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Aliases for IGLC1 Gene

Aliases for IGLC1 Gene

  • Immunoglobulin Lambda Constant 1 (Mcg Marker) 2 3
  • IGLC 3 6
  • Immunoglobulin Lambda Constant Region 1 (Mcg Marker) 3
  • C1 Segment 3

External Ids for IGLC1 Gene

Previous HGNC Symbols for IGLC1 Gene

  • IGLC

Previous GeneCards Identifiers for IGLC1 Gene

  • GC22P019928
  • GC22U900022
  • GC22P021089
  • GC22P021092
  • GC22P021095
  • GC22P021098
  • GC22P021562
  • GC22P021295
  • GC22P021568
  • GC22P023238
  • GC22P006205
  • GC22P023245
  • GC22P023251
  • GC22P023314

Summaries for IGLC1 Gene

GeneCards Summary for IGLC1 Gene

IGLC1 (Immunoglobulin Lambda Constant 1 (Mcg Marker)) is a Protein Coding gene. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLL5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLC1 Gene

Genomics for IGLC1 Gene

Genomic Location for IGLC1 Gene

Start:
22,895,375 bp from pter
End:
22,895,834 bp from pter
Size:
460 bases
Orientation:
Plus strand

Genomic View for IGLC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGLC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLC1 Gene

No data available for Regulatory Elements for IGLC1 Gene

Proteins for IGLC1 Gene

  • Protein details for IGLC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG04-LAC1_HUMAN
    Recommended name:
    Ig lambda-1 chain C regions
    Protein Accession:
    P0CG04
    Secondary Accessions:
    • A0M8Q4
    • P01842
    • P80423

    Protein attributes for IGLC1 Gene

    Size:
    106 amino acids
    Molecular mass:
    11348 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Displays the following serological isotype: Mcg+, Kern+ and Oz-. The Mcg isotype marker is characterized by Asn-6, Thr-8 and Lys-57; the Ke marker by Gly-46 and the Oz- marker by Arg-83
    SequenceCaution:
    • Sequence=CAA36047.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGLC1 Gene

neXtProt entry for IGLC1 Gene

Proteomics data for IGLC1 Gene at MOPED

Post-translational modifications for IGLC1 Gene

No Post-translational modifications

Other Protein References for IGLC1 Gene

ENSEMBL proteins:
Reactome Protein details:

No data available for DME Specific Peptides for IGLC1 Gene

Domains for IGLC1 Gene

Gene Families for IGLC1 Gene

HGNC:
  • IGL :Immunoglobulins / IGL locus

Protein Domains for IGLC1 Gene

Suggested Antigen Peptide Sequences for IGLC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CG04

UniProtKB/Swiss-Prot:

LAC1_HUMAN :
  • P0CG04
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGLC1: view

Function for IGLC1 Gene

Molecular function for IGLC1 Gene

GENATLAS Biochemistry: immunoglobulin,lambda,constant segment 1 (Mcg marker)

Gene Ontology (GO) - Molecular Function for IGLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 4909564
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IGLC1: view

Phenotypes for IGLC1 Gene

genes like me logo Genes that share phenotypes with IGLC1: view

miRNA for IGLC1 Gene

miRTarBase miRNAs that target IGLC1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IGLC1 Gene

Localization for IGLC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGLC1 Gene COMPARTMENTS Subcellular localization image for IGLC1 gene
Compartment Confidence
extracellular 4
plasma membrane 4
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IGLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 23376485
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with IGLC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IGLC1 Gene

Pathways for IGLC1 Gene

genes like me logo Genes that share pathways with IGLC1: view

Interacting Proteins for IGLC1 Gene

Selected Interacting proteins: P0CG04-LAC1_HUMAN for IGLC1 Gene via I2D

Gene Ontology (GO) - Biological Process for IGLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 4909564
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
GO:0038095 Fc-epsilon receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with IGLC1: view

Compounds for IGLC1 Gene

(1) Drugbank Compounds for IGLC1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Pyroglutamic Acid
98-79-3 target
genes like me logo Genes that share compounds with IGLC1: view

Transcripts for IGLC1 Gene

mRNA/cDNA for IGLC1 Gene

Unigene Clusters for IGLC1 Gene

Immunoglobulin lambda constant 1 (Mcg marker):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGLC1 Gene

No ASD Table

Relevant External Links for IGLC1 Gene

GeneLoc Exon Structure for
IGLC1
ECgene alternative splicing isoforms for
IGLC1

Expression for IGLC1 Gene

mRNA expression in normal human tissues for IGLC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGLC1 Gene

This gene is overexpressed in Spleen (14.1), Colon - Transverse (7.6), Small Intestine - Terminal Ileum (6.9), and Minor Salivary Gland (6.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IGLC1 Gene

SOURCE GeneReport for Unigene cluster for IGLC1 Gene Hs.449585

genes like me logo Genes that share expressions with IGLC1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IGLC1 Gene

Orthologs for IGLC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 48 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 34 (a)
ManyToMany
IGLL1 36
  • 34 (a)
ManyToMany
VPREB 36
  • 30 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 36 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
-- 36
  • 86 (a)
ManyToMany
-- 36
  • 86 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Iglc1 16
Iglc2 36
  • 64 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
ManyToMany
-- 36
  • 9 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 27 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU571382.2 36
  • 10 (a)
ManyToMany
Species with no ortholog for IGLC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGLC1 Gene

ENSEMBL:
Gene Tree for IGLC1 (if available)
TreeFam:
Gene Tree for IGLC1 (if available)

Paralogs for IGLC1 Gene

Paralogs for IGLC1 Gene

Pseudogenes.org Pseudogenes for IGLC1 Gene

genes like me logo Genes that share paralogs with IGLC1: view

Variants for IGLC1 Gene

Relevant External Links for IGLC1 Gene

HapMap Linkage Disequilibrium report
IGLC1
Locus Specific Mutation Databases (LSDB)
IGLC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for IGLC1 Gene

Disorders for IGLC1 Gene

No disorders were found for IGLC1 Gene.

No data available for UniProtKB/Swiss-Prot for IGLC1 Gene

Publications for IGLC1 Gene

  1. Clustered arrangement of immunoglobulin lambda constant region genes in man. (PMID: 6273747) Hieter P.A. … Leder P. (Nature 1981) 3 4
  2. Structure and expression of the human immunoglobulin lambda genes. (PMID: 2115572) Vasicek T.J. … Leder P. (J. Exp. Med. 1990) 3 4
  3. Three-dimensional structure of a light chain dimer crystallized in water. Conformational flexibility of a molecule in two crystal forms. (PMID: 2515285) Ely K.R. … Edmundson A.B. (J. Mol. Biol. 1989) 3 4
  4. Primary structure of the Mcg lambda chain. (PMID: 4415202) Fett J.W. … Deutsch H.F. (Biochemistry 1974) 3 4
  5. Amino acid sequence of the (lambda) light chain of a human myeloma immunoglobulin (IgG New). (PMID: 4814727) Chen B.L. … Poljak R.J. (Biochemistry 1974) 3

Products for IGLC1 Gene

Sources for IGLC1 Gene

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