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IGLV7-43 Gene

protein-coding   GIFtS: 28
GCID: GC22P022749

Immunoglobulin Lambda Variable 7-43

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immunoglobulin Lambda Variable 7-431 2
V3-22 4
IGLV7432

External Ids:    HGNC: 59291   Entrez Gene: 287762   Ensembl: ENSG000002116527   UniProtKB: Q5NV804   

Export aliases for IGLV7-43 gene to outside databases

Previous GC identifers: GC22U990128 GC22P021073 GC22P021079


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IGLV7-43 Gene:
IGLV7-43 (immunoglobulin lambda variable 7-43) is a protein-coding gene. Diseases associated with IGLV7-43 include breast medullary carcinoma, and amyloidosis. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLV2-18.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for IGLV7-43
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGLV7-43


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

IGLV7-43 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLV7-43 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P022749:  view genomic region     (about GC identifiers)

Start:
22,749,356 bp from pter      End:
22,749,827 bp from pter
Size:
472 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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UniProtKB/TrEMBL: Q5NV80 (See protein sequence)
Recommended Name: V3-2 protein  
Size: 98 amino acids; 10368 Da

Explore proteomics data for IGLV7-43 at MOPED


See IGLV7-43 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000374833  
Reactome Protein details: Q5NV80

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
IGL: Immunoglobulins / IGL locus

4 InterPro protein domains:
 IPR003596 Ig_V-set_subgr
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set
 IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry Q5NV80

ProtoNet protein and cluster: Q5NV80

1 Blocks protein domain: IPB003596 Immunoglobulin V-type


IGLV7-43 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding NAS6091030
GO:0005515protein binding ----
     
IGLV7-43 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
plasma membrane4

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005886plasma membrane TAS--

IGLV7-43 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IGLV7-43 About   (see all 8)  
See pathways by source

SuperPathContained pathways About
1Creation of C4 and C2 activators
Creation of C4 and C2 activators0.85
FCGR activation0.54
Initial triggering of complement0.85
Role of phospholipids in phagocytosis0.53
Classical antibody-mediated complement activation0.82
FCERI mediated NF-kB activation0.32
Complement cascade0.68
2Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
FCERI mediated Ca+2 mobilization0.47
FCERI mediated MAPK activation0.45
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.47
3Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation0.77
Fcgamma receptor (FCGR) dependent phagocytosis0.77
4PI-3K cascade
Role of LAT2/NTAL/LAB on calcium mobilization0.80
Fc epsilon receptor (FCERI) signaling0.64
5Binding and Uptake of Ligands by Scavenger Receptors
Binding and Uptake of Ligands by Scavenger Receptors0.53
Scavenging of Heme from Plasma0.53

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


Selected Reactome Pathways for IGLV7-43 (see all 12)
    FCERI mediated MAPK activation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
FCERI mediated NF-kB activation
FCGR activation
Scavenging of heme from plasma



IGLV7-43 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGLV7-43
Interactions:

    Search GeneGlobe Interaction Network for IGLV7-43

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for IGLV7-43 (ENSP000003748334) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IGHV1-18ENSP000003750144STRING: ENSP00000375014
IGHV1-69ENSP000003750424STRING: ENSP00000375042
About this table

Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS6091030
GO:0006956complement activation TAS--
GO:0006958complement activation, classical pathway TAS--
GO:0038095Fc-epsilon receptor signaling pathway TAS--
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--

IGLV7-43 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for IGLV7-43



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390298
miRNA
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1 AceView cDNA sequence:

AF047274 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IGLV7-43 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGLV7-43 Expression
About this image

IGLV7-43 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IGLV7-43 Protein Expression
    Custom PCR Arrays for IGLV7-43
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for IGLV7-43 gene from Selected species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
oppossum
(Monodelphis domestica)
Mammalia --
--
Uncharacterized protein
62(a)
60(a)
many ↔ many
many ↔ many
3(525423484-525424024)
3(525413116-525413409)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
33(a)
many ↔ many
GL343282.1(546703-551441)


ENSEMBL Gene Tree for IGLV7-43 (if available)
TreeFam Gene Tree for IGLV7-43 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IGLV7-43 gene
IGLV2-182  IGLV3-92  IGLV3-122  IGLV3-192  IGLV1-502  IGLV3-252  IGLV2-82  IGLV1-512  
IGLV10-542  IGLV3-222  IGLV2-232  IGLV8-612  IGLV7-462  IGLV3-272  IGLV1-472  IGLV2-142  
IGLV1-402  IGLV3-12  IGLV2-332  IGLV3-322  IGLV6-572  IGLV1-442  IGLV3-212  IGLV2-112  
IGLV3-162  IGLV3-102  IGLV1-362  
Selected SIMAP similar genes for IGLV7-43 using alignment to 1 protein entry:     Q5NV80_HUMAN(see all similar genes):
IGLV7-46    DKFZp781M0386    IGLV8-61    V1-18    V1-22    IGLV1-40
IGLV2-11    IGLV1-44    V1-17    V1-19    V1-2    IGLV2-18
V1-4    VL6    IGL@    A30    HuC4lambda Vlambda    IGKV1-5

IGLV7-43 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for IGLV7-43
PGOHUM00000246444 PGOHUM00000246474


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing IGLV7-43
DNA2.0 Custom Variant and Variant Library Synthesis for IGLV7-43

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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3 diseases for IGLV7-43:    
About MalaCards
breast medullary carcinoma    amyloidosis    myeloma

2 diseases from the University of Copenhagen DISEASES database for IGLV7-43:
Myeloma     Amyloidosis

IGLV7-43 for disorders           About GeneDecksing


Export disorders for IGLV7-43 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IGLV7-43 gene integrated from 10 sources:
(articles sorted by number of sources associating them with IGLV7-43)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (Mol. Immunol. 2002)
  2. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1 Kawasaki K.... Shimizu N. (Genome Res. 1997)
  3. First genomic sequence of a human Ig variable lambda gene belonging to subgroup I. Functional genes, pseudogenes and vestigial sequences are interspersed in the IGLV locus. (PubMed id 2499871)1 Alexandre D....Lefranc M.P. (Nucleic Acids Res. 1989)
  4. The isolation of a human Ig V lambda gene from a recombinant library of chromosome 22 and estimation of its copy number. (PubMed id 6091030)1 Anderson M.L.M.... Young B.D. (Nucleic Acids Res. 1984)
  5. Activation of C1r by proteolytic cleavage. (PubMed id 1249422)1 Ziccardi R.J. and Cooper N.R. (J. Immunol. 1976)
  6. Physicochemical and functional characterization of the C1r subunit of the first complement component. (PubMed id 814163)1 Ziccardi R.J. and Cooper N.R. (J. Immunol. 1976)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 28776 HGNC: 5929 AceView: IGLV7-43 Ensembl:ENSG00000211652 euGenes: HUgn28776
ECgene: IGLV7-43 H-InvDB: IGLV7-43

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IGLV7-43 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGLV7-43 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IGLV7-43 gene:
Search GeneIP for patents involving IGLV7-43

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Browse SwitchGear 3'UTR luciferase reporter plasmids for IGLV7-43
 Browse SwitchGear Promoter luciferase reporter plasmids for IGLV7-43
 Search ThermoFisher Antibodies for IGLV7-43
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGLV7-43
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IGLV7-43
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IGLV7-43
 Search LSBio for Antibodies for IGLV7-43
Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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