Aliases for IGSF1 Gene
External Ids for IGSF1 Gene
Previous GeneCards Identifiers for IGSF1 Gene
This gene encodes a member of the immunoglobulin-like domain-containing superfamily. Proteins in this superfamily contain varying numbers of immunoglobulin-like domains and are thought to participate in the regulation of interactions between cells. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
GeneCards Summary for IGSF1 Gene
IGSF1 (Immunoglobulin Superfamily Member 1) is a Protein Coding gene. Diseases associated with IGSF1 include Hypothyroidism, Central, And Testicular Enlargement and Hypothyroidism. Among its related pathways are DNA Damage/Telomere Stress Induced Senescence. GO annotations related to this gene include receptor activity and inhibin binding. An important paralog of this gene is LILRB1.
UniProtKB/Swiss-Prot for IGSF1 Gene
Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription.