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IGLV3-10 Gene

protein-coding   GIFtS: 20
GCID: GC22P023154

Immunoglobulin Lambda Variable 3-10

  Try our
MalaCards

disease database 

Aliases
for IGLV3-10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Immunoglobulin Lambda Variable 3-101 2
IGLV3102
V2-72

External Ids:    HGNC: 58971   Entrez Gene: 288032   Ensembl: ENSG000002116697   UniProtKB: A2MYD44   

Export aliases for IGLV3-10 gene to outside databases

Previous GC identifers: GC22U990155 GC22P021479


Summaries
for IGLV3-10 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for IGLV3-10 Gene:
IGLV3-10 (immunoglobulin lambda variable 3-10) is a protein-coding gene. An important paralog of this gene is IGLV2-18.


Genomic Views
for IGLV3-10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

 Regulatory elements:
   Search for regulatory transcription factor binding sites for IGLV3-10
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGLV3-10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

IGLV3-10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLV3-10 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P023154:  view genomic region     (about GC identifiers)

Start:
 23,154,244 bp from pter      End:
 23,154,782 bp from pter
Size:
 539 bases      Orientation:
 plus strand

Proteins
for IGLV3-10 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section
UniProtKB/TrEMBL: A2MYD4 (See protein sequence)
Recommended Name: V2-7 protein  
Size: 96 amino acids; 10352 Da

Explore proteomics data for IGLV3-10 at MOPED


See IGLV3-10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000374850  

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Domains /
Families
for IGLV3-10 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

 HGNC Gene Families:
IGL: Immunoglobulins / IGL locus

4 InterPro protein domains:
 IPR003596 Ig_V-set_subgr
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set
 IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry A2MYD4

ProtoNet protein and cluster: A2MYD4


Find genes that share domains with IGLV3-10           About GenesLikeMe


Function
for IGLV3-10 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with IGLV3-10           About GenesLikeMe


Animal Models:
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miRNA
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Localization
for IGLV3-10 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3

Pathways & Interactions
for IGLV3-10 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section






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Drugs & Compounds
for IGLV3-10 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section
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Transcripts
for IGLV3-10 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390315
miRNA
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Primer
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Selected AceView cDNA sequences (see all 97):

AF194648 AF194698 CR592011 CR623617 AF194645 L35920 CR623132 AF194669 
AF064507 L25296 CR605950 AF194679 CR593480 AF063703 AY573191 AF194643 
AF058069 AF194714 AJ318021 CR617925 BC033102 AF194651 AJ318022 AB064037 

GeneLoc Exon Structure


Expression
for IGLV3-10 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGLV3-10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGLV3-10 Expression
About this image

IGLV3-10 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

IGLV3-10 Protein Expression
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In Situ
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Orthologs
for IGLV3-10 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for IGLV3-10 gene from Selected species (see all 4)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
dog
(Canis familiaris)		 Mammalia --
 Uncharacterized protein
 42(a)
 1 → many
 26(27303190-27304407)
lizard
(Anolis carolinensis)		 Reptilia --
 Uncharacterized protein
 48(a)
 1 → many
 GL343282.1(569146-570830)


ENSEMBL Gene Tree for IGLV3-10 (if available)
TreeFam Gene Tree for IGLV3-10 (if available)

Paralogs
for IGLV3-10 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for IGLV3-10 gene
IGLV2-182  IGLV3-92  IGLV3-122  IGLV3-192  IGLV1-502  IGLV3-252  IGLV2-82  IGLV1-512  
IGLV10-542  IGLV3-222  IGLV2-232  IGLV7-432  IGLV8-612  IGLV7-462  IGLV3-272  IGLV1-472  
IGLV2-142  IGLV1-402  IGLV3-12  IGLV2-332  IGLV3-322  IGLV6-572  IGLV1-442  IGLV3-212  
IGLV2-112  IGLV3-162  IGLV1-362  

Find genes that share paralogs with IGLV3-10           About GenesLikeMe


2 Pseudogenes.org Pseudogenes for IGLV3-10
PGOHUM00000246496 PGOHUM00000246512


Genomic Variants
for IGLV3-10 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing IGLV3-10
DNA2.0 Custom Variant and Variant Library Synthesis for IGLV3-10

Disorders / Diseases
for IGLV3-10 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

   --

Publications
for IGLV3-10 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section


PubMed articles for IGLV3-10 gene integrated from 10 sources:
(articles sorted by number of sources associating them with IGLV3-10)

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1 Kawasaki K.... Shimizu N. (Genome Res. 1997)
  2. Sequence and evolution of the human germline V lambda repertoire. (PubMed id 8951372)1 Williams S.C....Winter G. (J. Mol. Biol. 1996)

External Searches for IGLV3-10 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGLV3-10 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28803 HGNC: 5897 AceView: IGL_ Ensembl:ENSG00000211669 euGenes: HUgn28803
ECgene: IGLV3-10 H-InvDB: IGLV3-10

Other Databases showing IGLV3-10 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGLV3-10 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGLV3-10 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGLV3-10 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGLV3-10 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGLV3-10 gene:
Search GeneIP for patents involving IGLV3-10

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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About This Section


 
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