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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGLV3-10 Gene

protein-coding   GIFtS: 19
GCID: GC22P023154

Immunoglobulin Lambda Variable 3-10
  Search for IGLV3-10
at
MalaCards
 

Aliases
for IGLV3-10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Immunoglobulin Lambda Variable 3-101 2
IGLV3102
V2-72

External Ids:    HGNC: 58971   Entrez Gene: 288032   Ensembl: ENSG000002116697   UniProtKB: A2MYD44   

Export aliases for IGLV3-10 gene to outside databases

Previous GC identifers: GC22U990155 GC22P021479


Summaries
for IGLV3-10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for IGLV3-10 Gene: 
IGLV3-10 (immunoglobulin lambda variable 3-10) is a protein-coding gene. An important paralog of this gene is IGLV2-18.


Genomic Views
for IGLV3-10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGLV3-10
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGLV3-10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

IGLV3-10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLV3-10 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P023154:  view genomic region     (about GC identifiers)

Start:
 23,154,244 bp from pter      End:
 23,154,782 bp from pter
Size:
 539 bases      Orientation:
 plus strand

Proteins
for IGLV3-10 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/TrEMBL: A2MYD4 (See protein sequence)
Recommended Name: V2-7 protein  
Size: 96 amino acids; 10352 Da

Explore proteomics data for IGLV3-10 at MOPED 

IGLV3-10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IGLV3-10 Protein Expression

ENSEMBL proteins: 
 ENSP00000374850  

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Protein Domains /
Families
for IGLV3-10 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
 HGNC Gene Families: 
IGL: Immunoglobulins / IGL locus

4 InterPro protein domains:
 IPR003596 Ig_V-set_subgr
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set
 IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry A2MYD4

ProtoNet protein and cluster: A2MYD4


IGLV3-10 for domains           About GeneDecksing


Function
for IGLV3-10 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
IGLV3-10 for ontologies           About GeneDecksing


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miRNA
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Pathways & Interactions
for IGLV3-10 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGLV3-10

Drugs & Compounds
for IGLV3-10 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for IGLV3-10

Search CenterWatch for drugs/clinical trials and news about IGLV3-10

Transcripts
for IGLV3-10 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390315
miRNA
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24/97 AceView cDNA sequences (see all 97):

AF194669 AF194698 CR623617 AF064507 AF063703 AF194643 CR592011 CR623132 
AF194645 AY573191 CR593480 AF194679 CR605950 L25296 L35920 AF194648 
Z18331 BC033102 CR617925 AF194744 BC012159 AF194736 AF194783 AF194651 

GeneLoc Exon Structure


Expression
for IGLV3-10 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGLV3-10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGLV3-10 Expression
About this image


See IGLV3-10 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for IGLV3-10
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In Situ
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Orthologs
for IGLV3-10 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for IGLV3-10 gene from 2/4 species (see all 4)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
dog
(Canis familiaris)		 Mammalia --
 --
 41(a)
 1 → many
 26(27303190-27304407)
lizard
(Anolis carolinensis)		 Reptilia --
 --
 32(a)
 possible ortholog
 GL343282.1(506859-507901)


ENSEMBL Gene Tree for IGLV3-10 (if available)
TreeFam Gene Tree for IGLV3-10 (if available)

Paralogs
for IGLV3-10 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGLV3-10 gene
IGLV2-182  IGLV3-122  IGLV3-192  IGLV1-512  IGLV9-492  IGLV3-222  IGLV2-232  IGLV8-612  
IGLV4-602  IGLV1-472  IGLV2-142  IGLV2-332  IGLV3-322  IGLV5-522  IGLV1-442  IGLV3-212  
IGLV2-112  IGLV3-92  IGLV1-502  IGLV5-372  VPREB32  IGLV3-252  IGLV2-82  IGLV10-542  
IGLV7-432  IGLV5-452  IGLV7-462  IGLV3-272  IGLV11-552  IGLV1-402  IGLV5-482  IGLV3-12  
IGLV4-32  VPREB12  IGLV6-572  IGLV3-162  IGLV1-362  IGLV4-692  

IGLV3-10 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for IGLV3-10
PGOHUM00000246496 PGOHUM00000246512


Genomic Variants
for IGLV3-10 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing IGLV3-10
DNA2.0 Custom Variant and Variant Library Synthesis for IGLV3-10

Disorders / Diseases
for IGLV3-10 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Publications
for IGLV3-10 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGLV3-10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGLV3-10)		    Utopia: connect your pdf to the dynamic
world of online information

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1 Kawasaki K....Shimizu N. (1997)
  2. Sequence and evolution of the human germline V lambda repertoire. (PubMed id 8951372)1 Williams S.C....Winter G. (1996)

External Searches for IGLV3-10 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGLV3-10 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28803 HGNC: 5897 AceView: IGL_ Ensembl:ENSG00000211669 euGenes: HUgn28803
ECgene: IGLV3-10 H-InvDB: IGLV3-10

Other Databases showing IGLV3-10 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGLV3-10 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGLV3-10 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGLV3-10 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGLV3-10 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGLV3-10 gene:
Search GeneIP for patents involving IGLV3-10

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
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