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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGLC7 Gene

protein-coding   GIFtS: 28
GCID: GC22P023310

Immunoglobulin Lambda Constant 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Immunoglobulin Lambda Constant 71 2
C72

External Ids:    HGNC: 58611   Entrez Gene: 288342   Ensembl: ENSG000002116857   UniProtKB: A0M8Q63   

Export aliases for IGLC7 gene to outside databases

Previous GC identifers: GC22U990186 GC22P021589 GC22P021597 GC22P021607 GC22P021617 GC22P021627 GC22P021638 GC22P021649 GC22P021662 GC22P021674 GC22P023269 GC22P006232 GC22P023274 GC22P023280 GC22P023285 GC22P023290 GC22P023294


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IGLC7 Gene: 
IGLC7 (immunoglobulin lambda constant 7) is a protein-coding gene. Diseases associated with IGLC7 include peripheral primitive neuroectodermal tumor, and primitive neuroectodermal tumor, and among its related super-pathways are Classical antibody-mediated complement activation and FCERI mediated MAPK activation. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGKC.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGLC7
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGLC7 promoter sequence
   Search SABiosciences Chromatin IP Primers for IGLC7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGLC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

IGLC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLC7 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P023310:  view genomic region     (about GC identifiers)

Start:
23,264,766 bp from pter      End:
23,265,085 bp from pter
Size:
320 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LAC7_HUMAN, A0M8Q6 (See protein sequence)
Recommended Name: Ig lambda-7 chain C region  
Size: 106 amino acids; 11303 Da
Miscellaneous: Displays the following serological isotype: Ke+, Oz- and two of the three characteristic amino
acids of Mgc-isotype: Ala-6 and Ser-8 but instead of Thr-57 it displays Lys-57. Ke+ has Gly-46 and Oz- has Arg-83
Sequence caution: Sequence=BAA20016.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAA36053.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW59556.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;

Explore the universe of human proteins at neXtProt for IGLC7: NX_A0M8Q6

Explore proteomics data for IGLC7 at MOPED 

IGLC7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IGLC7 Protein Expression

ENSEMBL proteins: 
 ENSP00000374859  
Reactome Protein details: A0M8Q6
Human Recombinant Protein Products for IGLC7: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005886plasma membrane TAS--

IGLC7 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IGL: Immunoglobulins / IGL locus

4 InterPro protein domains:
 IPR013783 Ig-like_fold
 IPR003597 Ig_C1-set
 IPR007110 Ig-like_dom
 IPR003006 Ig/MHC_CS

Graphical View of Domain Structure for InterPro Entry A0M8Q6

ProtoNet protein and cluster: A0M8Q6

UniProtKB/Swiss-Prot: LAC7_HUMAN, A0M8Q6
Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


IGLC7 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:
     Genatlas biochemistry entry for IGLC7:
immunoglobulin,lambda,constant segment 7 (Ke marker)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding IEA--
GO:0005515protein binding ----
     
IGLC7 for ontologies           About GeneDecksing


Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IGLC7 About   (see all 7)                                                                                              See pathways by source

SuperPathContained pathways About
1Classical antibody-mediated complement activation
Classical antibody-mediated complement activation0.88
FCGR activation0.70
Creation of C4 and C2 activators0.88
Role of phospholipids in phagocytosis0.65
Initial triggering of complement0.86
FCERI mediated NF-kB activation0.47
Complement cascade0.76
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30
2FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization0.60
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.31
FCERI mediated MAPK activation0.60
3Immune System
Immune System0.56
Innate Immune System0.50
Adaptive Immune System0.56
4Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation0.80
Fcgamma receptor (FCGR) dependent phagocytosis0.80
5Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling0.69
Role of LAT2/NTAL/LAB on calcium mobilization0.69

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


5/21        Reactome Pathways for IGLC7 (see all 21)
    FCERI mediated MAPK activation
FCERI mediated NF-kB activation
FCGR activation
Role of phospholipids in phagocytosis
Binding and Uptake of Ligands by Scavenger Receptors



IGLC7 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGLC7

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for IGLC7 (ENSP000003748594) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IGHG1ENSP000003749904STRING: ENSP00000374990
TSHRENSP000002981714STRING: ENSP00000298171
UBCENSP000003448184STRING: ENSP00000344818
About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006956complement activation TAS--
GO:0006958complement activation, classical pathway TAS--
GO:0038095Fc-epsilon receptor signaling pathway TAS--
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
GO:0045087innate immune response TAS--

IGLC7 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGLC7 (LAC7)

Search CenterWatch for drugs/clinical trials and news about IGLC7 / LAC7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390331
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGLC7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGLC7 Expression
About this image


See IGLC7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGLC7
    SABiosciences Custom PCR Arrays for IGLC7
Primer
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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGLC7

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IGLC7 gene from 3/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Iglc35 immunoglobulin lambda constant 3   --   16 (11.81 cM) 19065365 
chicken
(Gallus gallus)
Aves GGA.478466
Ig lambda chain V-1 region
28(a)
1 → many
15(7928727-7933299)
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
56(a)
24(a)
many ↔ many
many ↔ many
AAWZ02041299(1275-1595)
GL343282.1(588802-599691)


ENSEMBL Gene Tree for IGLC7 (if available)
TreeFam Gene Tree for IGLC7 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGLC7 gene
IGKC2  IGLL52  IGLC12  IGLC32  IGLL12  IGLC22  
18/43 SIMAP similar genes for IGLC7 using alignment to 1 protein entry:     LAC7_HUMAN(see all similar genes):
C1 segment    DKFZp667J0810    DKFZp781M0386    IGL@    IGLC1    IGLC2
IGLC3    IGLL5    IgLC-rG    IGLC6    IGLL1    IGK@
IGKC    DKFZp686E23209    IGHG2    B2M    IGHM    HLA-DQA1

IGLC7 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for IGLC7
PGOHUM00000250335 PGOHUM00000246569


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for IGLC7:    About MalaCards
peripheral primitive neuroectodermal tumor    primitive neuroectodermal tumor

1 disease from the University of Copenhagen DISEASES database for IGLC7:
Peripheral primitive neuroectodermal tumor

IGLC7 for disorders           About GeneDecksing

Genetic Association Database (GAD): IGLC7

Export disorders for IGLC7 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGLC7 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGLC7)
    Utopia: connect your pdf to the dynamic
world of online information

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1, 2 Kawasaki K....Shimizu N. (1997)
  2. Structure and expression of the human immunoglobulin lambda genes. (PubMed id 2115572)1, 2 Vasicek T.J. and Leder P. (1990)
  3. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
  4. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (2002)
  5. Physicochemical and functional characterization of the C1r subunit of the first complement component. (PubMed id 814163)1 Ziccardi R.J. and Cooper N.R. (1976)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28834 HGNC: 5861 Ensembl:ENSG00000211685 euGenes: HUgn28834 ECgene: IGLC7
H-InvDB: IGLC7

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGLC7 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGLC7 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGLC7&species=Homo+sapiens

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGLC7 gene:
Search GeneIP for patents involving IGLC7

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Biologicals
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 Search for Antibodies for IGLC7 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for IGLC7
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 Browse Proteins at Cloud-Clone Corp.
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 SwitchGear 3'UTR luciferase reporter plasmids for IGLC7
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 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGLC7
 inGenious Targeting Laboratory - Custom generated mouse model solutions for IGLC7
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGLC7
Customized:
 lentivirus for stable overexpression of IGLC7
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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