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Aliases for IGLON5 Gene

Aliases for IGLON5 Gene

  • IgLON Family Member 5 2 3 5
  • Ig-Like Domain-Containing Protein ENSP00000270642 3
  • HCG1651476 3

External Ids for IGLON5 Gene

Previous GeneCards Identifiers for IGLON5 Gene

  • GC19P056509
  • GC19P051815
  • GC19P048157

Summaries for IGLON5 Gene

GeneCards Summary for IGLON5 Gene

IGLON5 (IgLON Family Member 5) is a Protein Coding gene. Diseases associated with IGLON5 include Sleep Disorder and Aicardi-Goutieres Syndrome 1, Dominant And Recessive. An important paralog of this gene is NTM.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLON5 Gene

Genomics for IGLON5 Gene

Regulatory Elements for IGLON5 Gene

Enhancers for IGLON5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F051349 1.1 ENCODE 9.5 +39.5 39549 3.9 HDGF PKNOX1 ATF1 ARNT CREB3L1 DMAP1 ZNF48 YY1 GATA2 FOS ZNF649 VSIG10L ZNF577 ZNF616 SIGLEC8 RPL7P51 SIGLEC14 SIGLEC5 ZNF841 IGLON5
GH19F051319 0.4 FANTOM5 5.3 +7.4 7400 0.4 MIER1 CEBPB CEBPG REST FOSL1 ATF3 CEBPA TRIM24 IGLON5 GC19M051338
GH19F051646 0.2 ENCODE 4.9 +335.3 335313 0.6 BCOR RAD51 IKZF1 ZMYM3 KDM1A SIGLEC14 IGLON5 ENSG00000268500 RPL7P51
GH19F051687 1 FANTOM5 ENCODE 4.9 +378.6 378643 6.9 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 ZNF808 ZNF137P ENSG00000268970 ZNF836 ENSG00000269825 ZNF841 ZNF616 ZNF577 ZNF350 ZNF766
GH19F050962 0.9 FANTOM5 2.1 -349.5 -349460 0.3 DDX20 SP2 FOS TAF7 KLK4 SIGLECL1 C19orf81 KLK14 ACPT IGLON5 ETFB SYT3 ENSG00000279676 KLK5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IGLON5 on UCSC Golden Path with GeneCards custom track

Promoters for IGLON5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001818613 -48 801 POLR2A

Genomic Location for IGLON5 Gene

Chromosome:
19
Start:
51,311,848 bp from pter
End:
51,330,848 bp from pter
Size:
19,001 bases
Orientation:
Plus strand

Genomic View for IGLON5 Gene

Genes around IGLON5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLON5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLON5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLON5 Gene

Proteins for IGLON5 Gene

  • Protein details for IGLON5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGN9-IGLO5_HUMAN
    Recommended name:
    IgLON family member 5
    Protein Accession:
    A6NGN9

    Protein attributes for IGLON5 Gene

    Size:
    336 amino acids
    Molecular mass:
    36795 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGLON5 Gene

Post-translational modifications for IGLON5 Gene

  • Glycosylation at Asn 41, Asn 49, Asn 67, Asn 137, and Asn 288
  • Modification sites at PhosphoSitePlus

Other Protein References for IGLON5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGLON5 Gene

Domains & Families for IGLON5 Gene

Protein Domains for IGLON5 Gene

Suggested Antigen Peptide Sequences for IGLON5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NGN9

UniProtKB/Swiss-Prot:

IGLO5_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. IgLON family.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. IgLON family.
genes like me logo Genes that share domains with IGLON5: view

Function for IGLON5 Gene

genes like me logo Genes that share phenotypes with IGLON5: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGLON5 Gene

Localization for IGLON5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLON5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGLON5 Gene COMPARTMENTS Subcellular localization image for IGLON5 gene
Compartment Confidence
extracellular 4
plasma membrane 3
nucleus 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for IGLON5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with IGLON5: view

Pathways & Interactions for IGLON5 Gene

SuperPathways for IGLON5 Gene

No Data Available

Interacting Proteins for IGLON5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000270642%0d%0a9606.ENSP00000350364%0d%0a
Selected Interacting proteins: ENSP00000270642 A6NGN9-IGLO5_HUMAN for IGLON5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for IGLON5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IGLON5 Gene

Transcripts for IGLON5 Gene

mRNA/cDNA for IGLON5 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGLON5 Gene

IgLON family member 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGLON5 Gene

No ASD Table

Relevant External Links for IGLON5 Gene

GeneLoc Exon Structure for
IGLON5
ECgene alternative splicing isoforms for
IGLON5

Expression for IGLON5 Gene

mRNA expression in normal human tissues for IGLON5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGLON5 Gene

This gene is overexpressed in Brain - Cerebellum (x10.6), Brain - Cerebellar Hemisphere (x9.4), and Brain - Hypothalamus (x4.2).

Protein differential expression in normal tissues from HIPED for IGLON5 Gene

This gene is overexpressed in Fetal Brain (37.9), Cerebrospinal fluid (17.3), and Retina (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLON5 Gene



Protein tissue co-expression partners for IGLON5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGLON5 Gene:

IGLON5

SOURCE GeneReport for Unigene cluster for IGLON5 Gene:

Hs.546636
genes like me logo Genes that share expression patterns with IGLON5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for IGLON5 Gene

Orthologs for IGLON5 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGLON5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGLON5 34 35
  • 99.47 (n)
cow
(Bos Taurus)
Mammalia IGLON5 34 35
  • 93.06 (n)
dog
(Canis familiaris)
Mammalia IGLON5 34 35
  • 92.98 (n)
rat
(Rattus norvegicus)
Mammalia Iglon5 34
  • 90.58 (n)
mouse
(Mus musculus)
Mammalia Iglon5 34 16 35
  • 90.48 (n)
oppossum
(Monodelphis domestica)
Mammalia IGLON5 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGLON5 35
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGLON5 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488314 34
  • 66.67 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:110372 34
  • 63.13 (n)
IGLON5 35
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Lac 35
  • 24 (a)
ManyToMany
CG11320 35
  • 23 (a)
ManyToMany
Ama 35
  • 21 (a)
ManyToMany
CG14010 35
  • 20 (a)
ManyToMany
CG14521 35
  • 20 (a)
ManyToMany
CG40378 35
  • 20 (a)
ManyToMany
CG34391 35
  • 18 (a)
ManyToMany
CG42368 35
  • 18 (a)
ManyToMany
CG31708 35
  • 17 (a)
ManyToMany
CG32791 35
  • 16 (a)
ManyToMany
CG34353 35
  • 16 (a)
ManyToMany
CG42343 35
  • 16 (a)
ManyToMany
klg 35
  • 16 (a)
ManyToMany
wrapper 35
  • 16 (a)
ManyToMany
CG31646 35
  • 15 (a)
ManyToMany
CG7166 35
  • 15 (a)
ManyToMany
CG31814 35
  • 13 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea rig-5 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for IGLON5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IGLON5 Gene

ENSEMBL:
Gene Tree for IGLON5 (if available)
TreeFam:
Gene Tree for IGLON5 (if available)

Paralogs for IGLON5 Gene

Paralogs for IGLON5 Gene

(4) SIMAP similar genes for IGLON5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IGLON5 Gene

genes like me logo Genes that share paralogs with IGLON5: view

Variants for IGLON5 Gene

Sequence variations from dbSNP and Humsavar for IGLON5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10403256 -- 51,312,636(+) ATTCC(C/G)AAGCT intron-variant
rs10403450 -- 51,325,233(+) ACTCC(C/T)GGGTC intron-variant
rs10403524 -- 51,312,813(+) GTTAG(A/G)TAGCT intron-variant
rs10404230 -- 51,313,126(+) CCTGC(A/T)GACAC intron-variant
rs10407142 -- 51,328,573(+) AGGAC(C/G)CTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGLON5 Gene

Variant ID Type Subtype PubMed ID
dgv1060e212 CNV loss 25503493
esv2718770 CNV deletion 23290073
nsv1071943 CNV deletion 25765185
nsv1118837 CNV deletion 24896259
nsv1132479 CNV duplication 24896259
nsv1138723 CNV deletion 24896259
nsv1140251 OTHER inversion 24896259
nsv1151102 CNV duplication 26484159

Variation tolerance for IGLON5 Gene

Residual Variation Intolerance Score: 53.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGLON5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLON5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGLON5 Gene

Disorders for IGLON5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IGLON5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sleep disorder
  • non-organic sleep disorder
aicardi-goutieres syndrome 1, dominant and recessive
  • aicardi-goutieres syndrome 5
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IGLON5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGLON5
genes like me logo Genes that share disorders with IGLON5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGLON5 Gene

Publications for IGLON5 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  2. A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study. (PMID: 24703753) Sabater L. … Graus F. (Lancet Neurol 2014) 3 64

Products for IGLON5 Gene

Sources for IGLON5 Gene

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