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Aliases for IGLC2 Gene

Aliases for IGLC2 Gene

  • Immunoglobulin Lambda Constant 2 2 3 5
  • Immunoglobulin Lambda Constant 2 (Kern-Oz- Marker) 2 3
  • Immunoglobulin Lambda Constant Region 2 (Kern- Oz- Marker) 3
  • Ig Light-Chain, Partial Ke-Oz- Polypeptide, C-Term 3
  • C2 Segment 3
  • IGLC 3

External Ids for IGLC2 Gene

Previous HGNC Symbols for IGLC2 Gene

  • IGLC

Previous GeneCards Identifiers for IGLC2 Gene

  • GC22U990026
  • GC22P021090
  • GC22P021093
  • GC22P021096
  • GC22P021100
  • GC22P021102
  • GC22P021567
  • GC22P021296
  • GC22P021574
  • GC22P023243
  • GC22P006211

Summaries for IGLC2 Gene

GeneCards Summary for IGLC2 Gene

IGLC2 (Immunoglobulin Lambda Constant 2) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and RET signaling. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLC3.

Gene Wiki entry for IGLC2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLC2 Gene

Genomics for IGLC2 Gene

Regulatory Elements for IGLC2 Gene

Enhancers for IGLC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F022899 1.1 Ensembl ENCODE 18.4 +0.8 829 4.8 TBL1XR1 WRNIP1 BMI1 ZNF335 GLIS2 EGR1 ZNF548 ZNF263 MCM3 CEBPZ ZNF70 IGLC2 IGLV3-4 IGLV2-5 IGLV5-52 ENSG00000272779 IGLC7 IGLJ2 IGLC5 IGLV10-54
GH22F022904 0.9 Ensembl 16.8 +5.5 5499 4.4 ELF3 ARID4B RAD21 ZNF48 RARA ZNF263 MCM3 SP5 SMAD5 MCM5 IGLC7 IGLV5-52 IGLC2 ENSG00000234630 ENSG00000272779 ZNF70 ENSG00000272578 IGLC3 IGLJ4
GH22F022915 0.7 Ensembl 19.2 +13.4 13426 0.8 ZNF263 MCM3 ZIC2 ZBTB7A RAD21 YY1 NR2F2 IKZF1 HNF4G SETDB1 IGLC2 IGLC7 IGLC5 IGLJ5
GH22F022925 1.6 FANTOM5 Ensembl ENCODE 7.8 +30.7 30711 11.7 HDGF PKNOX1 ATF1 WRNIP1 SIN3A GATA2 ELK1 ZNF143 ZNF548 ZMIZ1 IGLV5-52 ENSG00000272779 IGLV3-4 IGLV2-5 ZNF70 IGLC2 IGLV7-43 IGLC7 IGLL5 IGLC3
GH22F022937 1.6 FANTOM5 Ensembl ENCODE 6.3 +40.1 40050 6.2 HDGF ATF1 WRNIP1 SIN3A ARID4B YBX1 ZNF2 ZNF48 GLIS2 CBX5 ZNF70 IGLV2-5 IGLV3-4 IGLC2 RSPH14 CHCHD10 IGLL5 LOC105372947 PIR39792
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGLC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGLC2 Gene

Chromosome:
22
Start:
22,900,976 bp from pter
End:
22,901,437 bp from pter
Size:
462 bases
Orientation:
Plus strand

Genomic View for IGLC2 Gene

Genes around IGLC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLC2 Gene

Proteins for IGLC2 Gene

  • Protein details for IGLC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG05-LAC2_HUMAN
    Recommended name:
    Ig lambda-2 chain C regions
    Protein Accession:
    P0CG05
    Secondary Accessions:
    • A0M8Q4
    • P80423

    Protein attributes for IGLC2 Gene

    Size:
    106 amino acids
    Molecular mass:
    11294 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Displays the following serological isotype: Mcg-, Kern- and Oz-. The Mcg- isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz- marker by Arg-83.
    SequenceCaution:
    • Sequence=AAA59107.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA20015.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA20026.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA20028.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA36049.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB38569.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW59547.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW59549.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGLC2 Gene

neXtProt entry for IGLC2 Gene

Post-translational modifications for IGLC2 Gene

No Post-translational modifications

Other Protein References for IGLC2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLC2 Gene

Domains & Families for IGLC2 Gene

Gene Families for IGLC2 Gene

Protein Domains for IGLC2 Gene

Suggested Antigen Peptide Sequences for IGLC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CG05

UniProtKB/Swiss-Prot:

LAC2_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGLC2: view

Function for IGLC2 Gene

Molecular function for IGLC2 Gene

GENATLAS Biochemistry:
immunoglobulin,lambda,constant segment 2 (Kern-Oz-marker)

Gene Ontology (GO) - Molecular Function for IGLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGLC2: view

Animal Model Products

miRNA for IGLC2 Gene

miRTarBase miRNAs that target IGLC2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGLC2 Gene

Localization for IGLC2 Gene

Gene Ontology (GO) - Cellular Components for IGLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 22664934
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA --
GO:0042571 immunoglobulin complex, circulating IBA --
genes like me logo Genes that share ontologies with IGLC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for IGLC2 Gene

Pathways & Interactions for IGLC2 Gene

genes like me logo Genes that share pathways with IGLC2: view

Interacting Proteins for IGLC2 Gene

Selected Interacting proteins: P0CG05-LAC2_HUMAN for IGLC2 Gene via IID

Symbol External ID(s) Details
NFKB1

Gene Ontology (GO) - Biological Process for IGLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGLC2: view

No data available for SIGNOR curated interactions for IGLC2 Gene

Transcripts for IGLC2 Gene

mRNA/cDNA for IGLC2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGLC2 Gene

No ASD Table

Relevant External Links for IGLC2 Gene

GeneLoc Exon Structure for
IGLC2
ECgene alternative splicing isoforms for
IGLC2

Expression for IGLC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGLC2 Gene

mRNA differential expression in normal tissues according to GTEx for IGLC2 Gene

This gene is overexpressed in Spleen (x14.6), Colon - Transverse (x7.3), Minor Salivary Gland (x6.9), and Small Intestine - Terminal Ileum (x5.3).

Protein differential expression in normal tissues from HIPED for IGLC2 Gene

This gene is overexpressed in Pancreatic juice (15.8), Plasma (12.3), and Cerebrospinal fluid (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLC2 Gene



NURSA nuclear receptor signaling pathways regulating expression of IGLC2 Gene:

IGLC2
genes like me logo Genes that share expression patterns with IGLC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IGLC2 Gene

Orthologs for IGLC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLC2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 85 (a)
ManyToMany
-- 35
  • 85 (a)
ManyToMany
-- 35
  • 71 (a)
ManyToMany
-- 35
  • 70 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
-- 35
  • 40 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Iglc2 35
  • 63 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 42 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 9 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 34 (a)
ManyToMany
IGLL1 35
  • 34 (a)
ManyToMany
VPREB 35
  • 30 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 27 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 53 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU571382.2 35
  • 11 (a)
ManyToMany
Species where no ortholog for IGLC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGLC2 Gene

ENSEMBL:
Gene Tree for IGLC2 (if available)
TreeFam:
Gene Tree for IGLC2 (if available)

Paralogs for IGLC2 Gene

Paralogs for IGLC2 Gene

Pseudogenes.org Pseudogenes for IGLC2 Gene

genes like me logo Genes that share paralogs with IGLC2: view

Variants for IGLC2 Gene

Relevant External Links for IGLC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLC2 Gene

Disorders for IGLC2 Gene

No disorders were found for IGLC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGLC2 Gene

Publications for IGLC2 Gene

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K. … Shimizu N. (Genome Res. 1997) 3 4 64
  2. Structure and expression of the human immunoglobulin lambda genes. (PMID: 2115572) Vasicek T.J. … Leder P. (J. Exp. Med. 1990) 3 4 64
  3. Comparative studies on the structure of the light chains of human immunoglobulins. IV. Assignment of a subsubgroup. (PMID: 6404900) Kametani F. … Shimizu A. (J. Biochem. 1983) 3 4 64
  4. Clustered arrangement of immunoglobulin lambda constant region genes in man. (PMID: 6273747) Hieter P.A. … Leder P. (Nature 1981) 3 4 64
  5. Structural rule of antibodies. Primary structure of a monoclonal immunoglobulin-L-chain of the lambda type, subgroup IV (Bence-Jones- protein Kern). V. The complete amino acid sequence and its genetic interpretation. (PMID: 5549568) Ponstingl H. … Hilschmann N. (Hoppe-Seyler's Z. Physiol. Chem. 1971) 3 4 64

Products for IGLC2 Gene

Sources for IGLC2 Gene

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