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Aliases for IGLL5 Gene

Aliases for IGLL5 Gene

  • Immunoglobulin Lambda Like Polypeptide 5 2 3 5
  • Immunoglobulin Lambda-Like Polypeptide 5 2 3
  • Germline Immunoglobulin Lambda 1 3 4
  • G Lambda-1 3 4
  • Immunoglobin Anti-GranzymeB Light Chain Variable Region 3
  • Immunoglobulin Lambda-3 Surrogate Light Chain 3
  • Anti HBs Antibody Light-Chain Fab Fragment 3
  • Omega Light Chain Protein 14.1 3
  • VL-MAR 3
  • IGLV 3
  • IGL 3

External Ids for IGLL5 Gene

Previous GeneCards Identifiers for IGLL5 Gene

  • GC22U900705
  • GC22P006197
  • GC22P023231
  • GC22P023233
  • GC22P023239
  • GC22P023299
  • GC22P023317
  • GC22P022807
  • GC22P022849
  • GC22P022897
  • GC22P022965
  • GC22P023072
  • GC22P023130

Summaries for IGLL5 Gene

Entrez Gene Summary for IGLL5 Gene

  • This gene encodes one of the immunoglobulin lambda-like polypeptides. It is located within the immunoglobulin lambda locus but it does not require somatic rearrangement for expression. The first exon of this gene is unrelated to immunoglobulin variable genes; the second and third exons are the immunoglobulin lambda joining 1 and the immunoglobulin lambda constant 1 gene segments. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for IGLL5 Gene

IGLL5 (Immunoglobulin Lambda Like Polypeptide 5) is a Protein Coding gene. Diseases associated with IGLL5 include Solitary Osseous Plasmacytoma. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLL1.

Additional gene information for IGLL5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLL5 Gene

Genomics for IGLL5 Gene

Regulatory Elements for IGLL5 Gene

Enhancers for IGLL5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H022883 1.3 FANTOM5 ENCODE dbSUPER 10.9 -3.6 -3553 0 TBP CTCF ATF1 RB1 TBL1XR1 TAL1 RAD21 CC2D1A POLR2A SMC3 IGLL5 MIR5571 LOC102724638
GH22H022926 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6 +44.3 44331 10 HDGF PKNOX1 ATF1 GATA2 ZNF143 ATF7 RUNX3 MCM3 MCM5 ZC3H11A TOP3B MIF-AS1 IGLV5-52 ENSG00000272578 IGLV3-4 IGLV2-5 MMP11 ENSG00000234630 ZNF70 IGLC2
GH22H022937 1.5 FANTOM5 ENCODE dbSUPER 2.7 +53.2 53246 6 HDGF ATF1 FOXA2 SIN3A YBX1 ZNF2 CBX5 ZNF143 ATF7 RUNX3 TOP3B MIF-AS1 MMP11 IGLV2-5 IGLV3-4 ZNF70 IGLC2 RSPH14 CHCHD10 IGLL5
GH22H022887 0.6 dbSUPER 0.7 +0.9 895 2 HNRNPUL1 KLF1 RUNX1 TBL1XR1 POLR2A ZNF341 REST TOP3B MMP11 ZNF70 IGLC3 IGLV7-43 IGLL5 IGLJ1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGLL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGLL5 Gene

Chromosome:
22
Start:
22,887,780 bp from pter
End:
22,896,107 bp from pter
Size:
8,328 bases
Orientation:
Plus strand

Genomic View for IGLL5 Gene

Genes around IGLL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLL5 Gene

Proteins for IGLL5 Gene

  • Protein details for IGLL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B9A064-IGLL5_HUMAN
    Recommended name:
    Immunoglobulin lambda-like polypeptide 5
    Protein Accession:
    B9A064

    Protein attributes for IGLL5 Gene

    Size:
    214 amino acids
    Molecular mass:
    23063 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Located within the immunoglobulin lambda locus, but does not require somatic rearrangement for expression.

    Alternative splice isoforms for IGLL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGLL5 Gene

Post-translational modifications for IGLL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGLL5 Gene

No data available for DME Specific Peptides for IGLL5 Gene

Domains & Families for IGLL5 Gene

Gene Families for IGLL5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IGLL5 Gene

Suggested Antigen Peptide Sequences for IGLL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGLL5: view

No data available for UniProtKB/Swiss-Prot for IGLL5 Gene

Function for IGLL5 Gene

Gene Ontology (GO) - Molecular Function for IGLL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGLL5: view

Phenotypes for IGLL5 Gene

genes like me logo Genes that share phenotypes with IGLL5: view

Animal Models for IGLL5 Gene

MGI Knock Outs for IGLL5:

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for IGLL5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IGLL5 Gene

Localization for IGLL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLL5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGLL5 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for IGLL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0009897 external side of plasma membrane IBA --
GO:0042571 immunoglobulin complex, circulating IBA --
GO:0070062 extracellular exosome IDA 23533145
GO:0072562 blood microparticle IBA --
genes like me logo Genes that share ontologies with IGLL5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IGLL5 Gene

Pathways & Interactions for IGLL5 Gene

SuperPathways for IGLL5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGLL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006958 complement activation, classical pathway IBA --
GO:0042742 defense response to bacterium IBA --
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with IGLL5: view

No data available for Pathways by source and SIGNOR curated interactions for IGLL5 Gene

Drugs & Compounds for IGLL5 Gene

No Compound Related Data Available

Transcripts for IGLL5 Gene

mRNA/cDNA for IGLL5 Gene

(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for IGLL5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IGLL5 Gene

No ASD Table

Relevant External Links for IGLL5 Gene

GeneLoc Exon Structure for
IGLL5
ECgene alternative splicing isoforms for
IGLL5

Expression for IGLL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGLL5 Gene

mRNA differential expression in normal tissues according to GTEx for IGLL5 Gene

This gene is overexpressed in Spleen (x14.2), Colon - Transverse (x7.6), Small Intestine - Terminal Ileum (x6.9), and Minor Salivary Gland (x6.6).

Protein differential expression in normal tissues from HIPED for IGLL5 Gene

This gene is overexpressed in Pancreatic juice (16.2) and Plasma (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGLL5 Gene



Protein tissue co-expression partners for IGLL5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGLL5 Gene:

IGLL5

mRNA Expression by UniProt/SwissProt for IGLL5 Gene:

B9A064-IGLL5_HUMAN
Tissue specificity: Contrary to IGLL1, not expressed in pre-B-cells.
genes like me logo Genes that share expression patterns with IGLL5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLL5 Gene

Orthologs for IGLL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100614342 33
  • 92.19 (n)
-- 34
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 87 (a)
ManyToMany
-- 34
  • 87 (a)
ManyToMany
LOC607582 33
  • 83.33 (n)
-- 34
  • 80 (a)
ManyToMany
-- 34
  • 79 (a)
ManyToMany
-- 34
  • 69 (a)
ManyToMany
-- 34
  • 56 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia LOC100847119 33
  • 78.26 (n)
-- 34
  • 42 (a)
ManyToMany
IGLL1 34
  • 40 (a)
ManyToMany
VPREB 34
  • 36 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Igll1 33
  • 72.67 (n)
mouse
(Mus musculus)
Mammalia Igll1 33 16 34
  • 72.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 50 (a)
ManyToMany
-- 34
  • 49 (a)
ManyToMany
-- 34
  • 48 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
-- 34
  • 12 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 35 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101735033 33
  • 54.93 (n)
zebrafish
(Danio rerio)
Actinopterygii FP016018.1 34
  • 12 (a)
ManyToMany
Species where no ortholog for IGLL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGLL5 Gene

ENSEMBL:
Gene Tree for IGLL5 (if available)
TreeFam:
Gene Tree for IGLL5 (if available)

Paralogs for IGLL5 Gene

Paralogs for IGLL5 Gene

(15) SIMAP similar genes for IGLL5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IGLL5 Gene

genes like me logo Genes that share paralogs with IGLL5: view

Variants for IGLL5 Gene

Sequence variations from dbSNP and Humsavar for IGLL5 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000284846 -- 22,891,719(+) CACAC(-/TTTG)TTTTT intron-variant
rs1000491809 -- 22,888,175(+) GCGCC(C/T)AATGG reference, missense, stop-gained
rs1000506244 -- 22,890,807(+) TCTGA(G/T)GAGCA intron-variant
rs1000842761 -- 22,888,050(+) TGAAG(A/G)CCAAT utr-variant-5-prime
rs1001171010 -- 22,893,181(+) ATGAA(A/C)AGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGLL5 Gene

Variant ID Type Subtype PubMed ID
dgv4511n100 CNV gain 25217958
dgv4517n100 CNV gain 25217958
dgv4523n100 CNV gain 25217958
dgv551n27 CNV loss 19166990
dgv561n27 CNV gain 19166990
dgv562n27 CNV loss 19166990
dgv569n27 CNV loss 19166990
dgv570n27 CNV loss 19166990
dgv571n27 CNV loss 19166990
dgv572n27 CNV loss 19166990
dgv573n27 CNV loss 19166990
dgv574n27 CNV loss 19166990
dgv731n67 CNV loss 20364138
dgv733n67 CNV loss 20364138
dgv744n67 CNV loss 20364138
dgv745n67 CNV loss 20364138
dgv8005n54 CNV loss 21841781
dgv8015n54 CNV loss 21841781
dgv8025n54 CNV loss 21841781
dgv8033n54 CNV loss 21841781
dgv8034n54 CNV loss 21841781
dgv8035n54 CNV loss 21841781
dgv8036n54 CNV loss 21841781
dgv822e199 CNV deletion 23128226
dgv826e214 CNV loss 21293372
esv2658780 CNV deletion 23128226
esv2662193 CNV deletion 23128226
esv33722 CNV gain 17666407
esv34158 CNV loss 18971310
esv3568289 CNV loss 25503493
esv3647375 CNV loss 21293372
esv3647377 CNV loss 21293372
esv3647379 CNV loss 21293372
esv3647381 CNV loss 21293372
esv3647383 CNV loss 21293372
esv3647384 CNV loss 21293372
esv3647385 CNV loss 21293372
esv3893457 CNV gain 25118596
esv990735 CNV gain 20482838
esv997030 CNV gain 20482838
nsv1057157 CNV gain 25217958
nsv1061433 CNV gain+loss 25217958
nsv1065323 CNV gain 25217958
nsv1066435 CNV loss 25217958
nsv1066891 CNV gain 25217958
nsv195 CNV deletion 15895083
nsv3572 CNV insertion 18451855
nsv433178 CNV loss 18776910
nsv438338 CNV loss 16468122
nsv459553 CNV loss 19166990
nsv459655 CNV loss 19166990
nsv459673 CNV loss 19166990
nsv469839 CNV gain+loss 16826518
nsv471597 CNV loss 15918152
nsv498982 CNV loss 21111241
nsv508728 CNV insertion 20534489
nsv514964 CNV loss 21397061
nsv517485 CNV gain+loss 19592680
nsv521695 CNV loss 19592680
nsv588512 CNV loss 21841781
nsv588516 CNV gain 21841781
nsv588582 CNV loss 21841781
nsv588587 CNV loss 21841781
nsv7350 OTHER inversion 18451855
nsv819772 CNV gain 19587683
nsv820258 CNV gain 19587683
nsv820655 CNV deletion 20802225
nsv828979 CNV gain+loss 20364138
nsv829058 CNV loss 20364138
nsv829059 CNV loss 20364138
nsv829069 CNV loss 20364138
nsv829078 CNV loss 20364138
nsv829079 CNV loss 20364138
nsv829080 CNV gain 20364138
nsv834153 CNV loss 17160897

Variation tolerance for IGLL5 Gene

Residual Variation Intolerance Score: 90.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGLL5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGLL5 Gene

Disorders for IGLL5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGLL5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
solitary osseous plasmacytoma
  • isolated osseous plasmacytoma
- elite association - COSMIC cancer census association via MalaCards
Search IGLL5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IGLL5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGLL5
genes like me logo Genes that share disorders with IGLL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGLL5 Gene

Publications for IGLL5 Gene

  1. Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution. (PMID: 1703205) Evans RJ … Hollis GF (The Journal of experimental medicine 1991) 3 4 60
  2. Expression of a novel type of immunoglobulin C lambda transcripts in human mature B lymphocytes producing kappa light chains. (PMID: 1900243) Guglielmi P … Davi F (European journal of immunology 1991) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2016) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for IGLL5 Gene

Sources for IGLL5 Gene

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