IGLON5 Gene
protein-coding GIFtS: 37
GCID: GC19P051815
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IgLON family member 5
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Aliases
for IGLON5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| IgLON Family Member 51 2 | | LOC4026651 | | HCG16514761 | | Ig-Like Domain-Containing Protein ENSP000002706422 |
Export aliases for IGLON5 gene to outside databasesPrevious GC identifers: GC19P056509 GC19P048157 |
Summaries
for IGLON5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for IGLON5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IGLON5 gene promoter:
COUP-TF1 LHX3b/Lhx3b MAZR COUP HNF-4alpha2 C/EBPalpha HNF-4alpha1 COUP-TF LHX3a/Lhx3a Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for IGLON5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGLON5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.33IGLON5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P051815: view genomic region
(about GC identifiers)
Start:
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51,815,102 bp from pter |
End:
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51,834,102 bp from pter |
Size:
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19,001 bases |
Orientation:
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plus strand |
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Proteins
for IGLON5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IGLO5_HUMAN, A6NGN9 (See
protein sequence)Recommended Name: IgLON family member 5 precursor Size: 336 amino acids; 36795 Da
Subcellular location: Secreted (Potential)Explore the universe of human proteins at neXtProt for IGLON5: NX_A6NGN9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NGN9
IGLON5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001094842.1
ENSEMBL proteins: ENSP00000270642
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
IGLON5 for ontologies About GeneDecksing
IGLON5 Antibody Products:
Assay Products for IGLON5: |
Protein
Domains /
Families
for IGLON5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IGLON5 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NGN9ProtoNet protein and cluster: A6NGN9 UniProtKB/Swiss-Prot: IGLO5_HUMAN, A6NGN9Similarity: Belongs to the immunoglobulin superfamily. IgLON familySimilarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains |
Function
for IGLON5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGLON5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGLON5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IGLON5 (NM_001101372) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IGLON5 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGLON5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGLON5 |
2 GenomeRNAi human phenotypes for IGLON5:
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Pathways & Interactions
for IGLON5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGLON5
|
Drugs & Compounds
for IGLON5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IGLON5
Search CenterWatch for drugs/clinical trials and news about IGLON5 / IGLO5
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Transcripts
for IGLON5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IGLON5 gene: NM_001101372.1 Unigene Cluster for IGLON5: IgLON family member 5 Hs.546636 [show with all ESTs]Unigene Representative Sequence: NM_0011013721 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000270642(uc002pwc.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGLON5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGLON5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IGLON5 (NM_001101372) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IGLON5 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGLON5 |
5 DOTS entries: DT.430434 DT.92026257 DT.100661534 DT.121053209 DT.97807439 17 AceView cDNA sequences: CR592222 AA330878 BX371354 AL521811 BX389379 AA339379 AL583491 BG105760 BX433198 AA352013 AI825605 AI815935 AA401292 BM711641 AA404290 AA317509 AW966303
GeneLoc Exon Structure
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Expression
for IGLON5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IGLON5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTCCAATT
About this image
See IGLON5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGLON5
SOURCE GeneReport for Unigene cluster: Hs.546636
SABiosciences Custom PCR Arrays for IGLON5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGLON5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IGLON5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGLON5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGLON5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGLON5 |
Orthologs
for IGLON5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for IGLON5 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for IGLON5 (if available)
TreeFam Gene Tree for IGLON5 (if available) |
Paralogs
for IGLON5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IGLON5 gene
- NCAM22 NTM2 NEGR12 LSAMP2 NCAM12 OPCML2
4 SIMAP similar genes for IGLON5 using alignment to 1 protein entry: IGLO5_HUMAN:LSAMP OPCML NTM NEGR1
IGLON5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for IGLON5
PGOHUM00000232826
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Genomic Variants
for IGLON5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IGLON5 (51815102 - 51834102 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IGLON5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGLON5 |
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Disorders
/ Diseases
for IGLON5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for IGLON5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed article for IGLON5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGLON5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
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External Searches for IGLON5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing IGLON5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing IGLON5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IGLON5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IGLON5 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for IGLON5 gene:
Search GeneIP for patents involving IGLON5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IGLON5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IGLON5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGLON5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGLON5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IGLON5 | | OriGene 3'-UTR Clone for IGLON5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGLON5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGLON5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for IGLON5 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IGLON5 | | OriGene Custom Protein Services for IGLON5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGLON5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGLON5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGLON5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGLON5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGLON5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGLON5 |
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 |  |  |  | |
| | | | Search Tocris compounds for IGLON5 |
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 | | | IGLON5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGLON5 |
|  |  |  | | | | Search ThermoFisher Antibodies for IGLON5 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGLON5 |
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