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IGLV4-69 Gene

protein-coding   GIFtS: 21
GCID: GC22P022385

Immunoglobulin Lambda Variable 4-69

  Search for IGLV4-69
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immunoglobulin Lambda Variable 4-691 2
V5-62 4
IGLV4692

External Ids:    HGNC: 59211   Entrez Gene: 287842   Ensembl: ENSG000002116377   UniProtKB: Q5NV924   

Export aliases for IGLV4-69 gene to outside databases

Previous GC identifers: GC22U990136 GC22P020710 GC22P020709 GC22P020715 GC22P005342


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IGLV4-69 Gene:
IGLV4-69 (immunoglobulin lambda variable 4-69) is a protein-coding gene. An important paralog of this gene is IGLV5-37.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for IGLV4-69
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGLV4-69


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

IGLV4-69 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLV4-69 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P022385:  view genomic region     (about GC identifiers)

Start:
22,385,332 bp from pter      End:
22,385,870 bp from pter
Size:
539 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/TrEMBL: Q5NV92 (See protein sequence)
Recommended Name: V5-6 protein  
Size: 99 amino acids; 10574 Da

Explore proteomics data for IGLV4-69 at MOPED


See IGLV4-69 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000374817  
Reactome Protein details: Q5NV92

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
IGL: Immunoglobulins / IGL locus

4 InterPro protein domains:
 IPR003596 Ig_V-set_subgr
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set
 IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry Q5NV92

ProtoNet protein and cluster: Q5NV92

2 Blocks protein domains:
IPB003596 Immunoglobulin V-type
IPB013106 Immunoglobulin V-set



Find genes that share domains with IGLV4-69           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with IGLV4-69           About GenesLikeMe


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Find genes that share SuperPaths with IGLV4-69           About GenesLikeMe

Pathways by sourceSee SuperPaths
Show all pathways


Selected Reactome Pathways for IGLV4-69 (see all 12)
    FCERI mediated MAPK activation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
FCERI mediated NF-kB activation
FCGR activation
Scavenging of heme from plasma


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Interactions:

    Search GeneGlobe Interaction Network for IGLV4-69

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for IGLV4-69 (ENSP000003748174) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IGHV3-23ENSP000003750184STRING: ENSP00000375018
IGHV3-53ENSP000003750364STRING: ENSP00000375036
IGHV3-66ENSP000003750414STRING: ENSP00000375041
--ENSP000004118554STRING: ENSP00000411855
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for IGLV4-69



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390282
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IGLV4-69 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGLV4-69 Expression
About this image

IGLV4-69 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IGLV4-69 Protein Expression
    Custom PCR Arrays for IGLV4-69
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for IGLV4-69 gene from Selected species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
oppossum
(Monodelphis domestica)
Mammalia --
--
(see all 37)
Uncharacterized protein
(see all 37)
63(a)
62(a)
(see all 37)
many ↔ many
many ↔ many
(see all 37)
3(524112433-524112906)
3(524138189-524138934)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
43(a)
1 → many
GL343282.1(538034-539834)


ENSEMBL Gene Tree for IGLV4-69 (if available)
TreeFam Gene Tree for IGLV4-69 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IGLV4-69 gene
IGLV5-372  VPREB32  IGLV11-552  IGLV5-482  IGLV9-492  IGLV4-32  VPREB12  IGLV5-522  
IGLV5-452  IGLV4-602  
Selected SIMAP similar genes for IGLV4-69 using alignment to 1 protein entry:     Q5NV92_HUMAN(see all similar genes):
VLC8    IGLV4-60    IGLV4-3    V5-2    IGLV5-45    V2-13
V4-3    IGLV3-19    IGLV3-25    IGLV5-37    IGKV1-5    V4-4
VL4    V1-18    V3    VPREB1    HuC4lambda Vlambda    HuD11lambda Vlambda

Find genes that share paralogs with IGLV4-69           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing IGLV4-69
DNA2.0 Custom Variant and Variant Library Synthesis for IGLV4-69

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IGLV4-69 gene integrated from 10 sources:
(articles sorted by number of sources associating them with IGLV4-69)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (Mol. Immunol. 2002)
  2. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1 Kawasaki K.... Shimizu N. (Genome Res. 1997)
  3. Sequence and evolution of the human germline V lambda repertoire. (PubMed id 8951372)1 Williams S.C....Winter G. (J. Mol. Biol. 1996)
  4. Activation of C1r by proteolytic cleavage. (PubMed id 1249422)1 Ziccardi R.J. and Cooper N.R. (J. Immunol. 1976)
  5. Physicochemical and functional characterization of the C1r subunit of the first complement component. (PubMed id 814163)1 Ziccardi R.J. and Cooper N.R. (J. Immunol. 1976)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 28784 HGNC: 5921 Ensembl:ENSG00000211637 euGenes: HUgn28784 ECgene: IGLV4-69
H-InvDB: IGLV4-69

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IGLV4-69 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGLV4-69 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IGLV4-69 gene:
Search GeneIP for patents involving IGLV4-69

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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