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Aliases for IGLC7 Gene

Aliases for IGLC7 Gene

  • Immunoglobulin Lambda Constant 7 2 3
  • C7 3

External Ids for IGLC7 Gene

Previous GeneCards Identifiers for IGLC7 Gene

  • GC22U990186
  • GC22P021589
  • GC22P021597
  • GC22P021607
  • GC22P021617
  • GC22P021627
  • GC22P021638
  • GC22P021649
  • GC22P021662
  • GC22P021674
  • GC22P023269
  • GC22P006232
  • GC22P023274
  • GC22P023280
  • GC22P023285
  • GC22P023290
  • GC22P023294
  • GC22P023310
  • GC22P023325

Summaries for IGLC7 Gene

GeneCards Summary for IGLC7 Gene

IGLC7 (Immunoglobulin Lambda Constant 7) is a Protein Coding gene. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLC7 Gene

Genomics for IGLC7 Gene

Genomic Location for IGLC7 Gene

Start:
22,922,594 bp from pter
End:
22,923,034 bp from pter
Size:
441 bases
Orientation:
Plus strand

Genomic View for IGLC7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGLC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLC7 Gene

No data available for Regulatory Elements for IGLC7 Gene

Proteins for IGLC7 Gene

  • Protein details for IGLC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0M8Q6-LAC7_HUMAN
    Recommended name:
    Ig lambda-7 chain C region
    Protein Accession:
    A0M8Q6
    Secondary Accessions:

    Protein attributes for IGLC7 Gene

    Size:
    106 amino acids
    Molecular mass:
    11303 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Displays the following serological isotype: Ke+, Oz- and two of the three characteristic amino acids of Mgc-isotype: Ala-6 and Ser-8 but instead of Thr-57 it displays Lys-57. Ke+ has Gly-46 and Oz- has Arg-83
    SequenceCaution:
    • Sequence=BAA20016.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA36053.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW59556.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for IGLC7 Gene

Proteomics data for IGLC7 Gene at MOPED

Post-translational modifications for IGLC7 Gene

No Post-translational modifications

Other Protein References for IGLC7 Gene

ENSEMBL proteins:
Reactome Protein details:

No data available for DME Specific Peptides for IGLC7 Gene

Domains for IGLC7 Gene

Gene Families for IGLC7 Gene

HGNC:
  • IGL :Immunoglobulins / IGL locus

Protein Domains for IGLC7 Gene

Suggested Antigen Peptide Sequences for IGLC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0M8Q6

UniProtKB/Swiss-Prot:

LAC7_HUMAN :
  • A0M8Q6
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGLC7: view

Function for IGLC7 Gene

Molecular function for IGLC7 Gene

GENATLAS Biochemistry: immunoglobulin,lambda,constant segment 7 (Ke marker)

Gene Ontology (GO) - Molecular Function for IGLC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IGLC7: view

miRNA for IGLC7 Gene

miRTarBase miRNAs that target IGLC7

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IGLC7 Gene

Localization for IGLC7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGLC7 Gene COMPARTMENTS Subcellular localization image for IGLC7 gene
Compartment Confidence
extracellular 4
plasma membrane 4
nucleus 1

Gene Ontology (GO) - Cellular Components for IGLC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with IGLC7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IGLC7 Gene

Pathways for IGLC7 Gene

genes like me logo Genes that share pathways with IGLC7: view

Interacting Proteins for IGLC7 Gene

Gene Ontology (GO) - Biological Process for IGLC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
GO:0038095 Fc-epsilon receptor signaling pathway TAS --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
genes like me logo Genes that share ontologies with IGLC7: view

Transcripts for IGLC7 Gene

mRNA/cDNA for IGLC7 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGLC7 Gene

No ASD Table

Relevant External Links for IGLC7 Gene

GeneLoc Exon Structure for
IGLC7
ECgene alternative splicing isoforms for
IGLC7

Expression for IGLC7 Gene

mRNA expression in normal human tissues for IGLC7 Gene

mRNA differential expression in normal tissues according to GTEx for IGLC7 Gene

This gene is overexpressed in Spleen (18.4), Minor Salivary Gland (7.6), and Colon - Transverse (6.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IGLC7 Gene

genes like me logo Genes that share expressions with IGLC7: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGLC7 Gene

Orthologs for IGLC7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGLC7 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 34 (a)
ManyToMany
IGLL1 36
  • 34 (a)
ManyToMany
VPREB 36
  • 30 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 36 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
-- 36
  • 87 (a)
ManyToMany
-- 36
  • 87 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Iglc2 36
  • 63 (a)
ManyToMany
Iglc3 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
ManyToMany
-- 36
  • 9 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 27 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU571382.2 36
  • 10 (a)
ManyToMany
Species with no ortholog for IGLC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGLC7 Gene

ENSEMBL:
Gene Tree for IGLC7 (if available)
TreeFam:
Gene Tree for IGLC7 (if available)

Paralogs for IGLC7 Gene

Paralogs for IGLC7 Gene

Pseudogenes.org Pseudogenes for IGLC7 Gene

genes like me logo Genes that share paralogs with IGLC7: view

Variants for IGLC7 Gene

Relevant External Links for IGLC7 Gene

HapMap Linkage Disequilibrium report
IGLC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for IGLC7 Gene

Disorders for IGLC7 Gene

(1) University of Copenhagen DISEASES for IGLC7 Gene

Relevant External Links for IGLC7

Genetic Association Database (GAD)
IGLC7
genes like me logo Genes that share disorders with IGLC7: view

No data available for UniProtKB/Swiss-Prot for IGLC7 Gene

Publications for IGLC7 Gene

  1. Structure and expression of the human immunoglobulin lambda genes. (PMID: 2115572) Vasicek T.J. … Leder P. (J. Exp. Med. 1990) 3 4
  2. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K. … Shimizu N. (Genome Res. 1997) 3 4
  3. Recognition of immunoglobulins by Fcgamma receptors. (PMID: 11955599) Radaev S. … Sun P. (Mol. Immunol. 2002) 3
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Physicochemical and functional characterization of the C1r subunit of the first complement component. (PMID: 814163) Ziccardi R.J. … Cooper N.R. (J. Immunol. 1976) 3

Products for IGLC7 Gene

Sources for IGLC7 Gene

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