Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IGLC3 Gene

Aliases for IGLC3 Gene

  • Immunoglobulin Lambda Constant 3 (Kern-Oz+ Marker) 2 3 5
  • Immunoglobulin Lambda Constant Region 3 (Kern- Oz+ Marker) 3
  • Ig Lambda-3 Chain C Regions 3
  • C3 Segment 3
  • IGLC 3

External Ids for IGLC3 Gene

Previous HGNC Symbols for IGLC3 Gene

  • IGLC

Previous GeneCards Identifiers for IGLC3 Gene

  • GC22U990027
  • GC22P021091
  • GC22P021094
  • GC22P021097
  • GC22P021101
  • GC22P021105
  • GC22P021107
  • GC22P021573
  • GC22P021298
  • GC22P021601
  • GC22P021611
  • GC22P021621
  • GC22P021631
  • GC22P021642
  • GC22P021655
  • GC22P021666
  • GC22P023249
  • GC22P006216
  • GC22P023298
  • GC22P023316
  • GC22P022909
  • GC22P022920
  • GC22P022971

Summaries for IGLC3 Gene

GeneCards Summary for IGLC3 Gene

IGLC3 (Immunoglobulin Lambda Constant 3 (Kern-Oz+ Marker)) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and RET signaling. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLC3 Gene

Genomics for IGLC3 Gene

Regulatory Elements for IGLC3 Gene

Enhancers for IGLC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F022925 1.6 FANTOM5 Ensembl ENCODE 5.4 +25.3 25345 11.7 HDGF PKNOX1 ATF1 WRNIP1 SIN3A GATA2 ELK1 ZNF143 ZNF548 ZMIZ1 IGLV5-52 ENSG00000272779 IGLV3-4 IGLV2-5 ZNF70 IGLC2 IGLV7-43 IGLC7 IGLL5 IGLC3
GH22F022904 0.9 Ensembl 0.8 +0.1 133 4.4 ELF3 ARID4B RAD21 ZNF48 RARA ZNF263 MCM3 SP5 SMAD5 MCM5 IGLC7 IGLV5-52 IGLC2 ENSG00000234630 ENSG00000272779 ZNF70 ENSG00000272578 IGLC3 IGLJ4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGLC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGLC3 Gene

Chromosome:
22
Start:
22,906,342 bp from pter
End:
22,906,803 bp from pter
Size:
462 bases
Orientation:
Plus strand

Genomic View for IGLC3 Gene

Genes around IGLC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLC3 Gene

Proteins for IGLC3 Gene

  • Protein details for IGLC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG06-LAC3_HUMAN
    Recommended name:
    Ig lambda-3 chain C regions
    Protein Accession:
    P0CG06
    Secondary Accessions:
    • A0M8Q4
    • P80423

    Protein attributes for IGLC3 Gene

    Size:
    106 amino acids
    Molecular mass:
    11238 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Alleles IGLC3*01, IGLC3*02, and IGLC3*03 display the following serological isotype: Mcg-, Kern- and Oz+. The Mcg-isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz+ marker by Lys-83. Allele IGLC3*04 displays the following serological isotype: Mcg-, Kern- and Oz-. The Mcg- isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz- marker by Arg-83.
    SequenceCaution:
    • Sequence=AAA59109.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAB36581.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA36051.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGLC3 Gene

neXtProt entry for IGLC3 Gene

Post-translational modifications for IGLC3 Gene

No Post-translational modifications

Other Protein References for IGLC3 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLC3 Gene

Domains & Families for IGLC3 Gene

Gene Families for IGLC3 Gene

Protein Domains for IGLC3 Gene

Suggested Antigen Peptide Sequences for IGLC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CG06

UniProtKB/Swiss-Prot:

LAC3_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGLC3: view

Function for IGLC3 Gene

Molecular function for IGLC3 Gene

GENATLAS Biochemistry:
immunoglobulin,lambda,constant segment 3 (Kern-Oz+ marker)

Gene Ontology (GO) - Molecular Function for IGLC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGLC3: view

Animal Model Products

miRNA for IGLC3 Gene

miRTarBase miRNAs that target IGLC3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGLC3 Gene

Localization for IGLC3 Gene

Gene Ontology (GO) - Cellular Components for IGLC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 23580065
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA --
GO:0042571 immunoglobulin complex, circulating IBA --
genes like me logo Genes that share ontologies with IGLC3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for IGLC3 Gene

Pathways & Interactions for IGLC3 Gene

genes like me logo Genes that share pathways with IGLC3: view

Interacting Proteins for IGLC3 Gene

Gene Ontology (GO) - Biological Process for IGLC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGLC3: view

No data available for SIGNOR curated interactions for IGLC3 Gene

Transcripts for IGLC3 Gene

mRNA/cDNA for IGLC3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGLC3 Gene

No ASD Table

Relevant External Links for IGLC3 Gene

GeneLoc Exon Structure for
IGLC3
ECgene alternative splicing isoforms for
IGLC3

Expression for IGLC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGLC3 Gene

mRNA differential expression in normal tissues according to GTEx for IGLC3 Gene

This gene is overexpressed in Spleen (x13.8), Minor Salivary Gland (x8.0), Colon - Transverse (x7.0), and Small Intestine - Terminal Ileum (x6.7).

Protein differential expression in normal tissues from HIPED for IGLC3 Gene

This gene is overexpressed in Skin (38.1), Ovary (13.7), and Serum (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLC3 Gene



NURSA nuclear receptor signaling pathways regulating expression of IGLC3 Gene:

IGLC3
genes like me logo Genes that share expression patterns with IGLC3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IGLC3 Gene

Orthologs for IGLC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLC3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 85 (a)
ManyToMany
-- 35
  • 85 (a)
ManyToMany
-- 35
  • 71 (a)
ManyToMany
-- 35
  • 70 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Iglc2 35
  • 63 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 42 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 9 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 34 (a)
ManyToMany
IGLL1 35
  • 34 (a)
ManyToMany
VPREB 35
  • 30 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 27 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 53 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU571382.2 35
  • 11 (a)
ManyToMany
Species where no ortholog for IGLC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGLC3 Gene

ENSEMBL:
Gene Tree for IGLC3 (if available)
TreeFam:
Gene Tree for IGLC3 (if available)

Paralogs for IGLC3 Gene

Paralogs for IGLC3 Gene

genes like me logo Genes that share paralogs with IGLC3: view

Variants for IGLC3 Gene

Relevant External Links for IGLC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLC3 Gene

Disorders for IGLC3 Gene

No disorders were found for IGLC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGLC3 Gene

Publications for IGLC3 Gene

  1. Recombinant human Fab antibody fragments to HIV-1 Rev and Tat regulatory proteins: direct selection from a combinatorial phage display library. (PMID: 8676895) Pilkington G.R. … Pomerantz R.J. (Mol. Immunol. 1996) 3 4 64
  2. Characterization of the two unique human anti-flavin monoclonal immunoglobulins. (PMID: 7737190) Stoppini M. … Ferri G. (Eur. J. Biochem. 1995) 3 4 64
  3. Structure and expression of the human immunoglobulin lambda genes. (PMID: 2115572) Vasicek T.J. … Leder P. (J. Exp. Med. 1990) 3 4 64
  4. Clustered arrangement of immunoglobulin lambda constant region genes in man. (PMID: 6273747) Hieter P.A. … Leder P. (Nature 1981) 3 4 64
  5. The three-dimensional structure of the fab' fragment of a human myeloma immunoglobulin at 2.0-A resolution. (PMID: 4215080) Poljak R.J. … Saul F. (Proc. Natl. Acad. Sci. U.S.A. 1974) 3 4 64

Products for IGLC3 Gene

Sources for IGLC3 Gene

Content
Loading form....