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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGLC7 Gene

protein-coding   GIFtS: 29
GCID: GC22P023294

immunoglobulin lambda constant 7
 Explore 3 diseases affiliated with
IGLC7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGLC7    

Aliases
for IGLC7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immunoglobulin Lambda Constant 71 2
C72

External Ids:    HGNC: 58611   Entrez Gene: 288342   Ensembl: ENSG000002116857   UniProtKB: A0M8Q63   

Export aliases for IGLC7 gene to outside databases

Previous GC identifers: GC22U990186 GC22P021589 GC22P021597 GC22P021607 GC22P021617 GC22P021627 GC22P021638 GC22P021649 GC22P021662 GC22P021674 GC22P023269 GC22P006232 GC22P023274 GC22P023280 GC22P023285 GC22P023290


Summaries
for IGLC7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for IGLC7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGLC7
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IGLC7 promoter sequence
   Search SABiosciences Chromatin IP Primers for IGLC7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGLC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

IGLC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLC7 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P023294:  view genomic region     (about GC identifiers)

Start:
 23,264,766 bp from pter      End:
 23,265,085 bp from pter
Size:
 320 bases      Orientation:
 plus strand

Proteins
for IGLC7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LAC7_HUMAN, A0M8Q6 (See protein sequence)
Recommended Name: Ig lambda-7 chain C region  
Size: 106 amino acids; 11303 Da
Miscellaneous: Displays the following serological isotype: Ke+, Oz- and two of the three characteristic amino acids of
Mgc-isotype: Ala-6 and Ser-8 but instead of Thr-57 it displays Lys-57. Ke+ has Gly-46 and Oz- has Arg-83
Sequence caution: Sequence=BAA20016.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAA36053.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW59556.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;

Explore the universe of human proteins at neXtProt for IGLC7: NX_A0M8Q6

IGLC7 Protein expression data from MOPED and PaxDb:    About this image 
IGLC7 Protein Expression

ENSEMBL proteins: 
 ENSP00000374859  
Reactome Protein details: A0M8Q6
Human Recombinant Protein Products for IGLC7: 
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Uscn Proteins for IGLC7

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005886plasma membrane TAS--

IGLC7 for ontologies           About GeneDecksing



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Protein Domains /
Families
for IGLC7 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
IGLC7 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR007110 Ig-like_dom
 IPR013783 Ig-like_fold
 IPR003006 Ig/MHC_CS
 IPR003597 Ig_C1-set

Graphical View of Domain Structure for InterPro Entry A0M8Q6

ProtoNet protein and cluster: A0M8Q6

UniProtKB/Swiss-Prot: LAC7_HUMAN, A0M8Q6
Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


Function
for IGLC7 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Molecular Function:
     Genatlas biochemistry entry for IGLC7:
immunoglobulin,lambda,constant segment 7 (Ke marker)

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding IEA--
     
IGLC7 for ontologies           About GeneDecksing


Animal Models:
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miRNA
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SwitchGear 3'UTR luciferase reporter plasmid: IGLC7 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Pathways & Interactions
for IGLC7 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Cleavage of Alpha-1-Microglobulin
8/11 pathways (see all 11)
Cleavage of Alpha-1-Microglobulin1.00
FCGR activation0.65
Binding and Uptake of Ligands by Scavenger Receptors0.79
Initial triggering of complement0.60
Scavenging of Heme from Plasma0.79
Role of phospholipids in phagocytosis0.53
Classical antibody-mediated complement activation0.74
Complement cascade0.47
2Immune System
Immune System1.00
Innate Immune System0.46
Adaptive Immune System0.59
3Assembly of Signalosomes at the Activated BCR
Assembly of Signalosomes at the Activated BCR1.00
Phosphorylation of ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)0.45
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.78
4Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation1.00
Fcgamma receptor (FCGR) dependent phagocytosis0.80
Role of myosins in phagosome formation0.80
5Signaling by the B Cell Receptor (BCR)
Signaling by the B Cell Receptor (BCR)1.00

Pathway sources
See GeneCards unified pathways
Show all pathways


5/21        Reactome Pathways for IGLC7 (see all 21)
    Role of myosins in phagosome formation
FCGR activation
Cleavage of Alpha-1-Microglobulin
Sequestering and phosphorylation Fc gamma receptors in the lipid rafts
Role of phospholipids in phagocytosis



IGLC7 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGLC7

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for IGLC7 (ENSP000003748594) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IGHG1ENSP000003749904STRING: ENSP00000374990
TSHRENSP000002981714STRING: ENSP00000298171
UBCENSP000003448184STRING: ENSP00000344818
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006956complement activation TAS--
GO:0006958complement activation, classical pathway TAS--
GO:0045087innate immune response TAS--
GO:0050776regulation of immune response TAS--

IGLC7 for ontologies           About GeneDecksing



Drugs & Compounds
for IGLC7 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGLC7
Search CenterWatch for drugs/clinical trials and news about IGLC7 / LAC7 

Transcripts
for IGLC7 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390331

miRNA
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Inhib. RNA
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Clone
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Primer
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GeneLoc Exon Structure


Expression
for IGLC7 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGLC7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
IGLC7 Expression
About this image
See IGLC7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGLC7
    SABiosciences Custom PCR Arrays for IGLC7

Primer
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In Situ
Assay Products: 
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Orthologs
for IGLC7 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for IGLC7 gene from 2/6 species (see all 6)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
lizard
(Anolis carolinensis)		 Reptilia --
 --
 55(a)
 1 → many
 AAWZ02041299(1275-1595)
zebrafish
(Danio rerio)		 Actinopterygii CU570684.46
igic1s16
(see all 5)		 immunoglobulin light iota constant 1, s1
(see all 5)		 25(a)
22(a)
(see all 5)		 many ↔ many
many ↔ many
(see all 5)		 3(59697601-59699495)
24(39697150-39700054)


ENSEMBL Gene Tree for IGLC7 (if available)
TreeFam Gene Tree for IGLC7 (if available) 

Paralogs
for IGLC7 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGLC7 gene
IGLL52  IGKC2  IGLC12  IGLL12  IGLC32  IGLC22  TRBC22  
18/51 SIMAP similar genes for IGLC7 using alignment to 1 protein entry:     LAC7_HUMAN(see all similar genes):
C1 segment    DKFZp667J0810    DKFZp781M0386    IGL@    IGLC1    IGLC2
IGLC3    IGLL5    IgLC-rG    IGLC6    IGLL1    IGK@
IGKC    DKFZp686E23209    IGHG2    B2M    IGHM    HLA-DQA1

IGLC7 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for IGLC7
PGOHUM00000250335 PGOHUM00000246569


Genomic Variants
for IGLC7 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGLC7
DNA2.0 Custom Variant and Variant Library Synthesis for IGLC7

Disorders / Diseases
for IGLC7 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
IGLC7 for disorders           About GeneDecksing

3 diseases for IGLC7:    About MalaCards
peripheral primitive neuroectodermal tumor    primitive neuroectodermal tumor    neuroectodermal tumors


Export disorders for IGLC7 gene to outside databases

Publications
for IGLC7 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGLC7 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGLC7)		    Utopia: connect your pdf to the dynamic
world of online information

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1, 2 Kawasaki K....Shimizu N. (1997)
  2. Structure and expression of the human immunoglobulin lambda genes. (PubMed id 2115572)1, 2 Vasicek T.J. and Leder P. (1990)
  3. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
  4. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (2002)
  5. Physicochemical and functional characterization of the C1r subunit of the first complement component. (PubMed id 814163)1 Ziccardi R.J. and Cooper N.R. (1976)

External Searches for IGLC7 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGLC7 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28834 HGNC: 5861 Ensembl:ENSG00000211685 euGenes: HUgn28834 ECgene: IGLC7
H-InvDB: IGLC7

Other Databases showing IGLC7 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGLC7 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGLC7 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGLC7 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGLC7&species=Homo+sapiens

Intellectual Property
for IGLC7 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGLC7 gene:
Search GeneIP for patents involving IGLC7

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
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About This Section

 
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