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Aliases for IGLC1 Gene

Aliases for IGLC1 Gene

  • Immunoglobulin Lambda Constant 1 (Mcg Marker) 2 3 5
  • Immunoglobulin Lambda Constant Region 1 (Mcg Marker) 3
  • C1 Segment 3
  • IGLC 3

External Ids for IGLC1 Gene

Previous HGNC Symbols for IGLC1 Gene

  • IGLC

Previous GeneCards Identifiers for IGLC1 Gene

  • GC22P019928
  • GC22U900022
  • GC22P021089
  • GC22P021092
  • GC22P021095
  • GC22P021098
  • GC22P021562
  • GC22P021295
  • GC22P021568
  • GC22P023238
  • GC22P006205
  • GC22P023245
  • GC22P023251
  • GC22P023314

Summaries for IGLC1 Gene

GeneCards Summary for IGLC1 Gene

IGLC1 (Immunoglobulin Lambda Constant 1 (Mcg Marker)) is a Protein Coding gene. Among its related pathways are Immune System and Regulation of actin dynamics for phagocytic cup formation. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLL5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLC1 Gene

Genomics for IGLC1 Gene

Genomic Location for IGLC1 Gene

Chromosome:
22
Start:
22,895,375 bp from pter
End:
22,895,834 bp from pter
Size:
460 bases
Orientation:
Plus strand

Genomic View for IGLC1 Gene

Genes around IGLC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLC1 Gene

No data available for Regulatory Elements for IGLC1 Gene

Proteins for IGLC1 Gene

  • Protein details for IGLC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG04-LAC1_HUMAN
    Recommended name:
    Ig lambda-1 chain C regions
    Protein Accession:
    P0CG04
    Secondary Accessions:
    • A0M8Q4
    • P01842
    • P80423

    Protein attributes for IGLC1 Gene

    Size:
    106 amino acids
    Molecular mass:
    11348 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Displays the following serological isotype: Mcg+, Kern+ and Oz-. The Mcg isotype marker is characterized by Asn-6, Thr-8 and Lys-57; the Ke marker by Gly-46 and the Oz- marker by Arg-83.
    SequenceCaution:
    • Sequence=CAA36047.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGLC1 Gene

neXtProt entry for IGLC1 Gene

Proteomics data for IGLC1 Gene at MOPED

Post-translational modifications for IGLC1 Gene

No Post-translational modifications

Other Protein References for IGLC1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLC1 Gene

Domains & Families for IGLC1 Gene

Gene Families for IGLC1 Gene

Protein Domains for IGLC1 Gene

Suggested Antigen Peptide Sequences for IGLC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CG04

UniProtKB/Swiss-Prot:

LAC1_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGLC1: view

Function for IGLC1 Gene

Molecular function for IGLC1 Gene

GENATLAS Biochemistry:
immunoglobulin,lambda,constant segment 1 (Mcg marker)

Animal Model Products

  • Taconic Biosciences Mouse Models for IGLC1

miRNA for IGLC1 Gene

miRTarBase miRNAs that target IGLC1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGLC1 Gene

Localization for IGLC1 Gene

Gene Ontology (GO) - Cellular Components for IGLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IBA --
genes like me logo Genes that share ontologies with IGLC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for IGLC1 Gene

Pathways & Interactions for IGLC1 Gene

genes like me logo Genes that share pathways with IGLC1: view

Interacting Proteins for IGLC1 Gene

Gene Ontology (GO) - Biological Process for IGLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS --
GO:0006956 complement activation TAS --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0045087 innate immune response IBA --
GO:0050871 positive regulation of B cell activation IBA --
genes like me logo Genes that share ontologies with IGLC1: view

No data available for SIGNOR curated interactions for IGLC1 Gene

Drugs & Compounds for IGLC1 Gene

(1) Drugs for IGLC1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyroglutamic acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with IGLC1: view

Transcripts for IGLC1 Gene

mRNA/cDNA for IGLC1 Gene

Unigene Clusters for IGLC1 Gene

Immunoglobulin lambda constant 1 (Mcg marker):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGLC1 Gene

No ASD Table

Relevant External Links for IGLC1 Gene

GeneLoc Exon Structure for
IGLC1
ECgene alternative splicing isoforms for
IGLC1

Expression for IGLC1 Gene

mRNA expression in normal human tissues for IGLC1 Gene

mRNA differential expression in normal tissues according to GTEx for IGLC1 Gene

This gene is overexpressed in Spleen (x14.1), Colon - Transverse (x7.6), Small Intestine - Terminal Ileum (x6.9), and Minor Salivary Gland (x6.7).

Protein differential expression in normal tissues from HIPED for IGLC1 Gene

This gene is overexpressed in Skin (30.0), Plasma (16.0), Urine (9.9), and Serum (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLC1 Gene



SOURCE GeneReport for Unigene cluster for IGLC1 Gene Hs.449585

genes like me logo Genes that share expression patterns with IGLC1: view

Protein tissue co-expression partners for IGLC1 Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGLC1 Gene

Orthologs for IGLC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 34 (a)
ManyToMany
IGLL1 36
  • 34 (a)
ManyToMany
VPREB 36
  • 30 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 36 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
-- 36
  • 86 (a)
ManyToMany
-- 36
  • 86 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
ManyToMany
-- 36
  • 9 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Iglc2 36
  • 64 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 48 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 27 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU571382.2 36
  • 10 (a)
ManyToMany
Species with no ortholog for IGLC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGLC1 Gene

ENSEMBL:
Gene Tree for IGLC1 (if available)
TreeFam:
Gene Tree for IGLC1 (if available)

Paralogs for IGLC1 Gene

Paralogs for IGLC1 Gene

Pseudogenes.org Pseudogenes for IGLC1 Gene

genes like me logo Genes that share paralogs with IGLC1: view

Variants for IGLC1 Gene

Relevant External Links for IGLC1 Gene

HapMap Linkage Disequilibrium report
IGLC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLC1 Gene

Disorders for IGLC1 Gene

Relevant External Links for IGLC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGLC1

No disorders were found for IGLC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGLC1 Gene

Publications for IGLC1 Gene

  1. Structure and expression of the human immunoglobulin lambda genes. (PMID: 2115572) Vasicek T.J. … Leder P. (J. Exp. Med. 1990) 3 4 67
  2. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25 26
  3. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/IgI_/IgI> loci bearing the rat CH region. (PMID: 23303672) Osborn M.J. … BrA1ggemann M. (J. Immunol. 2013) 3

Products for IGLC1 Gene

Sources for IGLC1 Gene

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