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Aliases for IGLL1 Gene

Aliases for IGLL1 Gene

  • Immunoglobulin Lambda-Like Polypeptide 1 2 3
  • Immunoglobulin-Related Protein 14.1 3 4
  • CD179 Antigen-Like Family Member B 3 4
  • CD179b Antigen 3 4
  • Ig Lambda-5 3 4
  • VPREB2 3 6
  • AGM2 3 6
  • IGL5 3 6
  • IGL1 3 4
  • IGO 3 6
  • Immunoglobulin Omega Polypeptide Chain 3
  • Pre-B Lymphocyte-Specific Protein-2 3
  • Immunoglobulin-Related 14.1 Protein 3
  • Immunoglobulin Omega Polypeptide 4
  • IGLJ14.1 3
  • Lambda5 3
  • CD179b 3
  • IGVPB 3
  • 14.1 3
  • IGLL 3

External Ids for IGLL1 Gene

Previous HGNC Symbols for IGLL1 Gene

  • IGLL

Previous GeneCards Identifiers for IGLL1 Gene

  • GC22M020611
  • GC22M022239
  • GC22M022245
  • GC22M023915
  • GC22M006905

Summaries for IGLL1 Gene

Entrez Gene Summary for IGLL1 Gene

  • The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for IGLL1 Gene

IGLL1 (Immunoglobulin Lambda-Like Polypeptide 1) is a Protein Coding gene. Diseases associated with IGLL1 include agammaglobulinemia 2 and autosomal recessive disease. Among its related pathways are Primary immunodeficiency. An important paralog of this gene is IGLC1.

UniProtKB/Swiss-Prot for IGLL1 Gene

  • Critical for B-cell development.

Gene Wiki entry for IGLL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLL1 Gene

Genomics for IGLL1 Gene

Regulatory Elements for IGLL1 Gene

Transcription factor binding sites by QIAGEN in the IGLL1 gene promoter:

Genomic Location for IGLL1 Gene

Start:
23,573,125 bp from pter
End:
23,580,308 bp from pter
Size:
7,184 bases
Orientation:
Minus strand

Genomic View for IGLL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGLL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLL1 Gene

Proteins for IGLL1 Gene

  • Protein details for IGLL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15814-IGLL1_HUMAN
    Recommended name:
    Immunoglobulin lambda-like polypeptide 1
    Protein Accession:
    P15814
    Secondary Accessions:
    • Q0P681

    Protein attributes for IGLL1 Gene

    Size:
    213 amino acids
    Molecular mass:
    22963 Da
    Quaternary structure:
    • Associates non-covalently with VPREB1.

    Three dimensional structures from OCA and Proteopedia for IGLL1 Gene

    Alternative splice isoforms for IGLL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGLL1 Gene

Proteomics data for IGLL1 Gene at MOPED

Post-translational modifications for IGLL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGLL1 Gene

No data available for DME Specific Peptides for IGLL1 Gene

Domains for IGLL1 Gene

Gene Families for IGLL1 Gene

HGNC:
  • C1SET :Immunoglobulin superfamily / C1-set domain containing
  • CD :CD molecules

Protein Domains for IGLL1 Gene

Suggested Antigen Peptide Sequences for IGLL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15814

UniProtKB/Swiss-Prot:

IGLL1_HUMAN :
  • P15814
Domain:
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGLL1: view

Function for IGLL1 Gene

Molecular function for IGLL1 Gene

GENATLAS Biochemistry: immunoglobulin,lambda-like (14.1),encoding a gene associating with VpreB gene product,pre-B-cell specific
UniProtKB/Swiss-Prot Function: Critical for B-cell development.

Gene Ontology (GO) - Molecular Function for IGLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IGLL1: view

Phenotypes for IGLL1 Gene

MGI mutant phenotypes for IGLL1:
inferred from 2 alleles
GenomeRNAi human phenotypes for IGLL1:
genes like me logo Genes that share phenotypes with IGLL1: view

Animal Models for IGLL1 Gene

MGI Knock Outs for IGLL1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGLL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IGLL1 Gene

Localization for IGLL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGLL1 Gene COMPARTMENTS Subcellular localization image for IGLL1 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for IGLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane NAS 2501791
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with IGLL1: view

Pathways for IGLL1 Gene

SuperPathways for IGLL1 Gene

Superpath Contained pathways
1 Primary immunodeficiency
genes like me logo Genes that share pathways with IGLL1: view

Pathways by source for IGLL1 Gene

1 KEGG pathway for IGLL1 Gene

Gene Ontology (GO) - Biological Process for IGLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 2501791
genes like me logo Genes that share ontologies with IGLL1: view

Transcripts for IGLL1 Gene

mRNA/cDNA for IGLL1 Gene

Unigene Clusters for IGLL1 Gene

Immunoglobulin lambda-like polypeptide 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGLL1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGLL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c
SP1:
SP2:
SP3: -

Relevant External Links for IGLL1 Gene

GeneLoc Exon Structure for
IGLL1
ECgene alternative splicing isoforms for
IGLL1

Expression for IGLL1 Gene

mRNA expression in normal human tissues for IGLL1 Gene

mRNA differential expression in normal tissues according to GTEx for IGLL1 Gene

This gene is overexpressed in Testis (44.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IGLL1 Gene

SOURCE GeneReport for Unigene cluster for IGLL1 Gene Hs.348935

mRNA Expression by UniProt/SwissProt for IGLL1 Gene

P15814-IGLL1_HUMAN
Tissue specificity: Expressed only in pre-B-cells and a special B-cell line (which is surface Ig negative).
genes like me logo Genes that share expressions with IGLL1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IGLL1 Gene

Orthologs for IGLL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100614342 35
  • 83.85 (n)
  • 77.34 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 39 (a)
ManyToMany
IGLL1 36
  • 41 (a)
ManyToMany
LOC100847119 35
  • 77.39 (n)
  • 69.57 (a)
VPREB 36
  • 32 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 42 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 79 (a)
ManyToMany
-- 36
  • 79 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
LOC607582 35
  • 83.76 (n)
  • 79.49 (a)
mouse
(Mus musculus)
Mammalia Iglc2 36
  • 63 (a)
ManyToMany
Igll1 35
  • 71.53 (n)
  • 61.62 (a)
Igll1 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 38 (a)
ManyToMany
-- 36
  • 11 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Igll1 35
  • 72.97 (n)
  • 63.24 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101735033 35
  • 54.2 (n)
  • 49.57 (a)
zebrafish
(Danio rerio)
Actinopterygii CU571382.2 36
  • 10 (a)
ManyToMany
Species with no ortholog for IGLL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGLL1 Gene

ENSEMBL:
Gene Tree for IGLL1 (if available)
TreeFam:
Gene Tree for IGLL1 (if available)

Paralogs for IGLL1 Gene

Paralogs for IGLL1 Gene

Selected SIMAP similar genes for IGLL1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for IGLL1 Gene

genes like me logo Genes that share paralogs with IGLL1: view

Variants for IGLL1 Gene

Sequence variations from dbSNP and Humsavar for IGLL1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs131418 -- 23,574,124(+) TCACA(G/T)CGGCT intron-variant
rs131419 -- 23,574,126(+) ACATC(A/G)GCTGG intron-variant
rs131420 -- 23,577,889(+) ATACC(-/T)TTTTT intron-variant
rs131421 -- 23,579,015(+) CAGAG(A/G)TGCAC intron-variant
rs140173 -- 23,573,938(+) AAACT(A/G)TACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGLL1 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
nsv9876 CNV Gain+Loss 18304495
dgv4903n71 CNV Gain 21882294
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
nsv511073 CNV Complex 20534489
dgv4905n71 CNV Loss 21882294
nsv471186 CNV Loss 18288195
nsv914589 CNV Gain 21882294
nsv459677 CNV Loss 19166990
nsv914590 CNV Gain+Loss 21882294
nsv914591 CNV Loss 21882294
nsv436353 CNV Deletion 17901297
esv23191 CNV Loss 19812545
esv2724056 CNV Deletion 23290073
nsv520582 CNV Gain 19592680
nsv914592 CNV Gain 21882294
nsv471187 CNV Gain 18288195
nsv459682 CNV Gain 19166990

Relevant External Links for IGLL1 Gene

HapMap Linkage Disequilibrium report
IGLL1
Human Gene Mutation Database (HGMD)
IGLL1
Locus Specific Mutation Databases (LSDB)
IGLL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGLL1 Gene

Disorders for IGLL1 Gene

(1) OMIM Diseases for IGLL1 Gene (146770)

UniProtKB/Swiss-Prot

IGLL1_HUMAN
  • Agammaglobulinemia 2, autosomal recessive (AGM2) [MIM:613500]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. {ECO:0000269 PubMed:9419212}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for IGLL1 Gene

Relevant External Links for IGLL1

Genetic Association Database (GAD)
IGLL1
genes like me logo Genes that share disorders with IGLL1: view

Publications for IGLL1 Gene

  1. Physical location of the human immunoglobulin lambda-like genes, 14.1, 16.1, and 16.2. (PMID: 8406611) Bauer T.R. … Blomberg B.B. (Immunogenetics 1993) 3 23
  2. Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution. (PMID: 1703205) Evans R.J. … Hollis G.F. (J. Exp. Med. 1991) 3 4
  3. The immunoglobulin lambda-like gene cluster (14.1, 16.1 and F lambda 1) contains gene(s) selectively expressed in pre-B cells and is the human counterpart of the mouse lambda 5 gene. (PMID: 2128466) Schiff C. … Fougereau M. (Int. Immunol. 1990) 3 4
  4. Immunoglobulin lambda light-chain-related genes 14.1 and 16.1 are expressed in pre-B cells and may encode the human immunoglobulin omega light-chain protein. (PMID: 2501791) Hollis G.F. … McKearn J.P. (Proc. Natl. Acad. Sci. U.S.A. 1989) 3 4
  5. Isolation of early immunoglobulin lambda-like gene transcripts in human fetal liver. (PMID: 2511029) Schiff C. … Fougereau M. (Eur. J. Immunol. 1989) 2 3

Products for IGLL1 Gene

Sources for IGLL1 Gene

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