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Aliases for IGLV2-8 Gene

Aliases for IGLV2-8 Gene

  • Immunoglobulin Lambda Variable 2-8 2 3 5
  • Ig Lambda Chain V-II Region MGC 3 4
  • Ig Lambda Chain V-II Region BO 4
  • IGLV28 3
  • V1-2 3

External Ids for IGLV2-8 Gene

Previous GeneCards Identifiers for IGLV2-8 Gene

  • GC22U990169
  • GC22P021490
  • GC22P021497
  • GC22P023166
  • GC22P006133
  • GC22P023168
  • GC22P023170
  • GC22P023172
  • GC22P023174
  • GC22P022823
  • GC22P022867
  • GC22P022941
  • GC22P022956

Summaries for IGLV2-8 Gene

GeneCards Summary for IGLV2-8 Gene

IGLV2-8 (Immunoglobulin Lambda Variable 2-8) is a Protein Coding gene. An important paralog of this gene is IGLV2-11.

UniProtKB/Swiss-Prot for IGLV2-8 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLV2-8 Gene

Genomics for IGLV2-8 Gene

Regulatory Elements for IGLV2-8 Gene

Enhancers for IGLV2-8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F022815 1.2 Ensembl ENCODE 0.8 -3.2 -3158 9.0 PKNOX1 TBL1XR1 ZFP64 SIN3A THRB ETV6 EGR2 MCM3 SP5 TBX21 IGLV5-52 ENSG00000272779 IGLV2-8 IGLV3-9 MIR650
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IGLV2-8 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGLV2-8 Gene

Chromosome:
22
Start:
22,822,658 bp from pter
End:
22,823,293 bp from pter
Size:
636 bases
Orientation:
Plus strand

Genomic View for IGLV2-8 Gene

Genes around IGLV2-8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLV2-8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLV2-8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLV2-8 Gene

Proteins for IGLV2-8 Gene

  • Protein details for IGLV2-8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01709-LV208_HUMAN
    Recommended name:
    Immunoglobulin lambda variable 2-8
    Protein Accession:
    P01709
    Secondary Accessions:
    • A0A087WZW9
    • P01710

    Protein attributes for IGLV2-8 Gene

    Size:
    118 amino acids
    Molecular mass:
    12382 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains, linked by disulfide bonds.

    Three dimensional structures from OCA and Proteopedia for IGLV2-8 Gene

neXtProt entry for IGLV2-8 Gene

Post-translational modifications for IGLV2-8 Gene

No Post-translational modifications

Other Protein References for IGLV2-8 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLV2-8 Gene

Domains & Families for IGLV2-8 Gene

Gene Families for IGLV2-8 Gene

Protein Domains for IGLV2-8 Gene

Suggested Antigen Peptide Sequences for IGLV2-8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01709

UniProtKB/Swiss-Prot:

LV208_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGLV2-8: view

Function for IGLV2-8 Gene

Molecular function for IGLV2-8 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGLV2-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 4415202
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGLV2-8: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLV2-8 Gene

Localization for IGLV2-8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLV2-8 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLV2-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS,TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with IGLV2-8: view

No data available for Subcellular locations from COMPARTMENTS for IGLV2-8 Gene

Pathways & Interactions for IGLV2-8 Gene

SuperPathways for IGLV2-8 Gene

No Data Available

Interacting Proteins for IGLV2-8 Gene

Gene Ontology (GO) - Biological Process for IGLV2-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 4415202
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
genes like me logo Genes that share ontologies with IGLV2-8: view

No data available for Pathways by source and SIGNOR curated interactions for IGLV2-8 Gene

Transcripts for IGLV2-8 Gene

mRNA/cDNA for IGLV2-8 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGLV2-8 Gene

No ASD Table

Relevant External Links for IGLV2-8 Gene

GeneLoc Exon Structure for
IGLV2-8
ECgene alternative splicing isoforms for
IGLV2-8

Expression for IGLV2-8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGLV2-8 Gene

mRNA differential expression in normal tissues according to GTEx for IGLV2-8 Gene

This gene is overexpressed in Spleen (x16.1), Colon - Transverse (x8.9), Minor Salivary Gland (x6.7), and Small Intestine - Terminal Ileum (x5.3).

Protein differential expression in normal tissues from HIPED for IGLV2-8 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLV2-8 Gene



Protein tissue co-expression partners for IGLV2-8 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGLV2-8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGLV2-8 Gene

Orthologs for IGLV2-8 Gene

Evolution for IGLV2-8 Gene

ENSEMBL:
Gene Tree for IGLV2-8 (if available)
TreeFam:
Gene Tree for IGLV2-8 (if available)

No data available for Orthologs for IGLV2-8 Gene

Paralogs for IGLV2-8 Gene

Variants for IGLV2-8 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLV2-8 Gene

LV208_HUMAN-P01709
There are several alleles. The sequence shown is that of IMGT allele IGLV2-8*01.

Relevant External Links for IGLV2-8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLV2-8

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLV2-8 Gene

Disorders for IGLV2-8 Gene

No disorders were found for IGLV2-8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGLV2-8 Gene

Publications for IGLV2-8 Gene

  1. Primary structure of the Mcg lambda chain. (PMID: 4415202) Fett J.W. … Deutsch H.F. (Biochemistry 1974) 3 4 64
  2. Amino acid sequence of human lambda chains. 3. Tryptic peptides, chymotryptic peptides, and sequence of protein Bo. (PMID: 5532228) Wikler M. … Putnam F.W. (J. Biol. Chem. 1970) 3 4 64
  3. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  4. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  5. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64

Products for IGLV2-8 Gene

Sources for IGLV2-8 Gene

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