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Aliases for IGLV2-8 Gene

Aliases for IGLV2-8 Gene

  • Immunoglobulin Lambda Variable 2-8 2 3 5
  • Ig Lambda Chain V-II Region MGC 3 4
  • Ig Lambda Chain V-II Region BO 4
  • IGLV28 3
  • V1-2 3

External Ids for IGLV2-8 Gene

Previous GeneCards Identifiers for IGLV2-8 Gene

  • GC22U990169
  • GC22P021490
  • GC22P021497
  • GC22P023166
  • GC22P006133
  • GC22P023168
  • GC22P023170
  • GC22P023172
  • GC22P023174
  • GC22P022823
  • GC22P022867
  • GC22P022941
  • GC22P022956
  • GC22P023033
  • GC22P023124

Summaries for IGLV2-8 Gene

GeneCards Summary for IGLV2-8 Gene

IGLV2-8 (Immunoglobulin Lambda Variable 2-8) is a Protein Coding gene. An important paralog of this gene is IGLV2-11.

UniProtKB/Swiss-Prot for IGLV2-8 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Additional gene information for IGLV2-8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLV2-8 Gene

Genomics for IGLV2-8 Gene

Regulatory Elements for IGLV2-8 Gene

Enhancers for IGLV2-8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H022816 1 Ensembl ENCODE 0.7 -2.5 -2453 7 HNRNPUL1 CTCF PKNOX1 ETV1 TSC22D4 YBX1 EBF1 PYGO2 RELA CTBP1 TOP3B MMP11 ZNF70 IGLV5-52 ENSG00000272578 ENSG00000234630 IGLV3-9 IGLV2-8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGLV2-8 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGLV2-8 Gene

Chromosome:
22
Start:
22,822,658 bp from pter
End:
22,823,289 bp from pter
Size:
632 bases
Orientation:
Plus strand

Genomic View for IGLV2-8 Gene

Genes around IGLV2-8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLV2-8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLV2-8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLV2-8 Gene

Proteins for IGLV2-8 Gene

  • Protein details for IGLV2-8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01709-LV208_HUMAN
    Recommended name:
    Immunoglobulin lambda variable 2-8
    Protein Accession:
    P01709
    Secondary Accessions:
    • A0A087WZW9
    • P01710

    Protein attributes for IGLV2-8 Gene

    Size:
    118 amino acids
    Molecular mass:
    12382 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for IGLV2-8 Gene

neXtProt entry for IGLV2-8 Gene

Post-translational modifications for IGLV2-8 Gene

No Post-translational modifications

Other Protein References for IGLV2-8 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLV2-8 Gene

Domains & Families for IGLV2-8 Gene

Gene Families for IGLV2-8 Gene

Protein Domains for IGLV2-8 Gene

Suggested Antigen Peptide Sequences for IGLV2-8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGLV2-8: view

No data available for UniProtKB/Swiss-Prot for IGLV2-8 Gene

Function for IGLV2-8 Gene

Molecular function for IGLV2-8 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGLV2-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 4415202
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGLV2-8: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for IGLV2-8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLV2-8 Gene

Localization for IGLV2-8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLV2-8 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLV2-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGLV2-8: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGLV2-8 Gene

Pathways & Interactions for IGLV2-8 Gene

SuperPathways for IGLV2-8 Gene

No Data Available

Interacting Proteins for IGLV2-8 Gene

Gene Ontology (GO) - Biological Process for IGLV2-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 4415202
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGLV2-8: view

No data available for Pathways by source and SIGNOR curated interactions for IGLV2-8 Gene

Drugs & Compounds for IGLV2-8 Gene

No Compound Related Data Available

Transcripts for IGLV2-8 Gene

mRNA/cDNA for IGLV2-8 Gene

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for IGLV2-8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IGLV2-8 Gene

No ASD Table

Relevant External Links for IGLV2-8 Gene

GeneLoc Exon Structure for
IGLV2-8
ECgene alternative splicing isoforms for
IGLV2-8

Expression for IGLV2-8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGLV2-8 Gene

mRNA differential expression in normal tissues according to GTEx for IGLV2-8 Gene

This gene is overexpressed in Spleen (x16.1), Colon - Transverse (x8.9), Minor Salivary Gland (x6.7), and Small Intestine - Terminal Ileum (x5.3).

Protein differential expression in normal tissues from HIPED for IGLV2-8 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLV2-8 Gene



Protein tissue co-expression partners for IGLV2-8 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGLV2-8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLV2-8 Gene

Orthologs for IGLV2-8 Gene

Evolution for IGLV2-8 Gene

ENSEMBL:
Gene Tree for IGLV2-8 (if available)
TreeFam:
Gene Tree for IGLV2-8 (if available)

No data available for Orthologs for IGLV2-8 Gene

Paralogs for IGLV2-8 Gene

Variants for IGLV2-8 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLV2-8 Gene

LV208_HUMAN-P01709
There are several alleles. The sequence shown is that of IMGT allele IGLV2-8*01.

Relevant External Links for IGLV2-8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLV2-8

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLV2-8 Gene

Disorders for IGLV2-8 Gene

No disorders were found for IGLV2-8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGLV2-8 Gene

Publications for IGLV2-8 Gene

  1. Primary structure of the Mcg lambda chain. (PMID: 4415202) Fett JW … Deutsch HF (Biochemistry 1974) 3 4 60
  2. Amino acid sequence of human lambda chains. 3. Tryptic peptides, chymotryptic peptides, and sequence of protein Bo. (PMID: 5532228) Wikler M … Putnam FW (The Journal of biological chemistry 1970) 3 4 60
  3. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4 60
  4. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M … McHeyzer-Williams L (Nature reviews. Immunology 2011) 4 60
  5. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder HW … Cavacini L (The Journal of allergy and clinical immunology 2010) 4 60

Products for IGLV2-8 Gene

Sources for IGLV2-8 Gene

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