IGLL5 Gene
protein-coding GIFtS: 32
GCID: GC22P023239
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immunoglobulin lambda-like polypeptide 5
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Aliases for IGLL5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
| This gene clusters with an RNA gene Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
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| Immunoglobulin Lambda-Like Polypeptide 51 2 | | Germline Immunoglobulin Lambda 12 3 | | G Lambda-12 3 | | Immunoglobulin Lambda-3 Surrogate Light Chain2 | | Omega Light Chain Protein 14.12 |
| External Ids: | HGNC: 384761 | Entrez Gene: 1004230622 | Ensembl: ENSG000002547097 | UniProtKB: B9A0643 | | ORGUL members: | |
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| NONCODE:n409308 | |
Export aliases for IGLL5 gene to outside databasesPrevious GC identifers: GC22U900705 GC22P006197 GC22P023231 GC22P023233
Summaries for IGLL5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for IGLL5: This gene encodes one of the immunoglobulin lambda-like polypeptides. It is located within the immunoglobulin lambdalocus but it does not require somatic rearrangement for expression. The first exon of this gene is unrelated toimmunoglobulin variable genes; the second and third exons are the immunoglobulin lambda joining 1 and theimmunoglobulin lambda constant 1 gene segments. Alternative splicing results in multiple transcript variants.(provided by RefSeq, May 2010)
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Genomic Views for IGLL5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for IGLL5 Other transcription factors
Search SABiosciences Chromatin IP Primers for IGLL5
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGLL5 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.22 Ensembl cytogenetic band: 22q11.22 HGNC cytogenetic band: 22q11.22IGLL5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P023239: view genomic region
(about GC identifiers)
Start:
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23,229,960 bp from pter |
End:
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23,238,014 bp from pter |
Size:
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8,055 bases |
Orientation:
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plus strand |
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Proteins for IGLL5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: IGLL5_HUMAN, B9A064 (See
protein sequence)Recommended Name: Immunoglobulin lambda-like polypeptide 5 precursor Size: 214 amino acids; 23063 Da
Subcellular location: Secreted (By similarity)
Miscellaneous: Located within the immunoglobulin lambda locus, but does not require somatic rearrangement forexpressionAlternative splicing: 2 isoforms: B9A064-1 B9A064-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for IGLL5: NX_B9A064
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_B9A064 IGLL5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001171597.1 NP_001243225.1 ENSEMBL proteins: ENSP00000436353 ENSP00000431254 ENSP00000434368 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005886 | plasma membrane |
-- | -- |
IGLL5 for ontologies About GeneDecksing
IGLL5 Antibody Products: Assay Products for IGLL5: |
Protein
Domains / Families for IGLL5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IGLL5 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry B9A064ProtoNet protein and cluster: B9A064 UniProtKB/Swiss-Prot: IGLL5_HUMAN, B9A064Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain |
Function for IGLL5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGLL5 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGLL5 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IGLL5 (NM_001178126) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IGLL5 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGLL5  |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003823 | antigen binding |
-- | -- |
IGLL5 for ontologies About GeneDecksing
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Pathways & Interactions for IGLL5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGLL5
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
IGLL5 for ontologies About GeneDecksing
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Drugs & Compounds for IGLL5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for IGLL5 Search CenterWatch for drugs/clinical trials and news about IGLL5 
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Transcripts for IGLL5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for IGLL5 gene (2 alternative transcripts): NM_001178126.1 NM_001256296.1 3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000532223(uc021wmq.1) ENST00000526893(uc011aiw.2 uc010gtu.2) ENST00000531372
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGLL5 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGLL5 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IGLL5 (NM_001178126) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IGLL5 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGLL5  | GeneLoc Exon Structure
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Expression for IGLL5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IGLL5 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See IGLL5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for IGLL5 UniProtKB/Swiss-Prot: IGLL5_HUMAN, B9A064Tissue specificity: Contrary to IGLL1, not expressed in pre-B-cells SABiosciences Custom PCR Arrays for IGLL5
Primer Products: |  | Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IGLL5 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGLL5 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGLL5 |
Orthologs for IGLL5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for IGLL5 gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for IGLL5 (if available) TreeFam Gene Tree for IGLL5 (if available)  |
Paralogs for IGLL5 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for IGLL5 gene
- IGLL11 2 IGKC2 IGLC12 IGLC32 IGLC72 IGLC22 TRBC22
17 SIMAP similar genes for IGLL5 using alignment to 1 protein entry: IGLL5_HUMAN:C1 segment DKFZp781M0386 IGLC1 IGLC7 DKFZp667J0810 IGLC2 IGLC3 IGLC6 IGLL1 IGL@ IgLC-rG IGKC HLA-DRB1 HLA-DQA1 HLA-DMB HLA-DRB4 HLA-DMA
IGLL5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for IGLL5 PGOHUM00000246316
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Genomic Variants for IGLL5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 22 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for IGLL5 (23229960 - 23238014 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for IGLL5: --  | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases for IGLL5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IGLL5 for disorders About GeneDecksing
4 diseases for IGLL5: About MalaCardsbrachial plexus lesion carotid artery dissection fibromuscular dysplasia kimura disease 1 disease from the University of Copenhagen DISEASES database for IGLL5:Carotid artery dissection Export disorders for IGLL5 gene to outside databases
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Publications for IGLL5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IGLL5 gene integrated from 9 sources: (articles sorted by number of sources associating them with IGLL5) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution. (PubMed id 1703205)1, 2 Evans R.J. and Hollis G.F. (1991)
- Expression of a novel type of immunoglobulin C lambda transcripts in human mature B lymphocytes producing kappa light chains. (PubMed id 1900243)1, 2 Guglielmi P. and Davi F. (1991)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)
- Organization and expression of the lambda-like genes that contribute to the mu-psi light chain complex in human pre-B cells. (PubMed id 1760403)1 Bossy D....Schiff C. (1991)
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External Searches for IGLL5 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing IGLL5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing IGLL5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IGLL5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for IGLL5 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for IGLL5 gene: Search GeneIP for patents involving IGLL5
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products for IGLL5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGLL5 | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGLL5 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGLL5 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGLL5 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGLL5 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGLL5 |
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| | | Search Tocris compounds for IGLL5 |
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 | | IGLL5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | Search ThermoFisher Antibodies for IGLL5 |
| | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGLL5 |
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Last full update: 18 Mar 2013 -
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