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Aliases for IGLC3 Gene

Aliases for IGLC3 Gene

  • Immunoglobulin Lambda Constant 3 (Kern-Oz+ Marker) 2 3 5
  • Ig Lambda-3 Chain C Regions 3 4
  • Immunoglobulin Lambda Constant Region 3 (Kern- Oz+ Marker) 3
  • Ig Lambda Chain C Region NEWM 4
  • Ig Lambda Chain C Region DOT 4
  • C3 Segment 3
  • IGLC 3

External Ids for IGLC3 Gene

Previous HGNC Symbols for IGLC3 Gene

  • IGLC

Previous GeneCards Identifiers for IGLC3 Gene

  • GC22U990027
  • GC22P021091
  • GC22P021094
  • GC22P021097
  • GC22P021101
  • GC22P021105
  • GC22P021107
  • GC22P021573
  • GC22P021298
  • GC22P021601
  • GC22P021611
  • GC22P021621
  • GC22P021631
  • GC22P021642
  • GC22P021655
  • GC22P021666
  • GC22P023249
  • GC22P006216
  • GC22P023298
  • GC22P023316
  • GC22P022909
  • GC22P022920
  • GC22P022971
  • GC22P023084
  • GC22P023132

Summaries for IGLC3 Gene

GeneCards Summary for IGLC3 Gene

IGLC3 (Immunoglobulin Lambda Constant 3 (Kern-Oz+ Marker)) is a Protein Coding gene. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLC2.

UniProtKB/Swiss-Prot for IGLC3 Gene

  • Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Additional gene information for IGLC3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLC3 Gene

Genomics for IGLC3 Gene

Regulatory Elements for IGLC3 Gene

Enhancers for IGLC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H022926 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.4 +25.8 25769 10 HDGF PKNOX1 ATF1 GATA2 ZNF143 ATF7 RUNX3 MCM3 MCM5 ZC3H11A TOP3B MIF-AS1 IGLV5-52 ENSG00000272578 IGLV3-4 IGLV2-5 MMP11 ENSG00000234630 ZNF70 IGLC2
GH22H022923 0.7 dbSUPER 5.1 +17.9 17861 1 SMARCA5 HNRNPUL1 KLF1 MCM3 TSC22D4 MCM5 YBX1 MCM7 RUNX1 POLR2A TOP3B MIF-AS1 MMP11 ZNF70 IGLC2 IGLV7-43 IGLC3 LOC105372947 IGLC7
GH22H022887 0.6 dbSUPER 5.2 -17.7 -17668 2 HNRNPUL1 KLF1 RUNX1 TBL1XR1 POLR2A ZNF341 REST TOP3B MMP11 ZNF70 IGLC3 IGLV7-43 IGLL5 IGLJ1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGLC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGLC3 Gene

Chromosome:
22
Start:
22,906,342 bp from pter
End:
22,906,803 bp from pter
Size:
462 bases
Orientation:
Plus strand

Genomic View for IGLC3 Gene

Genes around IGLC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLC3 Gene

Proteins for IGLC3 Gene

  • Protein details for IGLC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DOY3-IGLC3_HUMAN
    Recommended name:
    Immunoglobulin lambda constant 3
    Protein Accession:
    P0DOY3
    Secondary Accessions:
    • A0A075B6L0
    • A0M8Q4
    • P0CG05
    • P0CG06
    • P80423

    Protein attributes for IGLC3 Gene

    Size:
    106 amino acids
    Molecular mass:
    11266 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
    Miscellaneous:
    • Alleles IGLC3*01, IGLC3*02, and IGLC3*03 display the following serological isotype: Mcg-, Kern- and Oz+. The Mcg-isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz+ marker by Lys-83. Allele IGLC3*04 displays the following serological isotype: Mcg-, Kern- and Oz-. The Mcg- isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz- marker by Arg-83.
    SequenceCaution:
    • Sequence=AAA59109.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAB36581.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA20015.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA20028.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA36051.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGLC3 Gene

neXtProt entry for IGLC3 Gene

Post-translational modifications for IGLC3 Gene

No Post-translational modifications

Other Protein References for IGLC3 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLC3 Gene

Domains & Families for IGLC3 Gene

Gene Families for IGLC3 Gene

Protein Domains for IGLC3 Gene

Suggested Antigen Peptide Sequences for IGLC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGLC3: view

No data available for UniProtKB/Swiss-Prot for IGLC3 Gene

Function for IGLC3 Gene

Molecular function for IGLC3 Gene

GENATLAS Biochemistry:
immunoglobulin,lambda,constant segment 3 (Kern-Oz+ marker)
UniProtKB/Swiss-Prot Function:
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGLC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
genes like me logo Genes that share ontologies with IGLC3: view

Animal Model Products

CRISPR Products

miRNA for IGLC3 Gene

miRTarBase miRNAs that target IGLC3

Clone Products

  • Applied Biological Materials Clones for IGLC3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGLC3 Gene

Localization for IGLC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLC3 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 22664934
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with IGLC3: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGLC3 Gene

Pathways & Interactions for IGLC3 Gene

SuperPathways for IGLC3 Gene

No Data Available

Interacting Proteins for IGLC3 Gene

Gene Ontology (GO) - Biological Process for IGLC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with IGLC3: view

No data available for Pathways by source and SIGNOR curated interactions for IGLC3 Gene

Drugs & Compounds for IGLC3 Gene

No Compound Related Data Available

Transcripts for IGLC3 Gene

mRNA/cDNA for IGLC3 Gene

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for IGLC3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IGLC3 Gene

No ASD Table

Relevant External Links for IGLC3 Gene

GeneLoc Exon Structure for
IGLC3
ECgene alternative splicing isoforms for
IGLC3

Expression for IGLC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGLC3 Gene

mRNA differential expression in normal tissues according to GTEx for IGLC3 Gene

This gene is overexpressed in Spleen (x13.8), Minor Salivary Gland (x8.0), Colon - Transverse (x7.0), and Small Intestine - Terminal Ileum (x6.7).

Protein differential expression in normal tissues from HIPED for IGLC3 Gene

This gene is overexpressed in Skin (38.1), Ovary (13.7), and Serum (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLC3 Gene



NURSA nuclear receptor signaling pathways regulating expression of IGLC3 Gene:

IGLC3
genes like me logo Genes that share expression patterns with IGLC3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLC3 Gene

Orthologs for IGLC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLC3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 85 (a)
ManyToMany
-- 34
  • 85 (a)
ManyToMany
-- 34
  • 71 (a)
ManyToMany
-- 34
  • 70 (a)
ManyToMany
-- 34
  • 58 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Iglc2 34
  • 63 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 63 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 42 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
-- 34
  • 9 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 34 (a)
ManyToMany
IGLL1 34
  • 34 (a)
ManyToMany
VPREB 34
  • 30 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 27 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 53 (a)
ManyToMany
-- 34
  • 25 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU571382.2 34
  • 11 (a)
ManyToMany
Species where no ortholog for IGLC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGLC3 Gene

ENSEMBL:
Gene Tree for IGLC3 (if available)
TreeFam:
Gene Tree for IGLC3 (if available)

Paralogs for IGLC3 Gene

Paralogs for IGLC3 Gene

genes like me logo Genes that share paralogs with IGLC3: view

Variants for IGLC3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLC3 Gene

IGLC3_HUMAN-P0DOY3
There are several alleles. The sequence shown is that of IMGT allele IGLC3*03.

Sequence variations from dbSNP and Humsavar for IGLC3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_077897 --

Relevant External Links for IGLC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLC3

No data available for Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLC3 Gene

Disorders for IGLC3 Gene

No disorders were found for IGLC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGLC3 Gene

Publications for IGLC3 Gene

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K … Shimizu N (Genome research 1997) 3 4 60
  2. Recombinant human Fab antibody fragments to HIV-1 Rev and Tat regulatory proteins: direct selection from a combinatorial phage display library. (PMID: 8676895) Pilkington GR … Pomerantz RJ (Molecular immunology 1996) 3 4 60
  3. Characterization of the two unique human anti-flavin monoclonal immunoglobulins. (PMID: 7737190) Stoppini M … Ferri G (European journal of biochemistry 1995) 3 4 60
  4. Structure and expression of the human immunoglobulin lambda genes. (PMID: 2115572) Vasicek TJ … Leder P (The Journal of experimental medicine 1990) 3 4 60
  5. Clustered arrangement of immunoglobulin lambda constant region genes in man. (PMID: 6273747) Hieter PA … Leder P (Nature 1981) 3 4 60

Products for IGLC3 Gene

Sources for IGLC3 Gene

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