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Aliases for IGLV6-57 Gene

Aliases for IGLV6-57 Gene

  • Immunoglobulin Lambda Variable 6-57 2 3 5
  • Ig Lambda Chain V-VI Region AR 3 4
  • Amyloid Lambda 6 Light Chain Variable Region PIP 3
  • Amyloid Lambda 6 Light Chain Variable Region SAR 3
  • Ig Lambda Chain V-VI Region NIG-48 4
  • Ig Lambda Chain V-VI Region EB4 4
  • Ig Lambda Chain V-VI Region SUT 4
  • Ig Lambda Chain V-VI Region WLT 4
  • IGLV657 3
  • V1-22 3

External Ids for IGLV6-57 Gene

Previous GeneCards Identifiers for IGLV6-57 Gene

  • GC22U990130
  • GC22P020874
  • GC22P020881
  • GC22P022550

Summaries for IGLV6-57 Gene

GeneCards Summary for IGLV6-57 Gene

IGLV6-57 (Immunoglobulin Lambda Variable 6-57) is a Protein Coding gene. An important paralog of this gene is IGLV1-40.

UniProtKB/Swiss-Prot for IGLV6-57 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLV6-57 Gene

Genomics for IGLV6-57 Gene

Regulatory Elements for IGLV6-57 Gene

Enhancers for IGLV6-57 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F022060 1.2 Ensembl ENCODE 4.6 -134.3 -134278 1.9 ATF1 TBL1XR1 ARID4B ZNF2 RAD21 RARA YY1 ZNF143 KDM4B CREM IGLV5-52 TOP3B PPM1F ENSG00000272779 CCDC116 ENSG00000225741 IGLV6-57 IGLVV-66 IGLVIV-65
GH22F022057 0.5 Ensembl ENCODE 4.6 -137.1 -137078 1.8 RNF2 TSC22D4 TEAD2 USF2 SPI1 TOP3B PPM1F IGLV3-21 IGLV6-57 CCDC116 IGLVIV-66-1 IGLVV-66
GH22F022194 1.3 Ensembl ENCODE 0.8 +0.0 39 1.6 HDGF ATF1 PKNOX1 ARNT CREB3L1 FEZF1 YBX1 ZNF2 GATA2 ZNF143 VPREB1 IGLV4-60 IGLV8-61 IGLV6-57 IGLVI-56
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IGLV6-57 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGLV6-57 Gene

Chromosome:
22
Start:
22,195,713 bp from pter
End:
22,196,460 bp from pter
Size:
748 bases
Orientation:
Plus strand

Genomic View for IGLV6-57 Gene

Genes around IGLV6-57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLV6-57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLV6-57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLV6-57 Gene

Proteins for IGLV6-57 Gene

  • Protein details for IGLV6-57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01721-LV657_HUMAN
    Recommended name:
    Immunoglobulin lambda variable 6-57
    Protein Accession:
    P01721
    Secondary Accessions:
    • A0A075B6I2
    • P01722
    • P06317
    • P06318
    • P06319

    Protein attributes for IGLV6-57 Gene

    Size:
    117 amino acids
    Molecular mass:
    12566 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains, linked by disulfide bonds.

    Three dimensional structures from OCA and Proteopedia for IGLV6-57 Gene

neXtProt entry for IGLV6-57 Gene

Post-translational modifications for IGLV6-57 Gene

No Post-translational modifications

Other Protein References for IGLV6-57 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLV6-57 Gene

Domains & Families for IGLV6-57 Gene

Gene Families for IGLV6-57 Gene

Protein Domains for IGLV6-57 Gene

Suggested Antigen Peptide Sequences for IGLV6-57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01721

UniProtKB/Swiss-Prot:

LV657_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGLV6-57: view

Function for IGLV6-57 Gene

Molecular function for IGLV6-57 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGLV6-57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 118171
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGLV6-57: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLV6-57 Gene

Localization for IGLV6-57 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLV6-57 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLV6-57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS,TAS --
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with IGLV6-57: view

No data available for Subcellular locations from COMPARTMENTS for IGLV6-57 Gene

Pathways & Interactions for IGLV6-57 Gene

SuperPathways for IGLV6-57 Gene

No Data Available

Interacting Proteins for IGLV6-57 Gene

Gene Ontology (GO) - Biological Process for IGLV6-57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 118171
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
genes like me logo Genes that share ontologies with IGLV6-57: view

No data available for Pathways by source and SIGNOR curated interactions for IGLV6-57 Gene

Transcripts for IGLV6-57 Gene

mRNA/cDNA for IGLV6-57 Gene

(197) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGLV6-57 Gene

Immunoglobulin lambda variable 6-57:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGLV6-57 Gene

No ASD Table

Relevant External Links for IGLV6-57 Gene

GeneLoc Exon Structure for
IGLV6-57
ECgene alternative splicing isoforms for
IGLV6-57

Expression for IGLV6-57 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGLV6-57 Gene

mRNA differential expression in normal tissues according to GTEx for IGLV6-57 Gene

This gene is overexpressed in Spleen (x15.1), Minor Salivary Gland (x6.1), Colon - Transverse (x5.4), Small Intestine - Terminal Ileum (x4.7), and Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for IGLV6-57 Gene

This gene is overexpressed in Skin (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLV6-57 Gene



Protein tissue co-expression partners for IGLV6-57 Gene

- Elite partner

SOURCE GeneReport for Unigene cluster for IGLV6-57 Gene:

Hs.535668
genes like me logo Genes that share expression patterns with IGLV6-57: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGLV6-57 Gene

Orthologs for IGLV6-57 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLV6-57 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 55 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 60 (a)
OneToMany
Species where no ortholog for IGLV6-57 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGLV6-57 Gene

ENSEMBL:
Gene Tree for IGLV6-57 (if available)
TreeFam:
Gene Tree for IGLV6-57 (if available)

Paralogs for IGLV6-57 Gene

Variants for IGLV6-57 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLV6-57 Gene

LV657_HUMAN-P01721
There are several alleles. The sequence shown is that of IMGT allele IGLV6-57*01.

Relevant External Links for IGLV6-57 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLV6-57

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLV6-57 Gene

Disorders for IGLV6-57 Gene

Relevant External Links for IGLV6-57

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGLV6-57

No disorders were found for IGLV6-57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGLV6-57 Gene

Publications for IGLV6-57 Gene

  1. Cloning and sequence analysis of an Ig lambda light chain mRNA expressed in the Burkitt's lymphoma cell line EB4. (PMID: 3923440) Anderson M.L.M. … Young B.D. (Nucleic Acids Res. 1985) 3 4 64
  2. Amino acid sequence of a lambda VI primary (AL) amyloid protein (WLT). (PMID: 4089539) Dwulet F.E. … Benson M.D. (Scand. J. Immunol. 1985) 3 4 64
  3. The complete amino acid sequence of a prototype immunoglobulin-lambda light-chain-type amyloid-fibril protein AR. (PMID: 6797401) Sletten K. … Juul J. (Biochem. J. 1981) 3 4 64
  4. Comparative study on the structure of the light chains of human immunoglobulins. II. Assignment of a new subgroup. (PMID: 118171) Takahashi N. … Shimizu A. (J. Biochem. 1979) 3 4 64
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 64

Products for IGLV6-57 Gene

Sources for IGLV6-57 Gene

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