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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGLC1 Gene

protein-coding   GIFtS: 34
GCID: GC22P023245

immunoglobulin lambda constant 1 (Mcg marker)


(Previous symbol: IGLC)
 Explore 2 diseases affiliated with
IGLC1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGLC1    

Aliases
for IGLC1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immunoglobulin Lambda Constant 1 (Mcg Marker)1 2
IGLC1 2 5

External Ids:    HGNC: 58551   Entrez Gene: 35372   Ensembl: ENSG000002116757   OMIM: 1472205   UniProtKB: P0CG043   

Export aliases for IGLC1 gene to outside databases

Previous GC identifers: GC22P019928 GC22U900022 GC22P021089 GC22P021092 GC22P021095 GC22P021098 GC22P021562 GC22P021295 GC22P021568 GC22P023238 GC22P006205


Summaries
for IGLC1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for IGLC1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGLC1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGLC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGLC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

IGLC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLC1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P023245:  view genomic region     (about GC identifiers)

Start:
 23,237,555 bp from pter      End:
 23,238,014 bp from pter
Size:
 460 bases      Orientation:
 plus strand

Proteins
for IGLC1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LAC1_HUMAN, P0CG04 (See protein sequence)
Recommended Name: Ig lambda-1 chain C regions  
Size: 106 amino acids; 11348 Da
Miscellaneous: Displays the following serological isotype: Mcg+, Kern+ and Oz-. The Mcg isotype marker is characterized
by Asn-6, Thr-8 and Lys-57; the Ke marker by Gly-46 and the Oz- marker by Arg-83
Sequence caution: Sequence=CAA36047.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for IGLC1:
1ZVO (3D)        2IG2 (3D)    
Secondary accessions: A0M8Q4 P01842 P80423

Explore the universe of human proteins at neXtProt for IGLC1: NX_P0CG04

IGLC1 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).


ENSEMBL proteins: 
 ENSP00000374855  
Reactome Protein details: P0CG04
Human Recombinant Protein Products: 
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Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005886plasma membrane TAS--


IGLC1 for ontologies           About GeneDecksing



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Browse ELISAs and CLIAs at Uscn

Protein Domains /
Families
for IGLC1 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
IGLC1 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR007110 Ig-like_dom
 IPR013783 Ig-like_fold
 IPR003006 Ig/MHC_CS
 IPR003597 Ig_C1-set

Graphical View of Domain Structure for InterPro Entry P0CG04

ProtoNet protein and cluster: P0CG04

UniProtKB/Swiss-Prot: LAC1_HUMAN, P0CG04
Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


Function
for IGLC1 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:
     Genatlas biochemistry entry for IGLC1:
immunoglobulin,lambda,constant segment 1 (Mcg marker)

miRNA
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Inhib. RNA
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Gene Editing
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Clone
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Cell Line
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Search LifeMap BioReagents cell lines for IGLC1

In Situ Assay
Products:   
 		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGLC1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding NAS4909564


IGLC1 for ontologies           About GeneDecksing


Animal Models:
     3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Iglc1):
 cellular  hematopoietic system  immune system 

IGLC1 for phenotypes           About GeneDecksing


Pathways & Interactions
for IGLC1 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Cleavage of Alpha-1-Microglobulin
8/11 pathways (see all 11)
Cleavage of Alpha-1-Microglobulin1.00
FCGR activation0.65
Binding and Uptake of Ligands by Scavenger Receptors0.79
Initial triggering of complement0.60
Scavenging of Heme from Plasma0.79
Role of phospholipids in phagocytosis0.53
Classical antibody-mediated complement activation0.74
Complement cascade0.47
2Immune System
Immune System1.00
Innate Immune System0.46
Adaptive Immune System0.59
3Assembly of Signalosomes at the Activated BCR
Assembly of Signalosomes at the Activated BCR1.00
Phosphorylation of ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)0.45
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.78
4Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation1.00
Fcgamma receptor (FCGR) dependent phagocytosis0.80
Role of myosins in phagosome formation0.80
5Signaling by the B Cell Receptor (BCR)
Signaling by the B Cell Receptor (BCR)1.00

Pathway sources
See GeneCards unified pathways
Show all pathways


5/21        Reactome Pathways for IGLC1 (see all 21)
    Role of myosins in phagosome formation
FCGR activation
Cleavage of Alpha-1-Microglobulin
Sequestering and phosphorylation Fc gamma receptors in the lipid rafts
Role of phospholipids in phagocytosis



IGLC1 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGLC1

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/16 Interacting proteins for IGLC1 (P0CG043 ENSP000003748554) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
InteractantInteraction Details
GeneCardExternal ID(s)
SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
IGHG1P018573, ENSP000003749904I2D: score=2 STRING: ENSP00000374990
UBQLN4Q9NRR53, ENSP000003572924I2D: score=1 STRING: ENSP00000357292
IGHA1P018763, ENSP000003749894I2D: score=1 STRING: ENSP00000374989
IGHV3-23ENSP000003750184STRING: ENSP00000375018
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS4909564
GO:0006956complement activation TAS--
GO:0006958complement activation, classical pathway TAS--
GO:0045087innate immune response TAS--
GO:0050776regulation of immune response TAS--


IGLC1 for ontologies           About GeneDecksing



Drugs & Compounds
for IGLC1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGLC1

1 DrugBank Compound for IGLC1    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Pyroglutamic Acid-- 98-79-3target--10592235

Search CenterWatch for drugs/clinical trials and news about IGLC1 / LAC1 

Transcripts
for IGLC1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390321(uc021wmr.1)

miRNA
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Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
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Browse OriGene siRNA
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Clone
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Primer
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  Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGLC1
  Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGLC1

24/97 AceView cDNA sequences (see all 97):

AF194648 CR623132 AF063703 CR592011 AF194698 AY573191 AF064507 L35920 
AF194643 AF194669 CR623617 CR593480 AF194679 CR605950 L25296 AF194645 
X53070 AF194767 AJ319671 AF194815 AF058069 BC071804 AY043110 AF194744 

GeneLoc Exon Structure


Expression
for IGLC1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGLC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGGAGCAC

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image
See IGLC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGLC1
    SABiosciences Custom PCR Arrays for IGLC1
Primer
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In Situ
Assay Products: 
 		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGLC1

Orthologs
for IGLC1 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for IGLC1 gene from 2/6 species (see all 6)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
lizard
(Anolis carolinensis)		 Reptilia --
 --
 55(a)
 1 → many
 AAWZ02041299(1275-1595)
zebrafish
(Danio rerio)		 Actinopterygii CU570684.46
igic1s16
(see all 5)		 immunoglobulin light iota constant 1, s1
(see all 5)		 25(a)
22(a)
(see all 5)		 many ↔ many
many ↔ many
(see all 5)		 3(59697601-59699495)
24(39697150-39700054)


ENSEMBL Gene Tree for IGLC1 (if available)
TreeFam Gene Tree for IGLC1 (if available) 

Paralogs
for IGLC1 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGLC1 gene
IGLL52  IGKC2  IGLL12  IGLC32  IGLC72  IGLC22  TRBC22  
18/32 SIMAP similar genes for IGLC1 using alignment to 1 protein entry:     LAC1_HUMAN(see all similar genes):
C1 segment    DKFZp781M0386    IGLL5    IGLC7    IGL@    DKFZp667J0810
IGLC2    IGLC3    IgLC-rG    IGLC6    IGLL1    IGKC
HLA-DQA1    TRBC1    HLA-DRB1    HLA DRB4    HLA-DR    HLA-DRB3

IGLC1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for IGLC1
PGOHUM00000246519


Genomic Variants
for IGLC1 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Locus Specific Mutation Databases (LSDB): IGLC1
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGLC1
DNA2.0 Custom Variant and Variant Library Synthesis for IGLC1

Disorders / Diseases
for IGLC1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
IGLC1 for disorders           About GeneDecksing

OMIM gene information: 147220    OMIM disorders: --

2 diseases for IGLC1:    About MalaCards
velocardiofacial syndrome    myeloma


Export disorders for IGLC1 gene to outside databases

Publications
for IGLC1 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGLC1 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with IGLC1)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Structure and expression of the human immunoglobulin lambda genes. (PubMed id 2115572)1, 2 Vasicek T.J. and Leder P. (1990)
  2. Three-dimensional structure of a light chain dimer crystallized in water. Conformational flexibility of a molecule in two crystal forms. (PubMed id 2515285)1, 2 Ely K.R.... Edmundson A.B. (1989)
  3. Clustered arrangement of immunoglobulin lambda constant region genes in man. (PubMed id 6273747)1, 2 Hieter P.A.... Leder P. (1981)
  4. Primary structure of the Mcg lambda chain. (PubMed id 4415202)1, 2 Fett J.W. and Deutsch H.F. (1974)
  5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
  6. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
  7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
  8. Unraveling of the polymorphic C lambda 2-C lambda 3 amplification and the Ke+Oz- polymorphism in the human Ig lambda locus. (PubMed id 12077254)1 van der Burg M....van Dongen J.J. (2002)
  9. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (2002)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

External Searches for IGLC1 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGLC1 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3537 HGNC: 5855 AceView: IGL_ Ensembl:ENSG00000211675 euGenes: HUgn3537
ECgene: IGLC1 H-InvDB: IGLC1

Other Databases showing IGLC1 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGLC1 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGLC1 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGLC1 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGLC1&species=Homo+sapiens

Intellectual Property
for IGLC1 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGLC1 gene:
Search GeneIP for patents involving IGLC1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for IGLC1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 
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