immunoglobulin lambda constant 6 (Kern+Oz- marker, gene/pseudogene) immunoglobulin lambda constant 6 (Kern+Oz- marker) )IGLC )
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Aliasesfor IGLC6 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Subcategory (RNA class): lncRNAQuality score for the ORGUL clustered with this gene is 3 Aliases Immunoglobulin Lambda Constant 6 (Kern+Oz- Marker, Gene/Pseudogene) 1 2 IGLC1 2 Immunoglobulin Lambda Constant 6 (Kern+Oz- Marker)1
External Ids: HGNC: 5860 1 Entrez Gene: 3542 2 Ensembl: ENSG00000222037 7 UniProtKB: P0CF74 3 ORGUL members: NONCODE:n387241
Export aliases for IGLC6 gene to outside databases Previous GC identifers: GC22U990030 GC22P021586 GC22P021595 GC22P021605 GC22P021615 GC22P021625 GC22P021636 GC22P021646 GC22P021659 GC22P021672 GC22P023267 GC22P006229 GC22P023273 GC22P023279 GC22P023284 GC22P023289
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Summariesfor IGLC6 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section
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Genomic Viewsfor IGLC6 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for IGLC6 Other transcription factors Search SABiosciences Chromatin IP Primers for IGLC6 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGLC6
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 22q11.2 Ensembl cytogenetic band: 22q11.22 HGNC cytogenetic band: 22q11.2 IGLC6 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 22 GeneLoc Exon Structure
GeneLoc location for GC22P023293: view genomic region
(about GC identifiers )
Start: 23,261,707 bp from pter End:
23,262,030 bp from pter
Size: 324 bases Orientation:
plus strand
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Proteinsfor IGLC6 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: LAC6_HUMAN, P0CF74 See
protein sequence )Recommended Name: Size : 106 amino acids; 11277 DaMiscellaneous : Displays the following serological isotype: Mgc-, Ke+, and Oz-. Mgc- has Ala-6, Ser-8 and Thr-57; Ke+has Gly-46 and Oz- has Arg-83 Explore the universe of human proteins at neXtProt for IGLC6: NX_P0CF74 IGLC6 Protein expression data from MOPED and PaxDb : About this image
Reactome Protein details: P0CF74 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
TAS -- GO:0005886 plasma membrane
TAS --
About GeneDecksing IGLC6 Antibody Products: Assay Products for IGLC6:
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Protein
Domains /for IGLC6 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P0CF74 ProtoNet protein and cluster: P0CF74
UniProtKB/Swiss-Prot: LAC6_HUMAN, P0CF74 Similarity : Contains 1 Ig-like (immunoglobulin-like) domain
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Functionfor IGLC6 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: Genatlas biochemistry entry for IGLC6 immunoglobulin,lambda,constant segment 6 (Kern+Oz-marker) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003823 antigen binding
IEA --
About GeneDecksing
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Pathways & Interactionsfor IGLC6 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Cleavage of Alpha-1-Microglobulin 2 Immune System 3 Assembly of Signalosomes at the Activated BCR 4 Regulation of actin dynamics for phagocytic cup formation 5 Signaling by the B Cell Receptor (BCR)
Pathway sources See GeneCards unified pathways Show all pathways 5/21 (see all 21 )About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGLC6 1 Interacting protein for IGLC6 (P0CF74 3 via UniProtKB, MINT, STRING, and/or I2D About this table Gene Ontology (GO): 4 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006956 complement activation
TAS -- GO:0006958 complement activation, classical pathway
TAS -- GO:0045087 innate immune response
TAS -- GO:0050776 regulation of immune response
TAS --
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Drugs & Compoundsfor IGLC6 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for IGLC6 IGLC6
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Transcriptsfor IGLC6 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000410078 GeneLoc Exon Structure
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Expression for IGLC6 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section IGLC6 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image See IGLC6 Protein Expression from SPIRE MOPED and PaxDB SABiosciences Custom PCR Arrays for IGLC6 Primer Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat IGLC6 Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGLC6 Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGLC6
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Orthologsfor IGLC6 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
ENSEMBL Gene Tree for IGLC6 (if available)TreeFam Gene Tree for IGLC6 (if available)
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Paralogsfor IGLC6 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section
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Genomic Variantsfor IGLC6 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section UniProtKB/Swiss-Prot: LAC6_HUMAN, P0CF74 Polymorphism : Only the allele IGLC6*01 is functional. The other existing alleles are pseudogenes
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor IGLC6 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
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Publicationsfor IGLC6 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for IGLC6 gene integrated from 9 sources :(articles sorted by number of sources associating them with IGLC6) Utopia : connect your pdf to the dynamic
The DNA sequence of human chromosome 22. (PubMed id 10591208) 1 , 2 (1999) Human immunoglobulin C lambda 6 gene encodes the Kern+Oz-lambda chain and C lambda 4 and C lambda 5 are pseudogenes. (PubMed id 3122211) 1 , 2 (1987) Clustered arrangement of immunoglobulin lambda constant region genes in man. (PubMed id 6273747) 1 , 2 (1981) Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599) 1 (2002) Physicochemical and functional characterization of the C1r subunit of the first complement component. (PubMed id 814163) 1 (1976)
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External Searches for IGLC6 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing IGLC6 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing IGLC6 gene
(According to HUGE )
About This Section --
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Specialized Databases showing IGLC6 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for IGLC6 Pharmacogenomics, SNPs, Pathways IMGT entry for IGLC6The international I mM unoG eneT ics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species. IMGT/GENE-DB http://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGLC6&species=Homo+sapiens
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About This Section Patent Information for IGLC6 gene: IGLC6 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor IGLC6 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGLC6 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGLC6 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGLC6 Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGLC6 Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGLC6 Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGLC6
Search Tocris compounds for IGLC6
Search ThermoFisher Antibodies for IGLC6
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGLC6
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