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Aliases for IGLV2-18 Gene

Aliases for IGLV2-18 Gene

  • Immunoglobulin Lambda Variable 2-18 2 3 5
  • IGLV218 3
  • V1-5 3

External Ids for IGLV2-18 Gene

Previous GeneCards Identifiers for IGLV2-18 Gene

  • GC22U990166
  • GC22P021401
  • GC22P021407
  • GC22P023077
  • GC22P022794
  • GC22P022833
  • GC22P022840
  • GC22P022945
  • GC22P023001
  • GC22P023111

Summaries for IGLV2-18 Gene

GeneCards Summary for IGLV2-18 Gene

IGLV2-18 (Immunoglobulin Lambda Variable 2-18) is a Protein Coding gene. An important paralog of this gene is IGLV2-14.

UniProtKB/Swiss-Prot for IGLV2-18 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Additional gene information for IGLV2-18 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLV2-18 Gene

Genomics for IGLV2-18 Gene

Regulatory Elements for IGLV2-18 Gene

Enhancers for IGLV2-18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H022737 0.4 ENCODE 0.7 +3.2 3201 0 ATF1 LL22NC03-102D1.18 IGLV3-22 IGLVVI-22-1 IGLV2-23 IGLV3-24 IGLV2-18 IGLV3-17
GH22H022731 0.2 dbSUPER 0.7 -2.1 -2118 0 LL22NC03-102D1.18 IGLV3-22 IGLV2-23 IGLVVI-22-1 IGLV3-24 IGLV3-4 IGLV2-5 ENSG00000278667 IGLV2-18
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGLV2-18 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGLV2-18 Gene

Chromosome:
22
Start:
22,734,607 bp from pter
End:
22,735,089 bp from pter
Size:
483 bases
Orientation:
Plus strand

Genomic View for IGLV2-18 Gene

Genes around IGLV2-18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLV2-18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLV2-18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLV2-18 Gene

Proteins for IGLV2-18 Gene

  • Protein details for IGLV2-18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A075B6J9-LV218_HUMAN
    Recommended name:
    Immunoglobulin lambda variable 2-18
    Protein Accession:
    A0A075B6J9

    Protein attributes for IGLV2-18 Gene

    Size:
    118 amino acids
    Molecular mass:
    12412 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
    SequenceCaution:
    • Sequence=EAW59533.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for IGLV2-18 Gene

Post-translational modifications for IGLV2-18 Gene

No Post-translational modifications

Other Protein References for IGLV2-18 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLV2-18 Gene

Domains & Families for IGLV2-18 Gene

Gene Families for IGLV2-18 Gene

Protein Domains for IGLV2-18 Gene

Suggested Antigen Peptide Sequences for IGLV2-18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGLV2-18: view

No data available for UniProtKB/Swiss-Prot for IGLV2-18 Gene

Function for IGLV2-18 Gene

Molecular function for IGLV2-18 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGLV2-18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
genes like me logo Genes that share ontologies with IGLV2-18: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for IGLV2-18
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLV2-18 Gene

Localization for IGLV2-18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLV2-18 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLV2-18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGLV2-18: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGLV2-18 Gene

Pathways & Interactions for IGLV2-18 Gene

SuperPathways for IGLV2-18 Gene

No Data Available

Interacting Proteins for IGLV2-18 Gene

Gene Ontology (GO) - Biological Process for IGLV2-18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002377 immunoglobulin production IBA --
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with IGLV2-18: view

No data available for Pathways by source and SIGNOR curated interactions for IGLV2-18 Gene

Drugs & Compounds for IGLV2-18 Gene

No Compound Related Data Available

Transcripts for IGLV2-18 Gene

mRNA/cDNA for IGLV2-18 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for IGLV2-18
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IGLV2-18 Gene

No ASD Table

Relevant External Links for IGLV2-18 Gene

GeneLoc Exon Structure for
IGLV2-18
ECgene alternative splicing isoforms for
IGLV2-18

Expression for IGLV2-18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGLV2-18 Gene

mRNA differential expression in normal tissues according to GTEx for IGLV2-18 Gene

This gene is overexpressed in Spleen (x21.0), Colon - Transverse (x7.3), and Whole Blood (x6.3).

Protein differential expression in normal tissues from HIPED for IGLV2-18 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLV2-18 Gene



Protein tissue co-expression partners for IGLV2-18 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGLV2-18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLV2-18 Gene

Orthologs for IGLV2-18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLV2-18 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 74 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 56 (a)
OneToMany
Species where no ortholog for IGLV2-18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGLV2-18 Gene

ENSEMBL:
Gene Tree for IGLV2-18 (if available)
TreeFam:
Gene Tree for IGLV2-18 (if available)

Paralogs for IGLV2-18 Gene

Pseudogenes.org Pseudogenes for IGLV2-18 Gene

genes like me logo Genes that share paralogs with IGLV2-18: view

Variants for IGLV2-18 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLV2-18 Gene

LV218_HUMAN-A0A075B6J9
There are several alleles. The sequence shown is that of IMGT allele IGLV2-18*01.

Relevant External Links for IGLV2-18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLV2-18

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLV2-18 Gene

Disorders for IGLV2-18 Gene

No disorders were found for IGLV2-18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGLV2-18 Gene

Publications for IGLV2-18 Gene

  1. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4 60
  2. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M … McHeyzer-Williams L (Nature reviews. Immunology 2011) 4 60
  3. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder HW … Cavacini L (The Journal of allergy and clinical immunology 2010) 4 60
  4. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G … Papavasiliou FN (Annual review of genetics 2007) 4 60
  5. Recognition of immunoglobulins by Fcgamma receptors. (PMID: 11955599) Radaev S … Sun P (Molecular immunology 2002) 3 60

Products for IGLV2-18 Gene

Sources for IGLV2-18 Gene

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