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Aliases for IGLV7-43 Gene

Aliases for IGLV7-43 Gene

  • Immunoglobulin Lambda Variable 7-43 2 3 5
  • Ig Lambda Chain V Region 4A 4
  • IGLV743 3
  • V3-2 3

External Ids for IGLV7-43 Gene

Previous GeneCards Identifiers for IGLV7-43 Gene

  • GC22U990128
  • GC22P021073
  • GC22P021079
  • GC22P022749

Summaries for IGLV7-43 Gene

GeneCards Summary for IGLV7-43 Gene

IGLV7-43 (Immunoglobulin Lambda Variable 7-43) is a Protein Coding gene. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLV7-46.

UniProtKB/Swiss-Prot for IGLV7-43 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLV7-43 Gene

Genomics for IGLV7-43 Gene

Regulatory Elements for IGLV7-43 Gene

Enhancers for IGLV7-43 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G022926 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.6 +537.1 537093 10.9 HDGF PKNOX1 ATF1 WRNIP1 SIN3A GATA2 ELK1 ZNF143 ZMIZ1 ZNF548 IGLV3-4 IGLV2-5 ZNF70 IGLV5-52 ENSG00000272779 IGLC2 IGLC7 IGLV7-43 IGLL5 IGLC3
GH22G022909 0.9 dbSUPER 7.1 +515.8 515782 2.4 HNRNPUL1 ATF1 TBL1XR1 KLF17 INSM2 GLIS2 ZNF366 SCRT2 FOS CREM IGLC2 IGLV7-43 IGLC7 IGLC4 IGLJ4
GH22G022923 0.7 dbSUPER 5.9 +529.2 529185 1.1 SMARCA5 HNRNPUL1 HDAC1 KLF1 STAT1 MCM3 TSC22D4 MCM5 YBX1 ZBTB7A IGLC2 IGLV7-43 IGLC3 IGLC7 LOC105372947
GH22G022924 0.8 FANTOM5 dbSUPER 5.1 +530.0 530044 0.2 ETS2 MCM7 SIN3A ID3 RSPH14 IGLV7-43 ZNF280B LOC105372947 PIR39792
GH22G022887 0.7 dbSUPER 4.5 +493.7 493657 2.9 HNRNPUL1 HDAC1 KLF1 HDAC6 TBL1XR1 REST ZIC2 ZNF121 RUNX1 HDAC2 IGLV5-52 ENSG00000272779 IGLC3 IGLV7-43 IGLL5 IGLJ1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGLV7-43 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGLV7-43 Gene

Chromosome:
22
Start:
22,395,018 bp from pter
End:
22,395,489 bp from pter
Size:
472 bases
Orientation:
Plus strand

Genomic View for IGLV7-43 Gene

Genes around IGLV7-43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLV7-43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLV7-43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLV7-43 Gene

Proteins for IGLV7-43 Gene

  • Protein details for IGLV7-43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04211-LV743_HUMAN
    Recommended name:
    Immunoglobulin lambda variable 7-43
    Protein Accession:
    P04211
    Secondary Accessions:
    • A0A0B4J1U2

    Protein attributes for IGLV7-43 Gene

    Size:
    117 amino acids
    Molecular mass:
    12451 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGLV7-43 Gene

Post-translational modifications for IGLV7-43 Gene

No Post-translational modifications

Other Protein References for IGLV7-43 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLV7-43 Gene

Domains & Families for IGLV7-43 Gene

Gene Families for IGLV7-43 Gene

Protein Domains for IGLV7-43 Gene

Suggested Antigen Peptide Sequences for IGLV7-43 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGLV7-43: view

No data available for UniProtKB/Swiss-Prot for IGLV7-43 Gene

Function for IGLV7-43 Gene

Molecular function for IGLV7-43 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGLV7-43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 6091030
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGLV7-43: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLV7-43 Gene

Localization for IGLV7-43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLV7-43 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLV7-43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGLV7-43: view

No data available for Subcellular locations from COMPARTMENTS for IGLV7-43 Gene

Pathways & Interactions for IGLV7-43 Gene

SuperPathways for IGLV7-43 Gene

No Data Available

Interacting Proteins for IGLV7-43 Gene

Selected Interacting proteins: P04211-LV743_HUMAN for IGLV7-43 Gene via IID

Symbol External ID(s) Details
IGHV1-46

Gene Ontology (GO) - Biological Process for IGLV7-43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 6091030
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGLV7-43: view

No data available for Pathways by source and SIGNOR curated interactions for IGLV7-43 Gene

Drugs & Compounds for IGLV7-43 Gene

No Compound Related Data Available

Transcripts for IGLV7-43 Gene

mRNA/cDNA for IGLV7-43 Gene

(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGLV7-43 Gene

No ASD Table

Relevant External Links for IGLV7-43 Gene

GeneLoc Exon Structure for
IGLV7-43
ECgene alternative splicing isoforms for
IGLV7-43

Expression for IGLV7-43 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGLV7-43 Gene

mRNA differential expression in normal tissues according to GTEx for IGLV7-43 Gene

This gene is overexpressed in Spleen (x15.5), Small Intestine - Terminal Ileum (x7.8), Colon - Transverse (x7.6), Minor Salivary Gland (x6.1), and Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for IGLV7-43 Gene

This gene is overexpressed in Skin (62.5) and Urine (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLV7-43 Gene



Protein tissue co-expression partners for IGLV7-43 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGLV7-43: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLV7-43 Gene

Orthologs for IGLV7-43 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLV7-43 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 62 (a)
ManyToMany
-- 35
  • 60 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 33 (a)
ManyToMany
Species where no ortholog for IGLV7-43 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGLV7-43 Gene

ENSEMBL:
Gene Tree for IGLV7-43 (if available)
TreeFam:
Gene Tree for IGLV7-43 (if available)

Paralogs for IGLV7-43 Gene

Pseudogenes.org Pseudogenes for IGLV7-43 Gene

genes like me logo Genes that share paralogs with IGLV7-43: view

Variants for IGLV7-43 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLV7-43 Gene

LV743_HUMAN-P04211
There are several alleles. The sequence shown is that of IMGT allele IGLV7-43*01.

Relevant External Links for IGLV7-43 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLV7-43

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLV7-43 Gene

Disorders for IGLV7-43 Gene

No disorders were found for IGLV7-43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGLV7-43 Gene

Publications for IGLV7-43 Gene

  1. The isolation of a human Ig V lambda gene from a recombinant library of chromosome 22 and estimation of its copy number. (PMID: 6091030) Anderson M.L.M. … Young B.D. (Nucleic Acids Res. 1984) 3 4 64
  2. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  3. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  4. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  5. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64

Products for IGLV7-43 Gene

Sources for IGLV7-43 Gene

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