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Aliases for IGLV8-61 Gene

Aliases for IGLV8-61 Gene

  • Immunoglobulin Lambda Variable 8-61 2 3 5
  • IGLV861 3
  • V3-4 3

External Ids for IGLV8-61 Gene

Previous GeneCards Identifiers for IGLV8-61 Gene

  • GC22U990126
  • GC22P020706
  • GC22P020707
  • GC22P020777
  • GC22P020708
  • GC22P020783
  • GC22P022454

Summaries for IGLV8-61 Gene

GeneCards Summary for IGLV8-61 Gene

IGLV8-61 (Immunoglobulin Lambda Variable 8-61) is a Protein Coding gene. An important paralog of this gene is IGLV7-43.

UniProtKB/Swiss-Prot for IGLV8-61 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLV8-61 Gene

Genomics for IGLV8-61 Gene

Regulatory Elements for IGLV8-61 Gene

Enhancers for IGLV8-61 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G022098 1.1 Ensembl ENCODE 18.3 +0.2 237 1.6 TBP PKNOX1 CBX3 YBX1 CBX5 RELB IKZF2 KLF13 MCM3 GATAD2B IGLV8-61 ENSG00000225741
GH22G022165 1.6 Ensembl ENCODE dbSUPER 7 +68.5 68456 4.2 PKNOX1 FOXA2 CREB3L1 ARNT SIN3A ARID4B ZNF766 CBX5 ZNF207 FOS IGLV4-60 IGLV8-61 PIR40060 ENSG00000227710
GH22G022109 1.2 Ensembl ENCODE 8 +12.8 12778 3.2 HDGF HNRNPUL1 WRNIP1 ZNF2 GATA2 ZNF143 FOS ZNF263 CAVIN1 JUNB TOP3B YPEL1 ABHD17AP5 IGLV8-61 LOC102724653 PIR46289
GH22G022195 1.3 ENCODE dbSUPER 4.6 +97.2 97184 1.0 HDGF PKNOX1 ATF1 CREB3L1 ARNT FEZF1 ZNF2 TCF12 GATA2 ZNF143 VPREB1 IGLV4-60 IGLV8-61 IGLV6-57 IGLVI-56
GH22G022170 0.7 dbSUPER 4.9 +72.3 72282 1.7 RING1 CTCF ESRRA KLF1 HDAC6 GTF2E2 RAD21 ZNF507 SNRNP70 NR4A1 IGLV4-60 IGLV5-52 ENSG00000234630 ENSG00000272779 IGLV8-61 ENSG00000227710 GC22M022170
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGLV8-61 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGLV8-61 Gene

Chromosome:
22
Start:
22,098,700 bp from pter
End:
22,099,212 bp from pter
Size:
513 bases
Orientation:
Plus strand

Genomic View for IGLV8-61 Gene

Genes around IGLV8-61 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLV8-61 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLV8-61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLV8-61 Gene

Proteins for IGLV8-61 Gene

  • Protein details for IGLV8-61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A075B6I0-LV861_HUMAN
    Recommended name:
    Immunoglobulin lambda variable 8-61
    Protein Accession:
    A0A075B6I0

    Protein attributes for IGLV8-61 Gene

    Size:
    122 amino acids
    Molecular mass:
    12814 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGLV8-61 Gene

Post-translational modifications for IGLV8-61 Gene

No Post-translational modifications

Other Protein References for IGLV8-61 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLV8-61 Gene

Domains & Families for IGLV8-61 Gene

Gene Families for IGLV8-61 Gene

Protein Domains for IGLV8-61 Gene

Suggested Antigen Peptide Sequences for IGLV8-61 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGLV8-61: view

No data available for UniProtKB/Swiss-Prot for IGLV8-61 Gene

Function for IGLV8-61 Gene

Molecular function for IGLV8-61 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGLV8-61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
genes like me logo Genes that share ontologies with IGLV8-61: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLV8-61 Gene

Localization for IGLV8-61 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLV8-61 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLV8-61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGLV8-61: view

No data available for Subcellular locations from COMPARTMENTS for IGLV8-61 Gene

Pathways & Interactions for IGLV8-61 Gene

SuperPathways for IGLV8-61 Gene

No Data Available

Interacting Proteins for IGLV8-61 Gene

Gene Ontology (GO) - Biological Process for IGLV8-61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002377 immunoglobulin production IBA --
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with IGLV8-61: view

No data available for Pathways by source and SIGNOR curated interactions for IGLV8-61 Gene

Drugs & Compounds for IGLV8-61 Gene

No Compound Related Data Available

Transcripts for IGLV8-61 Gene

mRNA/cDNA for IGLV8-61 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGLV8-61 Gene

No ASD Table

Relevant External Links for IGLV8-61 Gene

GeneLoc Exon Structure for
IGLV8-61
ECgene alternative splicing isoforms for
IGLV8-61

Expression for IGLV8-61 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGLV8-61 Gene

mRNA differential expression in normal tissues according to GTEx for IGLV8-61 Gene

This gene is overexpressed in Spleen (x12.5), Colon - Transverse (x8.7), Small Intestine - Terminal Ileum (x7.7), and Minor Salivary Gland (x5.9).

Protein differential expression in normal tissues from HIPED for IGLV8-61 Gene

This gene is overexpressed in Urine (41.1) and Skin (27.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLV8-61 Gene



Protein tissue co-expression partners for IGLV8-61 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGLV8-61: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLV8-61 Gene

Orthologs for IGLV8-61 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLV8-61 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 75 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
-- 35
  • 66 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 57 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
OneToMany
Species where no ortholog for IGLV8-61 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGLV8-61 Gene

ENSEMBL:
Gene Tree for IGLV8-61 (if available)
TreeFam:
Gene Tree for IGLV8-61 (if available)

Paralogs for IGLV8-61 Gene

Pseudogenes.org Pseudogenes for IGLV8-61 Gene

genes like me logo Genes that share paralogs with IGLV8-61: view

Variants for IGLV8-61 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLV8-61 Gene

LV861_HUMAN-A0A075B6I0
There are several alleles. The sequence shown is that of IMGT allele IGLV8-61*01.

Relevant External Links for IGLV8-61 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLV8-61

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLV8-61 Gene

Disorders for IGLV8-61 Gene

No disorders were found for IGLV8-61 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGLV8-61 Gene

Publications for IGLV8-61 Gene

  1. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  2. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  3. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  4. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64
  5. Recognition of immunoglobulins by Fcgamma receptors. (PMID: 11955599) Radaev S. … Sun P. (Mol. Immunol. 2002) 3 64

Products for IGLV8-61 Gene

Sources for IGLV8-61 Gene

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