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Aliases for IGLC7 Gene

Aliases for IGLC7 Gene

  • Immunoglobulin Lambda Constant 7 2 3 5
  • Ig Lambda-7 Chain C Region 4
  • C7 3

External Ids for IGLC7 Gene

Previous GeneCards Identifiers for IGLC7 Gene

  • GC22U990186
  • GC22P021589
  • GC22P021597
  • GC22P021607
  • GC22P021617
  • GC22P021627
  • GC22P021638
  • GC22P021649
  • GC22P021662
  • GC22P021674
  • GC22P023269
  • GC22P006232
  • GC22P023274
  • GC22P023280
  • GC22P023285
  • GC22P023290
  • GC22P023294
  • GC22P023310
  • GC22P023325
  • GC22P022925
  • GC22P022935
  • GC22P022984
  • GC22P023091

Summaries for IGLC7 Gene

GeneCards Summary for IGLC7 Gene

IGLC7 (Immunoglobulin Lambda Constant 7) is a Protein Coding gene. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLC2.

UniProtKB/Swiss-Prot for IGLC7 Gene

  • Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLC7 Gene

Genomics for IGLC7 Gene

Regulatory Elements for IGLC7 Gene

Enhancers for IGLC7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G022926 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.7 +9.5 9517 10.9 HDGF PKNOX1 ATF1 WRNIP1 SIN3A GATA2 ELK1 ZNF143 ZMIZ1 ZNF548 IGLV3-4 IGLV2-5 ZNF70 IGLV5-52 ENSG00000272779 IGLC2 IGLC7 IGLV7-43 IGLL5 IGLC3
GH22G022901 1.1 ENCODE dbSUPER 9.2 -19.8 -19764 2.8 HNRNPUL1 HDAC1 TBL1XR1 RB1 WRNIP1 BMI1 EGR1 RELB IKZF2 ZNF263 ZNF70 IGLC2 IGLV2-5 IGLV3-4 IGLC7 IGLV10-54 IGLJ3
GH22G022914 0.9 ENCODE dbSUPER 10.2 -7.5 -7474 0.3 ZNF263 KLF1 MAX RBBP5 RAD21 YY1 NR2F2 TFDP1 JUND ID3 IGLC7 IGLC5 IGLJ5
GH22G022898 0.8 dbSUPER 9.2 -23.1 -23097 3.2 BMI1 RAD21 ZNF335 GLIS2 FOS ZNF548 SMAD5 CBFB CEBPB JUNB IGLC2 IGLV2-5 IGLV3-4 ZNF70 IGLV5-52 ENSG00000272779 IGLC7 IGLJ2
GH22G022892 0.9 dbSUPER 6.7 -28.7 -28736 3.4 HNRNPUL1 HDAC1 TBL1XR1 KLF17 SCRT2 FOS RELB KDM4B IKZF2 EGR2 IGLV2-5 IGLV3-4 IGLC2 IGLC7 IGLC1 IGLJ1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGLC7 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGLC7 Gene

Chromosome:
22
Start:
22,922,594 bp from pter
End:
22,923,034 bp from pter
Size:
441 bases
Orientation:
Plus strand

Genomic View for IGLC7 Gene

Genes around IGLC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLC7 Gene

Proteins for IGLC7 Gene

  • Protein details for IGLC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0M8Q6-IGLC7_HUMAN
    Recommended name:
    Immunoglobulin lambda constant 7
    Protein Accession:
    A0M8Q6
    Secondary Accessions:
    • A0A075B6L1

    Protein attributes for IGLC7 Gene

    Size:
    106 amino acids
    Molecular mass:
    11254 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
    Miscellaneous:
    • Displays the following serological isotype: Ke+, Oz- and two of the three characteristic amino acids of Mgc-isotype: Ala-6 and Ser-8 but instead of Thr-57 it displays Lys-57. Ke+ has Gly-46 and Oz- has Arg-83.
    SequenceCaution:
    • Sequence=BAA20016.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA36053.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW59556.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for IGLC7 Gene

Post-translational modifications for IGLC7 Gene

No Post-translational modifications

Other Protein References for IGLC7 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLC7 Gene

Domains & Families for IGLC7 Gene

Gene Families for IGLC7 Gene

Protein Domains for IGLC7 Gene

Suggested Antigen Peptide Sequences for IGLC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGLC7: view

No data available for UniProtKB/Swiss-Prot for IGLC7 Gene

Function for IGLC7 Gene

Molecular function for IGLC7 Gene

GENATLAS Biochemistry:
immunoglobulin,lambda,constant segment 7 (Ke marker)
UniProtKB/Swiss-Prot Function:
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGLC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGLC7: view

Animal Model Products

miRNA for IGLC7 Gene

miRTarBase miRNAs that target IGLC7

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGLC7 Gene

Localization for IGLC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLC7 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA --
GO:0042571 immunoglobulin complex, circulating IBA --
GO:0072562 blood microparticle IBA --
genes like me logo Genes that share ontologies with IGLC7: view

No data available for Subcellular locations from COMPARTMENTS for IGLC7 Gene

Pathways & Interactions for IGLC7 Gene

SuperPathways for IGLC7 Gene

No Data Available

Interacting Proteins for IGLC7 Gene

Gene Ontology (GO) - Biological Process for IGLC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGLC7: view

No data available for Pathways by source and SIGNOR curated interactions for IGLC7 Gene

Drugs & Compounds for IGLC7 Gene

No Compound Related Data Available

Transcripts for IGLC7 Gene

mRNA/cDNA for IGLC7 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGLC7 Gene

No ASD Table

Relevant External Links for IGLC7 Gene

GeneLoc Exon Structure for
IGLC7
ECgene alternative splicing isoforms for
IGLC7

Expression for IGLC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGLC7 Gene

mRNA differential expression in normal tissues according to GTEx for IGLC7 Gene

This gene is overexpressed in Spleen (x18.4), Minor Salivary Gland (x7.6), and Colon - Transverse (x6.1).

Protein differential expression in normal tissues from HIPED for IGLC7 Gene

This gene is overexpressed in Skin (50.2) and Serum (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLC7 Gene



NURSA nuclear receptor signaling pathways regulating expression of IGLC7 Gene:

IGLC7
genes like me logo Genes that share expression patterns with IGLC7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLC7 Gene

Orthologs for IGLC7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGLC7 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 87 (a)
ManyToMany
-- 35
  • 87 (a)
ManyToMany
-- 35
  • 72 (a)
ManyToMany
-- 35
  • 71 (a)
ManyToMany
-- 35
  • 59 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 64 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Iglc2 35
  • 63 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 42 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 9 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 34 (a)
ManyToMany
IGLL1 35
  • 34 (a)
ManyToMany
VPREB 35
  • 30 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 27 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 55 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU571382.2 35
  • 10 (a)
ManyToMany
Species where no ortholog for IGLC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGLC7 Gene

ENSEMBL:
Gene Tree for IGLC7 (if available)
TreeFam:
Gene Tree for IGLC7 (if available)

Paralogs for IGLC7 Gene

Variants for IGLC7 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLC7 Gene

IGLC7_HUMAN-A0M8Q6
There are several alleles. The sequence shown is that of IMGT allele IGLC7*03.

Sequence variations from dbSNP and Humsavar for IGLC7 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_077896 --

Relevant External Links for IGLC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLC7

No data available for Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLC7 Gene

Disorders for IGLC7 Gene

Relevant External Links for IGLC7

Genetic Association Database (GAD)
IGLC7

No disorders were found for IGLC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGLC7 Gene

Publications for IGLC7 Gene

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K. … Shimizu N. (Genome Res. 1997) 3 4 64
  2. Structure and expression of the human immunoglobulin lambda genes. (PMID: 2115572) Vasicek T.J. … Leder P. (J. Exp. Med. 1990) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  5. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64

Products for IGLC7 Gene

Sources for IGLC7 Gene

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