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Aliases for IGLJ1 Gene

Aliases for IGLJ1 Gene

  • Immunoglobulin Lambda Joining 1 2 3 5
  • J1 3

External Ids for IGLJ1 Gene

Previous GeneCards Identifiers for IGLJ1 Gene

  • GC22U990185
  • GC22P021560
  • GC22P023236
  • GC22P023240
  • GC22P023300
  • GC22P023318

Summaries for IGLJ1 Gene

GeneCards Summary for IGLJ1 Gene

IGLJ1 (Immunoglobulin Lambda Joining 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IGLJ1 Gene

  • J region of the variable domain of immunoglobulin lambda light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLJ1 Gene

Genomics for IGLJ1 Gene

Regulatory Elements for IGLJ1 Gene

Enhancers for IGLJ1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G022423 0.9 ENCODE 5.2 -468.2 -468211 3.2 FOXA2 ARID4B THRB ZNF48 RARA SLC30A9 ZNF366 CAVIN1 ELF1 HDAC8 IGLJ1 IGLVI-38 ASH2LP1
GH22G022892 0.9 dbSUPER 0.7 +0.2 167 3.4 HNRNPUL1 HDAC1 TBL1XR1 KLF17 SCRT2 FOS RELB KDM4B IKZF2 EGR2 IGLV2-5 IGLV3-4 IGLC2 IGLC7 IGLC1 IGLJ1
GH22G022887 0.7 dbSUPER 0.4 -5.0 -5018 2.9 HNRNPUL1 HDAC1 KLF1 HDAC6 TBL1XR1 REST ZIC2 ZNF121 RUNX1 HDAC2 IGLV5-52 ENSG00000272779 IGLC3 IGLV7-43 IGLL5 IGLJ1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGLJ1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGLJ1 Gene

Chromosome:
22
Start:
22,893,692 bp from pter
End:
22,893,818 bp from pter
Size:
127 bases
Orientation:
Plus strand

Genomic View for IGLJ1 Gene

Genes around IGLJ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLJ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLJ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLJ1 Gene

Proteins for IGLJ1 Gene

  • Protein details for IGLJ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A0A0MT76-LJ01_HUMAN
    Recommended name:
    Immunoglobulin lambda joining 1
    Protein Accession:
    A0A0A0MT76

    Protein attributes for IGLJ1 Gene

    Size:
    42 amino acids
    Molecular mass:
    4776 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGLJ1 Gene

Post-translational modifications for IGLJ1 Gene

No Post-translational modifications

Other Protein References for IGLJ1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLJ1 Gene

Domains & Families for IGLJ1 Gene

Gene Families for IGLJ1 Gene

Protein Domains for IGLJ1 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGLJ1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGLJ1 Gene

Function for IGLJ1 Gene

Molecular function for IGLJ1 Gene

GENATLAS Biochemistry:
immunoglobulin,lambda,joining segment 1
UniProtKB/Swiss-Prot Function:
J region of the variable domain of immunoglobulin lambda light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLJ1 Gene

Localization for IGLJ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLJ1 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with IGLJ1: view

No data available for Subcellular locations from COMPARTMENTS for IGLJ1 Gene

Pathways & Interactions for IGLJ1 Gene

SuperPathways for IGLJ1 Gene

No Data Available

Interacting Proteins for IGLJ1 Gene

Gene Ontology (GO) - Biological Process for IGLJ1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IGLJ1 Gene

Transcripts for IGLJ1 Gene

mRNA/cDNA for IGLJ1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGLJ1 Gene

No ASD Table

Relevant External Links for IGLJ1 Gene

GeneLoc Exon Structure for
IGLJ1
ECgene alternative splicing isoforms for
IGLJ1

Expression for IGLJ1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGLJ1 Gene

mRNA differential expression in normal tissues according to GTEx for IGLJ1 Gene

This gene is overexpressed in Spleen (x15.3), Colon - Transverse (x8.5), Small Intestine - Terminal Ileum (x7.7), Minor Salivary Gland (x5.5), and Whole Blood (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of IGLJ1 Gene:

IGLJ1
genes like me logo Genes that share expression patterns with IGLJ1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLJ1 Gene

Orthologs for IGLJ1 Gene

Evolution for IGLJ1 Gene

ENSEMBL:
Gene Tree for IGLJ1 (if available)
TreeFam:
Gene Tree for IGLJ1 (if available)

No data available for Orthologs for IGLJ1 Gene

Paralogs for IGLJ1 Gene

No data available for Paralogs for IGLJ1 Gene

Variants for IGLJ1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLJ1 Gene

LJ01_HUMAN-A0A0A0MT76
The sequence shown is that of IMGT allele IGLJ1*01.

Relevant External Links for IGLJ1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLJ1

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLJ1 Gene

Disorders for IGLJ1 Gene

No disorders were found for IGLJ1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGLJ1 Gene

Publications for IGLJ1 Gene

  1. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  2. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  3. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  4. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64
  5. Nomenclature of the human immunoglobulin lambda (IGL) genes. (PMID: 11872955) Lefranc M.P. (Exp. Clin. Immunogenet. 2001) 4 64

Products for IGLJ1 Gene

Sources for IGLJ1 Gene

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