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Aliases for IGLC6 Gene

Subcategory (RNA class) for IGLC6 Gene

lncRNA

Aliases for IGLC6 Gene

  • Immunoglobulin Lambda Constant 6 (Kern+Oz- Marker, Gene/Pseudogene) 2 3
  • Immunoglobulin Lambda Constant 6 (Kern+Oz- Marker) 2 3
  • Immunoglobulin Lambda Constant Region 6 (Kern+ Oz- Marker) 3
  • Ig Lambda-6 Chain C Region 3
  • IGLC 3

External Ids for IGLC6 Gene

ORGUL Members for IGLC6 Gene

Previous HGNC Symbols for IGLC6 Gene

  • IGLC

Previous GeneCards Identifiers for IGLC6 Gene

  • GC22U990030
  • GC22P021586
  • GC22P021595
  • GC22P021605
  • GC22P021615
  • GC22P021625
  • GC22P021636
  • GC22P021646
  • GC22P021659
  • GC22P021672
  • GC22P023267
  • GC22P006229
  • GC22P023273
  • GC22P023279
  • GC22P023284
  • GC22P023289
  • GC22P023293
  • GC22P023308
  • GC22P023324

Summaries for IGLC6 Gene

GeneCards Summary for IGLC6 Gene

IGLC6 (Immunoglobulin Lambda Constant 6 (Kern+Oz- Marker, Gene/Pseudogene)) is a Pseudogene, and is affiliated with the lncRNA class. Among its related pathways are PI3K/AKT Signaling in Cancer and Immune System. GO annotations related to this gene include antigen binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLC6 Gene

Genomics for IGLC6 Gene

Genomic Location for IGLC6 Gene

Chromosome:
22
Start:
22,919,535 bp from pter
End:
22,919,858 bp from pter
Size:
324 bases
Orientation:
Plus strand

Genomic View for IGLC6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for IGLC6 Gene

No data available for Regulatory Elements for IGLC6 Gene

Proteins for IGLC6 Gene

  • Protein details for IGLC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CF74-LAC6_HUMAN
    Recommended name:
    Ig lambda-6 chain C region
    Protein Accession:
    P0CF74

    Protein attributes for IGLC6 Gene

    Size:
    106 amino acids
    Molecular mass:
    11277 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Displays the following serological isotype: Mgc-, Ke+, and Oz-. Mgc- has Ala-6, Ser-8 and Thr-57; Ke+ has Gly-46 and Oz- has Arg-83

neXtProt entry for IGLC6 Gene

Proteomics data for IGLC6 Gene at MOPED

Post-translational modifications for IGLC6 Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGLC6 Gene

Domains & Families for IGLC6 Gene

Gene Families for IGLC6 Gene

Protein Domains for IGLC6 Gene

Suggested Antigen Peptide Sequences for IGLC6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CF74

UniProtKB/Swiss-Prot:

LAC6_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGLC6: view

Function for IGLC6 Gene

Molecular function for IGLC6 Gene

GENATLAS Biochemistry:
immunoglobulin,lambda,constant segment 6 (Kern+Oz-marker)

Gene Ontology (GO) - Molecular Function for IGLC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGLC6: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLC6 Gene

Localization for IGLC6 Gene

Gene Ontology (GO) - Cellular Components for IGLC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 23580065
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA --
GO:0042571 immunoglobulin complex, circulating IBA --
genes like me logo Genes that share ontologies with IGLC6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for IGLC6 Gene

Pathways & Interactions for IGLC6 Gene

genes like me logo Genes that share pathways with IGLC6: view

Interacting Proteins for IGLC6 Gene

Selected Interacting proteins: P0CF74-LAC6_HUMAN for IGLC6 Gene via I2D

Symbol External ID(s) Details
IGHG2

Gene Ontology (GO) - Biological Process for IGLC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
genes like me logo Genes that share ontologies with IGLC6: view

No data available for SIGNOR curated interactions for IGLC6 Gene

Drugs & Compounds for IGLC6 Gene

No Compound Related Data Available

Transcripts for IGLC6 Gene

mRNA/cDNA for IGLC6 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGLC6 Gene

No ASD Table

Relevant External Links for IGLC6 Gene

GeneLoc Exon Structure for
IGLC6
ECgene alternative splicing isoforms for
IGLC6

Expression for IGLC6 Gene

mRNA expression in normal human tissues for IGLC6 Gene

mRNA differential expression in normal tissues according to GTEx for IGLC6 Gene

This gene is overexpressed in Spleen (x14.9), Small Intestine - Terminal Ileum (x8.4), Minor Salivary Gland (x6.7), and Colon - Transverse (x6.4).

Protein differential expression in normal tissues from HIPED for IGLC6 Gene

This gene is overexpressed in Testis (46.3) and Plasma (22.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLC6 Gene



genes like me logo Genes that share expression patterns with IGLC6: view

Protein tissue co-expression partners for IGLC6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGLC6 Gene

Orthologs for IGLC6 Gene

Evolution for IGLC6 Gene

ENSEMBL:
Gene Tree for IGLC6 (if available)
TreeFam:
Gene Tree for IGLC6 (if available)

No data available for Orthologs for IGLC6 Gene

Paralogs for IGLC6 Gene

genes like me logo Genes that share paralogs with IGLC6: view

No data available for Paralogs for IGLC6 Gene

Variants for IGLC6 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLC6 Gene

P0CF74-LAC6_HUMAN
Only the allele IGLC6*01 is functional. The other existing alleles are pseudogenes

Relevant External Links for IGLC6 Gene

HapMap Linkage Disequilibrium report
IGLC6

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLC6 Gene

Disorders for IGLC6 Gene

genes like me logo Genes that share disorders with IGLC6: view

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGLC6 Gene

Publications for IGLC6 Gene

  1. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naA^ve to therapy. (PMID: 23580065) Pieragostino D. … Del Boccio P. (Mol Biosyst 2013) 67
  2. Recognition of immunoglobulins by Fcgamma receptors. (PMID: 11955599) Radaev S. … Sun P. (Mol. Immunol. 2002) 67
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 67
  4. Human immunoglobulin C lambda 6 gene encodes the Kern+Oz-lambda chain and C lambda 4 and C lambda 5 are pseudogenes. (PMID: 3122211) Dariavach P. … Lefranc M.P. (Proc. Natl. Acad. Sci. U.S.A. 1987) 67
  5. Clustered arrangement of immunoglobulin lambda constant region genes in man. (PMID: 6273747) Hieter P.A. … Leder P. (Nature 1981) 67

Products for IGLC6 Gene

Sources for IGLC6 Gene

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