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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGLL5 Gene

protein-coding   GIFtS: 32
GCID: GC22P023239

immunoglobulin lambda-like polypeptide 5

 Explore 4 diseases affiliated with
IGLL5 via our new
 Human Malady Compendium 
Biological research products
for IGLL5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Immunoglobulin Lambda-Like Polypeptide 51 2
Germline Immunoglobulin Lambda 12 3
G Lambda-12 3
Immunoglobulin Lambda-3 Surrogate Light Chain2
Omega Light Chain Protein 14.12

External Ids:    HGNC: 384761   Entrez Gene: 1004230622   Ensembl: ENSG000002547097   UniProtKB: B9A0643   
ORGUL members:         
NONCODE:n409308    

Export aliases for IGLL5 gene to outside databases

Previous GC identifers: GC22U900705 GC22P006197 GC22P023231 GC22P023233


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGLL5:
This gene encodes one of the immunoglobulin lambda-like polypeptides. It is located within the immunoglobulin lambda
locus but it does not require somatic rearrangement for expression. The first exon of this gene is unrelated to
immunoglobulin variable genes; the second and third exons are the immunoglobulin lambda joining 1 and the
immunoglobulin lambda constant 1 gene segments. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, May 2010)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGLL5
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGLL5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGLL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.22   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.22

IGLL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLL5 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P023239:  view genomic region     (about GC identifiers)

Start:
23,229,960 bp from pter      End:
23,238,014 bp from pter
Size:
8,055 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IGLL5_HUMAN, B9A064 (See protein sequence)
Recommended Name: Immunoglobulin lambda-like polypeptide 5 precursor  
Size: 214 amino acids; 23063 Da
Subcellular location: Secreted (By similarity)
Miscellaneous: Located within the immunoglobulin lambda locus, but does not require somatic rearrangement for
expression
Alternative splicing: 2 isoforms:  B9A064-1   B9A064-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IGLL5: NX_B9A064

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_B9A064

  • IGLL5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171597.1  NP_001243225.1  

    ENSEMBL proteins: 
     ENSP00000436353   ENSP00000431254   ENSP00000434368  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane ----


    IGLL5 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    IGLL5 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR007110 Ig-like_dom
     IPR013783 Ig-like_fold
     IPR003006 Ig/MHC_CS
     IPR003597 Ig_C1-set

    Graphical View of Domain Structure for InterPro Entry B9A064

    ProtoNet protein and cluster: B9A064

    UniProtKB/Swiss-Prot: IGLL5_HUMAN, B9A064
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding ----


    IGLL5 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGLL5

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response ----
    GO:0006956complement activation ----
    GO:0006958complement activation, classical pathway ----
    GO:0045087innate immune response ----
    GO:0050776regulation of immune response ----


    IGLL5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGLL5
    Search CenterWatch for drugs/clinical trials and news about IGLL5 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for IGLL5 gene (2 alternative transcripts): 
    NM_001178126.1  NM_001256296.1  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000532223(uc021wmq.1) ENST00000526893(uc011aiw.2 uc010gtu.2)
    ENST00000531372

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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGLL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See IGLL5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGLL5

    UniProtKB/Swiss-Prot: IGLL5_HUMAN, B9A064
    Tissue specificity: Contrary to IGLL1, not expressed in pre-B-cells

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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGLL5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IGLL5 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    56(a)
    1 → many
    AAWZ02041299(1275-1595)
    zebrafish
    (Danio rerio)
    Actinopterygii CU570684.46
    zgc:1536596
    (see all 5)
    zgc:153659
    (see all 5)
    26(a)
    23(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    3(59697601-59699495)
    24(41268647-41270286)


    ENSEMBL Gene Tree for IGLL5 (if available)
    TreeFam Gene Tree for IGLL5 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGLL5 gene
    IGLL11 2  IGKC2  IGLC12  IGLC32  IGLC72  IGLC22  TRBC22  
    17 SIMAP similar genes for IGLL5 using alignment to 1 protein entry:     IGLL5_HUMAN:
    C1 segment    DKFZp781M0386    IGLC1    IGLC7    DKFZp667J0810    IGLC2
    IGLC3    IGLC6    IGLL1    IGL@    IgLC-rG    IGKC
    HLA-DRB1    HLA-DQA1    HLA-DMB    HLA-DRB4    HLA-DMA

    IGLL5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IGLL5
    PGOHUM00000246316


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/30 NCBI SNPs in IGLL5 are shown (see all 30    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1402982381,2
    --23230358(+) CCCAAA/TGGTTG 4 R W K M mis10--------
    rs60033681,2
    H--23230360(+) CAATGG/ATTGCA 4 /I /V /* /W mis1 stg14Minor allele frequency- A:0.00NS EA 396
    rs1889305491,2
    --23230361(+) AATGGG/TTGCAC 4 V L G mis10--------
    rs1918889361,2
    --23230374(+) CAAAGC/TGGGGA 4 A V S mis1 syn10--------
    rs1848037611,2
    --23230393(+) CTGGAA/GCCTCA 4 E T A syn1 mis10--------
    rs1893603941,2
    --23230400(+) CTCAGC/TTGGAA 4 L A V syn1 mis10--------
    rs1156531091,2
    --23230404(+) GTTGGA/GAGCAG 4 E G mis1 syn11Minor allele frequency- G:0.01WA 118
    rs1808448361,2
    --23230415(+) CCGATC/TCAGCC 4 S F P mis10--------
    rs1442752601,2
    --23230423(+) GCCTGC/TGGAGC 4 R W C mis1 syn10--------
    rs1511732311,2
    --23230428(+) CGGAGC/TCTGTG 4 A V S mis1 syn10--------

    HapMap Linkage Disequilibrium report for IGLL5 (23229960 - 23238014 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IGLL5: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IGLL5 for disorders           About GeneDecksing

    4 diseases for IGLL5:    About MalaCards
    brachial plexus lesion    carotid artery dissection    fibromuscular dysplasia    kimura disease

    1 disease from the University of Copenhagen DISEASES database for IGLL5:
    Carotid artery dissection

    Export disorders for IGLL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGLL5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with IGLL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution. (PubMed id 1703205)1, 2 Evans R.J. and Hollis G.F. (1991)
    2. Expression of a novel type of immunoglobulin C lambda transcripts in human mature B lymphocytes producing kappa light chains. (PubMed id 1900243)1, 2 Guglielmi P. and Davi F. (1991)
    3. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    4. The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)
    5. Organization and expression of the lambda-like genes that contribute to the mu-psi light chain complex in human pre-B cells. (PubMed id 1760403)1 Bossy D....Schiff C. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100423062 HGNC: 38476 Ensembl:ENSG00000254709 euGenes: HUgn100423062 ECgene: IGLL5
    H-InvDB: IGLL5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGLL5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IGLL5 gene:
    Search GeneIP for patents involving IGLL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
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