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Aliases for IGLV@ Gene

Aliases for IGLV@ Gene

  • Immunoglobulin Lambda Variable Cluster 3
  • Immunoglobulin Lambda Variable Region Gene Cluster 3
  • Variable Region Of Lambda Light Chains 3
  • Immunoglobulin Lambda Variable Group 3
  • IGLV 3

External Ids for IGLV@ Gene

Summaries for IGLV@ Gene

Entrez Gene Summary for IGLV@ Gene

  • Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains (see MIM 147100) and 2 identical light chains, either kappa (see MIM 147200) or lambda, joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. The kappa and lambda light chains have no apparent functional differences. Each Ig lambda light chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by a C region gene (IGLC1; MIM 147220), that provides signaling functions. The lambda light chain V region is encoded by 2 types of genes: V genes and joining (J) genes (see MIM 147230). Random selection of just 1 gene of each type to assemble a V region accounts for the great diversity of V regions among Ig molecules. The lambda light chain locus on chromosome 22 contains approximately 30 functional V genes, followed by approximately 4 functional J genes. Due to polymorphism, the numbers of functional V and J genes differ among individuals (Janeway et al., 2005).[supplied by OMIM, Apr 2008]

GeneCards Summary for IGLV@ Gene

IGLV@ (Immunoglobulin Lambda Variable Cluster) is a Gene Cluster. Among its related pathways are Immune response Fc epsilon RI pathway and Development Angiotensin activation of ERK.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLV@ Gene

Genomics for IGLV@ Gene

Genomic Location for IGLV@ Gene

Unknown strand

Genomic View for IGLV@ Gene

Cytogenetic band:
GeneLoc Logo Gene Density

No data available for Regulatory Elements and RefSeq DNA sequence for IGLV@ Gene

Proteins for IGLV@ Gene

Post-translational modifications for IGLV@ Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGLV@ Gene

Domains & Families for IGLV@ Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGLV@ Gene

Function for IGLV@ Gene

Molecular function for IGLV@ Gene

GENATLAS Biochemistry:
immunoglobulin,lambda,variable region,including some 36 genes and 33 pseudogenes belonging to 10 families I to X,organized within 800kb in 3 clusters or 5 regions,A (families II,III,region I),B (families I,V,VII,regions II,III),C (families IV,VI,VIII,X,regions IV,V)

Phenotypes for IGLV@ Gene

genes like me logo Genes that share phenotypes with IGLV@: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLV@ Gene

Localization for IGLV@ Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for IGLV@ Gene

Drugs & Compounds for IGLV@ Gene

(1) Additional Compounds for IGLV@ Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGLV@: view

Expression for IGLV@ Gene

SOURCE GeneReport for Unigene cluster for IGLV@ Gene Hs.640434

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IGLV@ Gene

Orthologs for IGLV@ Gene

No data available for Orthologs and Evolution for IGLV@ Gene

Paralogs for IGLV@ Gene

No data available for Paralogs for IGLV@ Gene

Variants for IGLV@ Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for IGLV@ Gene

Disorders for IGLV@ Gene

Relevant External Links for IGLV@

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for IGLV@ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGLV@ Gene

Publications for IGLV@ Gene

  1. Immunoglobulin light chain variable (V) region genes influence clinical presentation and outcome in light chain-associated amyloidosis (AL). (PMID: 12515719) Abraham R.S. … Fonseca R. (Blood 2003) 3 48 67
  2. Biased immunoglobulin light chain use in the Chlamydophila psittaci negative ocular adnexal marginal zone lymphomas. (PMID: 23418012) Zhu D. … Lossos I.S. (Am. J. Hematol. 2013) 3
  3. Characterization of immunoglobulin I> light chain variable region (IGLV) gene and its relationship with clinical features in patients with POEMS syndrome. (PMID: 22453306) Li J. … Zhou D.B. (Ann. Hematol. 2012) 3
  4. Structural repertoire of immunoglobulin I> light chains. (PMID: 21365679) Chailyan A. … Tramontano A. (Proteins 2011) 3
  5. Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3. (PMID: 17675554) Widhopf G.F. … Kipps T.J. (Blood 2008) 23

Products for IGLV@ Gene

Sources for IGLV@ Gene