play a role in cell recognition and the regulation of cell

behavior.[supplied by OMIM]

UniProtKB/Swiss-Prot: IGSF1_HUMAN, Q8N6C5

Function: Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity

inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By

similarity). Necessary to mediate a specific antagonistic effect of inhibin B on

activin-stimulated transcription

Gene Wiki entry for IGSF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IGSF1 gene

Entrez Gene cytogenetic band: Xq25 Ensembl cytogenetic band: Xq26.2 HGNC cytogenetic band: Xq25

IGSF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM130235: (about GC identifiers)

Start:	130,235,161 bp from pter
End:	130,361,358 bp from pter
Size:	126,198 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_011786.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IGSF1_HUMAN, Q8N6C5 (See protein sequence)

Recommended Name: Immunoglobulin superfamily member 1 precursor

Size: 1336 amino acids; 148936 Da

Subunit: Interacts with INHA (By similarity). In PubMed:12385827 does not interact with INHA;

standard receptor binding assay. Interacts with ACVR1B; the interaction appears to be

ligand-dependent as it is diminished by inhibin B and activin A. Interacts with ACVR2A, ACVR2B,

ACVRL1 and BMPR1B

Subcellular location: Isoform 1: Membrane; Multi-pass membrane protein (Potential)

Subcellular location: Isoform 2: Membrane; Multi-pass membrane protein (Potential)

Subcellular location: Isoform 3: Secreted (Potential)

Caution: It is uncertain whether Met-1 or Met-12 is the initiator

Secondary accessions: B5MEG2 O15070 Q9NTC8

Alternative splicing: 3 isoforms: Q8N6C5-1 Q8N6C5-2 Q8N6C5-3 (Additional isoforms seem to exist)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001546.2 NP_991402.1

ENSEMBL proteins:

ENSP00000359941 ENSP00000359938 ENSP00000359937 ENSP00000359947 ENSP00000359940 ENSP00000355010

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IGSF1)
	Human Recombinant Proteins from Abnova (IGSF1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0016020	membrane	IDA	11266516
GO:0016021	integral to membrane	IEA	--

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Antibodies for IGSF1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for IGSF1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (IGSF1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IGSF1)
	Novus Biologicals Antibodies for IGSF1

Assays for IGSF1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8N6C5

ProtoNet protein and cluster: Q8N6C5

1 Blocks protein family: IPB003599 Immunoglobulin subtype

UniProtKB/Swiss-Prot: IGSF1_HUMAN, Q8N6C5

Similarity: Contains 12 Ig-like C2-type (immunoglobulin-like) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IGSF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IGSF1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_205833

Applied Biosystems Silencer® siRNAs for IGSF1

Sigma-Aldrich siRNA for IGSF1

Sigma-Aldrich shRNA for IGSF1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001555
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001555
untagged cDNA clones in CMV expression vector (see all 2): NM_001555

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001555

UniProtKB/Swiss-Prot: IGSF1_HUMAN, Q8N6C5

Function: Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity

inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By

similarity). Necessary to mediate a specific antagonistic effect of inhibin B on

activin-stimulated transcription

Genatlas biochemistry entry for IGSF1:

immunoglobulin superfamily gene 1,highly expressed in adult testis and fetal liver,with a smaller

alternate form expressed in adult heart,potentially involved in cell-surface recognition or

cell-cell interaction

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Igsf1):

normal

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IDA	11266516
GO:0005515	protein binding	IPI	11266516
GO:0048186	inhibin beta-A binding	IDA	11266516
GO:0048187	inhibin beta-B binding	IDA	11266516

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for IGSF1

5/11 Interacting proteins for IGSF1 (ENSP00000359940³) via UniProtKB, MINT, and/or STRING (see all 11 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
INHBE	ENSP00000266646³	STRING (score=.891)
INHBB	ENSP00000295228³	STRING (score=.883)
INHBA	ENSP00000242208³	STRING (score=.881)
ACVR1B	ENSP00000257963³	STRING (score=.861)
ACVR2A	ENSP00000241416³	STRING (score=.841)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IDA	11266516
GO:0045449	regulation of transcription	IDA	11266516

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IGSF1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IGSF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IGSF1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_205833

Sigma-Aldrich siRNA for IGSF1

Sigma-Aldrich shRNA for IGSF1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001555 NM_205833

REFSEQ mRNAs for IGSF1 gene (2 alternative transcripts):

NM_001555.3 NM_205833.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001555 NM_205833

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001555
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001555
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001555

Additional cDNA sequence:

AB002362.1 AB058894.2 AF034198.1 AK057916.1 AK226008.1 AK295438.1 AK307871.1 AL137369.1

BC028312.1 BC063884.1 CR614008.1 Y10523.1

7 DOTS entries:

DT.92421077 DT.95351575 DT.215108 DT.101958623 DT.121318277 DT.95368130 DT.121318244

24/124 AceView cDNA sequences (see all 124 ):

AI222369 BM263194 BQ071925 CD108169 BU070763 R93268 CD238797 AF034198

AW952896 AA780028 AI022167 AA469974 CR614008 CD109006 BC063884 AL079599

BX091522 NM_001555 CD251252 BM709390 H48477 H52060 AB058894 AL526186

highest scoring ESTs for IGSF1:

AB002362 AB058894 AF034198 AK057916 AL110419 AL526227 BC063884 CD557252 Y10523 AA007647

Unigene Cluster for IGSF1:

Immunoglobulin superfamily, member 1

Hs.22111 [show with all ESTs]

Unigene Representative Sequence: AB002362

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for IGSF1 (see all 7 )

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15a	·	15b	·	15c	^	16	^	17a	·	17b	^	18	^
SP1:									-		-								-												-				-
SP2:			-
SP3:																																			-
SP4:
SP5:

ExUns:	19a	·	19b	^	20	^	21	^	22
SP1:
SP2:
SP3:
SP4:
SP5:	-

About this scheme

ECgene alternative splicing isoforms for IGSF1

6 Ensembl transcripts including schematic representations:

ENST00000370904 ENST00000370901 ENST00000370900 ENST00000370910 ENST00000370903 ENST00000361420

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IGSF1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IGSF1

¹ / ² / ³

6 probe-sets matching IGSF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34238_at²^{, 3}	U95-A	1	1.00	1.00	0.87	0.98	AB002362	1.00	0.84	0.92	1
92168_at²^{, 3}	U95-D	1	0.50	1.00	0.73	1.04	H78267	0.60	1.00	0.82	1
207695_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001555	0.60	1.00	0.82	1
223807_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AB058894	0.80	1.00	0.91	1
207695_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223807_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks IGSF1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAATTCTATT

SOURCE GeneReport for Unigene cluster: Hs.22111
Expression variation in blood from EXPOLDB for IGSF1
UniProtKB/Swiss-Prot: IGSF1_HUMAN, Q8N6C5
Tissue specificity: Highly expressed in pancreas, testis and fetal liver. Moderately expressed in
heart, prostate and small testine. Expressed at very low levels in brain, thymus, ovary, colon,
fetal lung and fetal kidney. Expressed in muscle. Isoform 3 is expressed in pituitary gland

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IGSF1 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IGSF1¹	--	immunoglobulin superfamily, member 1	91.98(n) 90.87(a)	481051 XM_538173.2 XP_538173.2
rat (Rattus norvegicus)	Igsf1¹	--	immunoglobulin superfamily, member 1	87.34(n) 86.32(a)	302822 NM_175763.2 NP_786939.1
mouse (Mus musculus)	Igsf1^{1, 5}	X⁵	immunoglobulin superfamily, member 1^{1, 5}	87.97(n)¹ 87.46(a)¹	209268¹ NM_177591.3¹ NP_808259.2¹ AI747649⁵ AI843147⁵ (see all 18)
chicken (Gallus gallus)	IGSF1¹	--	immunoglobulin superfamily, member 1	44.42(n) 31.3(a)	419114 XM_417301.2 XP_417301.2

About this table Species with no ortholog for IGSF1

ENSEMBL Gene Tree for IGSF1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IGSF1 gene

OSCAR² A1BG² NCR1² FCAR² GP6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/78 NCBI SNPs in IGSF1 are shown (see all 78 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 54)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs5930459^1,2	A,C,F,H	130251463(+)	`gaaacG/Tgaaac`	2	--	ng3¹		4		EU EA WA	410
	rs6637831^1,2	A,C,F,H	130251369(+)	`ctactG/Atgtgc`	2	--	ng3¹		4		EU EA WA	418
	rs6637825^1,2	C,F,H	130234981(+)	`AGTGAC/TTATGT`	1	--	ng5¹		11		EU EA WA NA	745
--	rs6637830^1,2	A,C	130251224(+)	`GTATTC/GTGGGG`	2	--	ng3¹		0	--	--	--	--
	rs6637826^1,2	C,H	130244204(+)	`TACATT/GGTTGA`	1	H/N	mis¹		4		EU EA WA	418
--	rs6637829^1,2	A,C	130251040(+)	`CCCTGC/GGCCGG`	2	--	ng3¹		0	--	--	--	--
--	rs4633201^1,2	C	130251713(+)	`aaactA/Cacagc`	2	--	ng3¹		0	--	--	--	--
--	rs4442295^1,2	C	130251735(+)	`agcatA/Gtagta`	2	--	ng3¹		0	--	--	--	--
	rs1128617^1,2	C,F,H,O	130243499(-)	`CTGGAG/ATTTTC`	1	E/E	syn¹		7		EU EA WA NA	556
	rs5930458^1,2	A,C,F,H	130247687(+)	`AACTCC/TGGTTG`	2	P/P	syn¹		4		EU EA WA	412

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HapMap Linkage Disequilibrium images for IGSF1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300137

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/20 PubMed articles for IGSF1 gene (see all 20 ):

Cloning and expression of an immunoglobulin superfamily gene (IGSF1) in Xq25. (PubMed id 9521868)^{2, 3, 4} Mazzarella R.... Schlessinger D. (1998)
Identification and genomic organization of a gene coding for a new member of the cell adhesion molecule family mapping to Xq25. (PubMed id 9729118)^{2, 3, 4} Frattini A....Vezzoni P. (1998)
Expression profile of active genes in the human pituitary gland. (PubMed id 11854097)^{3, 4} Tanaka S....Amino N. (2002)
Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP). (PubMed id 11266516)^{3, 4} Chapman S.C. and Woodruff T.K. (2001)
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)^{3, 4} Nagase T....Ohara O. (1997)
An internal signal sequence directs intramembrane proteolysis of a cellular immunoglobulin domain protein. (PubMed id 18981173)³ Robakis T....Scheiffele P. (2008)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
The LIFEdb database in 2006. (PubMed id 16381901)³ Mehrle A....Wiemann S. (2006)
The DNA sequence of the human X chromosome. (PubMed id 15772651)⁴ Ross M.T.... Bentley D.R. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3547	HGNC: 5948	AceView: IGSF1	Ensembl:ENSG00000147255	euGenes: HUgn3547
ECgene: IGSF1	H-InvDB: IGSF1

(According to HUGE)
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HUGE: KIAA0364

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for IGSF1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IGSF1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IGSF1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IGSF1		Antibodies for IGSF1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IGSF1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IGSF1)
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	Custom Service for Rabbit Pab from Full-length Protein

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IGSF1 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for IGSF1

Summaries
for IGSF1

Genomic Location
for IGSF1

Proteins
for IGSF1

Protein Domains/
Families
for IGSF1

Gene Function
for IGSF1

Pathways & Interactions
for IGSF1

Drugs & Compounds
for IGSF1

Transcripts
for IGSF1

Expression
for IGSF1

Orthologs
for IGSF1

Paralogs
for IGSF1

SNPs/Variants
for IGSF1

Disorders & Mutations
for IGSF1

Medical News
for IGSF1

Publications
for IGSF1

Search for IGSF1

Genome Databases showing IGSF1

Other Databases showing IGSF1

Specialized Databases showing IGSF1

Licensable Technologies
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Services
for IGSF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IGSF1 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor IGSF1

Summariesfor IGSF1

Genomic Locationfor IGSF1

Proteinsfor IGSF1

Protein Domains/Familiesfor IGSF1

Gene Functionfor IGSF1

Pathways & Interactionsfor IGSF1

Drugs & Compoundsfor IGSF1

Transcriptsfor IGSF1

Expression for IGSF1

Orthologsfor IGSF1

Paralogsfor IGSF1

SNPs/Variantsfor IGSF1

Disorders & Mutationsfor IGSF1

Medical Newsfor IGSF1

Publicationsfor IGSF1

Search for IGSF1

Genome Databases showing IGSF1

Other Databases showing IGSF1

Specialized Databases showing IGSF1

Licensable Technologiesfor IGSF1

Servicesfor IGSF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IGSF1

Summaries
for IGSF1

Genomic Location
for IGSF1

Proteins
for IGSF1

Protein Domains/
Families
for IGSF1

Gene Function
for IGSF1

Pathways & Interactions
for IGSF1

Drugs & Compounds
for IGSF1

Transcripts
for IGSF1

Expression
for IGSF1

Orthologs
for IGSF1

Paralogs
for IGSF1

SNPs/Variants
for IGSF1

Disorders & Mutations
for IGSF1

Medical News
for IGSF1

Publications
for IGSF1

Licensable Technologies
for IGSF1

Services
for IGSF1