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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGLV4-3 Gene

protein-coding   GIFtS: 26
GCID: GC22P023213

Immunoglobulin Lambda Variable 4-3
  Search for IGLV4-3
at
MalaCards
 

Aliases
for IGLV4-3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Immunoglobulin Lambda Variable 4-31 2
V5-12 4
IGLV432

External Ids:    HGNC: 59191   Entrez Gene: 287862   Ensembl: ENSG000002116727   UniProtKB: Q5NV614   

Export aliases for IGLV4-3 gene to outside databases

Previous GC identifers: GC22U990138 GC22P021538 GC22P021108 GC22P021294 GC22P021543


Summaries
for IGLV4-3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for IGLV4-3 Gene: 
IGLV4-3 (immunoglobulin lambda variable 4-3) is a protein-coding gene. Among its related super-pathways are Classical antibody-mediated complement activation and Immune System. An important paralog of this gene is IGLV2-18.


Genomic Views
for IGLV4-3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGLV4-3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGLV4-3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGLV4-3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

IGLV4-3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLV4-3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P023213:  view genomic region     (about GC identifiers)

Start:
 23,213,686 bp from pter      End:
 23,214,214 bp from pter
Size:
 529 bases      Orientation:
 plus strand

Proteins
for IGLV4-3 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/TrEMBL: Q5NV61 (See protein sequence)
Recommended Name: V5-1 protein  
Size: 103 amino acids; 11181 Da

Explore proteomics data for IGLV4-3 at MOPED 

IGLV4-3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IGLV4-3 Protein Expression

ENSEMBL proteins: 
 ENSP00000374853  
Reactome Protein details: Q5NV61
Human Recombinant Protein Products for IGLV4-3: 
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Protein Domains /
Families
for IGLV4-3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
 HGNC Gene Families: 
IGL: Immunoglobulins / IGL locus

4 InterPro protein domains:
 IPR003596 Ig_V-set_subgr
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set
 IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry Q5NV61

ProtoNet protein and cluster: Q5NV61

2 Blocks protein domains:
IPB003596 Immunoglobulin V-type
IPB013106 Immunoglobulin V-set



IGLV4-3 for domains           About GeneDecksing


Function
for IGLV4-3 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
IGLV4-3 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for IGLV4-3:
 Wnt reporter downregulated 

Animal Models:
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miRNA
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Pathways & Interactions
for IGLV4-3 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IGLV4-3 About   (see all 6)                                                                                              See pathways by source

SuperPathContained pathways About
1Classical antibody-mediated complement activation
Classical antibody-mediated complement activation0.88
FCGR activation0.70
Creation of C4 and C2 activators0.88
Role of phospholipids in phagocytosis0.65
Initial triggering of complement0.86
FCERI mediated NF-kB activation0.47
Complement cascade0.76
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30
2Immune System
Immune System0.56
Innate Immune System0.50
Adaptive Immune System0.56
3Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation0.80
Fcgamma receptor (FCGR) dependent phagocytosis0.80
4Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling0.69
Role of LAT2/NTAL/LAB on calcium mobilization0.69
5Binding and Uptake of Ligands by Scavenger Receptors
Binding and Uptake of Ligands by Scavenger Receptors0.63
Scavenging of Heme from Plasma0.63

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


5/19        Reactome Pathways for IGLV4-3 (see all 19)
    FCERI mediated MAPK activation
FCERI mediated NF-kB activation
FCGR activation
Role of phospholipids in phagocytosis
Binding and Uptake of Ligands by Scavenger Receptors



IGLV4-3 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGLV4-3

Drugs & Compounds
for IGLV4-3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGLV4-3

Search CenterWatch for drugs/clinical trials and news about IGLV4-3

Transcripts
for IGLV4-3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390318
miRNA
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Inhib. RNA
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Clone
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Primer
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24/97 AceView cDNA sequences (see all 97):

AF194645 CR623132 AF194648 L35920 L25296 CR605950 CR593480 AF064507 
AY573191 AF063703 AF194679 AF194643 AF194698 CR623617 AF194669 CR592011 
AF194668 AF194767 X53070 BC071804 AF058069 AJ319671 AF194815 AF194708 

GeneLoc Exon Structure


Expression
for IGLV4-3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGLV4-3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGLV4-3 Expression
About this image


See IGLV4-3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGLV4-3
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Primer
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In Situ
Assay Products: 
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Orthologs
for IGLV4-3 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for IGLV4-3 gene from 2/4 species (see all 4)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
dog
(Canis familiaris)		 Mammalia --
--
(see all 3)		 Uncharacterized protein
(see all 3)		 71(a)
69(a)
(see all 3)		 1 ↔ many
1 ↔ many
(see all 3)		 26(27400243-27458097)
26(27354222-27354548)
lizard
(Anolis carolinensis)		 Reptilia --
--
(see all 13)		 Uncharacterized protein
(see all 13)		 44(a)
40(a)
(see all 13)		 many ↔ many
many ↔ many
(see all 13)		 GL343282.1(567355-567654)
GL343282.1(534811-535116)


ENSEMBL Gene Tree for IGLV4-3 (if available)
TreeFam Gene Tree for IGLV4-3 (if available)

Paralogs
for IGLV4-3 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGLV4-3 gene
IGLV2-182  IGLV3-122  IGLV3-192  IGLV1-512  IGLV9-492  IGLV3-222  IGLV2-232  IGLV8-612  
IGLV4-602  IGLV1-472  IGLV2-142  IGLV2-332  IGLV3-322  IGLV5-522  IGLV1-442  IGLV3-212  
IGLV2-112  IGLV3-102  IGLV3-92  IGLV1-502  IGLV5-372  VPREB32  IGLV3-252  IGLV2-82  
IGLV10-542  IGLV7-432  IGLV5-452  IGLV7-462  IGLV3-272  IGLV11-552  IGLV1-402  IGLV5-482  
IGLV3-12  VPREB12  IGLV6-572  IGLV3-162  IGLV1-362  IGLV4-692  
18/87 SIMAP similar genes for IGLV4-3 using alignment to 1 protein entry:     Q5NV61_HUMAN(see all similar genes):
IGLV4-69    IGLV4-60    VLC8    V5-2    VPREB1    IGLV1-44
IGLV5-37    HuC4lambda Vlambda    IGLV2-23    IGLV3-25    IGLV5-45    V1-17
V1-18    V4-3    V4-4    IGLV1-40    IGLV2-11    V2-13

IGLV4-3 for paralogs           About GeneDecksing


5/6 Pseudogenes.org Pseudogenes for IGLV4-3 (see all 6)
PGOHUM00000238413 PGOHUM00000238752 PGOHUM00000246434 PGOHUM00000246446 PGOHUM00000246505


Genomic Variants
for IGLV4-3 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for IGLV4-3

Disorders / Diseases
for IGLV4-3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Publications
for IGLV4-3 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGLV4-3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGLV4-3)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  2. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (2002)
  3. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1 Kawasaki K....Shimizu N. (1997)
  4. Activation of C1r by proteolytic cleavage. (PubMed id 1249422)1 Ziccardi R.J. and Cooper N.R. (1976)
  5. Physicochemical and functional characterization of the C1r subunit of the first complement component. (PubMed id 814163)1 Ziccardi R.J. and Cooper N.R. (1976)

External Searches for IGLV4-3 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGLV4-3 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28786 HGNC: 5919 AceView: IGL_ Ensembl:ENSG00000211672 euGenes: HUgn28786
ECgene: IGLV4-3 H-InvDB: IGLV4-3

Other Databases showing IGLV4-3 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGLV4-3 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGLV4-3 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGLV4-3 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGLV4-3 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGLV4-3 gene:
Search GeneIP for patents involving IGLV4-3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
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About This Section

 
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