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Aliases for IGLON5 Gene

Aliases for IGLON5 Gene

  • IgLON Family Member 5 2 3
  • Ig-Like Domain-Containing Protein ENSP00000270642 3
  • HCG1651476 3

External Ids for IGLON5 Gene

Previous GeneCards Identifiers for IGLON5 Gene

  • GC19P056509
  • GC19P051815
  • GC19P048157

Summaries for IGLON5 Gene

GeneCards Summary for IGLON5 Gene

IGLON5 (IgLON Family Member 5) is a Protein Coding gene. An important paralog of this gene is NTM.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLON5 Gene

Genomics for IGLON5 Gene

Genomic Location for IGLON5 Gene

Start:
51,311,848 bp from pter
End:
51,330,848 bp from pter
Size:
19,001 bases
Orientation:
Plus strand

Genomic View for IGLON5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGLON5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLON5 Gene

Proteins for IGLON5 Gene

  • Protein details for IGLON5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGN9-IGLO5_HUMAN
    Recommended name:
    IgLON family member 5
    Protein Accession:
    A6NGN9
    Secondary Accessions:

    Protein attributes for IGLON5 Gene

    Size:
    336 amino acids
    Molecular mass:
    36795 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGLON5 Gene

Proteomics data for IGLON5 Gene at MOPED

Post-translational modifications for IGLON5 Gene

  • Glycosylation at Asn41, Asn49, Asn67, Asn137, and Asn288
  • Modification sites at PhosphoSitePlus

Other Protein References for IGLON5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGLON5 Gene

Domains for IGLON5 Gene

Gene Families for IGLON5 Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for IGLON5 Gene

Suggested Antigen Peptide Sequences for IGLON5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NGN9

UniProtKB/Swiss-Prot:

IGLO5_HUMAN :
  • A6NGN9
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. IgLON family.
genes like me logo Genes that share domains with IGLON5: view

Function for IGLON5 Gene

Gene Ontology (GO) - Molecular Function for IGLON5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IGLON5: view

Phenotypes for IGLON5 Gene

genes like me logo Genes that share phenotypes with IGLON5: view

Animal Model Products

CRISPR Products

miRNA for IGLON5 Gene

miRTarBase miRNAs that target IGLON5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGLON5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IGLON5 Gene

Localization for IGLON5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLON5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGLON5 Gene COMPARTMENTS Subcellular localization image for IGLON5 gene
Compartment Confidence
extracellular 3
plasma membrane 3
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IGLON5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IBA --
GO:0005911 cell-cell junction IBA --
GO:0009986 cell surface IBA --
GO:0043005 neuron projection IBA --
genes like me logo Genes that share ontologies with IGLON5: view

Pathways for IGLON5 Gene

SuperPathways for IGLON5 Gene

No Data Available

Interacting Proteins for IGLON5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000270642%0d%0a9606.ENSP00000350364%0d%0a
Selected Interacting proteins: ENSP00000270642 for IGLON5 Gene via STRING

Symbol External ID(s) Details
NEGR1

Gene Ontology (GO) - Biological Process for IGLON5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016337 single organismal cell-cell adhesion IBA --
GO:0050767 regulation of neurogenesis IBA --
genes like me logo Genes that share ontologies with IGLON5: view

No data available for Pathways by source for IGLON5 Gene

Transcripts for IGLON5 Gene

mRNA/cDNA for IGLON5 Gene

(17) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGLON5 Gene

IgLON family member 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGLON5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IGLON5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGLON5 Gene

No ASD Table

Relevant External Links for IGLON5 Gene

GeneLoc Exon Structure for
IGLON5
ECgene alternative splicing isoforms for
IGLON5

Expression for IGLON5 Gene

mRNA expression in normal human tissues for IGLON5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGLON5 Gene

This gene is overexpressed in Brain - Cerebellum (10.6), Brain - Cerebellar Hemisphere (9.4), and Brain - Hypothalamus (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IGLON5 Gene

SOURCE GeneReport for Unigene cluster for IGLON5 Gene Hs.546636

genes like me logo Genes that share expressions with IGLON5: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IGLON5 Gene

Orthologs for IGLON5 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGLON5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGLON5 35
  • 99.47 (n)
  • 99.04 (a)
IGLON5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGLON5 35
  • 93.06 (n)
  • 97.62 (a)
IGLON5 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGLON5 35
  • 92.98 (n)
  • 95.91 (a)
IGLON5 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Iglon5 35
  • 90.48 (n)
  • 97.92 (a)
Iglon5 16
Iglon5 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGLON5 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGLON5 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Iglon5 35
  • 90.58 (n)
  • 97.92 (a)
lizard
(Anolis carolinensis)
Reptilia IGLON5 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488314 35
  • 66.67 (n)
  • 66.43 (a)
zebrafish
(Danio rerio)
Actinopterygii IGLON5 36
  • 53 (a)
OneToOne
zgc:110372 35
  • 63.13 (n)
  • 59.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ama 36
  • 21 (a)
ManyToMany
CG11320 36
  • 23 (a)
ManyToMany
CG14010 36
  • 20 (a)
ManyToMany
CG14521 36
  • 20 (a)
ManyToMany
CG31646 36
  • 15 (a)
ManyToMany
CG31708 36
  • 17 (a)
ManyToMany
CG31814 36
  • 13 (a)
ManyToMany
CG32791 36
  • 16 (a)
ManyToMany
CG34353 36
  • 16 (a)
ManyToMany
CG34391 36
  • 18 (a)
ManyToMany
CG40378 36
  • 20 (a)
ManyToMany
CG42343 36
  • 16 (a)
ManyToMany
CG42368 36
  • 18 (a)
ManyToMany
CG7166 36
  • 15 (a)
ManyToMany
klg 36
  • 16 (a)
ManyToMany
Lac 36
  • 24 (a)
ManyToMany
wrapper 36
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea rig-5 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for IGLON5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IGLON5 Gene

ENSEMBL:
Gene Tree for IGLON5 (if available)
TreeFam:
Gene Tree for IGLON5 (if available)

Paralogs for IGLON5 Gene

Paralogs for IGLON5 Gene

Selected SIMAP similar genes for IGLON5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IGLON5 Gene

genes like me logo Genes that share paralogs with IGLON5: view

Variants for IGLON5 Gene

Sequence variations from dbSNP and Humsavar for IGLON5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs883032 -- 51,317,974(+) ACCAT(C/T)CATGC intron-variant
rs883033 -- 51,318,096(+) gccca(G/T)aagaa intron-variant
rs2063823 -- 51,313,635(-) AGAGA(A/G)AGAAA intron-variant
rs2063824 -- 51,313,633(-) AGAGA(A/G)AAAAA intron-variant
rs2411317 -- 51,318,380(-) GTCCA(C/T)TGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGLON5 Gene

Variant ID Type Subtype PubMed ID
esv2718770 CNV Deletion 23290073

Relevant External Links for IGLON5 Gene

HapMap Linkage Disequilibrium report
IGLON5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGLON5 Gene

Disorders for IGLON5 Gene

No disorders were found for IGLON5 Gene.

No data available for UniProtKB/Swiss-Prot for IGLON5 Gene

Publications for IGLON5 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  2. A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study. (PMID: 24703753) Sabater L. … Graus F. (Lancet Neurol 2014) 3

Products for IGLON5 Gene

Sources for IGLON5 Gene

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