Aliases for IGLV3-10 Gene
External Ids for IGLV3-10 Gene
- HGNC: 5897
- Entrez Gene: 28803
- Ensembl: ENSG00000211669
- UniProtKB: A0A075B6K4
Previous GeneCards Identifiers for IGLV3-10 Gene
- GC22U990155
- GC22P021479
- GC22P023154
Summaries for IGLV3-10 Gene
GeneCards Summary for IGLV3-10 Gene
IGLV3-10 (Immunoglobulin Lambda Variable 3-10) is a Protein Coding gene. An important paralog of this gene is IGLV3-25.
UniProtKB/Swiss-Prot for IGLV3-10 Gene
-
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
Additional gene information for IGLV3-10 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLV3-10 Gene
Genomics for IGLV3-10 Gene
GeneHancer (GH) Regulatory Elements for IGLV3-10 Gene
Promoters and enhancers for IGLV3-10 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH22I022810 | Enhancer | 0.5 | ENCODE | 550.8 | -1.6 | -1588 | 0.2 | CTCF RUNX1 MYNN TARDBP ZNF143 RAD21 | IGLV3-10 ENSG00000274381 IGL | |
| GH22I022809 | Enhancer | 0.3 | ENCODE | 550.8 | -1.8 | -1789 | 0.1 | CTCF | IGLV3-10 ENSG00000274381 IGL |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around IGLV3-10 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for IGLV3-10 Gene
Genomic Locations for IGLV3-10 Gene
- chr22:22,811,747-22,812,281
- (GRCh38/hg38)
- Size:
- 535 bases
- Orientation:
- Plus strand
- chr22:23,154,244-23,154,782
- (GRCh37/hg19)
Genomic View for IGLV3-10 Gene
Genes around IGLV3-10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.22 by Ensembl
- 22q11.22 by Entrez Gene
- 22q11.22 by HGNC
IGLV3-10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IGLV3-10 Gene
Proteins for IGLV3-10 Gene
-
Protein details for IGLV3-10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A0A075B6K4-LV310_HUMAN
- Recommended name:
- Immunoglobulin lambda variable 3-10
- Protein Accession:
- A0A075B6K4
Protein attributes for IGLV3-10 Gene
- Size:
- 115 amino acids
- Molecular mass:
- 12441 Da
- Quaternary structure:
-
- Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
- SequenceCaution:
-
- Sequence=EAW59538.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for IGLV3-10 Gene
Post-translational modifications for IGLV3-10 Gene
No Post-translational modifications
Other Protein References for IGLV3-10 Gene
- ENSEMBL proteins:
Antibody Products
- Search GeneTex for Antibodies for IGLV3-10
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for IGLV3-10
- Origene Custom Protein Services for IGLV3-10
- Search GeneTex for Proteins for IGLV3-10
No data available for DME Specific Peptides for IGLV3-10 Gene
Domains & Families for IGLV3-10 Gene
Gene Families for IGLV3-10 Gene
Protein Domains for IGLV3-10 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for IGLV3-10 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for IGLV3-10 Gene
Function for IGLV3-10 Gene
Molecular function for IGLV3-10 Gene
- UniProtKB/Swiss-Prot Function:
- V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003823 | antigen binding | IEA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IGLV3-10
-
- Search ViGene Biosciences for IGLV3-10
CRISPR Products
- Browse CRISPR knockouts for IGLV3-10
- Applied Biological Materials CRISPR for IGLV3-10
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA for IGLV3-10 Gene
- miRTarBase miRNAs that target IGLV3-10
miRNA Products
- Search ViGene Biosciences for IGLV3-10
Inhibitory RNA Products
- Search ViGene Biosciences for IGLV3-10
Clone Products
- GenScript: Custom all cDNA clones Services for IGLV3-10
- VectorBuilder custom plasmid, inducible vectors for IGLV3-10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IGLV3-10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for IGLV3-10
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGLV3-10 Gene
Localization for IGLV3-10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IGLV3-10 Gene
- Secreted. Cell membrane.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IBA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGLV3-10 Gene
Pathways & Interactions for IGLV3-10 Gene
No Data Available
Interacting Proteins for IGLV3-10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002377 | immunoglobulin production | IBA | -- |
| GO:0006955 | immune response | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for IGLV3-10 Gene
Transcripts for IGLV3-10 Gene
mRNA/cDNA for IGLV3-10 Gene
- (97) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for IGLV3-10
- Applied Biological Materials CRISPR for IGLV3-10
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for IGLV3-10
Inhibitory RNA Products
- Search ViGene Biosciences for IGLV3-10
Clone Products
- GenScript: Custom all cDNA clones Services for IGLV3-10
- VectorBuilder custom plasmid, inducible vectors for IGLV3-10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IGLV3-10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for IGLV3-10
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for IGLV3-10 Gene
mRNA differential expression in normal tissues according to GTEx for IGLV3-10 Gene
This gene is overexpressed in Spleen (x11.8), Minor Salivary Gland (x8.5), and Colon - Transverse (x6.1).
This gene is overexpressed in Serum (24.5), Skin (23.4), and Urine (21.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLV3-10 Gene
- Elite partner
Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLV3-10 Gene
Orthologs for IGLV3-10 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany |
- Species where no ortholog for IGLV3-10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for IGLV3-10 Gene
Paralogs for IGLV3-10 Gene
Pseudogenes.org Pseudogenes for IGLV3-10 Gene
Variants for IGLV3-10 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for IGLV3-10 Gene
- LV310_HUMAN-A0A075B6K4
- There are several alleles. The sequence shown is that of IMGT allele IGLV3-10*01.
Additional Variant Information for IGLV3-10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- IGLV3-10
No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLV3-10 Gene
Disorders for IGLV3-10 Gene
Additional Disease Information for IGLV3-10
No disorders were found for IGLV3-10 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGLV3-10 Gene
Publications for IGLV3-10 Gene
- Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4 58
- Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M … McHeyzer-Williams L (Nature reviews. Immunology 2011) 4 58
- Structure and function of immunoglobulins. (PMID: 20176268) Schroeder HW … Cavacini L (The Journal of allergy and clinical immunology 2010) 4 58
- Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G … Papavasiliou FN (Annual review of genetics 2007) 4 58
- Nomenclature of the human immunoglobulin lambda (IGL) genes. (PMID: 11872955) Lefranc MP (Experimental and clinical immunogenetics 2001) 4 58
Products for IGLV3-10 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for IGLV3-10
- VectorBuilder custom plasmid, inducible vectors for IGLV3-10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IGLV3-10
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for IGLV3-10
- Search GeneTex for Proteins for IGLV3-10
Sources for IGLV3-10 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew