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Aliases for IGLC6 Gene

Subcategory (RNA class) for IGLC6 Gene

lncRNA

Aliases for IGLC6 Gene

  • Immunoglobulin Lambda Constant 6 (Gene/Pseudogene) 2 3 5
  • Immunoglobulin Lambda Constant 6 (Kern+Oz- Marker) 2 3
  • Ig Lambda-6 Chain C Region 3 4
  • Immunoglobulin Lambda Constant 6 (Kern+Oz- Marker, Gene/Pseudogene) 3
  • Immunoglobulin Lambda Constant Region 6 (Kern+ Oz- Marker) 3
  • IGLC 3

External Ids for IGLC6 Gene

ORGUL Members for IGLC6 Gene

Previous HGNC Symbols for IGLC6 Gene

  • IGLC

Previous GeneCards Identifiers for IGLC6 Gene

  • GC22U990030
  • GC22P021586
  • GC22P021595
  • GC22P021605
  • GC22P021615
  • GC22P021625
  • GC22P021636
  • GC22P021646
  • GC22P021659
  • GC22P021672
  • GC22P023267
  • GC22P006229
  • GC22P023273
  • GC22P023279
  • GC22P023284
  • GC22P023289
  • GC22P023293
  • GC22P023308
  • GC22P023324

Summaries for IGLC6 Gene

GeneCards Summary for IGLC6 Gene

IGLC6 (Immunoglobulin Lambda Constant 6 (Gene/Pseudogene)) is a Pseudogene, and is affiliated with the lncRNA class. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Role of phospholipids in phagocytosis. GO annotations related to this gene include antigen binding.

UniProtKB/Swiss-Prot for IGLC6 Gene

  • Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLC6 Gene

Genomics for IGLC6 Gene

Genomic Location for IGLC6 Gene

Chromosome:
22
Start:
22,919,535 bp from pter
End:
22,919,858 bp from pter
Size:
324 bases
Orientation:
Plus strand

Genomic View for IGLC6 Gene

Genes around IGLC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLC6 Gene

No data available for Regulatory Elements for IGLC6 Gene

Proteins for IGLC6 Gene

  • Protein details for IGLC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CF74-IGLC6_HUMAN
    Recommended name:
    Immunoglobulin lambda constant 6
    Protein Accession:
    P0CF74

    Protein attributes for IGLC6 Gene

    Size:
    106 amino acids
    Molecular mass:
    11277 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
    Miscellaneous:
    • Displays the following serological isotype: Mgc-, Ke+, and Oz-. Mgc- has Ala-6, Ser-8 and Thr-57; Ke+ has Gly-46 and Oz- has Arg-83.

neXtProt entry for IGLC6 Gene

Post-translational modifications for IGLC6 Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGLC6 Gene

Domains & Families for IGLC6 Gene

Gene Families for IGLC6 Gene

Protein Domains for IGLC6 Gene

Suggested Antigen Peptide Sequences for IGLC6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGLC6: view

No data available for UniProtKB/Swiss-Prot for IGLC6 Gene

Function for IGLC6 Gene

Molecular function for IGLC6 Gene

GENATLAS Biochemistry:
immunoglobulin,lambda,constant segment 6 (Kern+Oz-marker)
UniProtKB/Swiss-Prot Function:
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGLC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGLC6: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLC6 Gene

Localization for IGLC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLC6 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 23580065
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA --
GO:0042571 immunoglobulin complex, circulating IBA --
genes like me logo Genes that share ontologies with IGLC6: view

No data available for Subcellular locations from COMPARTMENTS for IGLC6 Gene

Pathways & Interactions for IGLC6 Gene

genes like me logo Genes that share pathways with IGLC6: view

Interacting Proteins for IGLC6 Gene

Gene Ontology (GO) - Biological Process for IGLC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGLC6: view

No data available for SIGNOR curated interactions for IGLC6 Gene

Drugs & Compounds for IGLC6 Gene

No Compound Related Data Available

Transcripts for IGLC6 Gene

mRNA/cDNA for IGLC6 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGLC6 Gene

No ASD Table

Relevant External Links for IGLC6 Gene

GeneLoc Exon Structure for
IGLC6
ECgene alternative splicing isoforms for
IGLC6

Expression for IGLC6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGLC6 Gene

mRNA differential expression in normal tissues according to GTEx for IGLC6 Gene

This gene is overexpressed in Spleen (x14.9), Small Intestine - Terminal Ileum (x8.4), Minor Salivary Gland (x6.7), and Colon - Transverse (x6.4).

Protein differential expression in normal tissues from HIPED for IGLC6 Gene

This gene is overexpressed in Testis (46.3) and Plasma (22.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLC6 Gene



Protein tissue co-expression partners for IGLC6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGLC6 Gene:

IGLC6
genes like me logo Genes that share expression patterns with IGLC6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLC6 Gene

Orthologs for IGLC6 Gene

Evolution for IGLC6 Gene

ENSEMBL:
Gene Tree for IGLC6 (if available)
TreeFam:
Gene Tree for IGLC6 (if available)

No data available for Orthologs for IGLC6 Gene

Paralogs for IGLC6 Gene

No data available for Paralogs for IGLC6 Gene

Variants for IGLC6 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLC6 Gene

IGLC6_HUMAN-P0CF74
There are several alleles. The sequence shown is that of IMGT allele IGLC6*01 that is not represented on the reference genome assembly (GRCh38/hg38) and that is the only functional. The other existing alleles are pseudogenes. The sequence shown on the reference genome assembly (GRCh38/hg38) is that of IMGT allele IGLC6*05 that is a pseudogene due to a stop codon polymorphism at position 71.

Relevant External Links for IGLC6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLC6

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLC6 Gene

Disorders for IGLC6 Gene

No disorders were found for IGLC6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGLC6 Gene

Publications for IGLC6 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 64
  2. Human immunoglobulin C lambda 6 gene encodes the Kern+Oz-lambda chain and C lambda 4 and C lambda 5 are pseudogenes. (PMID: 3122211) Dariavach P. … Lefranc M.P. (Proc. Natl. Acad. Sci. U.S.A. 1987) 3 4 64
  3. Clustered arrangement of immunoglobulin lambda constant region genes in man. (PMID: 6273747) Hieter P.A. … Leder P. (Nature 1981) 3 4 64
  4. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naA^ve to therapy. (PMID: 23580065) Pieragostino D. … Del Boccio P. (Mol Biosyst 2013) 3 64
  5. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64

Products for IGLC6 Gene

Sources for IGLC6 Gene

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