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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGLJ3 Gene

protein-coding   GIFtS: 22
GCID: GC22P023297

Immunoglobulin Lambda Joining 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Immunoglobulin Lambda Joining 31 2
J32

External Ids:    HGNC: 58651   Entrez Gene: 288312   Ensembl: ENSG000002116787   

Export aliases for IGLJ3 gene to outside databases

Previous GC identifers: GC22U990183 GC22P021571 GC22P021109 GC22P021600 GC22P021610 GC22P021620 GC22P021630 GC22P021641 GC22P021653 GC22P021665 GC22P023248


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IGLJ3 Gene: 
IGLJ3 (immunoglobulin lambda joining 3) is a protein-coding gene. Diseases associated with IGLJ3 include demyelinating polyneuropathy, and polyneuropathy.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGLJ3
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGLJ3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

IGLJ3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLJ3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P023297:  view genomic region     (about GC identifiers)

Start:
23,247,030 bp from pter      End:
23,247,205 bp from pter
Size:
176 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --
IGLJ3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

ENSEMBL proteins: 
 ENSP00000419781  

Human Recombinant Protein Products for IGLJ3: 
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IGL: Immunoglobulins / IGL locus

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:
     Genatlas biochemistry entry for IGLJ3:
immunoglobulin,lambda,joining segment 3

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for IGLJ3 
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGLJ3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGLJ3

Search CenterWatch for drugs/clinical trials and news about IGLJ3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Clusters for IGLJ3:

Immunoglobulin lambda joining 3
Hs.728758  [show with all ESTs], Hs.729860  [show with all ESTs], Hs.744215  [show with all ESTs]
Unigene Representative Sequences: BQ710649, BX410976, BM914338
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390324
miRNA
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Additional mRNA sequence: 

AB064143.1 AB064147.1 AB064151.1 AB064169.1 AB064172.1 AB064177.1 AB064180.1 AB064181.1 
AB064182.1 AB064183.1 AB064185.1 AB064187.1 AB064190.1 AB064199.1 AB064201.1 AB064204.1 
AB064206.1 AB064211.1 AB064216.1 AB064218.1 AB064219.1 AB064226.1 AB064227.1 AB064231.1 
AB064232.1 AB064234.1 AF124173.1 AF211205.1 AJ001168.1 AY172962.1 AY515013.1 DQ240234.1 
DQ322983.1 EF589400.1 EF589430.1 EF589457.1 EF589479.1 EF589533.1 EF589542.1 EF589571.1 
EF710785.1 EF710999.1 EU169677.2 EU599320.1 EU599335.1 EU599339.1 EU599350.1 EU599359.1 
EU937523.1 HF541910.1 HF541912.1 HF541915.1 HM996166.1 HQ890349.1 JF791169.1 JN130389.1 
L29163.1 L35916.1 L38563.1 L38565.1 L38568.1 X57806.1 X57813.1 X57817.1 
X57821.1 X57824.1 

24/205 DOTS entries (see all 205):

DT.120676888  DT.420908  DT.95363053  DT.120676896  DT.92325691  DT.100885117  DT.120677744  DT.91795968 
DT.95332276  DT.120677970  DT.120677086  DT.91769053  DT.95299532  DT.100885135  DT.91962204  DT.95068785 
DT.95284511  DT.100044257  DT.100046142  DT.100885149  DT.91934757  DT.95149053  DT.100046628  DT.40267692 

24/97 AceView cDNA sequences (see all 97):

L25296 AY573191 AF194679 CR623132 AF063703 AF194648 CR605950 CR593480 
AF194645 L35920 AF194698 CR623617 AF064507 CR592011 AF194643 AF194669 
AF194651 BC071804 AJ319669 AF047246 AF194708 AF194707 AJ319670 BG757949 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGLJ3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCAAGGAGGC
IGLJ3 Expression
About this image


Genevestigator expression for IGLJ3

SOURCE GeneReport for Unigene clusters: Hs.728758 Hs.729860 Hs.744215
    SABiosciences Custom PCR Arrays for IGLJ3
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGLJ3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for IGLJ3 (if available)
TreeFam Gene Tree for IGLJ3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGLJ3 gene

IGLJ3 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for IGLJ3
PGOHUM00000246570


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing IGLJ3
DNA2.0 Custom Variant and Variant Library Synthesis for IGLJ3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for IGLJ3:    About MalaCards
demyelinating polyneuropathy    polyneuropathy


IGLJ3 for disorders           About GeneDecksing


Export disorders for IGLJ3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGLJ3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGLJ3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1 Kawasaki K....Shimizu N. (1997)
  2. Distinctive serologic, chemical, and molecular properties of human lambda IV light chains. (PubMed id 7897210)1 Eulitz M....Solomon A. (1995)
  3. V-region and class specific RT-PCR amplification of human immunoglobulin heavy and light chain genes from B-cell lines. (PubMed id 7569777)1 Watkins B.A....Reitz M.S. (1995)
  4. The anti-DNA-associated idiotype 8.12 is encoded by t he V lambda II gene family and maps to the vicinity of L chain CDR1. (PubMed id 1431128)1 Paul E....Diamond B. (1992)
  5. V lambda and J lambda-C lambda gene segments of the human immunoglobulin lambda light chain locus are separated by 14 kb and rearrange by a deletion mechanism. (PubMed id 1904362)1 Combriato G. and Klobeck H.G. (1991)
  6. Human lambda light chain locus: organization and DNA sequences of three genomic J regions. (PubMed id 3102359)1 Udey J.A. and Blomberg B. (1987)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28831 HGNC: 5865 AceView: IGL_ Ensembl:ENSG00000211678 euGenes: HUgn28831
ECgene: IGLJ3 H-InvDB: IGLJ3

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGLJ3 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGLJ3 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGLJ3 gene:
Search GeneIP for patents involving IGLJ3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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