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Aliases for IGLV1-40 Gene

Aliases for IGLV1-40 Gene

  • Immunoglobulin Lambda Variable 1-40 2 3 5
  • Ig Lambda Chain V-I Region NEWM 3 4
  • IGLV140 3
  • V1-13 3

External Ids for IGLV1-40 Gene

Previous GeneCards Identifiers for IGLV1-40 Gene

  • GC22U990177
  • GC22P021088
  • GC22P021117
  • GC22P021127
  • GC22P021133
  • GC22P022764
  • GC22P005722
  • GC22P022426
  • GC22P022459
  • GC22P022469
  • GC22P022477
  • GC22P022485

Summaries for IGLV1-40 Gene

GeneCards Summary for IGLV1-40 Gene

IGLV1-40 (Immunoglobulin Lambda Variable 1-40) is a Protein Coding gene. An important paralog of this gene is IGLV1-50.

UniProtKB/Swiss-Prot for IGLV1-40 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLV1-40 Gene

Genomics for IGLV1-40 Gene

Regulatory Elements for IGLV1-40 Gene

Enhancers for IGLV1-40 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G023178 1.7 FANTOM5 ENCODE dbSUPER 4.3 +773.9 773913 10.4 HDGF PKNOX1 FOXA2 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 FEZF1 RSPH14 BCR RAB36 IGLV1-40 BCRP8 RN7SL263P
GH22G023211 1.6 Ensembl ENCODE dbSUPER 4.4 +810.2 810235 16.6 PKNOX1 FOXA2 MLX ZFP64 ARID4B FEZF1 DMAP1 YY1 FOS ZNF263 BCR RSPH14 IGLV1-40 BCRP8 RN7SL263P
GH22G023152 1.1 Ensembl ENCODE 4.6 +743.5 743482 2.0 ELF3 TBP FOXA2 MLX TBL1XR1 ARID4B RAD21 ZBTB40 SLC30A9 ZNF121 BCR IGLV1-40 RAB36 LOC100420267
GH22G022409 0.9 ENCODE 0.7 +0.1 120 1.7 ATF1 RB1 TBL1XR1 YBX1 RAD21 ZNF143 RELB IKZF2 KLF13 KDM4B IGLV1-40 ASH2LP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGLV1-40 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGLV1-40 Gene

Chromosome:
22
Start:
22,409,766 bp from pter
End:
22,410,282 bp from pter
Size:
517 bases
Orientation:
Plus strand

Genomic View for IGLV1-40 Gene

Genes around IGLV1-40 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLV1-40 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLV1-40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLV1-40 Gene

Proteins for IGLV1-40 Gene

  • Protein details for IGLV1-40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01703-LV140_HUMAN
    Recommended name:
    Immunoglobulin lambda variable 1-40
    Protein Accession:
    P01703
    Secondary Accessions:
    • A0A075B6J0

    Protein attributes for IGLV1-40 Gene

    Size:
    118 amino acids
    Molecular mass:
    12302 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGLV1-40 Gene

Post-translational modifications for IGLV1-40 Gene

No Post-translational modifications

Other Protein References for IGLV1-40 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLV1-40 Gene

Domains & Families for IGLV1-40 Gene

Gene Families for IGLV1-40 Gene

Protein Domains for IGLV1-40 Gene

Suggested Antigen Peptide Sequences for IGLV1-40 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGLV1-40: view

No data available for UniProtKB/Swiss-Prot for IGLV1-40 Gene

Function for IGLV1-40 Gene

Molecular function for IGLV1-40 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGLV1-40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 4814727
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGLV1-40: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLV1-40 Gene

Localization for IGLV1-40 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLV1-40 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLV1-40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGLV1-40: view

No data available for Subcellular locations from COMPARTMENTS for IGLV1-40 Gene

Pathways & Interactions for IGLV1-40 Gene

SuperPathways for IGLV1-40 Gene

No Data Available

Interacting Proteins for IGLV1-40 Gene

Selected Interacting proteins: P01703-LV140_HUMAN for IGLV1-40 Gene via IID

Gene Ontology (GO) - Biological Process for IGLV1-40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 4814727
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGLV1-40: view

No data available for Pathways by source and SIGNOR curated interactions for IGLV1-40 Gene

Drugs & Compounds for IGLV1-40 Gene

No Compound Related Data Available

Transcripts for IGLV1-40 Gene

mRNA/cDNA for IGLV1-40 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGLV1-40 Gene

No ASD Table

Relevant External Links for IGLV1-40 Gene

GeneLoc Exon Structure for
IGLV1-40
ECgene alternative splicing isoforms for
IGLV1-40

Expression for IGLV1-40 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGLV1-40 Gene

mRNA differential expression in normal tissues according to GTEx for IGLV1-40 Gene

This gene is overexpressed in Spleen (x15.6), Minor Salivary Gland (x7.9), and Colon - Transverse (x5.9).

Protein differential expression in normal tissues from HIPED for IGLV1-40 Gene

This gene is overexpressed in Urine (57.4) and Serum (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLV1-40 Gene



Protein tissue co-expression partners for IGLV1-40 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGLV1-40: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLV1-40 Gene

Orthologs for IGLV1-40 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLV1-40 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 63 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 59 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 58 (a)
OneToMany
Species where no ortholog for IGLV1-40 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGLV1-40 Gene

ENSEMBL:
Gene Tree for IGLV1-40 (if available)
TreeFam:
Gene Tree for IGLV1-40 (if available)

Paralogs for IGLV1-40 Gene

genes like me logo Genes that share paralogs with IGLV1-40: view

Variants for IGLV1-40 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLV1-40 Gene

LV140_HUMAN-P01703
There are several alleles. The sequence shown is that of IMGT allele IGLV1-40*01.

Relevant External Links for IGLV1-40 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLV1-40

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLV1-40 Gene

Disorders for IGLV1-40 Gene

No disorders were found for IGLV1-40 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGLV1-40 Gene

Publications for IGLV1-40 Gene

  1. Amino acid sequence of the (lambda) light chain of a human myeloma immunoglobulin (IgG New). (PMID: 4814727) Chen B.L. … Poljak R.J. (Biochemistry 1974) 3 4 64
  2. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  3. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  4. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  5. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64

Products for IGLV1-40 Gene

Sources for IGLV1-40 Gene

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