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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGLON5 Gene

protein-coding   GIFtS: 37
GCID: GC19P051815

IgLON Family Member 5

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
IgLON Family Member 51 2
hCG16514762
Ig-Like Domain-Containing Protein ENSP000002706422

External Ids:    HGNC: 345501   Entrez Gene: 4026652   Ensembl: ENSG000001425497   UniProtKB: A6NGN93   

Export aliases for IGLON5 gene to outside databases

Previous GC identifers: GC19P056509 GC19P048157


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IGLON5 Gene: 
IGLON5 (IgLON family member 5) is a protein-coding gene. Diseases associated with IGLON5 include neuronitis. An important paralog of this gene is NTM.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IGLON5 gene promoter:
         COUP-TF1   LHX3b/Lhx3b   MAZR   COUP   HNF-4alpha2   C/EBPalpha   HNF-4alpha1   COUP-TF   LHX3a/Lhx3a   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGLON5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGLON5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.33

IGLON5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLON5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P051815:  view genomic region     (about GC identifiers)

Start:
51,815,102 bp from pter      End:
51,834,102 bp from pter
Size:
19,001 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IGLO5_HUMAN, A6NGN9 (See protein sequence)
Recommended Name: IgLON family member 5 precursor  
Size: 336 amino acids; 36795 Da
Subcellular location: Secreted (Potential)

Explore the universe of human proteins at neXtProt for IGLON5: NX_A6NGN9

Explore proteomics data for IGLON5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NGN9

  • IGLON5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IGLON5 Protein Expression
    REFSEQ proteins: NP_001094842.1  
    ENSEMBL proteins: 
     ENSP00000270642  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    IGLON5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry A6NGN9

    ProtoNet protein and cluster: A6NGN9

    UniProtKB/Swiss-Prot: IGLO5_HUMAN, A6NGN9
    Similarity: Belongs to the immunoglobulin superfamily. IgLON family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains


    IGLON5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    IGLON5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for IGLON5:
     Decreased homologous recombina  Small cells 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGLON5

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGLON5 (IGLO5)

    Search CenterWatch for drugs/clinical trials and news about IGLON5 / IGLO5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IGLON5 gene: 
    NM_001101372.1  

    Unigene Cluster for IGLON5:

    IgLON family member 5
    Hs.546636  [show with all ESTs]
    Unigene Representative Sequence: NM_001101372
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000270642(uc002pwc.2)
    miRNA
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    hsa-miR-640 hsa-let-7d hsa-miR-330-5p hsa-miR-188-5p hsa-miR-1914* hsa-miR-450a hsa-miR-128 hsa-miR-877*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    5 DOTS entries:

    DT.430434  DT.92026257  DT.100661534  DT.121053209  DT.97807439 

    17 AceView cDNA sequences:

    CR592222 BX433198 BG105760 BX389379 AA339379 AA330878 AL583491 BX371354 
    AL521811 AA352013 AA401292 AI825605 AI815935 BM711641 AA317509 AA404290 
    AW966303 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGLON5 expression in normal human tissues (normalized intensities)      IGLON5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTCCAATT
    IGLON5 Expression
    About this image


    IGLON5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             cerebellum   
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow

    See IGLON5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGLON5

    SOURCE GeneReport for Unigene cluster: Hs.546636
        SABiosciences Custom PCR Arrays for IGLON5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGLON5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IGLON5 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Iglon51 , 5 IgLON family member 51, 5 90.48(n)1
    97.92(a)1
      7 (28.25 cM)5
    2100941  NM_001164518.11  NP_001157990.11 
     434729075 
    lizard
    (Anolis carolinensis)
    Reptilia IGLON56
    Uncharacterized protein
    65(a)
    1 ↔ 1
    GL343281.1(1239815-1441736)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1103721 zgc:110372 62.51(n)
    58.25(a)
      550472  NM_001017775.2  NP_001017775.2 


    ENSEMBL Gene Tree for IGLON5 (if available)
    TreeFam Gene Tree for IGLON5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGLON5 gene
    NTM2  NEGR12  LSAMP2  OPCML2  
    4 SIMAP similar genes for IGLON5 using alignment to 1 protein entry:     IGLO5_HUMAN:
    LSAMP    OPCML    NTM    NEGR1

    IGLON5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IGLON5
    PGOHUM00000232826


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/484 SNPs in IGLON5 are shown (see all 484)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1878086151,2
    --51813164(+) ATAACA/GTAGAC 1 -- us2k10--------
    rs739327071,2
    C,F--51813191(+) TCCTGC/TGTATG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1926092661,2
    --51813488(+) CCTCCC/TCACCT 1 -- us2k10--------
    rs72497541,2
    C,F--51813491(+) CCCCAC/ACTGCT 1 -- us2k11Minor allele frequency- A:0.14WA 118
    rs1386117351,2
    --51813535(+) GCCTTA/CTTATA 1 -- us2k10--------
    rs762309141,2
    C,F--51813543(+) ATACTG/AGGGAT 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1847683501,2
    C--51813615(+) TGAAAA/TTAGAT 1 -- us2k10--------
    rs2021992331,2
    C--51813689(+) GAGGA-/GGGGGC 1 -- us2k10--------
    rs104145061,2
    C--51813822(+) actccA/Tgggtc 1 -- us2k10--------
    rs104145271,2
    C--51813841(+) gagggA/Gctggg 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IGLON5 (51815102 - 51834102 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IGLON5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718770CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for IGLON5:    About MalaCards
    neuronitis    


    IGLON5 for disorders           About GeneDecksing


    Export disorders for IGLON5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed article for IGLON5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with IGLON5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 402665 HGNC: 34550 AceView: LOC402665 Ensembl:ENSG00000142549 euGenes: HUgn402665
    ECgene: IGLON5 H-InvDB: IGLON5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGLON5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IGLON5 gene:
    Search GeneIP for patents involving IGLON5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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