Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IGLL5 Gene

Aliases for IGLL5 Gene

  • Immunoglobulin Lambda-Like Polypeptide 5 2 3
  • Germline Immunoglobulin Lambda 1 3 4
  • G Lambda-1 3 4
  • Immunoglobin Anti-GranzymeB Light Chain Variable Region 3
  • Immunoglobulin Lambda-3 Surrogate Light Chain 3
  • Anti HBs Antibody Light-Chain Fab Fragment 3
  • Omega Light Chain Protein 14.1 3
  • VL-MAR 3
  • IGLV 3
  • IGL 3

External Ids for IGLL5 Gene

Previous GeneCards Identifiers for IGLL5 Gene

  • GC22U900705
  • GC22P006197
  • GC22P023231
  • GC22P023233
  • GC22P023239
  • GC22P023299
  • GC22P023317
  • GC22P022807

Summaries for IGLL5 Gene

Entrez Gene Summary for IGLL5 Gene

  • This gene encodes one of the immunoglobulin lambda-like polypeptides. It is located within the immunoglobulin lambda locus but it does not require somatic rearrangement for expression. The first exon of this gene is unrelated to immunoglobulin variable genes; the second and third exons are the immunoglobulin lambda joining 1 and the immunoglobulin lambda constant 1 gene segments. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for IGLL5 Gene

IGLL5 (Immunoglobulin Lambda-Like Polypeptide 5) is a Protein Coding gene. Diseases associated with IGLL5 include carotid artery dissection. Among its related pathways are PI3K/AKT Signaling in Cancer and Immune System. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLC1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLL5 Gene

Genomics for IGLL5 Gene

Genomic Location for IGLL5 Gene

22,734,620 bp from pter
22,896,107 bp from pter
161,488 bases
Plus strand

Genomic View for IGLL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGLL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLL5 Gene

No data available for Regulatory Elements for IGLL5 Gene

Proteins for IGLL5 Gene

  • Protein details for IGLL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin lambda-like polypeptide 5
    Protein Accession:

    Protein attributes for IGLL5 Gene

    214 amino acids
    Molecular mass:
    23063 Da
    Quaternary structure:
    No Data Available
    • Located within the immunoglobulin lambda locus, but does not require somatic rearrangement for expression

    Alternative splice isoforms for IGLL5 Gene


neXtProt entry for IGLL5 Gene

Proteomics data for IGLL5 Gene at MOPED

Post-translational modifications for IGLL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IGLL5 Gene

Domains & Families for IGLL5 Gene

Gene Families for IGLL5 Gene

Protein Domains for IGLL5 Gene

Suggested Antigen Peptide Sequences for IGLL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGLL5: view

Function for IGLL5 Gene

Gene Ontology (GO) - Molecular Function for IGLL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0005515 protein binding --
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGLL5: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLL5 Gene

Localization for IGLL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLL5 Gene


Subcellular locations from

Jensen Localization Image for IGLL5 Gene COMPARTMENTS Subcellular localization image for IGLL5 gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 2

Gene Ontology (GO) - Cellular Components for IGLL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IBA --
GO:0042571 immunoglobulin complex, circulating IBA --
GO:0070062 extracellular exosome IDA 23533145
GO:0072562 blood microparticle IBA --
genes like me logo Genes that share ontologies with IGLL5: view

Pathways & Interactions for IGLL5 Gene

genes like me logo Genes that share pathways with IGLL5: view

Interacting Proteins for IGLL5 Gene

Gene Ontology (GO) - Biological Process for IGLL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IBA --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006958 complement activation, classical pathway IBA --
GO:0038095 Fc-epsilon receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with IGLL5: view

No data available for SIGNOR curated interactions for IGLL5 Gene

Drugs & Compounds for IGLL5 Gene

No Compound Related Data Available

Transcripts for IGLL5 Gene

mRNA/cDNA for IGLL5 Gene

(2) REFSEQ mRNAs :
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGLL5 Gene

No ASD Table

Relevant External Links for IGLL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGLL5 Gene

mRNA expression in normal human tissues for IGLL5 Gene

mRNA differential expression in normal tissues according to GTEx for IGLL5 Gene

This gene is overexpressed in Spleen (x14.2), Colon - Transverse (x7.6), Small Intestine - Terminal Ileum (x6.9), and Minor Salivary Gland (x6.6).

Protein differential expression in normal tissues from HIPED for IGLL5 Gene

This gene is overexpressed in Pancreatic juice (16.2) and Plasma (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGLL5 Gene

mRNA Expression by UniProt/SwissProt for IGLL5 Gene

Tissue specificity: Contrary to IGLL1, not expressed in pre-B-cells.
genes like me logo Genes that share expression patterns with IGLL5: view

Protein tissue co-expression partners for IGLL5 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IGLL5 Gene

Orthologs for IGLL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100847119 35
  • 78.26 (n)
  • 75.65 (a)
-- 36
  • 42 (a)
IGLL1 36
  • 40 (a)
  • 36 (a)
(Canis familiaris)
Mammalia LOC607582 35
  • 83.33 (n)
  • 83.06 (a)
-- 36
  • 44 (a)
-- 36
  • 69 (a)
-- 36
  • 87 (a)
-- 36
  • 87 (a)
-- 36
  • 80 (a)
-- 36
  • 56 (a)
-- 36
  • 79 (a)
(Mus musculus)
Mammalia Igll1 35
  • 72.17 (n)
  • 60.5 (a)
Igll1 36
  • 49 (a)
(Pan troglodytes)
Mammalia LOC100614342 35
  • 92.19 (n)
  • 89.84 (a)
-- 36
  • 83 (a)
(Rattus norvegicus)
Mammalia Igll1 35
  • 72.67 (n)
  • 60.5 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
-- 36
  • 12 (a)
-- 36
  • 50 (a)
-- 36
  • 49 (a)
-- 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
-- 36
  • 40 (a)
(Gallus gallus)
Aves -- 36
  • 35 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
-- 36
  • 31 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101735033 35
  • 54.93 (n)
  • 47.2 (a)
(Danio rerio)
Actinopterygii FP016018.1 36
  • 12 (a)
Species with no ortholog for IGLL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGLL5 Gene

Gene Tree for IGLL5 (if available)
Gene Tree for IGLL5 (if available)

Paralogs for IGLL5 Gene

Paralogs for IGLL5 Gene

(15) SIMAP similar genes for IGLL5 Gene using alignment to 1 proteins: Pseudogenes for IGLL5 Gene

genes like me logo Genes that share paralogs with IGLL5: view

Variants for IGLL5 Gene

Structural Variations from Database of Genomic Variants (DGV) for IGLL5 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
nsv828979 CNV Gain+Loss 20364138
dgv731n67 CNV Loss 20364138
dgv551n27 CNV Loss 19166990
nsv438338 CNV Loss 16468122
nsv459553 CNV Loss 19166990
dgv4900n71 CNV Gain 21882294
esv2662193 CNV Deletion 23128226
esv990735 CNV Gain 20482838
nsv521695 CNV Loss 19592680
dgv561n27 CNV Gain 19166990
dgv562n27 CNV Loss 19166990
nsv517485 CNV Gain+Loss 19592680
nsv433178 CNV Loss 18776910
dgv822e199 CNV Deletion 23128226
nsv514964 CNV Loss 21397061
dgv569n27 CNV Loss 19166990
nsv469839 CNV Complex 16826518
nsv471597 CNV Loss 15918152
dgv570n27 CNV Loss 19166990
dgv571n27 CNV Loss 19166990
nsv195 CNV Loss 15895083
nsv459655 CNV Loss 19166990
esv997030 CNV Gain 20482838
dgv733n67 CNV Loss 20364138
nsv820655 CNV Deletion 20802225
nsv498982 CNV Loss 21111241
esv33722 CNV Gain 17666407
dgv572n27 CNV Loss 19166990
nsv834153 CNV Loss 17160897
esv2658780 CNV Deletion 23128226
dgv573n27 CNV Loss 19166990
nsv508728 CNV Insertion 20534489
esv34158 CNV Loss 18971310
nsv829058 CNV Loss 20364138
nsv829059 CNV Loss 20364138
nsv459673 CNV Loss 19166990
dgv574n27 CNV Loss 19166990
nsv820258 CNV Gain 19587683
nsv829069 CNV Loss 20364138
nsv819772 CNV Gain 19587683
dgv744n67 CNV Loss 20364138
dgv745n67 CNV Loss 20364138
nsv3572 CNV Insertion 18451855
nsv829078 CNV Loss 20364138
nsv829079 CNV Loss 20364138
nsv829080 CNV Gain 20364138

Variation tolerance for IGLL5 Gene

Residual Variation Intolerance Score: 90.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGLL5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for IGLL5 Gene

Disorders for IGLL5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGLL5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
carotid artery dissection
  • dissection of carotid artery
- elite association
Search IGLL5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IGLL5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IGLL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGLL5 Gene

Publications for IGLL5 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 67
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 67
  5. Characterization of molecules binding to the 70K N-terminal region of fibronectin by IFAST purification coupled with mass spectrometry. (PMID: 23750785) Moussavi-Harami S.F. … Beebe D.J. (J. Proteome Res. 2013) 67

Products for IGLL5 Gene

Sources for IGLL5 Gene

Back to Top