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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGLL5 Gene

protein-coding   GIFtS: 31
GCID: GC22P023299

Immunoglobulin Lambda-Like Polypeptide 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Immunoglobulin Lambda-Like Polypeptide 51 2
Germline Immunoglobulin Lambda 12 3
G Lambda-12 3
Immunoglobulin Lambda-3 Surrogate Light Chain2
Omega Light Chain Protein 14.12

External Ids:    HGNC: 384761   Entrez Gene: 1004230622   Ensembl: ENSG000002547097   UniProtKB: B9A0643   
ORGUL members:         
NONCODE14:n409308      

Export aliases for IGLL5 gene to outside databases

Previous GC identifers: GC22U900705 GC22P006197 GC22P023231 GC22P023233 GC22P023239


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGLL5 Gene:
This gene encodes one of the immunoglobulin lambda-like polypeptides. It is located within the immunoglobulin
lambda locus but it does not require somatic rearrangement for expression. The first exon of this gene is
unrelated to immunoglobulin variable genes; the second and third exons are the immunoglobulin lambda joining 1
and the immunoglobulin lambda constant 1 gene segments. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, May 2010)

GeneCards Summary for IGLL5 Gene: 
IGLL5 (immunoglobulin lambda-like polypeptide 5) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with IGLL5 include brachial plexus lesion, and carotid artery dissection. An important paralog of this gene is IGKC.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGLL5
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGLL5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGLL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.22   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.22

IGLL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLL5 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P023299:  view genomic region     (about GC identifiers)

Start:
23,229,960 bp from pter      End:
23,238,014 bp from pter
Size:
8,055 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IGLL5_HUMAN, B9A064 (See protein sequence)
Recommended Name: Immunoglobulin lambda-like polypeptide 5 precursor  
Size: 214 amino acids; 23063 Da
Subcellular location: Secreted (By similarity)
Miscellaneous: Located within the immunoglobulin lambda locus, but does not require somatic rearrangement for
expression
Alternative splicing: 2 isoforms:  B9A064-1   B9A064-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IGLL5: NX_B9A064

Explore proteomics data for IGLL5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_B9A064

  • IGLL5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IGLL5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001171597.1  NP_001243225.1  

    ENSEMBL proteins: 
     ENSP00000436353   ENSP00000431254   ENSP00000434368  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane ----

    IGLL5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry B9A064

    ProtoNet protein and cluster: B9A064

    UniProtKB/Swiss-Prot: IGLL5_HUMAN, B9A064
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    IGLL5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding ----
    GO:0005515protein binding ----
         
    IGLL5 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGLL5

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response ----
    GO:0006956complement activation ----
    GO:0006958complement activation, classical pathway ----
    GO:0038095Fc-epsilon receptor signaling pathway ----
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis ----

    IGLL5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGLL5

    Search CenterWatch for drugs/clinical trials and news about IGLL5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for IGLL5 gene (2 alternative transcripts): 
    NM_001178126.1  NM_001256296.1  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000532223(uc021wmq.1) ENST00000526893(uc011aiw.2 uc010gtu.2)
    ENST00000531372
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGLL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IGLL5 Expression
    About this image


    See IGLL5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGLL5

    UniProtKB/Swiss-Prot: IGLL5_HUMAN, B9A064
    Tissue specificity: Contrary to IGLL1, not expressed in pre-B-cells

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGLL5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IGLL5 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igll11 immunoglobulin lambda-like polypeptide 1 72.17(n)
    60.5(a)
      16136  NM_001190325.1  NP_001177254.1 
    chicken
    (Gallus gallus)
    Aves GGA.478466
    Ig lambda chain V-1 region
    34(a)
    1 → many
    15(7928727-7933299)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    57(a)
    31(a)
    many ↔ many
    many ↔ many
    AAWZ02041299(1275-1595)
    GL343282.1(588802-599691)


    ENSEMBL Gene Tree for IGLL5 (if available)
    TreeFam Gene Tree for IGLL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGLL5 gene
    IGLL11 2  IGKC2  IGLC12  IGLC32  IGLC72  IGLC22  
    15 SIMAP similar genes for IGLL5 using alignment to 1 protein entry:     IGLL5_HUMAN:
    C1 segment    DKFZp781M0386    IGLC1    IGLC7    DKFZp667J0810    IGLC2
    IGLC3    IGLC6    IGLL1    IGL@    IgLC-rG    IGKC
    HLA-DRB1    HLA-DMB    HLA-DRB4

    IGLL5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IGLL5
    PGOHUM00000246316


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/715 SNPs in IGLL5 are shown (see all 715)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1834373031,2
    --23227973(+) TAAAAA/TGTAAG 2 -- us2k10--------
    rs96121601,2
    F--23227976(+) aaagtA/C/Tagcct 2 -- us2k10--------
    rs1885447251,2
    --23228006(+) TGGCAC/GAAGAT 2 -- us2k10--------
    rs1460871261,2
    --23228008(+) GCAGAA/GGATAC 2 -- us2k10--------
    rs1927359911,2
    --23228019(+) AAGACC/TCCTGG 2 -- us2k10--------
    rs1839179621,2
    --23228054(+) TTTCAC/TAGCAA 2 -- us2k10--------
    rs1388923431,2
    --23228062(+) CAATAA/GCAGTT 2 -- us2k10--------
    rs1867436401,2
    --23228076(+) AAGGTA/GTCAGC 2 -- us2k10--------
    rs1149624711,2
    --23228110(+) GGTGAC/TGCAAA 2 -- us2k10--------
    rs1912576781,2
    --23228112(+) TGATGC/TAAAGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for IGLL5 (23229960 - 23238014 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/47 variations for IGLL5 (see all 47):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662193CNV Deletion23128226
    nsv820655CNV Deletion20802225
    esv2658780CNV Deletion23128226
    dgv822e199CNV Deletion23128226
    nsv3572CNV Insertion18451855
    nsv508728CNV Insertion20534489
    nsv829059CNV Loss20364138
    nsv433178CNV Loss18776910
    dgv733n67CNV Loss20364138
    dgv551n27CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for IGLL5:    About MalaCards
    brachial plexus lesion    carotid artery dissection    fibromuscular dysplasia    kimura disease

    1 disease from the University of Copenhagen DISEASES database for IGLL5:
    Carotid artery dissection

    IGLL5 for disorders           About GeneDecksing


    Export disorders for IGLL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGLL5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with IGLL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution. (PubMed id 1703205)1, 2 Evans R.J. and Hollis G.F. (1991)
    2. Expression of a novel type of immunoglobulin C lambda transcripts in human mature B lymphocytes producing kappa light chains. (PubMed id 1900243)1, 2 Guglielmi P. and Davi F. (1991)
    3. Characterization of molecules binding to the 70K N-ter minal region of fibronectin by IFAST purification coupled with mass spectrometry . (PubMed id 23750785)1 Moussavi-Harami S.F....Beebe D.J. (2013)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)
    6. Organization and expression of the lambda-like genes that contribute to the mu-psi light chain complex in human pre-B cells. (PubMed id 1760403)1 Bossy D....Schiff C. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100423062 HGNC: 38476 Ensembl:ENSG00000254709 euGenes: HUgn100423062 ECgene: IGLL5
    H-InvDB: IGLL5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGLL5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IGLL5 gene:
    Search GeneIP for patents involving IGLL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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