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IGLV4-3 Gene

protein-coding   GIFtS: 25
GCID: GC22P023213

Immunoglobulin Lambda Variable 4-3

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Aliases
for IGLV4-3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immunoglobulin Lambda Variable 4-31 2
V5-12 4
IGLV432

External Ids:    HGNC: 59191   Entrez Gene: 287862   Ensembl: ENSG000002116727   UniProtKB: Q5NV614   

Export aliases for IGLV4-3 gene to outside databases

Previous GC identifers: GC22U990138 GC22P021538 GC22P021108 GC22P021294 GC22P021543


Summaries
for IGLV4-3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IGLV4-3 Gene:
IGLV4-3 (immunoglobulin lambda variable 4-3) is a protein-coding gene. An important paralog of this gene is IGLV5-37.


Genomic Views
for IGLV4-3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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TryGeneCards Plus		 Regulatory elements:
   Search for regulatory transcription factor binding sites for IGLV4-3
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGLV4-3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

IGLV4-3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLV4-3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P023213:  view genomic region     (about GC identifiers)

Start:
 23,213,686 bp from pter      End:
 23,214,214 bp from pter
Size:
 529 bases      Orientation:
 plus strand

Proteins
for IGLV4-3 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/TrEMBL: Q5NV61 (See protein sequence)
Recommended Name: V5-1 protein  
Size: 103 amino acids; 11181 Da

Explore proteomics data for IGLV4-3 at MOPED


See IGLV4-3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000374853  
Reactome Protein details: Q5NV61

IGLV4-3 Human Recombinant Protein Products:

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Domains /
Families
for IGLV4-3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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TryGeneCards Plus		 HGNC Gene Families:
IGL: Immunoglobulins / IGL locus

4 InterPro protein domains:
 IPR003596 Ig_V-set_subgr
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set
 IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry Q5NV61

ProtoNet protein and cluster: Q5NV61

2 Blocks protein domains:
IPB003596 Immunoglobulin V-type
IPB013106 Immunoglobulin V-set



Find genes that share domains with IGLV4-3           About GenesLikeMe


Function
for IGLV4-3 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with IGLV4-3           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for IGLV4-3:
 Wnt reporter downregulated 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for IGLV4-3

miRNA
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Localization
for IGLV4-3 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
plasma membrane2

Pathways & Interactions
for IGLV4-3 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Find genes that share SuperPaths with IGLV4-3           About GenesLikeMe

Pathways by sourceSee SuperPaths
Show all pathways


Selected Reactome Pathways for IGLV4-3 (see all 12)
    FCERI mediated MAPK activation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
FCERI mediated NF-kB activation
FCGR activation
Scavenging of heme from plasma


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Interactions:

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Drugs & Compounds
for IGLV4-3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for IGLV4-3



Transcripts
for IGLV4-3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390318
miRNA
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Primer
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Selected AceView cDNA sequences (see all 97):

AF194643 AF063703 CR605950 L25296 L35920 AF194648 CR623132 AF194645 
AF194698 CR623617 CR592011 AF194669 AY573191 AF194679 CR593480 AF064507 
AF194783 AF194744 AF194714 AF194666 AF063701 AF194642 AJ319670 AF194707 

GeneLoc Exon Structure


Expression
for IGLV4-3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IGLV4-3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGLV4-3 Expression
About this image

IGLV4-3 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

IGLV4-3 Protein Expression
    Custom PCR Arrays for IGLV4-3
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In Situ
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Orthologs
for IGLV4-3 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for IGLV4-3 gene from Selected species (see all 4)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
dog
(Canis familiaris)		 Mammalia --
--
(see all 3)		 Uncharacterized protein
(see all 3)		 72(a)
69(a)
(see all 3)		 1 ↔ many
1 ↔ many
(see all 3)		 26(27400243-27458097)
26(27354222-27354548)
lizard
(Anolis carolinensis)		 Reptilia --
 Uncharacterized protein
 41(a)
 1 → many
 GL343282.1(538034-539834)


ENSEMBL Gene Tree for IGLV4-3 (if available)
TreeFam Gene Tree for IGLV4-3 (if available)

Paralogs
for IGLV4-3 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IGLV4-3 gene
IGLV5-372  VPREB32  IGLV11-552  IGLV5-482  IGLV9-492  VPREB12  IGLV5-522  IGLV5-452  
IGLV4-602  IGLV4-692  
Selected SIMAP similar genes for IGLV4-3 using alignment to 1 protein entry:     Q5NV61_HUMAN(see all similar genes):
IGLV4-69    IGLV4-60    VLC8    V5-2    VPREB1    IGLV1-44
IGLV5-37    HuC4lambda Vlambda    IGLV2-23    IGLV3-25    IGLV5-45    V1-17
V1-18    V4-3    V4-4    IGLV1-40    IGLV2-11    V2-13

Find genes that share paralogs with IGLV4-3           About GenesLikeMe


Selected Pseudogenes.org Pseudogenes for IGLV4-3 (see all 6)
PGOHUM00000238413 PGOHUM00000238752 PGOHUM00000246434 PGOHUM00000246446 PGOHUM00000246505


Genomic Variants
for IGLV4-3 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing IGLV4-3
DNA2.0 Custom Variant and Variant Library Synthesis for IGLV4-3

Disorders / Diseases
for IGLV4-3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Publications
for IGLV4-3 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IGLV4-3 gene integrated from 10 sources:
(articles sorted by number of sources associating them with IGLV4-3)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  2. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (Mol. Immunol. 2002)
  3. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1 Kawasaki K.... Shimizu N. (Genome Res. 1997)
  4. Activation of C1r by proteolytic cleavage. (PubMed id 1249422)1 Ziccardi R.J. and Cooper N.R. (J. Immunol. 1976)
  5. Physicochemical and functional characterization of the C1r subunit of the first complement component. (PubMed id 814163)1 Ziccardi R.J. and Cooper N.R. (J. Immunol. 1976)

External Searches for IGLV4-3 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGLV4-3 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 28786 HGNC: 5919 AceView: IGL_ Ensembl:ENSG00000211672 euGenes: HUgn28786
ECgene: IGLV4-3 H-InvDB: IGLV4-3

Other Databases showing IGLV4-3 gene

(According to HUGE)
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Specialized Databases showing IGLV4-3 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IGLV4-3 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGLV4-3 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGLV4-3 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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TryGeneCards Plus		Patent Information for IGLV4-3 gene:
Search GeneIP for patents involving IGLV4-3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for IGLV4-3 gene

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