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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGLV7-43 Gene

protein-coding   GIFtS: 28
GCID: GC22P022749

immunoglobulin lambda variable 7-43
 Explore 6 diseases affiliated with
IGLV7-43 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGLV7-43    

Aliases
for IGLV7-43 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immunoglobulin Lambda Variable 7-431 2
V3-22 4
IGLV7432

External Ids:    HGNC: 59291   Entrez Gene: 287762   Ensembl: ENSG000002116527   UniProtKB: Q5NV804   

Export aliases for IGLV7-43 gene to outside databases

Previous GC identifers: GC22U990128 GC22P021073 GC22P021079


Summaries
for IGLV7-43 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for IGLV7-43 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGLV7-43
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGLV7-43

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGLV7-43


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

IGLV7-43 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLV7-43 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P022749:  view genomic region     (about GC identifiers)

Start:
 22,749,356 bp from pter      End:
 22,749,827 bp from pter
Size:
 472 bases      Orientation:
 plus strand

Proteins
for IGLV7-43 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/TrEMBL: Q5NV80 (See protein sequence)
Recommended Name: V3-2 protein  
Size: 98 amino acids; 10368 Da

IGLV7-43 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).


ENSEMBL proteins: 
 ENSP00000374833  
Reactome Protein details: Q5NV80
Human Recombinant Protein Products: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005886plasma membrane TAS--


IGLV7-43 for ontologies           About GeneDecksing



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Protein Domains /
Families
for IGLV7-43 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
IGLV7-43 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR007110 Ig-like_dom
 IPR003596 Ig_V-set_subgr
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry Q5NV80

ProtoNet protein and cluster: Q5NV80

1 Blocks protein family: IPB003596 Immunoglobulin V-type


Function
for IGLV7-43 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
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In Situ Assay
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding NAS6091030


IGLV7-43 for ontologies           About GeneDecksing



Pathways & Interactions
for IGLV7-43 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Cleavage of Alpha-1-Microglobulin
8/11 pathways (see all 11)
Cleavage of Alpha-1-Microglobulin1.00
FCGR activation0.65
Binding and Uptake of Ligands by Scavenger Receptors0.79
Initial triggering of complement0.60
Scavenging of Heme from Plasma0.79
Role of phospholipids in phagocytosis0.53
Classical antibody-mediated complement activation0.74
Complement cascade0.47
2Immune System
Immune System1.00
Innate Immune System0.46
Adaptive Immune System0.59
3Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation1.00
Fcgamma receptor (FCGR) dependent phagocytosis0.80
Role of myosins in phagosome formation0.80

Pathway sources
See GeneCards unified pathways
Show all pathways


5/17        Reactome Pathways for IGLV7-43 (see all 17)
    Role of myosins in phagosome formation
FCGR activation
Cleavage of Alpha-1-Microglobulin
Sequestering and phosphorylation Fc gamma receptors in the lipid rafts
Role of phospholipids in phagocytosis



IGLV7-43 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGLV7-43

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS6091030
GO:0006956complement activation TAS--
GO:0006958complement activation, classical pathway TAS--
GO:0045087innate immune response TAS--
GO:0050776regulation of immune response TAS--


IGLV7-43 for ontologies           About GeneDecksing



Drugs & Compounds
for IGLV7-43 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGLV7-43
Search CenterWatch for drugs/clinical trials and news about IGLV7-43 

Transcripts
for IGLV7-43 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390298

miRNA
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Inhib. RNA
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Clone
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Primer
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  Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGLV7-43

1 AceView cDNA sequence:

AF047274 

GeneLoc Exon Structure


Expression
for IGLV7-43 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGLV7-43 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image
See IGLV7-43 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGLV7-43
    SABiosciences Custom PCR Arrays for IGLV7-43
Primer
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In Situ
Assay Products: 
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Orthologs
for IGLV7-43 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for IGLV7-43 gene from 1/3 species (see all 3)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
lizard
(Anolis carolinensis)		 Reptilia --
 --
 42(a)
 1 → many
 GL343282.1(512019-512757)


ENSEMBL Gene Tree for IGLV7-43 (if available)
TreeFam Gene Tree for IGLV7-43 (if available) 

Paralogs
for IGLV7-43 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGLV7-43 gene
IGLV3-122  IGLV2-182  IGLV3-192  IGLV1-512  IGLV9-492  IGLV3-222  IGLV2-232  IGLV8-612  
IGLV4-602  IGLV1-472  IGLV2-142  IGLV2-332  IGLV3-322  IGLV5-522  IGLV1-442  IGLV3-212  
IGLV2-112  IGLV3-102  IGLV3-92  IGLV5-372  IGLV1-502  VPREB32  IGLV3-252  IGLV2-82  
IGLV10-542  IGLV5-452  IGLV3-272  IGLV7-462  IGLV1-402  IGLV11-552  IGLV5-482  IGLV3-12  
IGLV4-32  VPREB12  IGLV6-572  IGLV3-162  IGLV4-692  IGLV1-362  
18/71 SIMAP similar genes for IGLV7-43 using alignment to 1 protein entry:     Q5NV80_HUMAN(see all similar genes):
IGLV7-46    DKFZp781M0386    IGLV8-61    V1-18    V1-22    IGLV1-40
IGLV2-11    IGLV1-44    V1-17    V1-19    V1-2    IGLV2-18
V1-4    VL6    IGL@    A30    HuC4lambda Vlambda    IGKV1-5

IGLV7-43 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for IGLV7-43
PGOHUM00000246444 PGOHUM00000246474


Genomic Variants
for IGLV7-43 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGLV7-43
DNA2.0 Custom Variant and Variant Library Synthesis for IGLV7-43

Disorders / Diseases
for IGLV7-43 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
IGLV7-43 for disorders           About GeneDecksing

6 diseases for IGLV7-43:    About MalaCards
systemic lupus erythematosus    breast medullary carcinoma    lupus erythematosus    amyloidosis
myeloma    carcinoma

2 diseases from the University of Copenhagen DISEASES database for IGLV7-43:
Myeloma     Amyloidosis

Export disorders for IGLV7-43 gene to outside databases

Publications
for IGLV7-43 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGLV7-43 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGLV7-43)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (2002)
  2. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1 Kawasaki K....Shimizu N. (1997)
  3. First genomic sequence of a human Ig variable lambda gene belonging to subgroup I. Functional genes, pseudogenes and vestigial sequences are interspersed in the IGLV locus. (PubMed id 2499871)1 Alexandre D....Lefranc M.P. (1989)
  4. The isolation of a human Ig V lambda gene from a recombinant library of chromosome 22 and estimation of its copy number. (PubMed id 6091030)1 Anderson M.L.M.... Young B.D. (1984)
  5. Activation of C1r by proteolytic cleavage. (PubMed id 1249422)1 Ziccardi R.J. and Cooper N.R. (1976)
  6. Physicochemical and functional characterization of the C1r subunit of the first complement component. (PubMed id 814163)1 Ziccardi R.J. and Cooper N.R. (1976)

External Searches for IGLV7-43 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGLV7-43 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28776 HGNC: 5929 AceView: IGLV7-43 Ensembl:ENSG00000211652 euGenes: HUgn28776
ECgene: IGLV7-43 H-InvDB: IGLV7-43

Other Databases showing IGLV7-43 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGLV7-43 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGLV7-43 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGLV7-43 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGLV7-43 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGLV7-43 gene:
Search GeneIP for patents involving IGLV7-43

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
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About This Section

 
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 Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGLV7-43
 Browse SwitchGear 3'UTR luciferase reporter plasmids for IGLV7-43
 Browse SwitchGear Promoter luciferase reporter plasmids for IGLV7-43
 Search ThermoFisher Antibodies for IGLV7-43
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGLV7-43
       
GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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VWF
(GIFTS: 73)
von Willebrand factor
GIFtS Group
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