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Aliases for IGLON5 Gene

Aliases for IGLON5 Gene

  • IgLON Family Member 5 2 3 5
  • Ig-Like Domain-Containing Protein ENSP00000270642 3
  • HCG1651476 3

External Ids for IGLON5 Gene

Previous GeneCards Identifiers for IGLON5 Gene

  • GC19P056509
  • GC19P051815
  • GC19P048157

Summaries for IGLON5 Gene

GeneCards Summary for IGLON5 Gene

IGLON5 (IgLON Family Member 5) is a Protein Coding gene. Diseases associated with IGLON5 include Sleep Disorder and Aicardi-Goutieres Syndrome. An important paralog of this gene is NTM.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLON5 Gene

Genomics for IGLON5 Gene

Regulatory Elements for IGLON5 Gene

Enhancers for IGLON5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G051349 1 ENCODE 9.5 +39.5 39549 3.9 HDGF PKNOX1 FOXA2 CREB3L1 ARNT SIN3A DMAP1 YY1 ZNF766 FOS VSIG10L SIGLEC8 SIGLEC14 RPL7P51 SIGLEC5 IGLON5 NKG7 ENSG00000267984 ENSG00000268520
GH19G051687 1.8 FANTOM5 ENCODE dbSUPER 4.9 +378.6 378643 6.9 CREB3L1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ZNF610 ZNF808 ZNF836 ZNF616 ZNF841 ZNF137P ENSG00000268970 ZNF766 ENSG00000269825 ZNF528 ZNF175
GH19G051644 1.1 Ensembl ENCODE dbSUPER 4.9 +334.0 334028 3.1 BCOR RAD51 BHLHE40 IKZF1 ZMYM3 KDM1A SPI1 SIGLEC14 IGLON5 SIGLEC5
GH19G051319 0.7 FANTOM5 5.3 +7.4 7400 0.4 MIER1 ZSCAN4 CEBPB REST CEBPG FOSL1 ATF3 CEBPA TRIM24 IGLON5 GC19M051338
GH19G050835 2 FANTOM5 Ensembl ENCODE dbSUPER 1.1 -475.6 -475602 1.7 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 YY1 ZNF766 ZNF143 NUP62 PTOV1-AS2 ZNF175 LINC01869 SNORD88C C19orf48 KLK2 SNORD88A SNORD88B PNKP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGLON5 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGLON5 Gene

Chromosome:
19
Start:
51,311,848 bp from pter
End:
51,330,848 bp from pter
Size:
19,001 bases
Orientation:
Plus strand

Genomic View for IGLON5 Gene

Genes around IGLON5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLON5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLON5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLON5 Gene

Proteins for IGLON5 Gene

  • Protein details for IGLON5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGN9-IGLO5_HUMAN
    Recommended name:
    IgLON family member 5
    Protein Accession:
    A6NGN9

    Protein attributes for IGLON5 Gene

    Size:
    336 amino acids
    Molecular mass:
    36795 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGLON5 Gene

Post-translational modifications for IGLON5 Gene

  • Glycosylation at isoforms=41, posLast=4949, isoforms=67, posLast=137137, and posLast=288288
  • Modification sites at PhosphoSitePlus

Other Protein References for IGLON5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGLON5 Gene

Domains & Families for IGLON5 Gene

Protein Domains for IGLON5 Gene

Suggested Antigen Peptide Sequences for IGLON5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NGN9

UniProtKB/Swiss-Prot:

IGLO5_HUMAN :
  • Belongs to the immunoglobulin superfamily. IgLON family.
Family:
  • Belongs to the immunoglobulin superfamily. IgLON family.
genes like me logo Genes that share domains with IGLON5: view

Function for IGLON5 Gene

genes like me logo Genes that share phenotypes with IGLON5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGLON5 Gene

Localization for IGLON5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLON5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGLON5 gene
Compartment Confidence
extracellular 4
plasma membrane 3
nucleus 2
lysosome 1

Gene Ontology (GO) - Cellular Components for IGLON5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with IGLON5: view

Pathways & Interactions for IGLON5 Gene

SuperPathways for IGLON5 Gene

No Data Available

Interacting Proteins for IGLON5 Gene

Gene Ontology (GO) - Biological Process for IGLON5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IGLON5 Gene

Drugs & Compounds for IGLON5 Gene

No Compound Related Data Available

Transcripts for IGLON5 Gene

mRNA/cDNA for IGLON5 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGLON5 Gene

IgLON family member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGLON5 Gene

No ASD Table

Relevant External Links for IGLON5 Gene

GeneLoc Exon Structure for
IGLON5
ECgene alternative splicing isoforms for
IGLON5

Expression for IGLON5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGLON5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGLON5 Gene

This gene is overexpressed in Brain - Cerebellum (x10.6), Brain - Cerebellar Hemisphere (x9.4), and Brain - Hypothalamus (x4.2).

Protein differential expression in normal tissues from HIPED for IGLON5 Gene

This gene is overexpressed in Fetal Brain (37.9), Cerebrospinal fluid (17.3), and Retina (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLON5 Gene



Protein tissue co-expression partners for IGLON5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGLON5 Gene:

IGLON5

SOURCE GeneReport for Unigene cluster for IGLON5 Gene:

Hs.546636
genes like me logo Genes that share expression patterns with IGLON5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLON5 Gene

Orthologs for IGLON5 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGLON5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGLON5 34 35
  • 99.47 (n)
cow
(Bos Taurus)
Mammalia IGLON5 34 35
  • 93.06 (n)
dog
(Canis familiaris)
Mammalia IGLON5 34 35
  • 92.98 (n)
rat
(Rattus norvegicus)
Mammalia Iglon5 34
  • 90.58 (n)
mouse
(Mus musculus)
Mammalia Iglon5 34 16 35
  • 90.48 (n)
oppossum
(Monodelphis domestica)
Mammalia IGLON5 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGLON5 35
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGLON5 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488314 34
  • 66.67 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:110372 34
  • 63.13 (n)
IGLON5 35
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Lac 35
  • 24 (a)
ManyToMany
CG11320 35
  • 23 (a)
ManyToMany
Ama 35
  • 21 (a)
ManyToMany
CG14010 35
  • 20 (a)
ManyToMany
CG40378 35
  • 20 (a)
ManyToMany
CG14521 35
  • 20 (a)
ManyToMany
CG34391 35
  • 18 (a)
ManyToMany
CG42368 35
  • 18 (a)
ManyToMany
CG31708 35
  • 17 (a)
ManyToMany
CG32791 35
  • 16 (a)
ManyToMany
CG34353 35
  • 16 (a)
ManyToMany
CG42343 35
  • 16 (a)
ManyToMany
wrapper 35
  • 16 (a)
ManyToMany
klg 35
  • 16 (a)
ManyToMany
CG31646 35
  • 15 (a)
ManyToMany
CG7166 35
  • 15 (a)
ManyToMany
CG31814 35
  • 13 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea rig-5 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for IGLON5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IGLON5 Gene

ENSEMBL:
Gene Tree for IGLON5 (if available)
TreeFam:
Gene Tree for IGLON5 (if available)

Paralogs for IGLON5 Gene

Paralogs for IGLON5 Gene

(4) SIMAP similar genes for IGLON5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IGLON5 Gene

genes like me logo Genes that share paralogs with IGLON5: view

Variants for IGLON5 Gene

Sequence variations from dbSNP and Humsavar for IGLON5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000170095 -- 51,316,045(+) TGGGA(A/C)CAACA intron-variant
rs1000191350 -- 51,328,158(+) AGCAA(C/T)AAACA intron-variant
rs1000199803 -- 51,316,680(+) GTAGA(A/G)ACGGG intron-variant
rs1000934567 -- 51,317,805(+) CCTCA(C/T)AGAAA intron-variant
rs1001095556 -- 51,311,986(+) GTAAT(C/T)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGLON5 Gene

Variant ID Type Subtype PubMed ID
dgv1060e212 CNV loss 25503493
esv2718770 CNV deletion 23290073
nsv1071943 CNV deletion 25765185
nsv1118837 CNV deletion 24896259
nsv1132479 CNV duplication 24896259
nsv1138723 CNV deletion 24896259
nsv1140251 OTHER inversion 24896259
nsv1151102 CNV duplication 26484159

Variation tolerance for IGLON5 Gene

Residual Variation Intolerance Score: 53.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGLON5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLON5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGLON5 Gene

Disorders for IGLON5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IGLON5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
sleep disorder
  • non-organic sleep disorder
aicardi-goutieres syndrome
  • cree encephalitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IGLON5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGLON5
genes like me logo Genes that share disorders with IGLON5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGLON5 Gene

Publications for IGLON5 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  2. A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study. (PMID: 24703753) Sabater L. … Graus F. (Lancet Neurol 2014) 3 64

Products for IGLON5 Gene

Sources for IGLON5 Gene

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