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Aliases for IGLC2 Gene

Aliases for IGLC2 Gene

  • Immunoglobulin Lambda Constant 2 2 3 5
  • Immunoglobulin Lambda Constant 2 (Kern-Oz- Marker) 2 3
  • Immunoglobulin Lambda Constant Region 2 (Kern- Oz- Marker) 3
  • Ig Light-Chain, Partial Ke-Oz- Polypeptide, C-Term 3
  • Ig Lambda Chain C Region NIG-64 4
  • Ig Lambda Chain C Region Kern 4
  • Ig Lambda Chain C Region SH 4
  • Ig Lambda Chain C Region X 4
  • Ig Lambda-2 Chain C Region 4
  • C2 Segment 3
  • IGLC 3

External Ids for IGLC2 Gene

Previous HGNC Symbols for IGLC2 Gene

  • IGLC

Previous GeneCards Identifiers for IGLC2 Gene

  • GC22U990026
  • GC22P021090
  • GC22P021093
  • GC22P021096
  • GC22P021100
  • GC22P021102
  • GC22P021567
  • GC22P021296
  • GC22P021574
  • GC22P023243
  • GC22P006211

Summaries for IGLC2 Gene

GeneCards Summary for IGLC2 Gene

IGLC2 (Immunoglobulin Lambda Constant 2) is a Protein Coding gene. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLC3.

UniProtKB/Swiss-Prot for IGLC2 Gene

  • Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Wiki entry for IGLC2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLC2 Gene

Genomics for IGLC2 Gene

Regulatory Elements for IGLC2 Gene

Enhancers for IGLC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G022901 1.1 ENCODE dbSUPER 18.4 +1.9 1855 2.8 HNRNPUL1 HDAC1 TBL1XR1 RB1 WRNIP1 BMI1 EGR1 RELB IKZF2 ZNF263 ZNF70 IGLC2 IGLV2-5 IGLV3-4 IGLC7 IGLV10-54 IGLJ3
GH22G022926 1.9 FANTOM5 Ensembl ENCODE dbSUPER 7.9 +31.1 31135 10.9 HDGF PKNOX1 ATF1 WRNIP1 SIN3A GATA2 ELK1 ZNF143 ZMIZ1 ZNF548 IGLV3-4 IGLV2-5 ZNF70 IGLV5-52 ENSG00000272779 IGLC2 IGLC7 IGLV7-43 IGLL5 IGLC3
GH22G022909 0.9 dbSUPER 15.9 +9.8 9824 2.4 HNRNPUL1 ATF1 TBL1XR1 KLF17 INSM2 GLIS2 ZNF366 SCRT2 FOS CREM IGLC2 IGLV7-43 IGLC7 IGLC4 IGLJ4
GH22G022898 0.8 dbSUPER 17.8 -1.5 -1479 3.2 BMI1 RAD21 ZNF335 GLIS2 FOS ZNF548 SMAD5 CBFB CEBPB JUNB IGLC2 IGLV2-5 IGLV3-4 ZNF70 IGLV5-52 ENSG00000272779 IGLC7 IGLJ2
GH22G022937 1.6 FANTOM5 ENCODE dbSUPER 6.3 +40.1 40050 6.2 HDGF FOXA2 WRNIP1 SIN3A ARID4B YBX1 ZNF2 CBX5 ZNF207 ZNF143 ZNF70 IGLV2-5 IGLV3-4 IGLC2 RSPH14 CHCHD10 IGLL5 LOC105372947 PIR39792
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGLC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGLC2 Gene

Chromosome:
22
Start:
22,900,976 bp from pter
End:
22,901,437 bp from pter
Size:
462 bases
Orientation:
Plus strand

Genomic View for IGLC2 Gene

Genes around IGLC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLC2 Gene

Proteins for IGLC2 Gene

  • Protein details for IGLC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DOY2-IGLC2_HUMAN
    Recommended name:
    Immunoglobulin lambda constant 2
    Protein Accession:
    P0DOY2
    Secondary Accessions:
    • A0A075B6K9
    • A0M8Q4
    • P0CG05
    • P0CG06
    • P80423

    Protein attributes for IGLC2 Gene

    Size:
    106 amino acids
    Molecular mass:
    11294 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
    Miscellaneous:
    • Displays the following serological isotype: Mcg-, Kern- and Oz-. The Mcg- isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz- marker by Arg-83.
    SequenceCaution:
    • Sequence=AAA59107.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA20026.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA36049.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB38569.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW59547.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW59549.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGLC2 Gene

neXtProt entry for IGLC2 Gene

Post-translational modifications for IGLC2 Gene

No Post-translational modifications

Other Protein References for IGLC2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLC2 Gene

Domains & Families for IGLC2 Gene

Gene Families for IGLC2 Gene

Protein Domains for IGLC2 Gene

Suggested Antigen Peptide Sequences for IGLC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGLC2: view

No data available for UniProtKB/Swiss-Prot for IGLC2 Gene

Function for IGLC2 Gene

Molecular function for IGLC2 Gene

GENATLAS Biochemistry:
immunoglobulin,lambda,constant segment 2 (Kern-Oz-marker)
UniProtKB/Swiss-Prot Function:
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
genes like me logo Genes that share ontologies with IGLC2: view

Animal Model Products

miRNA for IGLC2 Gene

miRTarBase miRNAs that target IGLC2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGLC2 Gene

Localization for IGLC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLC2 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005886 plasma membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with IGLC2: view

No data available for Subcellular locations from COMPARTMENTS for IGLC2 Gene

Pathways & Interactions for IGLC2 Gene

SuperPathways for IGLC2 Gene

No Data Available

Interacting Proteins for IGLC2 Gene

Gene Ontology (GO) - Biological Process for IGLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
genes like me logo Genes that share ontologies with IGLC2: view

No data available for Pathways by source and SIGNOR curated interactions for IGLC2 Gene

Drugs & Compounds for IGLC2 Gene

No Compound Related Data Available

Transcripts for IGLC2 Gene

mRNA/cDNA for IGLC2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGLC2 Gene

No ASD Table

Relevant External Links for IGLC2 Gene

GeneLoc Exon Structure for
IGLC2
ECgene alternative splicing isoforms for
IGLC2

Expression for IGLC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGLC2 Gene

mRNA differential expression in normal tissues according to GTEx for IGLC2 Gene

This gene is overexpressed in Spleen (x14.6), Colon - Transverse (x7.3), Minor Salivary Gland (x6.9), and Small Intestine - Terminal Ileum (x5.3).

Protein differential expression in normal tissues from HIPED for IGLC2 Gene

This gene is overexpressed in Pancreatic juice (15.8), Plasma (12.3), and Cerebrospinal fluid (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLC2 Gene



NURSA nuclear receptor signaling pathways regulating expression of IGLC2 Gene:

IGLC2
genes like me logo Genes that share expression patterns with IGLC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLC2 Gene

Orthologs for IGLC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLC2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 85 (a)
ManyToMany
-- 35
  • 85 (a)
ManyToMany
-- 35
  • 71 (a)
ManyToMany
-- 35
  • 70 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Iglc2 35
  • 63 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 42 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 9 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 34 (a)
ManyToMany
IGLL1 35
  • 34 (a)
ManyToMany
VPREB 35
  • 30 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 27 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 53 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU571382.2 35
  • 11 (a)
ManyToMany
Species where no ortholog for IGLC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGLC2 Gene

ENSEMBL:
Gene Tree for IGLC2 (if available)
TreeFam:
Gene Tree for IGLC2 (if available)

Paralogs for IGLC2 Gene

Paralogs for IGLC2 Gene

Pseudogenes.org Pseudogenes for IGLC2 Gene

genes like me logo Genes that share paralogs with IGLC2: view

Variants for IGLC2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLC2 Gene

IGLC2_HUMAN-P0DOY2
There are several alleles. The sequence shown is that of IMGT allele IGLC2*02.

Relevant External Links for IGLC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLC2

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLC2 Gene

Disorders for IGLC2 Gene

No disorders were found for IGLC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGLC2 Gene

Publications for IGLC2 Gene

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K. … Shimizu N. (Genome Res. 1997) 3 4 64
  2. Structure and expression of the human immunoglobulin lambda genes. (PMID: 2115572) Vasicek T.J. … Leder P. (J. Exp. Med. 1990) 3 4 64
  3. Comparative studies on the structure of the light chains of human immunoglobulins. IV. Assignment of a subsubgroup. (PMID: 6404900) Kametani F. … Shimizu A. (J. Biochem. 1983) 3 4 64
  4. Clustered arrangement of immunoglobulin lambda constant region genes in man. (PMID: 6273747) Hieter P.A. … Leder P. (Nature 1981) 3 4 64
  5. Structural rule of antibodies. Primary structure of a monoclonal immunoglobulin-L-chain of the lambda type, subgroup IV (Bence-Jones- protein Kern). V. The complete amino acid sequence and its genetic interpretation. (PMID: 5549568) Ponstingl H. … Hilschmann N. (Hoppe-Seyler's Z. Physiol. Chem. 1971) 3 4 64

Products for IGLC2 Gene

Sources for IGLC2 Gene

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