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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGLC6 Gene

pseudogene   GIFtS: 23
GCID: GC22P023308

Immunoglobulin Lambda Constant 6 (Kern+Oz- Marker, Gene/Pseudogene)

(Previous name: immunoglobulin lambda constant 6 (Kern+Oz- marker))
(Previous symbol: IGLC)
  Search for IGLC6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Immunoglobulin Lambda Constant 6 (Kern+Oz- Marker, Gene/Pseudogene)1 2
IGLC1 2
Immunoglobulin Lambda Constant 6 (Kern+Oz- Marker)1

External Ids:    HGNC: 58601   Entrez Gene: 35422   Ensembl: ENSG000002220377   UniProtKB: P0CF743   
ORGUL members:         
NONCODE14:n387241      

Export aliases for IGLC6 gene to outside databases

Previous GC identifers: GC22U990030 GC22P021586 GC22P021595 GC22P021605 GC22P021615 GC22P021625 GC22P021636 GC22P021646 GC22P021659 GC22P021672 GC22P023267 GC22P006229 GC22P023273 GC22P023279 GC22P023284 GC22P023289 GC22P023293


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IGLC6 Gene: 
IGLC6 (immunoglobulin lambda constant 6 (Kern+Oz- marker, gene/pseudogene)) is a pseudogene, and is affiliated with the lncRNA class. Among its related super-pathways are Classical antibody-mediated complement activation and FCERI mediated MAPK activation. GO annotations related to this gene include antigen binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGLC6
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGLC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

IGLC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLC6 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P023308:  view genomic region     (about GC identifiers)

Start:
23,261,707 bp from pter      End:
23,262,030 bp from pter
Size:
324 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: LAC6_HUMAN, P0CF74 (See protein sequence)
Recommended Name: Ig lambda-6 chain C region  
Size: 106 amino acids; 11277 Da
Miscellaneous: Displays the following serological isotype: Mgc-, Ke+, and Oz-. Mgc- has Ala-6, Ser-8 and Thr-57;
Ke+ has Gly-46 and Oz- has Arg-83

Explore the universe of human proteins at neXtProt for IGLC6: NX_P0CF74

Explore proteomics data for IGLC6 at MOPED 

IGLC6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IGLC6 Protein Expression
Reactome Protein details: P0CF74
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005886plasma membrane TAS--

IGLC6 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IGL: Immunoglobulins / IGL locus

4 InterPro protein domains:
 IPR013783 Ig-like_fold
 IPR003597 Ig_C1-set
 IPR007110 Ig-like_dom
 IPR003006 Ig/MHC_CS

Graphical View of Domain Structure for InterPro Entry P0CF74

ProtoNet protein and cluster: P0CF74

UniProtKB/Swiss-Prot: LAC6_HUMAN, P0CF74
Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


IGLC6 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:
     Genatlas biochemistry entry for IGLC6:
immunoglobulin,lambda,constant segment 6 (Kern+Oz-marker)

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding IEA--
     
IGLC6 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IGLC6 About   (see all 7)                                                                                              See pathways by source

SuperPathContained pathways About
1Classical antibody-mediated complement activation
Classical antibody-mediated complement activation0.88
FCGR activation0.70
Creation of C4 and C2 activators0.88
Role of phospholipids in phagocytosis0.65
Initial triggering of complement0.86
FCERI mediated NF-kB activation0.47
Complement cascade0.76
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30
2FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization0.60
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.31
FCERI mediated MAPK activation0.60
3Immune System
Immune System0.56
Innate Immune System0.50
Adaptive Immune System0.56
4Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation0.80
Fcgamma receptor (FCGR) dependent phagocytosis0.80
5Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling0.69
Role of LAT2/NTAL/LAB on calcium mobilization0.69

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


5/21        Reactome Pathways for IGLC6 (see all 21)
    FCERI mediated MAPK activation
FCERI mediated NF-kB activation
FCGR activation
Role of phospholipids in phagocytosis
Binding and Uptake of Ligands by Scavenger Receptors



IGLC6 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGLC6

1 Interacting protein for IGLC6 (P0CF743) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IGHG2P018593I2D: score=1 
About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006956complement activation TAS--
GO:0006958complement activation, classical pathway TAS--
GO:0038095Fc-epsilon receptor signaling pathway TAS--
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
GO:0045087innate immune response TAS--

IGLC6 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for IGLC6 (LAC6)

Search CenterWatch for drugs/clinical trials and news about IGLC6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000410078
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGLC6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGLC6 Expression
About this image


See IGLC6 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for IGLC6
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGLC6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for IGLC6 (if available)
TreeFam Gene Tree for IGLC6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGLC6 gene
18/53 SIMAP similar genes for IGLC6 using alignment to 1 protein entry:     LAC6_HUMAN(see all similar genes):
DKFZp667J0810    IGLC2    IGLC3    IgLC-rG    IGL@    IGLC7
C1 segment    DKFZp781M0386    IGLC1    IGLL5    IGLL1    IGK@
IGKC    IGHG2    DKFZp686E23209    IGHM    HLA-DQA1    B2M

IGLC6 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: LAC6_HUMAN, P0CF74
Polymorphism: Only the allele IGLC6*01 is functional. The other existing alleles are pseudogenes

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGLC6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGLC6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
  2. Human immunoglobulin C lambda 6 gene encodes the Kern+Oz-lambda chain and C lambda 4 and C lambda 5 are pseudogenes. (PubMed id 3122211)1, 2 Dariavach P.... Lefranc M.P. (1987)
  3. Clustered arrangement of immunoglobulin lambda constant region genes in man. (PubMed id 6273747)1, 2 Hieter P.A.... Leder P. (1981)
  4. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (2002)
  5. Physicochemical and functional characterization of the C1r subunit of the first complement component. (PubMed id 814163)1 Ziccardi R.J. and Cooper N.R. (1976)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3542 HGNC: 5860 Ensembl:ENSG00000222037 euGenes: HUgn3542 ECgene: IGLC6
H-InvDB: IGLC6

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGLC6 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGLC6 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGLC6&species=Homo+sapiens

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGLC6 gene:
Search GeneIP for patents involving IGLC6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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