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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGLV@ Cluster

gene cluster   GIFtS: 23
GCID: GC22U990033

Immunoglobulin Lambda Variable Cluster


  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section


Aliases
IGLV2
Immunoglobulin Lambda Variable Cluster2

External Ids:    Entrez Gene: 35462   OMIM: 1472405   

Export aliases for IGLV@ gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGLV@ Gene:
Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical
heavy chains (see MIM 147100) and 2 identical light chains, either kappa (see MIM 147200) or lambda, joined by
disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together.
The kappa and lambda light chains have no apparent functional differences. Each Ig lambda light chain has an
N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded
by a C region gene (IGLC1; MIM 147220), that provides signaling functions. The lambda light chain V region is
encoded by 2 types of genes: V genes and joining (J) genes (see MIM 147230). Random selection of just 1 gene of
each type to assemble a V region accounts for the great diversity of V regions among Ig molecules. The lambda
light chain locus on chromosome 22 contains approximately 30 functional V genes, followed by approximately 4
functional J genes. Due to polymorphism, the numbers of functional V and J genes differ among individuals
(Janeway et al., 2005).(supplied by OMIM, Apr 2008)

GeneCards Summary for IGLV@ Gene: 
IGLV@ is a gene cluster. Diseases associated with IGLV@ include splenic marginal zone lymphoma, and silicosis, and among its related super-pathways are Immune response Lectin induced complement pathway and Immune response Role of DAP12 receptors in NK cells.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGLV@
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGLV@


Genomic Location:
Chromosome:22   

Entrez Gene cytogenetic band: 22q11.2   

GeneLoc information about chromosome 22        


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:
     Genatlas biochemistry entry for IGLV@:
immunoglobulin,lambda,variable region,including some 36 genes and 33 pseudogenes belonging to 10 families I to
X,organized within 800kb in 3 clusters or 5 regions,A (families II,III,region I),B (families I,V,VII,regions
II,III),C (families IV,VI,VIII,X,regions IV,V)

Phenotypes:
     2 GenomeRNAi human phenotypes for IGLV@:
 Synthetic lethal with Ras  Synthetic lethal with c-Myc af 

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IGLV@ About                                                                                                See pathways by source

SuperPathContained pathways About
1Immune response Lectin induced complement pathway
Immune response Classic complement pathway0.53
Immune response Classical complement pathway0.52
2Immune response Fc epsilon RI pathway
Immune response Fc epsilon RI pathway0.45
Immune response IL-4 signaling pathway0.38
Immune response BCR pathway0.45
Immune response CD16 signaling in NK cells0.32
3Signal transduction IP3 signaling
Signal transduction IP3 signaling0.92
4Immune response NFAT in immune response
Immune response NFAT in immune response0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

5/7 EMD Millipore Pathways for IGLV@ (see all 7)
    Immune response Classic complement pathway
Immune response BCR pathway
Immune response CD16 signaling in NK cells
Signal transduction IP3 signaling
Immune response IL-4 signaling pathway


5/7 GeneGo (Thomson Reuters) Pathways for IGLV@ (see all 7)
    Immune response IL-4 signaling pathway
Immune response Fc epsilon RI pathway
Immune response CD16 signaling in NK cells
Immune response Classical complement pathway
Immune response BCR pathway



IGLV@ for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGLV@

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IGLV@ for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGLV@

1 Novoseek inferred chemical compound relationship for IGLV@ gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
ecori 50.5 2 12679855 (2)

Search CenterWatch for drugs/clinical trials and news about IGLV@

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for IGLV@:

Immunoglobulin lambda variable cluster
Hs.640434  [show with all ESTs]
Unigene Representative Sequence: AK130446
miRNA
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Additional mRNA sequence: 

AB063978.1 AB064000.1 AB064013.1 AB064015.1 AB064017.1 AB064020.1 AB064024.1 AB064037.1 
AB363347.1 AB363354.1 AB363357.1 AB363365.1 AB363384.1 AB649271.1 AF026923.1 AF026924.1 
AF032351.1 AF047202.1 AF052772.1 AF052797.1 AF054643.1 AF054644.1 AF054646.1 AF058057.1 
AF058068.1 AF058069.1 AF060121.1 AF060125.1 AF063701.1 AF063711.1 AF063721.1 AF063742.1 
AF063756.1 AF063760.1 AF063778.1 AF064498.1 AF076200.1 AF076201.1 AF103591.1 AF103598.1 
AF103611.1 AF103617.1 AF103632.1 AF103634.1 AF103636.1 AF103637.1 AF103649.1 AF103653.1 
AF103654.2 AF103661.1 AF103673.1 AF103674.1 AF103704.1 AF103706.1 AF103713.1 AF103718.1 
AF124176.1 AF194579.1 AF194582.1 AF194583.1 AF194584.1 AF194590.1 AF194591.1 AF194595.1 
AF194602.1 AF194603.1 AF194608.1 AF194609.1 AF320843.1 AF462648.1 AF462659.1 AF462662.1 
AF462679.1 AF462680.1 AJ006162.1 AJ132855.1 AJ233717.1 AJ233718.1 AJ233727.1 AJ233728.1 
AJ233734.1 AJ241394.1 AJ298039.1 AJ298040.1 AJ298043.1 AJ298049.1 AJ298050.1 AJ298615.1 
AJ399847.1 AJ408280.1 AJ408287.1 AJ430754.1 AJ430763.1 AJ430764.1 AJ430768.1 AJ430773.1 
AJ496492.1 AJ496502.1 AK130446.1 AM181367.1 AM183998.1 AM183999.1 AM184000.1 AM184064.1 
AY043088.1 AY043106.1 AY043155.1 AY043159.1 AY043162.1 AY062362.1 AY193807.1 AY204760.1 
AY683199.1 AY683200.1 AY683201.1 AY685288.1 AY685292.1 AY685293.1 AY685294.1 AY685362.1 
AY685364.1 AY685365.1 AY685367.1 AY685368.1 AY685370.1 AY685372.1 AY685375.1 AY685381.1 
AY685385.1 AY685386.1 AY685387.1 AY941993.1 AY942087.1 AY942125.1 AY950794.1 AY950800.1 
D84136.1 D84140.1 D84141.1 DQ187496.1 DQ187500.1 DQ187501.1 DQ187535.1 DQ187537.1 
DQ187540.1 DQ187588.1 DQ187724.1 DQ205172.1 DQ322733.1 DQ322771.1 DQ322787.1 DQ322788.1 
DQ322869.1 DQ490733.1 EF589389.1 EF589397.1 EF589412.1 EF589416.1 EF589447.1 EF589453.1 
EF589467.1 EF589506.1 EF589521.1 EF589530.1 EF589541.1 EF589560.1 EF589562.1 EF589566.1 
EU599348.1 EU599349.1 EU599351.1 EU599354.1 FJ385437.1 HM996015.1 HM996270.1 HQ129867.1 
HQ172111.1 HQ172115.1 HQ172126.1 HQ172133.1 HQ172141.1 HQ172143.1 HQ890357.1 JF740067.1 
JF740072.1 JQ301913.1 KC417414.1 L03628.1 L03630.1 L03680.1 L21959.1 L22483.1 
L25295.1 L38432.1 M12025.1 S80758.1 U36537.1 U36538.1 U36540.1 U36541.1 
U38335.1 U38336.1 U38338.1 U38339.1 U38341.1 U38342.1 U38343.1 U38344.1 
U38345.1 U38346.1 U38662.1 U63213.1 U70234.1 U76676.1 U97248.1 X57823.1 
X87892.1 X99990.1 Y08149.1 Y08198.1 Y09387.1 Y12721.1 Y17956.1 Z18331.1 
Z18823.1 Z18844.1 

24/134 DOTS entries (see all 134):

DT.95068785  DT.40267692  DT.87079052  DT.91830905  DT.95363045  DT.120676987  DT.120677966  DT.91683758 
DT.92006280  DT.95090606  DT.100885135  DT.100046533  DT.100046628  DT.100885115  DT.120677017  DT.91753654 
DT.92029152  DT.95284511  DT.91934757  DT.100046938  DT.120676837  DT.420912  DT.86855867  DT.91720675 

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for IGLV@:none

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --


Genevestigator expression for IGLV@

SOURCE GeneReport for Unigene cluster: Hs.640434
    SABiosciences Custom PCR Arrays for IGLV@
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGLV@

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Locus Specific Mutation Databases (LSDB): IGLV@
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing IGLV@
DNA2.0 Custom Variant and Variant Library Synthesis for IGLV@

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 147240    OMIM disorders: --

14 diseases for IGLV@:    About MalaCards
splenic marginal zone lymphoma    silicosis    poems syndrome    multiple myeloma
chronic lymphocytic leukemia    dilated cardiomyopathy    amyloidosis    systemic lupus erythematosus
burkitt's lymphoma    myeloma    lupus erythematosus    rheumatoid arthritis
arthritis    leukemia


IGLV@ for disorders           About GeneDecksing

Genetic Association Database (GAD): IGLV@
Human Genome Epidemiology (HuGE) Navigator: IGLV@ (2 documents)

Export disorders for IGLV@ gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGLV@ gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with IGLV@)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Immunoglobulin light chain variable (V) region genes influence clinical presentation and outcome in light chain-associated amyloidosis (AL). (PubMed id 12515719)1, 4 Abraham R.S....Fonseca R. (2003)
  2. Association between EcoRI fragment-length polymorphism of the immunoglobulin lambda variable 8 (IGLV8) gene family with rheumatoid arthritis and systemic lupus erythematosus. (PubMed id 11285465)1, 4 Queiroz R.G....Passos G.A. (2001)
  3. Biased immunoglobulin light chain use in the Chlamydop hila psittaci negative ocular adnexal marginal zone lymphomas. (PubMed id 23418012)1 Zhu D....Lossos I.S. (2013)
  4. Characterization of immunoglobulin l light chain varia ble region (IGLV) gene and its relationship with clinical features in patients w ith POEMS syndrome. (PubMed id 22453306)1 Li J....Zhou D.B. (2012)
  5. Structural repertoire of immunoglobulin I> light chain s. (PubMed id 21365679)1 Chailyan A....Tramontano A. (2011)
  6. Chromosomal orientation of the lambda light chain locus: V lambda is proximal to C lambda in 22q11. (PubMed id 3923432)1 Emanuel B.S....Croce C.M. (1985)
  7. Burkitt lymphoma cell line carrying a variant translocation creates new DNA at the breakpoint and violates the hierarchy of immunoglobulin gene rearrangement. (PubMed id 3018508)1 Denny C.T....Kirsch I.R. (1985)
  8. Immunoglobulin V-lambda transcription profiling of systemic lupus erythematosus patients reveals biased usage of genes located near the Jlambda-Clambda segments. (PubMed id 15049783)9 Trevisan G.L....Passos G.A. (2004)
  9. Characterization of a lymphoblastoid line deleted for lambda immunglobulin genes. (PubMed id 7759132)9 Hough C.A....Holden J.J. (1995)
  10. Definition of the human immunoglobulin variable lambd a (IGLV) gene subgroups. (PubMed id 2114999)9 Chuchana P....Lefranc M.P. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3546 euGenes: HUgn3546

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGLV@ Pharmacogenomics, SNPs, Pathways
IMGT entry for IGLV@ The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGLV@ gene:
Search GeneIP for patents involving IGLV@

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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 inGenious Targeting Laboratory - Custom generated mouse model solutions for IGLV@
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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