Aliases for IGLV4-3 Gene
External Ids for IGLV4-3 Gene
- HGNC: 5919
- Entrez Gene: 28786
- Ensembl: ENSG00000211672
- UniProtKB: A0A075B6K6
Previous GeneCards Identifiers for IGLV4-3 Gene
- GC22U990138
- GC22P021538
- GC22P021108
- GC22P021294
- GC22P021543
- GC22P023213
Summaries for IGLV4-3 Gene
GeneCards Summary for IGLV4-3 Gene
IGLV4-3 (Immunoglobulin Lambda Variable 4-3) is a Protein Coding gene. An important paralog of this gene is IGLV4-69.
UniProtKB/Swiss-Prot for IGLV4-3 Gene
-
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
Additional gene information for IGLV4-3 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLV4-3 Gene
Genomics for IGLV4-3 Gene
GeneHancer (GH) Regulatory Elements for IGLV4-3 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH22I022873 | Enhancer | 0.6 | ENCODE dbSUPER | 550.8 | -0.3 | -330 | 0.2 | CTCF RB1 SPI1 | IGLV3-2 IGLV4-3 IGLV3-4 LOC105372948 IGL | |
GH22I022872 | Enhancer | 0.4 | dbSUPER | 550.8 | +1.4 | 1366 | 1.2 | MCM7 ATF1 FOXA1 | IGLV3-2 GC22P023394 IGLV4-3 LOC105372948 IGL | |
GH22I022871 | Enhancer | 0.4 | dbSUPER | 550.8 | +0.2 | 189 | 0.8 | CTCF RB1 SPI1 | IGLV3-2 GC22P023394 IGLV4-3 LOC105372948 IGL | |
GH22I022863 | Enhancer | 0.9 | ENCODE dbSUPER | 0.4 | -5.6 | -5556 | 4.1 | LEF1 ZBTB21 KLF17 RELA ZNF366 ZBTB48 PHF20 RBM34 CBFA2T2 GATAD2A | IGLV3-4 IGLV4-3 LOC105372948 IGL |
Regulatory Element Products
Genomic Locations for IGLV4-3 Gene
- chr22:22,871,507-22,872,035
- (GRCh38/hg38)
- Size:
- 529 bases
- Orientation:
- Plus strand
- chr22:23,213,686-23,214,214
- (GRCh37/hg19)
Genomic View for IGLV4-3 Gene
- Cytogenetic band:
-
- 22q11.22 by Ensembl
- 22q11.22 by Entrez Gene
- 22q11.22 by HGNC


RefSeq DNA sequence for IGLV4-3 Gene
Proteins for IGLV4-3 Gene
-
Protein details for IGLV4-3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A0A075B6K6-LV403_HUMAN
- Recommended name:
- Immunoglobulin lambda variable 4-3
- Protein Accession:
- A0A075B6K6
Protein attributes for IGLV4-3 Gene
- Size:
- 122 amino acids
- Molecular mass:
- 13330 Da
- Quaternary structure:
-
- Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
Post-translational modifications for IGLV4-3 Gene
Other Protein References for IGLV4-3 Gene
- ENSEMBL proteins:
Antibody Products
- Search GeneTex for Antibodies for IGLV4-3
Protein Products
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Assay Products
No data available for DME Specific Peptides for IGLV4-3 Gene
Domains & Families for IGLV4-3 Gene
Gene Families for IGLV4-3 Gene
Protein Domains for IGLV4-3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for IGLV4-3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for IGLV4-3 Gene
Function for IGLV4-3 Gene
Molecular function for IGLV4-3 Gene
- UniProtKB/Swiss-Prot Function:
- V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003823 | antigen binding | IEA | -- |
Phenotypes for IGLV4-3 Gene
- GenomeRNAi human phenotypes for IGLV4-3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IGLV4-3
-
- Search ViGene Biosciences for IGLV4-3
CRISPR Products
- Browse CRISPR knockouts for IGLV4-3
- genomics-online: gRNA clones - Search results for 15 available IGLV4-3 gene related products
- Overview of 15 available IGLV4-3 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for IGLV4-3
Inhibitory RNA Products
- genomics-online: shRNA clones - Search results for 15 available IGLV4-3 gene related products
- Overview of 15 available IGLV4-3 gene related products
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Clone Products
- GenScript: Custom all cDNA clones Services for IGLV4-3
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for IGLV4-3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLV4-3 Gene
Localization for IGLV4-3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IGLV4-3 Gene
- Secreted. Cell membrane.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IBA | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGLV4-3 Gene
Pathways & Interactions for IGLV4-3 Gene
Interacting Proteins for IGLV4-3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002250 | adaptive immune response | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0002377 | immunoglobulin production | IBA | -- |
GO:0006955 | immune response | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for IGLV4-3 Gene
Transcripts for IGLV4-3 Gene
mRNA/cDNA for IGLV4-3 Gene
- (97) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for IGLV4-3
- genomics-online: gRNA clones - Search results for 15 available IGLV4-3 gene related products
- Overview of 15 available IGLV4-3 gene related products
- Applied Biological Materials CRISPR for IGLV4-3
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for IGLV4-3
Inhibitory RNA Products
- genomics-online: shRNA clones - Search results for 15 available IGLV4-3 gene related products
- Overview of 15 available IGLV4-3 gene related products
- Search ViGene Biosciences for IGLV4-3
Clone Products
- GenScript: Custom all cDNA clones Services for IGLV4-3
- VectorBuilder custom plasmid, inducible vectors for IGLV4-3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IGLV4-3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for IGLV4-3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for IGLV4-3 Gene
mRNA differential expression in normal tissues according to GTEx for IGLV4-3 Gene
Primer Products
- genomics-online: primer clones - Search results for 15 available IGLV4-3 gene related products
- Overview of 15 available IGLV4-3 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLV4-3 Gene
Orthologs for IGLV4-3 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
-- 34 |
|
OneToMany | |||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
-- 34 |
|
ManyToMany | |||
oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany |
- Species where no ortholog for IGLV4-3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for IGLV4-3 Gene
Paralogs for IGLV4-3 Gene
(87) SIMAP similar genes for IGLV4-3 Gene using alignment to 1 proteins:
- IGLV4-69
- IGLV4-60
- VLC8
- V5-2
- VPREB1
- IGLV5-37
- IGLV1-44
- V4-4
- V4-3
- V1-18
- V1-17
- IGLV5-45
- IGLV3-25
- IGLV2-23
- HuC4lambda Vlambda
- V2-13
- IGLV2-11
- IGLV1-40
- V2-1
- V1-2
- VKA17
- V2-6
- V1-19
- IGLV3-16
- IGLV2-18
- IGLV11-55
- IGLV3-19
- IGL@
- VL4
- V<lambda>3
- V2-7
- V2-14
- IGLV3-27
- IGLV3-12
- VL3L
- V<kappa>1
- V1-4
- V1-11
- IgLC-rG
- IGLV1-36
- HuD11lambda Vlambda
- DKFZp686E23209
- V1-22
- IGLV8-61
- IGKV1-5
- scFv
- VH
- V<kappa>3
- IGLV3-22
- DKFZp686O01196
- DKFZp686C15213
- SDNK1
- VL1
- HuVH8B VH
- A30
- VL87-2
- VH3
- IGHV
- HEL180
- BV05S1J2.1
- TRGV9
- VHCH1
- IGLV7-43
- IGLV2-33
- DKFZp686G11190
- VPREB3
- IGLV
- VL6
- VHC8
- TCRBV5S1A1T
- DKFZp686O16217
- IGKV4-1
- VH-7 family (N54P3)D/J
- TCRBV6S5A2
- IGLV10-54
- DKFZp686M08189
- IGK@
- IGH@
- VK3
- VH-3 family (VH26.)D/J
- IGLV7-46
- IGKV A18
- TCRBV23S1A2T
- VH-3 family (VH26)D/J
- TRA@
- TCRBV5S6A3N2T
- DKFZp781M0386
Pseudogenes.org Pseudogenes for IGLV4-3 Gene
Variants for IGLV4-3 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for IGLV4-3 Gene
- LV403_HUMAN-A0A075B6K6
- There are several alleles. The sequence shown is that of IMGT allele IGLV4-3*01.
Additional Variant Information for IGLV4-3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- IGLV4-3
No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLV4-3 Gene
Disorders for IGLV4-3 Gene
Additional Disease Information for IGLV4-3
No disorders were found for IGLV4-3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGLV4-3 Gene
Publications for IGLV4-3 Gene
- Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4 58
- Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M … McHeyzer-Williams L (Nature reviews. Immunology 2011) 4 58
- Structure and function of immunoglobulins. (PMID: 20176268) Schroeder HW … Cavacini L (The Journal of allergy and clinical immunology 2010) 4 58
- Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G … Papavasiliou FN (Annual review of genetics 2007) 4 58
- Recognition of immunoglobulins by Fcgamma receptors. (PMID: 11955599) Radaev S … Sun P (Molecular immunology 2002) 3 58
Products for IGLV4-3 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for IGLV4-3
- VectorBuilder custom plasmid, inducible vectors for IGLV4-3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IGLV4-3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for IGLV4-3
- Search GeneTex for Proteins for IGLV4-3
- genomics-online: cdna clones - Search results for 15 available IGLV4-3 gene related products
- Overview of 15 available IGLV4-3 gene related products
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- Overview of 15 available IGLV4-3 gene related products
- genomics-online: gRNA clones - Search results for 15 available IGLV4-3 gene related products
- Overview of 15 available IGLV4-3 gene related products
- genomics-online: primer clones - Search results for 15 available IGLV4-3 gene related products
- Overview of 15 available IGLV4-3 gene related products
- genomics-online: shRNA clones - Search results for 15 available IGLV4-3 gene related products
- Overview of 15 available IGLV4-3 gene related products
Sources for IGLV4-3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
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