Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IGLC1 Gene

protein-coding   GIFtS: 39
GCID: GC22P023314

Immunoglobulin Lambda Constant 1 (Mcg Marker)


(Previous symbol: IGLC)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Immunoglobulin Lambda Constant 1 (Mcg Marker)1 2
IGLC1 2 5

External Ids:    HGNC: 58551   Entrez Gene: 35372   Ensembl: ENSG000002116757   OMIM: 1472205   UniProtKB: P0CG043   

Export aliases for IGLC1 gene to outside databases

Previous GC identifers: GC22P019928 GC22U900022 GC22P021089 GC22P021092 GC22P021095 GC22P021098 GC22P021562 GC22P021295 GC22P021568 GC22P023238 GC22P006205 GC22P023245 GC22P023251


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for IGLC1 Gene:
IGLC1 (immunoglobulin lambda constant 1 (Mcg marker)) is a protein-coding gene. Diseases associated with IGLC1 include myeloma, and ataxia. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGKC.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for IGLC1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for IGLC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGLC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

IGLC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGLC1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P023314:  view genomic region     (about GC identifiers)

Start:
23,237,555 bp from pter      End:
23,238,014 bp from pter
Size:
460 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LAC1_HUMAN, P0CG04 (See protein sequence)
Recommended Name: Ig lambda-1 chain C regions  
Size: 106 amino acids; 11348 Da
Miscellaneous: Displays the following serological isotype: Mcg+, Kern+ and Oz-. The Mcg isotype marker is
characterized by Asn-6, Thr-8 and Lys-57; the Ke marker by Gly-46 and the Oz- marker by Arg-83
Sequence caution: Sequence=CAA36047.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for IGLC1:
1ZVO (3D)        2IG2 (3D)    
Secondary accessions: A0M8Q4 P01842 P80423

Explore the universe of human proteins at neXtProt for IGLC1: NX_P0CG04

Explore proteomics data for IGLC1 at MOPED


See IGLC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000374855  
Reactome Protein details: P0CG04

IGLC1 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
Browse OriGene Protein Over-expression Lysates
OriGene Custom MassSpec
OriGene Custom Protein Services for IGLC1
GenScript Custom Purified and Recombinant Proteins Services for IGLC1
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

IGLC1 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for IGLC1
Abcam antibodies for IGLC1 (P01701, P01842, P15391)
Browse Antibodies at Cloud-Clone Corp.
Search ThermoFisher Antibodies for IGLC1
Search LSBio for Antibodies for IGLC1

IGLC1 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for IGLC1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for IGLC1
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
IGL: Immunoglobulins / IGL locus

4 InterPro protein domains:
 IPR013783 Ig-like_fold
 IPR003597 Ig_C1-set
 IPR007110 Ig-like_dom
 IPR003006 Ig/MHC_CS

Graphical View of Domain Structure for InterPro Entry P0CG04

ProtoNet protein and cluster: P0CG04

UniProtKB/Swiss-Prot: LAC1_HUMAN, P0CG04
Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


IGLC1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:
     Genatlas biochemistry entry for IGLC1:
immunoglobulin,lambda,constant segment 1 (Mcg marker)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding NAS4909564
GO:0005515protein binding ----
     
IGLC1 for ontologies           About GeneDecksing


Phenotypes:
     2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Iglc1):
 hematopoietic system  immune system 

IGLC1 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IGLC1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IGLC1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGLC1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGLC1

miRNA
Products:
    
miRTarBase miRNAs that target IGLC1:
hsa-mir-335-5p (MIRT019074)

Block miRNA regulation of human, mouse, rat IGLC1 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate IGLC1
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
Browse OriGene RNAi
Predesigned siRNA for gene silencing in human, mouse, rat IGLC1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IGLC1

Clone
Products:
     
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for IGLC1
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGLC1
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGLC1

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IGLC1
Browse ESI BIO Cell Lines and PureStem Progenitors for IGLC1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGLC1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular4
plasma membrane4
cytosol1
mitochondrion1
nucleus1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IDA--
GO:0005886plasma membrane TAS--
GO:0072562blood microparticle IDA--

IGLC1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for IGLC1 About   (see all 8)  
See pathways by source

SuperPathContained pathways About
1Creation of C4 and C2 activators
Creation of C4 and C2 activators0.85
FCGR activation0.54
Initial triggering of complement0.85
Role of phospholipids in phagocytosis0.53
Classical antibody-mediated complement activation0.82
FCERI mediated NF-kB activation0.32
Complement cascade0.68
2Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
FCERI mediated Ca+2 mobilization0.47
FCERI mediated MAPK activation0.45
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.47
3Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation0.77
Fcgamma receptor (FCGR) dependent phagocytosis0.77
4PI-3K cascade
Role of LAT2/NTAL/LAB on calcium mobilization0.80
Fc epsilon receptor (FCERI) signaling0.64
5Binding and Uptake of Ligands by Scavenger Receptors
Binding and Uptake of Ligands by Scavenger Receptors0.53
Scavenging of Heme from Plasma0.53

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


Selected Reactome Pathways for IGLC1 (see all 13)
    FCERI mediated MAPK activation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
FCERI mediated NF-kB activation
FCGR activation
Scavenging of heme from plasma



IGLC1 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGLC1
Interactions:

    Search GeneGlobe Interaction Network for IGLC1

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

Selected Interacting proteins for IGLC1 (P0CG043 ENSP000003748554) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
InteractantInteraction Details
GeneCardExternal ID(s)
SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
IGHG1P018573, ENSP000003749904I2D: score=2 STRING: ENSP00000374990
UBQLN4Q9NRR53, ENSP000003572924I2D: score=1 STRING: ENSP00000357292
IGHA1P018763, ENSP000003749894I2D: score=1 STRING: ENSP00000374989
IGHV3-23ENSP000003750184STRING: ENSP00000375018
About this table

Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS4909564
GO:0006956complement activation TAS--
GO:0006958complement activation, classical pathway TAS--
GO:0038095Fc-epsilon receptor signaling pathway TAS--
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--

IGLC1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for IGLC1 (LAC1)

1 DrugBank Compound for IGLC1    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Pyroglutamic Acid-- 98-79-3target--10592235



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

Unigene Cluster for IGLC1:

Immunoglobulin lambda constant 1 (Mcg marker)
Hs.449585  [show with all ESTs]
Unigene Representative Sequence: AK057174
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390321(uc021wmr.1)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat IGLC1 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate IGLC1
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse OriGene RNAi
Predesigned siRNA for gene silencing in human, mouse, rat IGLC1
Clone
Products:
     
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for IGLC1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGLC1
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGLC1
Primer
Products:
    
Browse OriGene qPCR
Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat IGLC1
  QuantiTect SYBR Green Assays in human, mouse, rat IGLC1
  QuantiFast Probe-based Assays in human, mouse, rat IGLC1

Additional mRNA sequence: 

AB063972.1 AB063973.1 AB063976.1 AB063979.1 AB063988.1 AB063990.1 AB064008.1 AB064012.1 
AB064027.1 AB064030.1 AB064036.1 AB064142.1 AB064154.1 AB064155.1 AB064157.1 AB064159.1 
AB064165.1 AB064167.1 AB087878.1 AB363345.1 AB363353.1 AB363358.1 AB363359.1 AB363361.1 
AB363364.1 AB777476.1 AF026919.1 AF026920.1 AF026925.1 AF026932.1 AF047229.1 AF047230.1 
AF047231.1 AF047233.1 AF047234.1 AF047239.1 AF047241.1 AF052765.1 AF052801.1 AF052802.1 
AF052804.1 AF052806.1 AF052809.1 AF052819.1 AF052820.1 AF052821.1 AF052822.1 AF052825.1 
AF052826.1 AF058063.1 AF058072.1 AF058075.1 AF058078.1 AF060120.1 AF060123.1 AF060130.1 
AF060131.1 AF060134.1 AF060135.1 AF060136.1 AF060138.1 AF060140.1 AF060145.1 AF060147.1 
AF063694.1 AF063695.1 AF063703.1 AF063704.1 AF063705.1 AF063706.1 AF063707.1 AF063709.1 
AF063715.1 AF063716.1 AF063720.1 AF063723.1 AF063726.1 AF063727.1 AF063730.1 AF063731.1 
AF063735.1 AF063736.1 AF063737.1 AF063738.1 AF063739.1 AF063740.1 AF063741.1 AF063745.1 
AF063748.1 AF063754.1 AF063755.1 AF063757.1 AF063759.1 AF063765.1 AF063771.1 AF063772.1 
AF063773.1 AF063774.1 AF063775.1 AF063780.1 AF064500.1 AF064502.1 AF064503.1 AF064505.1 
AF064506.1 AF064507.1 AF064513.1 AF099192.1 AF103594.1 AF103595.1 AF103601.1 AF103605.1 
AF103610.1 AF103612.1 AF103614.1 AF103618.1 AF103622.1 AF103623.1 AF103625.1 AF103628.1 
AF103629.1 AF103630.1 AF103638.1 AF103639.1 AF103640.1 AF103641.1 AF103643.1 AF103646.1 
AF103657.1 AF103662.1 AF103667.1 AF103668.1 AF103669.1 AF103681.1 AF103683.1 AF103689.1 
AF103694.1 AF103700.1 AF103709.1 AF103710.1 AF103719.1 AF103720.1 AF103723.1 AF115355.1 
AF124170.1 AF124178.1 AF124186.1 AF194542.1 AF194543.1 AF194544.1 AF194547.1 AF194548.1 
AF194550.1 AF194552.1 AF194554.1 AF194555.1 AF194556.1 AF194557.1 AF194558.1 AF194559.1 
AF194560.1 AF194561.1 AF194562.1 AF194563.1 AF194564.1 AF194565.1 AF194566.1 AF194567.1 
AF194568.1 AF194570.1 AF194571.1 AF194572.1 AF194573.1 AF194574.1 AF194575.1 AF194576.1 
AF194577.1 AF194578.1 AF194580.1 AF194581.1 AF194585.1 AF194586.1 AF194587.1 AF194588.1 
AF194589.1 AF194592.1 AF194593.1 AF194598.1 AF194599.1 AF194600.1 AF194605.1 AF194613.1 
AF194614.1 AF194615.1 AF194616.1 AF194617.1 AF194618.1 AF194619.1 AF194620.1 AF194621.1 
AF194622.1 AF194623.1 AF194624.1 AF194625.1 AF194626.1 AF194627.1 AF194628.1 AF194629.1 
AF194630.1 AF194631.1 AF194632.1 AF194633.1 AF194634.1 AF194635.1 AF194636.1 AF194637.1 
AF194638.1 AF194639.1 AF194640.1 AF194641.1 AF194643.1 AF194644.1 AF194645.1 AF194646.1 
AF194648.1 AF194649.1 AF194651.1 AF194655.1 AF194657.1 AF194658.1 AF194659.1 AF194660.1 
AF194661.1 AF194662.1 AF194663.1 AF194664.1 AF194665.1 AF194666.1 AF194667.1 AF194668.1 
AF194669.1 AF194670.1 AF194671.1 AF194672.1 AF194673.1 AF194674.1 AF194675.1 AF194676.1 
AF194677.1 AF194678.1 AF194679.1 AF194680.1 AF194681.1 AF194682.1 AF194683.1 AF194684.1 
AF194685.1 AF194686.1 AF194687.1 AF194688.1 AF194689.1 AF194690.1 AF194691.1 AF194692.1 
AF194693.1 AF194694.1 AF194695.1 AF194696.1 AF194697.1 AF194698.1 AF194699.1 AF194700.1 
AF194701.1 AF194702.1 AF194703.1 AF194704.1 AF194705.1 AF194706.1 AF194707.1 AF194708.1 
AF194709.1 AF194710.1 AF194711.1 AF194712.1 AF194713.1 AF194714.1 AF194787.1 AF194788.1 
AF194789.1 AF194790.1 AF194791.1 AF194792.1 AF194793.1 AF194794.1 AF194795.1 AF194796.1 
AF194797.1 AF194798.1 AF194799.1 AF194800.1 AF194801.1 AF194802.1 AF194803.1 AF194804.1 
AF194805.1 AF194806.1 AF194807.1 AF194808.1 AF194809.1 AF194810.1 AF194811.1 AF194812.1 
AF194813.1 AF194814.1 AF194815.1 AF194816.1 AF233255.1 AF320832.1 AF417851.1 AF417852.1 
AF462664.1 AF462668.1 AF462688.1 AJ006164.1 AJ007955.1 AJ132425.1 AJ132856.1 AJ224900.1 
AJ233724.1 AJ233735.1 AJ241391.1 AJ241403.1 AJ241405.1 AJ249377.1 AJ278777.1 AJ298051.1 
AJ298614.1 AJ298619.1 AJ308452.1 AJ308454.1 AJ308455.1 AJ308456.1 AJ308457.1 AJ308461.1 
AJ309319.1 AJ319669.1 AJ319671.1 AJ388658.1 AJ388659.1 AJ388660.1 AJ388665.1 AJ388666.1 
AJ399863.1 AJ408274.1 AJ408283.1 AJ408290.1 AJ496501.1 AJ697911.1 AJ697912.1 AJ697913.1 
AJ698337.1 AJ698338.1 AK057174.1 AK097035.1 AK097040.1 AK098158.1 AK125585.1 AK125629.1 
AK127411.1 AK129585.1 AK129603.1 AK130461.1 AK130519.1 AL713800.1 AM181303.1 AM181363.1 
AM181364.1 AM181373.1 AM181375.1 AM181376.1 AM181378.1 AM184001.1 AM184002.1 AM184003.1 
AM184004.1 AM184005.1 AM184012.1 AM184013.1 AM184014.1 AM184015.1 AM184016.1 AM184017.1 
AM184018.1 AM184019.1 AM184068.1 AM184069.1 AM184071.1 AY043090.1 AY043110.1 AY043115.1 
AY043118.1 AY043122.1 AY043153.1 AY062356.1 AY062358.1 AY062360.1 AY172960.1 AY180389.1 
AY190819.1 AY190821.1 AY190825.1 AY190827.1 AY190829.1 AY204762.1 AY206993.1 AY574936.1 
AY574941.1 AY574946.1 AY685290.1 AY685291.1 AY685363.1 AY685366.1 AY685369.1 AY685377.1 
AY685382.1 AY685384.1 AY686895.1 AY686896.1 AY941990.1 AY941992.1 AY942000.1 AY942005.1 
AY942021.1 AY942032.1 AY942033.1 AY942037.1 AY942071.1 AY942077.1 AY942083.1 AY942102.1 
AY942109.1 AY955080.1 AY998674.1 BC007782.2 BC012159.1 BC015833.1 BC018749.1 BC020233.1 
BC020236.1 BC022098.1 BC022822.1 BC022823.1 BC028090.1 BC030983.1 BC030984.1 BC032452.1 
BC033102.1 BC054883.1 BC054893.1 BC062711.1 BC064491.1 BC071725.1 BC071804.1 BC072392.1 
BC073762.1 BC073769.1 BC073770.1 BC073787.1 BC073794.1 BC089413.1 BC089414.1 BC089418.1 
BC093098.1 BC107852.1 D01059.1 DQ109967.1 DQ187536.1 DQ187622.1 DQ187723.1 DQ205170.1 
DQ205174.1 DQ234400.1 DQ322734.1 DQ322762.1 DQ322763.1 DQ322773.1 DQ322816.1 DQ322938.1 
DQ322939.1 DQ322940.1 DQ322941.1 DQ322979.1 DQ323004.1 EF589387.1 EF589391.1 EF589406.1 
EF589407.1 EF589410.1 EF589413.1 EF589423.1 EF589424.1 EF589428.1 EF589429.1 EF589444.1 
EF589454.1 EF589461.1 EF589466.1 EF589473.1 EF589489.1 EF589500.1 EF589510.1 EF589549.1 
EF589556.1 EF589557.1 EF710783.1 EF710784.1 EF710908.1 EF710909.1 EF710910.1 EF710936.1 
EF710937.1 EF710938.1 EF710939.1 EF710940.1 EF710941.1 EF710942.1 EF710943.1 EF710944.1 
EF710945.1 EF710994.1 EF710995.1 EF710996.1 EF710997.1 EF710998.1 EF711016.1 EF711017.1 
EF711018.1 EF711019.1 EF711020.1 EF711021.1 EF711022.1 EF711023.1 EU599321.1 EU599322.1 
EU599330.1 EU599356.1 EU599360.1 EU825948.1 FJ039804.1 FJ039805.1 FJ200244.1 FJ385438.1 
FJ385442.1 FJ385443.1 FJ385449.1 FJ385456.1 FJ385462.1 FJ385474.1 FJ385505.1 FJ385507.1 
FJ385525.1 FJ385551.1 FJ385552.1 FJ385555.1 FJ385558.1 FJ429651.1 HF541916.1 HF541917.1 
HF541918.1 HM995992.1 HM996058.1 HM996111.1 HM996172.1 HM996203.1 HM996209.1 HM996218.1 
HM996488.1 HM996513.1 HQ129865.1 HQ172120.1 HQ172123.1 HQ172130.1 HQ172144.1 HQ172151.1 
HQ890344.1 HQ890351.1 HQ890354.1 HQ890360.1 JF740071.1 JF806289.1 JN201911.1 JQ301919.1 
KC417396.1 KC417398.1 KC417400.1 KC417404.1 KC417412.1 L01277.1 L03629.1 L03631.1 
L03633.1 L03682.1 L21956.1 L25296.1 L26400.1 L26532.1 L26534.1 L26902.1 
L29158.1 L29159.1 L29160.1 L29161.1 L29164.1 L33026.1 L38436.1 L39129.1 
L43084.1 L43088.1 M18645.1 M75139.1 M75282.1 M87790.1 M97924.1 S42404.1 
S56194.1 S62232.1 S66100.1 S67986.1 S73129.1 S73510.1 S77601.1 S80751.1 
U07991.1 U09085.1 U09893.1 U09898.1 U09899.1 U09900.1 U31964.1 U38589.1 
U43772.1 U70239.1 U76675.1 U76678.1 U76680.1 U76684.1 U86669.1 U86805.1 
U95247.1 U95248.1 X14583.1 X52112.1 X57801.1 X57803.1 X57804.1 X57809.1 
X57810.1 X57811.1 X57812.1 X57814.1 X57815.1 X57816.1 X57818.1 X57822.1 
X62125.1 X64132.1 X64169.1 X72746.1 X83712.1 X91131.1 X91805.1 X95739.1 
Y14738.1 Y15770.1 Y16714.1 Y17143.1 Z18332.1 Z18333.1 Z46346.1 Z46623.1 
Z46848.1 Z46858.1 Z74694.1 Z75558.1 

Selected DOTS entries (see all 259):

DT.100885122  DT.95222178  DT.91962204  DT.91720675  DT.91939027  DT.40267692  DT.91769116  DT.100046818 
DT.120678012  DT.100885115  DT.91934757  DT.87018169  DT.95068785  DT.120676905  DT.87079052  DT.100885135 
DT.40231338  DT.87003223  DT.120676930  DT.91877966  DT.120677735  DT.92049444  DT.97856613  DT.100046628 

Selected AceView cDNA sequences (see all 97):

L35920 AF194645 CR623132 AF194648 L25296 CR605950 AF194679 CR593480 
AF063703 AF194698 CR623617 AF194643 AF064507 AF194669 AY573191 CR592011 
AF194707 X53070 AJ319671 AF058069 AF194708 AF194767 AF194668 AF047246 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

IGLC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGGGAGCAC
IGLC1 Expression
About this image


IGLC1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 7) fully expand
 
 Bone (Muscoskeletal System)
         Bone Marrow
 
 Blood (Hematopoietic System)
         Plasmacytoid Dendritic cells Peripheral Blood
 
 Heart (Cardiovascular System)
 
 Lung (Respiratory System)
 
 Colon (Gastrointestinal Tract)
IGLC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IGLC1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.449585
    Custom PCR Arrays for IGLC1
Primer
Products:
Browse OriGene qPCR
Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat IGLC1
QuantiTect SYBR Green Assays in human, mouse, rat IGLC1
QuantiFast Probe-based Assays in human, mouse, rat IGLC1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGLC1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for IGLC1 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Iglc15 immunoglobulin lambda constant 1   --   16 (11.80 cM) 19061752 
chicken
(Gallus gallus)
Aves --
Ig lambda chain V-1 region
27(a)
1 → many
15(7928727-7933299)
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
55(a)
24(a)
many ↔ many
many ↔ many
AAWZ02041299(1275-1595)
GL343282.1(588802-599691)
zebrafish
(Danio rerio)
Actinopterygii CU571382.26
Uncharacterized protein
10(a)
many ↔ many
3(59523312-59523605) ENSDARG00000094966


ENSEMBL Gene Tree for IGLC1 (if available)
TreeFam Gene Tree for IGLC1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for IGLC1 gene
IGKC2  IGLL52  IGLC32  IGLL12  IGLC72  IGLC22  
Selected SIMAP similar genes for IGLC1 using alignment to 1 protein entry:     LAC1_HUMAN(see all similar genes):
C1 segment    DKFZp781M0386    IGLL5    IGLC7    IGL@    DKFZp667J0810
IGLC2    IGLC3    IgLC-rG    IGLC6    IGLL1    IGKC
HLA-DQA1    TRBC1    HLA-DRB1    HLA DRB4    HLA-DR    HLA-DRB3

IGLC1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for IGLC1
PGOHUM00000246519


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus
Locus Specific Mutation Databases (LSDB): IGLC1

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing IGLC1
DNA2.0 Custom Variant and Variant Library Synthesis for IGLC1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 147220    OMIM disorders: --

2 diseases for IGLC1:    
About MalaCards
myeloma    ataxia


IGLC1 for disorders           About GeneDecksing


Export disorders for IGLC1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for IGLC1 gene, integrated from 10 sources (see all 22):
(articles sorted by number of sources associating them with IGLC1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Structure and expression of the human immunoglobulin lambda genes. (PubMed id 2115572)1, 2 Vasicek T.J. and Leder P. (J. Exp. Med. 1990)
  2. Three-dimensional structure of a light chain dimer crystallized in water. Conformational flexibility of a molecule in two crystal forms. (PubMed id 2515285)1, 2 Ely K.R.... Edmundson A.B. (J. Mol. Biol. 1989)
  3. Clustered arrangement of immunoglobulin lambda constant region genes in man. (PubMed id 6273747)1, 2 Hieter P.A.... Leder P. (Nature 1981)
  4. Primary structure of the Mcg lambda chain. (PubMed id 4415202)1, 2 Fett J.W. and Deutsch H.F. (Biochemistry 1974)
  5. High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/IgI_/IgI> loci bearing the rat CH region. (PubMed id 23303672)1 Osborn M.J....BrA1ggemann M. (J. Immunol. 2013)
  6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
  7. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)
  8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
  9. Unraveling of the polymorphic C lambda 2-C lambda 3 amplification and the Ke+Oz- polymorphism in the human Ig lambda locus. (PubMed id 12077254)1 van der Burg M....van Dongen J.J. (J. Immunol. 2002)
  10. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (Mol. Immunol. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 3537 HGNC: 5855 AceView: IGL_ Ensembl:ENSG00000211675 euGenes: HUgn3537
ECgene: IGLC1 H-InvDB: IGLC1

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for IGLC1 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGLC1 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGLC1&species=Homo+sapiens

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for IGLC1 gene:
Search GeneIP for patents involving IGLC1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   Browse OriGene RNAi products  
 Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
 OriGene Custom Mass Spec   Browse OriGene clones  
 Browse OriGene qSTAR qPCR primer pairs   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for IGLC1   OriGene Custom Protein Services for IGLC1  

 
 
 Block miRNA regulation of human, mouse, rat IGLC1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IGLC1
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGLC1 Predesigned siRNA for gene silencing in human, mouse, rat IGLC1
 QuantiFast Probe-based Assays in human, mouse, rat IGLC1 QuantiTect SYBR Green Assays in human, mouse, rat IGLC1
 Custom PCR Arrays for IGLC1 Search Chromatin IP Primers for IGLC1
 Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat IGLC1 Search GeneGlobe Interaction Network for IGLC1
 Search Regulatory tfbs for IGLC1
 GenScript Custom Purified and Recombinant Proteins Services for IGLC1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for IGLC1
 GenScript Custom Assay Services for IGLC1 GenScript Custom overexpressing Cell Line Services for IGLC1
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for IGLC1 (LAC1)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Biologicals
 Novus Tissue Slides
 Antibodies for IGLC1
 See all of Abcam's Antibodies, Kits and Proteins for IGLC1
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for IGLC1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGLC1
 Browse SwitchGear 3'UTR luciferase reporter plasmids for IGLC1
 Browse SwitchGear Promoter luciferase reporter plasmids for IGLC1
 Search ThermoFisher Antibodies for IGLC1
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGLC1
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IGLC1
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IGLC1
 Search LSBio for Antibodies for IGLC1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      IGLC1 gene at Home site.
Version: 3.12.164 25 Aug 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4