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Aliases for IGLV2-23 Gene

Aliases for IGLV2-23 Gene

  • Immunoglobulin Lambda Variable 2-23 2 3 5
  • Ig Lambda Chain V-II Region NEI 3 4
  • IGLV223 3
  • V1-7 3

External Ids for IGLV2-23 Gene

Previous GeneCards Identifiers for IGLV2-23 Gene

  • GC22U990165
  • GC22P021365
  • GC22P021370
  • GC22P023041
  • GC22P006008
  • GC22P023049
  • GC22P023052
  • GC22P023053
  • GC22P023056
  • GC22P023061
  • GC22P023065
  • GC22P023067
  • GC22P022746
  • GC22P022825
  • GC22P022869
  • GC22P022929

Summaries for IGLV2-23 Gene

GeneCards Summary for IGLV2-23 Gene

IGLV2-23 (Immunoglobulin Lambda Variable 2-23) is a Protein Coding gene. An important paralog of this gene is IGLV2-14.

UniProtKB/Swiss-Prot for IGLV2-23 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLV2-23 Gene

Genomics for IGLV2-23 Gene

Regulatory Elements for IGLV2-23 Gene

Enhancers for IGLV2-23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F022719 1.1 Ensembl ENCODE 12.7 +23.3 23312 2.6 CTCF PKNOX1 KLF1 ATF1 TBL1XR1 JUN EBF1 RAD21 RELA ZFHX2 IGLV2-23 IGLVVI-22-1 IGLV3-24 IGLV3-19 ENSG00000278667
GH22F022737 0.4 ENCODE 13.2 +40.0 40019 0.2 ATF1 NFIA LL22NC03-102D1.18 IGLV3-22 IGLVVI-22-1 IGLV2-23 IGLV3-24 IGLV2-18 IGLV3-17
GH22F022697 0.6 Ensembl 0.8 +0.0 6 1.5 CTCF USF1 SMAD5 POLR2A ZBED1 CBFB SPI1 IGLV2-23 IGLVVI-22-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGLV2-23 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGLV2-23 Gene

Chromosome:
22
Start:
22,697,789 bp from pter
End:
22,698,421 bp from pter
Size:
633 bases
Orientation:
Plus strand

Genomic View for IGLV2-23 Gene

Genes around IGLV2-23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLV2-23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLV2-23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLV2-23 Gene

Proteins for IGLV2-23 Gene

  • Protein details for IGLV2-23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01705-LV223_HUMAN
    Recommended name:
    Immunoglobulin lambda variable 2-23
    Protein Accession:
    P01705
    Secondary Accessions:
    • A0A075B6J5

    Protein attributes for IGLV2-23 Gene

    Size:
    113 amino acids
    Molecular mass:
    11893 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains, linked by disulfide bonds.

neXtProt entry for IGLV2-23 Gene

Post-translational modifications for IGLV2-23 Gene

No Post-translational modifications

Other Protein References for IGLV2-23 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLV2-23 Gene

Domains & Families for IGLV2-23 Gene

Gene Families for IGLV2-23 Gene

Protein Domains for IGLV2-23 Gene

Suggested Antigen Peptide Sequences for IGLV2-23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01705

UniProtKB/Swiss-Prot:

LV223_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGLV2-23: view

Function for IGLV2-23 Gene

Molecular function for IGLV2-23 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGLV2-23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 5043326
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGLV2-23: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLV2-23 Gene

Localization for IGLV2-23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLV2-23 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLV2-23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS,TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with IGLV2-23: view

No data available for Subcellular locations from COMPARTMENTS for IGLV2-23 Gene

Pathways & Interactions for IGLV2-23 Gene

SuperPathways for IGLV2-23 Gene

No Data Available

Interacting Proteins for IGLV2-23 Gene

Gene Ontology (GO) - Biological Process for IGLV2-23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 5043326
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
genes like me logo Genes that share ontologies with IGLV2-23: view

No data available for Pathways by source and SIGNOR curated interactions for IGLV2-23 Gene

Transcripts for IGLV2-23 Gene

mRNA/cDNA for IGLV2-23 Gene

(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGLV2-23 Gene

No ASD Table

Relevant External Links for IGLV2-23 Gene

GeneLoc Exon Structure for
IGLV2-23
ECgene alternative splicing isoforms for
IGLV2-23

Expression for IGLV2-23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGLV2-23 Gene

mRNA differential expression in normal tissues according to GTEx for IGLV2-23 Gene

This gene is overexpressed in Spleen (x13.8), Colon - Transverse (x6.8), Minor Salivary Gland (x4.7), and Small Intestine - Terminal Ileum (x4.6).
genes like me logo Genes that share expression patterns with IGLV2-23: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IGLV2-23 Gene

Orthologs for IGLV2-23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLV2-23 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 51 (a)
OneToMany
Species where no ortholog for IGLV2-23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGLV2-23 Gene

ENSEMBL:
Gene Tree for IGLV2-23 (if available)
TreeFam:
Gene Tree for IGLV2-23 (if available)

Paralogs for IGLV2-23 Gene

genes like me logo Genes that share paralogs with IGLV2-23: view

Variants for IGLV2-23 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLV2-23 Gene

LV223_HUMAN-P01705
There are several alleles. The sequence shown is that of IMGT allele IGLV2-23*01 and IMGT allele IGLV2-23*03.

Relevant External Links for IGLV2-23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLV2-23

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLV2-23 Gene

Disorders for IGLV2-23 Gene

No disorders were found for IGLV2-23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGLV2-23 Gene

Publications for IGLV2-23 Gene

  1. The primary structure of a monoclonal human lambda-type immunoglobulin L-chain of subgroup II (Bence-Jones protein NEI). (PMID: 5043326) Garver F.A. … Hilschmann N. (Eur. J. Biochem. 1972) 3 4 64
  2. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  3. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  4. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64
  5. Recognition of immunoglobulins by Fcgamma receptors. (PMID: 11955599) Radaev S. … Sun P. (Mol. Immunol. 2002) 3 64

Products for IGLV2-23 Gene

Sources for IGLV2-23 Gene

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