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Aliases for IGLV5-39 Gene

Aliases for IGLV5-39 Gene

  • Immunoglobulin Lambda Variable 5-39 2 3
  • IGLV539 3

External Ids for IGLV5-39 Gene

Previous GeneCards Identifiers for IGLV5-39 Gene

  • GC22U990134

Summaries for IGLV5-39 Gene

GeneCards Summary for IGLV5-39 Gene

IGLV5-39 (Immunoglobulin Lambda Variable 5-39) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IGLV5-39 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLV5-39 Gene

Genomics for IGLV5-39 Gene

Genomic Location for IGLV5-39 Gene

Chromosome:
22
Start:
29,116 bp from pter
End:
29,715 bp from pter
Size:
600 bases
Orientation:
Plus strand

Genomic View for IGLV5-39 Gene

Genes around IGLV5-39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
  • 22q11.2 alternate reference locus by Entrez Gene
  • 22q11.2 alternate reference locus by HGNC
GeneLoc Logo Gene Density

RefSeq DNA sequence for IGLV5-39 Gene

No data available for Regulatory Elements for IGLV5-39 Gene

Proteins for IGLV5-39 Gene

  • Protein details for IGLV5-39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A0G2JS06-LV539_HUMAN
    Recommended name:
    Immunoglobulin lambda variable 5-39
    Protein Accession:
    A0A0G2JS06

    Protein attributes for IGLV5-39 Gene

    Size:
    123 amino acids
    Molecular mass:
    13394 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGLV5-39 Gene

Post-translational modifications for IGLV5-39 Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGLV5-39 Gene

Domains & Families for IGLV5-39 Gene

Gene Families for IGLV5-39 Gene

Protein Domains for IGLV5-39 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGLV5-39: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGLV5-39 Gene

Function for IGLV5-39 Gene

Molecular function for IGLV5-39 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGLV5-39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
genes like me logo Genes that share ontologies with IGLV5-39: view

Phenotypes for IGLV5-39 Gene

GenomeRNAi human phenotypes for IGLV5-39:
genes like me logo Genes that share phenotypes with IGLV5-39: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLV5-39 Gene

Localization for IGLV5-39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLV5-39 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLV5-39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with IGLV5-39: view

No data available for Subcellular locations from COMPARTMENTS for IGLV5-39 Gene

Pathways & Interactions for IGLV5-39 Gene

SuperPathways for IGLV5-39 Gene

No Data Available

Interacting Proteins for IGLV5-39 Gene

Gene Ontology (GO) - Biological Process for IGLV5-39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002377 immunoglobulin production IBA --
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with IGLV5-39: view

No data available for Pathways by source and SIGNOR curated interactions for IGLV5-39 Gene

Drugs & Compounds for IGLV5-39 Gene

No Compound Related Data Available

Transcripts for IGLV5-39 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGLV5-39 Gene

No ASD Table

Relevant External Links for IGLV5-39 Gene

GeneLoc Exon Structure for
IGLV5-39
ECgene alternative splicing isoforms for
IGLV5-39

No data available for mRNA/cDNA for IGLV5-39 Gene

Expression for IGLV5-39 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLV5-39 Gene

Orthologs for IGLV5-39 Gene

No data available for Orthologs and Evolution for IGLV5-39 Gene

Paralogs for IGLV5-39 Gene

No data available for Paralogs for IGLV5-39 Gene

Variants for IGLV5-39 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLV5-39 Gene

LV539_HUMAN-A0A0G2JS06
There are several alleles. The sequence shown is that of IMGT allele IGLV5-39*01.

Relevant External Links for IGLV5-39 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLV5-39

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLV5-39 Gene

Disorders for IGLV5-39 Gene

No disorders were found for IGLV5-39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGLV5-39 Gene

Publications for IGLV5-39 Gene

  1. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  2. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  3. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  4. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64
  5. Finishing the euchromatic sequence of the human genome. (PMID: 15496913) (Nature 2004) 3 64

Products for IGLV5-39 Gene

Sources for IGLV5-39 Gene

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