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Aliases for IGLC7 Gene

Aliases for IGLC7 Gene

  • Immunoglobulin Lambda Constant 7 2 3 5
  • C7 3

External Ids for IGLC7 Gene

Previous GeneCards Identifiers for IGLC7 Gene

  • GC22U990186
  • GC22P021589
  • GC22P021597
  • GC22P021607
  • GC22P021617
  • GC22P021627
  • GC22P021638
  • GC22P021649
  • GC22P021662
  • GC22P021674
  • GC22P023269
  • GC22P006232
  • GC22P023274
  • GC22P023280
  • GC22P023285
  • GC22P023290
  • GC22P023294
  • GC22P023310
  • GC22P023325
  • GC22P022925
  • GC22P022935
  • GC22P022984

Summaries for IGLC7 Gene

GeneCards Summary for IGLC7 Gene

IGLC7 (Immunoglobulin Lambda Constant 7) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and RET signaling. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLC7 Gene

Genomics for IGLC7 Gene

Regulatory Elements for IGLC7 Gene

Enhancers for IGLC7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F022904 0.6 Ensembl 28.8 -16.1 -16120 4.4 ELF3 ARID4B RAD21 ZNF48 RARA ZNF263 MCM3 SP5 SMAD5 MCM5 IGLC7 IGLV5-52 IGLC2 ENSG00000234630 ENSG00000272779 ZNF70 ENSG00000272578 IGLC3 IGLJ4
GH22F022914 0.7 ENCODE 10.2 -7.5 -7474 0.3 ZNF263 KLF1 ID3 HNF4G RAD21 YY1 NR2F2 IGLC7 IGLC5 IGLJ5
GH22F022915 0.6 Ensembl 9.2 -8.2 -8193 0.8 ZNF263 MCM3 ZIC2 ZBTB7A RAD21 YY1 NR2F2 IKZF1 HNF4G SETDB1 IGLC2 IGLC7 IGLC5 IGLJ5
GH22F022899 0.9 Ensembl ENCODE 9.2 -20.8 -20790 4.8 TBL1XR1 WRNIP1 BMI1 ZNF335 GLIS2 EGR1 ZNF548 ZNF263 MCM3 CEBPZ ZNF70 IGLC2 IGLV3-4 IGLV2-5 IGLV5-52 ENSG00000272779 IGLC7 IGLJ2 IGLC5 IGLV10-54
GH22F022925 1.3 FANTOM5 Ensembl ENCODE 6.7 +9.1 9093 11.7 HDGF PKNOX1 ATF1 WRNIP1 SIN3A GATA2 ELK1 ZNF143 ZNF548 ZMIZ1 IGLV5-52 ENSG00000272779 IGLV3-4 IGLV2-5 ZNF70 IGLC2 IGLV7-43 IGLC7 IGLL5 IGLC3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IGLC7 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGLC7 Gene

Chromosome:
22
Start:
22,922,594 bp from pter
End:
22,923,034 bp from pter
Size:
441 bases
Orientation:
Plus strand

Genomic View for IGLC7 Gene

Genes around IGLC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLC7 Gene

Proteins for IGLC7 Gene

  • Protein details for IGLC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0M8Q6-LAC7_HUMAN
    Recommended name:
    Ig lambda-7 chain C region
    Protein Accession:
    A0M8Q6

    Protein attributes for IGLC7 Gene

    Size:
    106 amino acids
    Molecular mass:
    11303 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Displays the following serological isotype: Ke+, Oz- and two of the three characteristic amino acids of Mgc-isotype: Ala-6 and Ser-8 but instead of Thr-57 it displays Lys-57. Ke+ has Gly-46 and Oz- has Arg-83.
    SequenceCaution:
    • Sequence=BAA20016.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA36053.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW59556.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for IGLC7 Gene

Post-translational modifications for IGLC7 Gene

No Post-translational modifications

Other Protein References for IGLC7 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLC7 Gene

Domains & Families for IGLC7 Gene

Gene Families for IGLC7 Gene

Protein Domains for IGLC7 Gene

Suggested Antigen Peptide Sequences for IGLC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0M8Q6

UniProtKB/Swiss-Prot:

LAC7_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGLC7: view

Function for IGLC7 Gene

Molecular function for IGLC7 Gene

GENATLAS Biochemistry:
immunoglobulin,lambda,constant segment 7 (Ke marker)

Gene Ontology (GO) - Molecular Function for IGLC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGLC7: view

Animal Model Products

miRNA for IGLC7 Gene

miRTarBase miRNAs that target IGLC7

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGLC7 Gene

Localization for IGLC7 Gene

Gene Ontology (GO) - Cellular Components for IGLC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA --
GO:0042571 immunoglobulin complex, circulating IBA --
GO:0072562 blood microparticle IBA --
genes like me logo Genes that share ontologies with IGLC7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for IGLC7 Gene

Pathways & Interactions for IGLC7 Gene

genes like me logo Genes that share pathways with IGLC7: view

Interacting Proteins for IGLC7 Gene

Gene Ontology (GO) - Biological Process for IGLC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGLC7: view

No data available for SIGNOR curated interactions for IGLC7 Gene

Transcripts for IGLC7 Gene

mRNA/cDNA for IGLC7 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGLC7 Gene

No ASD Table

Relevant External Links for IGLC7 Gene

GeneLoc Exon Structure for
IGLC7
ECgene alternative splicing isoforms for
IGLC7

Expression for IGLC7 Gene

mRNA expression in normal human tissues for IGLC7 Gene

mRNA differential expression in normal tissues according to GTEx for IGLC7 Gene

This gene is overexpressed in Spleen (x18.4), Minor Salivary Gland (x7.6), and Colon - Transverse (x6.1).

Protein differential expression in normal tissues from HIPED for IGLC7 Gene

This gene is overexpressed in Skin (50.2) and Serum (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLC7 Gene



NURSA nuclear receptor signaling pathways regulating expression of IGLC7 Gene:

IGLC7
genes like me logo Genes that share expression patterns with IGLC7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IGLC7 Gene

Orthologs for IGLC7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGLC7 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 87 (a)
ManyToMany
-- 35
  • 87 (a)
ManyToMany
-- 35
  • 72 (a)
ManyToMany
-- 35
  • 71 (a)
ManyToMany
-- 35
  • 59 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 64 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Iglc2 35
  • 63 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 42 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 9 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 34 (a)
ManyToMany
IGLL1 35
  • 34 (a)
ManyToMany
VPREB 35
  • 30 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 27 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 55 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU571382.2 35
  • 10 (a)
ManyToMany
Species where no ortholog for IGLC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGLC7 Gene

ENSEMBL:
Gene Tree for IGLC7 (if available)
TreeFam:
Gene Tree for IGLC7 (if available)

Paralogs for IGLC7 Gene

Variants for IGLC7 Gene

Relevant External Links for IGLC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLC7 Gene

Disorders for IGLC7 Gene

Relevant External Links for IGLC7

Genetic Association Database (GAD)
IGLC7

No disorders were found for IGLC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGLC7 Gene

Publications for IGLC7 Gene

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K. … Shimizu N. (Genome Res. 1997) 3 4 64
  2. Structure and expression of the human immunoglobulin lambda genes. (PMID: 2115572) Vasicek T.J. … Leder P. (J. Exp. Med. 1990) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Recognition of immunoglobulins by Fcgamma receptors. (PMID: 11955599) Radaev S. … Sun P. (Mol. Immunol. 2002) 3 64
  5. Physicochemical and functional characterization of the C1r subunit of the first complement component. (PMID: 814163) Ziccardi R.J. … Cooper N.R. (J. Immunol. 1976) 3 64

Products for IGLC7 Gene

Sources for IGLC7 Gene

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