Free for academic non-profit institutions. Other users need a Commercial license

IGLV4-3 Gene(Protein Coding)

Immunoglobulin Lambda Variable 4-3

GCID:
GC22P022871
GIFtS:
19
Genes Participants
UDN Logo

Aliases for IGLV4-3 Gene

Aliases for IGLV4-3 Gene

  • Immunoglobulin Lambda Variable 4-3 2 3 5
  • IGLV43 3
  • V5-1 3

External Ids for IGLV4-3 Gene

Previous GeneCards Identifiers for IGLV4-3 Gene

  • GC22U990138
  • GC22P021538
  • GC22P021108
  • GC22P021294
  • GC22P021543
  • GC22P023213

Summaries for IGLV4-3 Gene

GeneCards Summary for IGLV4-3 Gene

IGLV4-3 (Immunoglobulin Lambda Variable 4-3) is a Protein Coding gene. An important paralog of this gene is IGLV4-69.

UniProtKB/Swiss-Prot for IGLV4-3 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Additional gene information for IGLV4-3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLV4-3 Gene

Genomics for IGLV4-3 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for IGLV4-3 Gene

Promoters and enhancers for IGLV4-3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH22I022873 Enhancer 0.6 ENCODE dbSUPER 550.8 -0.3 -330 0.2 CTCF RB1 SPI1 IGLV3-2 IGLV4-3 IGLV3-4 LOC105372948 IGL
GH22I022872 Enhancer 0.4 dbSUPER 550.8 +1.4 1366 1.2 MCM7 ATF1 FOXA1 IGLV3-2 GC22P023394 IGLV4-3 LOC105372948 IGL
GH22I022871 Enhancer 0.4 dbSUPER 550.8 +0.2 189 0.8 CTCF RB1 SPI1 IGLV3-2 GC22P023394 IGLV4-3 LOC105372948 IGL
GH22I022863 Enhancer 0.9 ENCODE dbSUPER 0.4 -5.6 -5556 4.1 LEF1 ZBTB21 KLF17 RELA ZNF366 ZBTB48 PHF20 RBM34 CBFA2T2 GATAD2A IGLV3-4 IGLV4-3 LOC105372948 IGL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGLV4-3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for IGLV4-3 Gene

Genomic Locations for IGLV4-3 Gene
chr22:22,871,507-22,872,035
(GRCh38/hg38)
Size:
529 bases
Orientation:
Plus strand
chr22:23,213,686-23,214,214
(GRCh37/hg19)

Genomic View for IGLV4-3 Gene

Genes around IGLV4-3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLV4-3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLV4-3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IGLV4-3 Gene

Proteins for IGLV4-3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IGLV4-3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A075B6K6-LV403_HUMAN
    Recommended name:
    Immunoglobulin lambda variable 4-3
    Protein Accession:
    A0A075B6K6

    Protein attributes for IGLV4-3 Gene

    Size:
    122 amino acids
    Molecular mass:
    13330 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGLV4-3 Gene

Post-translational modifications for IGLV4-3 Gene

No Post-translational modifications

Other Protein References for IGLV4-3 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLV4-3 Gene

Domains & Families for IGLV4-3 Gene

Gene Families for IGLV4-3 Gene

HGNC:

Protein Domains for IGLV4-3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IGLV4-3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGLV4-3: view

No data available for UniProtKB/Swiss-Prot for IGLV4-3 Gene

Function for IGLV4-3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for IGLV4-3 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGLV4-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
genes like me logo Genes that share ontologies with IGLV4-3: view

Phenotypes for IGLV4-3 Gene

GenomeRNAi human phenotypes for IGLV4-3:
genes like me logo Genes that share phenotypes with IGLV4-3: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLV4-3 Gene

Localization for IGLV4-3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLV4-3 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLV4-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGLV4-3: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGLV4-3 Gene

Pathways & Interactions for IGLV4-3 Gene

SuperPathways for IGLV4-3 Gene

PathCards logo More details on SuperPathways for IGLV4-3
No Data Available

Interacting Proteins for IGLV4-3 Gene

Gene Ontology (GO) - Biological Process for IGLV4-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002377 immunoglobulin production IBA --
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with IGLV4-3: view

No data available for Pathways by source and SIGNOR curated interactions for IGLV4-3 Gene

Drugs & Compounds for IGLV4-3 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for IGLV4-3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IGLV4-3 Gene

(97) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGLV4-3 Gene

No ASD Table

Relevant External Links for IGLV4-3 Gene

GeneLoc Exon Structure for
IGLV4-3
ECgene alternative splicing isoforms for
IGLV4-3

Expression for IGLV4-3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGLV4-3 Gene

mRNA expression in normal human tissues for IGLV4-3 Gene
mRNA expression by BioGPS for IGLV4-3 GenemRNA expression by GTEx for IGLV4-3 Gene

mRNA differential expression in normal tissues according to GTEx for IGLV4-3 Gene

This gene is overexpressed in Spleen (x13.7), Colon - Transverse (x8.1), Small Intestine - Terminal Ileum (x7.9), Minor Salivary Gland (x5.5), and Whole Blood (x4.3).
genes like me logo Genes that share expression patterns with IGLV4-3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLV4-3 Gene

Orthologs for IGLV4-3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLV4-3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia -- 34
  • 72 (a)
 OneToMany
-- 34
  • 69 (a)
 OneToMany
-- 34
  • 68 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 69 (a)
 ManyToMany
-- 34
  • 50 (a)
 ManyToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 56 (a)
 ManyToMany
-- 34
  • 53 (a)
 ManyToMany
-- 34
  • 53 (a)
 ManyToMany
-- 34
  • 51 (a)
 ManyToMany
-- 34
  • 50 (a)
 ManyToMany
-- 34
  • 50 (a)
 ManyToMany
-- 34
  • 50 (a)
 ManyToMany
-- 34
  • 50 (a)
 ManyToMany
-- 34
  • 50 (a)
 ManyToMany
-- 34
  • 49 (a)
 ManyToMany
-- 34
  • 48 (a)
 ManyToMany
-- 34
  • 48 (a)
 ManyToMany
-- 34
  • 48 (a)
 ManyToMany
-- 34
  • 47 (a)
 ManyToMany
-- 34
  • 47 (a)
 ManyToMany
-- 34
  • 46 (a)
 ManyToMany
-- 34
  • 46 (a)
 ManyToMany
-- 34
  • 46 (a)
 ManyToMany
-- 34
  • 46 (a)
 ManyToMany
-- 34
  • 46 (a)
 ManyToMany
-- 34
  • 46 (a)
 ManyToMany
-- 34
  • 46 (a)
 ManyToMany
-- 34
  • 46 (a)
 ManyToMany
-- 34
  • 46 (a)
 ManyToMany
-- 34
  • 46 (a)
 ManyToMany
-- 34
  • 46 (a)
 ManyToMany
-- 34
  • 46 (a)
 ManyToMany
-- 34
  • 45 (a)
 ManyToMany
-- 34
  • 45 (a)
 ManyToMany
-- 34
  • 45 (a)
 ManyToMany
-- 34
  • 45 (a)
 ManyToMany
-- 34
  • 44 (a)
 ManyToMany
-- 34
  • 44 (a)
 ManyToMany
-- 34
  • 44 (a)
 ManyToMany
-- 34
  • 44 (a)
 ManyToMany
-- 34
  • 44 (a)
 ManyToMany
-- 34
  • 41 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 41 (a)
 OneToMany
Species where no ortholog for IGLV4-3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGLV4-3 Gene

ENSEMBL:
Gene Tree for IGLV4-3 (if available)
TreeFam:
Gene Tree for IGLV4-3 (if available)

Paralogs for IGLV4-3 Gene

Paralogs for IGLV4-3 Gene

(87) SIMAP similar genes for IGLV4-3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IGLV4-3 Gene

genes like me logo Genes that share paralogs with IGLV4-3: view

Variants for IGLV4-3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLV4-3 Gene

LV403_HUMAN-A0A075B6K6
There are several alleles. The sequence shown is that of IMGT allele IGLV4-3*01.

Additional Variant Information for IGLV4-3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLV4-3

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLV4-3 Gene

Disorders for IGLV4-3 Gene

Additional Disease Information for IGLV4-3

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IGLV4-3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGLV4-3 Gene

Publications for IGLV4-3 Gene

  1. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4 58
  2. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M … McHeyzer-Williams L (Nature reviews. Immunology 2011) 4 58
  3. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder HW … Cavacini L (The Journal of allergy and clinical immunology 2010) 4 58
  4. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G … Papavasiliou FN (Annual review of genetics 2007) 4 58
  5. Recognition of immunoglobulins by Fcgamma receptors. (PMID: 11955599) Radaev S … Sun P (Molecular immunology 2002) 3 58

Products for IGLV4-3 Gene

Sources for IGLV4-3 Gene

Content
Loading form....