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IGLV3-10 Gene(Protein Coding)

Immunoglobulin Lambda Variable 3-10

GCID:
GC22P022811
GIFtS:
21
Genes Participants
UDN Logo

Aliases for IGLV3-10 Gene

Aliases for IGLV3-10 Gene

  • Immunoglobulin Lambda Variable 3-10 2 3 5
  • IGLV310 3
  • V2-7 3

External Ids for IGLV3-10 Gene

Previous GeneCards Identifiers for IGLV3-10 Gene

  • GC22U990155
  • GC22P021479
  • GC22P023154

Summaries for IGLV3-10 Gene

GeneCards Summary for IGLV3-10 Gene

IGLV3-10 (Immunoglobulin Lambda Variable 3-10) is a Protein Coding gene. An important paralog of this gene is IGLV3-25.

UniProtKB/Swiss-Prot for IGLV3-10 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLV3-10 Gene

Genomics for IGLV3-10 Gene

Products:

  1. Regulatory Element

Regulatory Elements for IGLV3-10 Gene

Enhancers for IGLV3-10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G022810 0.8 ENCODE 0.7 -1.6 -1589 0.2 CTCF ARID4B DMAP1 RAD21 SLC30A9 RERE GATAD1 POLR2A ZNF143 SMC3 IGLV3-10 ENSG00000274381
GH22G022809 0.4 ENCODE 0.7 -1.8 -1790 0.1 CTCF IGLV3-10 ENSG00000274381
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGLV3-10 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGLV3-10 Gene

Chromosome:
22
Start:
22,811,747 bp from pter
End:
22,812,285 bp from pter
Size:
539 bases
Orientation:
Plus strand

Genomic View for IGLV3-10 Gene

Genes around IGLV3-10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLV3-10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLV3-10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IGLV3-10 Gene

Proteins for IGLV3-10 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IGLV3-10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A075B6K4-LV310_HUMAN
    Recommended name:
    Immunoglobulin lambda variable 3-10
    Protein Accession:
    A0A075B6K4

    Protein attributes for IGLV3-10 Gene

    Size:
    115 amino acids
    Molecular mass:
    12441 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
    SequenceCaution:
    • Sequence=EAW59538.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for IGLV3-10 Gene

Protein Expression for IGLV3-10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for IGLV3-10 Gene

No Post-translational modifications

Other Protein References for IGLV3-10 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLV3-10 Gene

Domains & Families for IGLV3-10 Gene

Gene Families for IGLV3-10 Gene

HGNC:

Protein Domains for IGLV3-10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IGLV3-10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGLV3-10: view

No data available for UniProtKB/Swiss-Prot for IGLV3-10 Gene

Function for IGLV3-10 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for IGLV3-10 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGLV3-10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
genes like me logo Genes that share ontologies with IGLV3-10: view

Animal Model Products

miRNA for IGLV3-10 Gene

miRTarBase miRNAs that target IGLV3-10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGLV3-10 Gene

Localization for IGLV3-10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLV3-10 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLV3-10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGLV3-10: view

No data available for Subcellular locations from COMPARTMENTS for IGLV3-10 Gene

Pathways & Interactions for IGLV3-10 Gene

SuperPathways for IGLV3-10 Gene

PathCards logo More details on SuperPathways for IGLV3-10
No Data Available

Interacting Proteins for IGLV3-10 Gene

Gene Ontology (GO) - Biological Process for IGLV3-10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002377 immunoglobulin production IBA --
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with IGLV3-10: view

No data available for Pathways by source and SIGNOR curated interactions for IGLV3-10 Gene

Drugs & Compounds for IGLV3-10 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for IGLV3-10 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IGLV3-10 Gene

(97) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGLV3-10 Gene

No ASD Table

Relevant External Links for IGLV3-10 Gene

GeneLoc Exon Structure for
IGLV3-10
ECgene alternative splicing isoforms for
IGLV3-10

Expression for IGLV3-10 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGLV3-10 Gene

mRNA expression in normal human tissues for IGLV3-10 Gene
mRNA expression by GTEx for IGLV3-10 Gene

mRNA differential expression in normal tissues according to GTEx for IGLV3-10 Gene

This gene is overexpressed in Spleen (x11.8), Minor Salivary Gland (x8.5), and Colon - Transverse (x6.1).

Protein differential expression in normal tissues from HIPED for IGLV3-10 Gene

This gene is overexpressed in Serum (24.5), Skin (23.4), and Urine (21.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLV3-10 Gene



Protein tissue co-expression partners for IGLV3-10 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGLV3-10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLV3-10 Gene

Orthologs for IGLV3-10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLV3-10 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 65 (a)
 ManyToMany
-- 35
  • 65 (a)
 ManyToMany
-- 35
  • 64 (a)
 ManyToMany
-- 35
  • 62 (a)
 ManyToMany
-- 35
  • 58 (a)
 ManyToMany
-- 35
  • 57 (a)
 ManyToMany
-- 35
  • 57 (a)
 ManyToMany
-- 35
  • 56 (a)
 ManyToMany
-- 35
  • 55 (a)
 ManyToMany
-- 35
  • 53 (a)
 ManyToMany
-- 35
  • 52 (a)
 ManyToMany
-- 35
  • 49 (a)
 ManyToMany
-- 35
  • 48 (a)
 ManyToMany
-- 35
  • 40 (a)
 ManyToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 63 (a)
 ManyToMany
-- 35
  • 61 (a)
 ManyToMany
dog
(Canis familiaris)
 Mammalia -- 35
  • 42 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 48 (a)
 OneToMany
Species where no ortholog for IGLV3-10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGLV3-10 Gene

ENSEMBL:
Gene Tree for IGLV3-10 (if available)
TreeFam:
Gene Tree for IGLV3-10 (if available)

Paralogs for IGLV3-10 Gene

Variants for IGLV3-10 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLV3-10 Gene

LV310_HUMAN-A0A075B6K4
There are several alleles. The sequence shown is that of IMGT allele IGLV3-10*01.

Relevant External Links for IGLV3-10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLV3-10

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLV3-10 Gene

Disorders for IGLV3-10 Gene

Relevant External Links for IGLV3-10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGLV3-10

No disorders were found for IGLV3-10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGLV3-10 Gene

Publications for IGLV3-10 Gene

  1. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  2. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  3. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  4. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64
  5. Nomenclature of the human immunoglobulin lambda (IGL) genes. (PMID: 11872955) Lefranc M.P. (Exp. Clin. Immunogenet. 2001) 4 64

Products for IGLV3-10 Gene

Sources for IGLV3-10 Gene

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