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IGLON5 Gene

protein-coding   GIFtS: 42
GCID: GC19P051815

IgLON Family Member 5

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
IgLON Family Member 51 2
hCG16514762
Ig-Like Domain-Containing Protein ENSP000002706422

External Ids:    HGNC: 345501   Entrez Gene: 4026652   Ensembl: ENSG000001425497   UniProtKB: A6NGN93   

Export aliases for IGLON5 gene to outside databases

Previous GC identifers: GC19P056509 GC19P048157


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IGLON5 Gene:
IGLON5 (IgLON family member 5) is a protein-coding gene. An important paralog of this gene is NTM.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IGLON5 gene promoter:
         COUP-TF1   LHX3b/Lhx3b   MAZR   COUP   HNF-4alpha2   C/EBPalpha   HNF-4alpha1   COUP-TF   LHX3a/Lhx3a   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for IGLON5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGLON5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.33

IGLON5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLON5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P051815:  view genomic region     (about GC identifiers)

Start:
51,815,102 bp from pter      End:
51,834,102 bp from pter
Size:
19,001 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IGLO5_HUMAN, A6NGN9 (See protein sequence)
Recommended Name: IgLON family member 5 precursor  
Size: 336 amino acids; 36795 Da

Explore the universe of human proteins at neXtProt for IGLON5: NX_A6NGN9

Explore proteomics data for IGLON5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn41, Asn49, Asn67, Asn137, Asn288

  • See IGLON5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001094842.1  
    ENSEMBL proteins: 
     ENSP00000270642  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry A6NGN9

    ProtoNet protein and cluster: A6NGN9

    UniProtKB/Swiss-Prot: IGLO5_HUMAN, A6NGN9
    Similarity: Belongs to the immunoglobulin superfamily. IgLON family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with IGLON5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with IGLON5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for IGLON5:
     Decreased homologous recombina  Small cells 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IGLON5

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    Selected qRT-PCR Assays for microRNAs that regulate IGLON5 (see all 53):
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IGLO5_HUMAN, A6NGN9: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3
    lysosome1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with IGLON5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGLON5
    Interactions:

        Search GeneGlobe Interaction Network for IGLON5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for IGLON5 (ENSP000002706424) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEGR1ENSP000003503644STRING: ENSP00000350364
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for IGLON5 (IGLO5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IGLON5 gene: 
    NM_001101372.1  

    Unigene Cluster for IGLON5:

    IgLON family member 5
    Hs.546636  [show with all ESTs]
    Unigene Representative Sequence: NM_001101372
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000270642(uc002pwc.2)
    miRNA
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    hsa-miR-640 hsa-let-7d hsa-miR-330-5p hsa-miR-188-5p hsa-miR-1914* hsa-miR-450a hsa-miR-128 hsa-miR-877*
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    5 DOTS entries:

    DT.430434  DT.92026257  DT.100661534  DT.121053209  DT.97807439 

    17 AceView cDNA sequences:

    CR592222 AA330878 AA339379 BG105760 BX433198 AL583491 BX389379 BX371354 
    AL521811 AI825605 AA401292 AI815935 AA352013 AA317509 BM711641 AA404290 
    AW966303 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGLON5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTCCAATT
    IGLON5 Expression
    About this image


    IGLON5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    IGLON5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGLON5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.546636
        Custom PCR Arrays for IGLON5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGLON5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for IGLON5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Iglon51 , 5 IgLON family member 51, 5 90.48(n)1
    97.92(a)1
      7 (28.25 cM)5
    2100941  NM_001164518.11  NP_001157990.11 
     434729075 
    lizard
    (Anolis carolinensis)
    Reptilia IGLON56
    IgLON family member 5
    67(a)
    1 ↔ 1
    GL343281.1(1239815-1441736)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004883141 igLON family member 5-like 66.67(n)
    66.43(a)
      100488314  XM_002938206.2  XP_002938252.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1103721 zgc:110372 63.13(n)
    59.01(a)
      550472  NM_001017775.2  NP_001017775.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Lac6
    CG113206
    (see all 17)
    --
    24(a)
    23(a)
    (see all 17)
    many ↔ many
    many ↔ many
    (see all 17)
    2R(8340696-8353154)
    2L(6617134-6621700)
    worm
    (Caenorhabditis elegans)
    Secernentea rig-56
    Protein RIG-5, isoform b
    17(a)
    1 → many
    I(9565394-9574377) WBGene00004372


    ENSEMBL Gene Tree for IGLON5 (if available)
    TreeFam Gene Tree for IGLON5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGLON5 gene
    NTM2  NEGR12  LSAMP2  OPCML2  
    4 SIMAP similar genes for IGLON5 using alignment to 1 protein entry:     IGLO5_HUMAN:
    LSAMP    OPCML    NTM    NEGR1

    Find genes that share paralogs with IGLON5           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for IGLON5
    PGOHUM00000232826


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IGLON5 (see all 484)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1878086151,2
    --51813164(+) ATAACA/GTAGAC 1 -- us2k10--------
    rs739327071,2
    C,F--51813191(+) TCCTGC/TGTATG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1926092661,2
    --51813488(+) CCTCCC/TCACCT 1 -- us2k10--------
    rs72497541,2
    C,F--51813491(+) CCCCAC/ACTGCT 1 -- us2k11Minor allele frequency- A:0.14WA 118
    rs1386117351,2
    --51813535(+) GCCTTA/CTTATA 1 -- us2k10--------
    rs762309141,2
    C,F--51813543(+) ATACTG/AGGGAT 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1847683501,2
    C--51813615(+) TGAAAA/TTAGAT 1 -- us2k10--------
    rs2021992331,2
    C--51813689(+) GAGGA-/GGGGGC 1 -- us2k10--------
    rs104145061,2
    C--51813822(+) actccA/Tgggtc 1 -- us2k10--------
    rs104145271,2
    C--51813841(+) gagggA/Gctggg 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IGLON5 (51815102 - 51834102 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IGLON5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718770CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IGLON5
    DNA2.0 Custom Variant and Variant Library Synthesis for IGLON5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed article for IGLON5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with IGLON5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 402665 HGNC: 34550 AceView: LOC402665 Ensembl:ENSG00000142549 euGenes: HUgn402665
    ECgene: IGLON5 H-InvDB: IGLON5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IGLON5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGLON5 gene:
    Search GeneIP for patents involving IGLON5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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