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IGLV1-44 Gene

protein-coding   GIFtS: 31
GCID: GC22P022734

Immunoglobulin Lambda Variable 1-44

  See IGLV1-44-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immunoglobulin Lambda Variable 1-441 2
V1-162 4
IGLV1442

External Ids:    HGNC: 58791   Entrez Gene: 288232   Ensembl: ENSG000002116517   UniProtKB: Q5NV814   

Export aliases for IGLV1-44 gene to outside databases

Previous GC identifers: GC22U990175 GC22P021059 GC22P021065 GC22P005692


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IGLV1-44 Gene:
IGLV1-44 (immunoglobulin lambda variable 1-44) is a protein-coding gene. Diseases associated with IGLV1-44 include papilledema. An important paralog of this gene is IGLV2-18.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for IGLV1-44
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGLV1-44


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

IGLV1-44 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLV1-44 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P022734:  view genomic region     (about GC identifiers)

Start:
22,734,288 bp from pter      End:
22,735,716 bp from pter
Size:
1,429 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/TrEMBL: Q5NV81 (See protein sequence)
Recommended Name: V1-16 protein  
Size: 99 amino acids; 10284 Da

Explore proteomics data for IGLV1-44 at MOPED


See IGLV1-44 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000374832  
Reactome Protein details: Q5NV81

IGLV1-44 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
IGL: Immunoglobulins / IGL locus

4 InterPro protein domains:
 IPR003596 Ig_V-set_subgr
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set
 IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry Q5NV81

ProtoNet protein and cluster: Q5NV81

1 Blocks protein domain: IPB003596 Immunoglobulin V-type


Find genes that share domains with IGLV1-44           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with IGLV1-44           About GenesLikeMe


Animal Models:
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hsa-mir-335-5p (MIRT019214)

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Find genes that share SuperPaths with IGLV1-44           About GenesLikeMe

Pathways by sourceSee SuperPaths
Show all pathways


Selected Reactome Pathways for IGLV1-44 (see all 12)
    FCERI mediated MAPK activation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
FCERI mediated NF-kB activation
FCGR activation
Scavenging of heme from plasma


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Interactions:

    Search GeneGlobe Interaction Network for IGLV1-44

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for IGLV1-44 (ENSP000003748324) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
UBCENSP000003448184STRING: ENSP00000344818
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for IGLV1-44



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Unigene Cluster for IGLV1-44:

Immunoglobulin lambda variable 1-44
Hs.655198  [show with all ESTs]
Unigene Representative Sequence: BQ708343
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390297
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Additional mRNA sequence: 

AB063980.1 AB063981.1 AB063982.1 AB064003.1 AB064007.1 AB064038.1 AB064039.1 AB064040.1 
AB729123.1 AF001790.1 AF063767.1 AF063777.1 AF103604.1 AF103619.1 AF103691.1 AF103721.1 
AF396471.1 AF396473.1 AF396475.1 AF396477.1 AF396479.1 AF533987.1 AJ001170.1 AJ241360.1 
AJ408273.1 AJ408278.1 AJ430770.1 AJ430772.1 AM184067.1 AY043091.1 AY099260.1 AY193809.1 
AY193811.1 AY193813.1 AY193815.1 AY193817.1 AY193819.1 AY206991.1 AY577301.1 AY685379.1 
AY685380.1 AY686916.1 AY686929.1 AY847517.1 AY942030.1 AY950796.1 AY950798.1 AY957533.1 
DQ187504.1 DQ187523.1 DQ187610.1 DQ187635.1 DQ205148.1 DQ322743.1 DQ322761.1 DQ322772.1 
DQ322815.1 DQ322903.1 DQ322953.1 EF589436.1 EF589440.1 EF589531.1 FJ385510.1 HF541913.1 
HF541914.1 HM996235.1 HM996274.1 HM996539.1 HQ890346.1 HQ890352.1 JF740069.1 JF806462.1 
JX213638.1 L26896.1 M28137.1 U86802.1 U96394.1 X54438.1 X54446.1 X98752.1 
Y09389.1 Z46312.1 Z46625.1 Z74670.1 

Selected DOTS entries (see all 41):

DT.100885149  DT.120676987  DT.120676837  DT.120677017  DT.319469  DT.100032366  DT.100046825  DT.420912 
DT.91769054  DT.91728360  DT.95090606  DT.95183816  DT.95298046  DT.100046157  DT.95303883  DT.120677826 
DT.87002873  DT.91660956  DT.91927893  DT.97867854  DT.95215487  DT.120676886  DT.91832774  DT.97868390 

2 AceView cDNA sequences:

U09907 M88312 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IGLV1-44 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGLV1-44 Expression
About this image


IGLV1-44 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 7) fully expand
 
 Epithelial Cells
         Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
 
 Bone (Muscoskeletal System)
         Bone Marrow
 
 Blood (Hematopoietic System)
         Plasmacytoid Dendritic cells Peripheral Blood
 
 Eye (Sensory Organs)
         Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
 
 Lung (Respiratory System)
IGLV1-44 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IGLV1-44 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.655198
    Custom PCR Arrays for IGLV1-44
Primer
Products:
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for IGLV1-44 gene from Selected species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia --
Uncharacterized protein
54(a)
many ↔ many
26(25571077-25571668)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
52(a)
1 → many
GL343282.1(521925-522514)


ENSEMBL Gene Tree for IGLV1-44 (if available)
TreeFam Gene Tree for IGLV1-44 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IGLV1-44 gene
IGLV2-182  IGLV3-92  IGLV3-122  IGLV3-192  IGLV1-502  IGLV3-252  IGLV2-82  IGLV1-512  
IGLV10-542  IGLV3-222  IGLV2-232  IGLV7-432  IGLV8-612  IGLV7-462  IGLV3-272  IGLV1-472  
IGLV2-142  IGLV1-402  IGLV3-12  IGLV2-332  IGLV3-322  IGLV6-572  IGLV3-212  IGLV2-112  
IGLV3-162  IGLV3-102  IGLV1-362  
Selected SIMAP similar genes for IGLV1-44 using alignment to 1 protein entry:     Q5NV81_HUMAN(see all similar genes):
V1-17    V1-18    V1-19    IGLV1-40    IGLV1-36    V1-11
IGLV2-18    HuC4lambda Vlambda    IGLV2-11    V1-2    V1-4    VL1
IGL@    IGLV2-23    V3    V1-22    V2-1    V2-14

Find genes that share paralogs with IGLV1-44           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing IGLV1-44
DNA2.0 Custom Variant and Variant Library Synthesis for IGLV1-44

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for IGLV1-44:    
About MalaCards
papilledema

3 diseases from the University of Copenhagen DISEASES database for IGLV1-44:
Papilledema     POEMS syndrome     Hypertrichosis

Find genes that share disorders with IGLV1-44           About GenesLikeMe


Export disorders for IGLV1-44 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IGLV1-44 gene integrated from 10 sources:
(articles sorted by number of sources associating them with IGLV1-44)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
  2. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (Mol. Immunol. 2002)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  4. Molecular analysis of polyreactive monoclonal antibodies from rheumatic carditis: human anti-N-acetylglucosamine/anti-myosin antibody V region genes. (PubMed id 9712075)1 Adderson E.E.... Cunningham M.W. (J. Immunol. 1998)
  5. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1 Kawasaki K.... Shimizu N. (Genome Res. 1997)
  6. Sequence and evolution of the human germline V lambda repertoire. (PubMed id 8951372)1 Williams S.C....Winter G. (J. Mol. Biol. 1996)
  7. Activation of C1r by proteolytic cleavage. (PubMed id 1249422)1 Ziccardi R.J. and Cooper N.R. (J. Immunol. 1976)
  8. Physicochemical and functional characterization of the C1r subunit of the first complement component. (PubMed id 814163)1 Ziccardi R.J. and Cooper N.R. (J. Immunol. 1976)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 28823 HGNC: 5879 AceView: IGLV1-44 Ensembl:ENSG00000211651 euGenes: HUgn28823
ECgene: IGLV1-44 H-InvDB: IGLV1-44

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IGLV1-44 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGLV1-44 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IGLV1-44 gene:
Search GeneIP for patents involving IGLV1-44

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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