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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGLC3 Gene

protein-coding   GIFtS: 26
GCID: GC22P023298

Immunoglobulin Lambda Constant 3 (Kern-Oz+ Marker)


(Previous symbol: IGLC)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Immunoglobulin Lambda Constant 3 (Kern-Oz+ Marker)1 2
IGLC1 2

External Ids:    HGNC: 58571   Entrez Gene: 35392   Ensembl: ENSG000002116797   UniProtKB: P0CG063   

Export aliases for IGLC3 gene to outside databases

Previous GC identifers: GC22U990027 GC22P021091 GC22P021094 GC22P021097 GC22P021101 GC22P021105 GC22P021107 GC22P021573 GC22P021298 GC22P021601 GC22P021611 GC22P021621 GC22P021631 GC22P021642 GC22P021655 GC22P021666 GC22P023249 GC22P006216


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IGLC3 Gene: 
IGLC3 (immunoglobulin lambda constant 3 (Kern-Oz+ marker)) is a protein-coding gene. Diseases associated with IGLC3 include myeloma, and among its related super-pathways are Classical antibody-mediated complement activation and FCERI mediated MAPK activation. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGKC.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGLC3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGLC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGLC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

IGLC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLC3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P023298:  view genomic region     (about GC identifiers)

Start:
23,248,512 bp from pter      End:
23,248,973 bp from pter
Size:
462 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LAC3_HUMAN, P0CG06 (See protein sequence)
Recommended Name: Ig lambda-3 chain C regions  
Size: 106 amino acids; 11238 Da
Miscellaneous: Alleles IGLC3*01, IGLC3*02, and IGLC3*03 display the following serological isotype: Mcg-, Kern- and
Oz+. The Mcg-isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz+
marker by Lys-83. Allele IGLC3*04 displays the following serological isotype: Mcg-, Kern- and Oz-. The Mcg-
isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz- marker by Arg-83
Sequence caution: Sequence=AAA59109.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAB36581.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAA36051.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for IGLC3:
1AQK (3D)        7FAB (3D)    
Secondary accessions: A0M8Q4 P80423

Explore the universe of human proteins at neXtProt for IGLC3: NX_P0CG06

Explore proteomics data for IGLC3 at MOPED 

IGLC3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IGLC3 Protein Expression

ENSEMBL proteins: 
 ENSP00000374857  
Reactome Protein details: P0CG06
Human Recombinant Protein Products for IGLC3: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005886plasma membrane TAS--

IGLC3 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IGL: Immunoglobulins / IGL locus

4 InterPro protein domains:
 IPR013783 Ig-like_fold
 IPR003597 Ig_C1-set
 IPR007110 Ig-like_dom
 IPR003006 Ig/MHC_CS

Graphical View of Domain Structure for InterPro Entry P0CG06

ProtoNet protein and cluster: P0CG06

UniProtKB/Swiss-Prot: LAC3_HUMAN, P0CG06
Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


IGLC3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:
     Genatlas biochemistry entry for IGLC3:
immunoglobulin,lambda,constant segment 3 (Kern-Oz+ marker)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding IEA--
GO:0005515protein binding ----
     
IGLC3 for ontologies           About GeneDecksing


Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IGLC3 About   (see all 7)                                                                                              See pathways by source

SuperPathContained pathways About
1Classical antibody-mediated complement activation
Classical antibody-mediated complement activation0.88
FCGR activation0.70
Creation of C4 and C2 activators0.88
Role of phospholipids in phagocytosis0.65
Initial triggering of complement0.86
FCERI mediated NF-kB activation0.47
Complement cascade0.76
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30
2FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization0.60
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.31
FCERI mediated MAPK activation0.60
3Immune System
Immune System0.56
Innate Immune System0.50
Adaptive Immune System0.56
4Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation0.80
Fcgamma receptor (FCGR) dependent phagocytosis0.80
5Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling0.69
Role of LAT2/NTAL/LAB on calcium mobilization0.69

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


5/21        Reactome Pathways for IGLC3 (see all 21)
    FCERI mediated MAPK activation
FCERI mediated NF-kB activation
FCGR activation
Role of phospholipids in phagocytosis
Binding and Uptake of Ligands by Scavenger Receptors



IGLC3 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGLC3

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for IGLC3 (ENSP000003748574) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IGHG1ENSP000003749904STRING: ENSP00000374990
IGLV2-8ENSP000003748524STRING: ENSP00000374852
UBQLN4ENSP000003572924STRING: ENSP00000357292
About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006956complement activation TAS--
GO:0006958complement activation, classical pathway TAS--
GO:0038095Fc-epsilon receptor signaling pathway TAS--
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
GO:0045087innate immune response TAS--

IGLC3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGLC3 (LAC3)

Search CenterWatch for drugs/clinical trials and news about IGLC3 / LAC3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390325
miRNA
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Inhib. RNA
Products:
     
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Clone
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24/97 AceView cDNA sequences (see all 97):

AF194669 AF194648 AY573191 AF194679 AF194698 AF063703 CR605950 AF194645 
CR593480 AF064507 CR623617 L25296 CR592011 L35920 AF194643 CR623132 
Z18331 CR617925 AJ318021 AB064037 BC020236 AF194707 AF194646 AF194737 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGLC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGLC3 Expression
About this image


See IGLC3 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for IGLC3
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGLC3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IGLC3 gene from 2/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves GGA.478466
Ig lambda chain V-1 region
27(a)
1 → many
15(7928727-7933299)
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
54(a)
25(a)
many ↔ many
many ↔ many
AAWZ02041299(1275-1595)
GL343282.1(588802-599691)
        Species with no ortholog for IGLC3

ENSEMBL Gene Tree for IGLC3 (if available)
TreeFam Gene Tree for IGLC3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGLC3 gene
IGKC2  IGLL52  IGLC12  IGLL12  IGLC72  IGLC22  
18/24 SIMAP similar genes for IGLC3 using alignment to 1 protein entry:     LAC3_HUMAN(see all similar genes):
DKFZp667J0810    IGLC2    IgLC-rG    IGL@    IGLC6    IGLC7
C1 segment    DKFZp781M0386    IGLC1    IGLL5    IGLL1    IGKC
HLA-DQA1    HLA-DMB    HLA DRB4    HLA-DRB4    HLA-DR    HLA-DRB1

IGLC3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing IGLC3
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for IGLC3:    About MalaCards
myeloma    


IGLC3 for disorders           About GeneDecksing


Export disorders for IGLC3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGLC3 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with IGLC3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Recombinant human Fab antibody fragments to HIV-1 Rev and Tat regulatory proteins: direct selection from a combinatorial phage displ ay library. (PubMed id 8676895)1, 2 Pilkington G.R....Pomerantz R.J. (1996)
  2. Characterization of the two unique human anti-flavin monoclonal immunoglobulins. (PubMed id 7737190)1, 2 Stoppini M.... Ferri G. (1995)
  3. Structure and expression of the human immunoglobulin lambda genes. (PubMed id 2115572)1, 2 Vasicek T.J. and Leder P. (1990)
  4. Clustered arrangement of immunoglobulin lambda constant region genes in man. (PubMed id 6273747)1, 2 Hieter P.A.... Leder P. (1981)
  5. Amino acid sequence of the (lambda) light chain of a human myeloma immunoglobulin (IgG New). (PubMed id 4814727)1, 2 Chen B.L. and Poljak R.J. (1974)
  6. The three-dimensional structure of the fab' fragment of a human myeloma immunoglobulin at 2.0-A resolution. (PubMed id 4215080)1, 2 Poljak R.J....Saul F. (1974)
  7. Unraveling of the polymorphic C lambda 2-C lambda 3 amplification and the Ke+Oz- polymorphism in the human Ig lambda locus. (PubMed id 12077254)1 van der Burg M....van Dongen J.J. (2002)
  8. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (2002)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  10. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1 Kawasaki K....Shimizu N. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3539 HGNC: 5857 AceView: IGL_ Ensembl:ENSG00000211679 euGenes: HUgn3539
ECgene: IGLC3 H-InvDB: IGLC3

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGLC3 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGLC3 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGLC3&species=Homo+sapiens

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGLC3 gene:
Search GeneIP for patents involving IGLC3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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