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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGL@ Cluster

gene cluster   GIFtS: 35
GCID: GC22P022396

immunoglobulin lambda locus
 Explore 4 diseases affiliated with
IGL@ via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGL@    

Aliases
for IGL@ gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immunoglobulin Lambda Locus1 2
IGL1 2
IGLC62
Ig Lambda-6 Chain C Region2
Immunoglobulin Lambda Gene Cluster2

External Ids:    HGNC: 58531   Entrez Gene: 35352   UniProtKB: Q567P14   UniProtKB: Q5FWF94   UniProtKB: Q6GMW34   
UniProtKB: Q6GMW44   UniProtKB: Q6GMX34   UniProtKB: Q6GMX44   UniProtKB: Q6IN994   UniProtKB: Q6IPQ04   
UniProtKB: Q6NS954   UniProtKB: Q6PIK14   UniProtKB: Q6PIQ74   UniProtKB: Q6PJR74   UniProtKB: Q8N3554   
UniProtKB: Q8N5F44   

Export aliases for IGL@ gene to outside databases

Previous GC identifers: GC22U990023 GC00U920621 GC22P020712 GC22P020714 GC22P020720 GC22P022381 GC22P005337 GC22P022384


Summaries
for IGL@ gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IGL@:
Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement
system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are
two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light
chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a
recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by
splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of
antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of
nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell
maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of
encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of
which are pseudogenes or are predicted by automated computational analysis or homology to other species. (provided by
RefSeq, Jul 2008)

Gene Wiki entry for IGL@


Genomic Views
for IGL@ gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGL@
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGL@

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGL@


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   HGNC cytogenetic band: 22q11.2

IGL@ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGL@ gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P022396:  view genomic region     (about GC identifiers)

Start:
 22,380,474 bp from pter      End:
 23,265,085 bp from pter
Size:
 884,612 bases      Orientation:
 plus strand
IGL@ has overlapping exons with:
 IGLV4-60 ENSG00000236118 IGLVI-42 ENSG00000227710 ENSG00000225741

Proteins
for IGL@ gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/TrEMBL: Q567P1 (See protein sequence)
Recommended Name: IGL@ protein  
Size: 235 amino acids; 24800 Da

UniProtKB/TrEMBL: Q5FWF9 (See protein sequence)

Recommended Name: IGL@ protein  
Size: 232 amino acids; 24795 Da

UniProtKB/TrEMBL: Q6GMW3 (See protein sequence)

Recommended Name: IGL@ protein  
Size: 234 amino acids; 24654 Da

UniProtKB/TrEMBL: Q6GMW4 (See protein sequence)

Recommended Name: IGL@ protein  
Size: 233 amino acids; 24855 Da

UniProtKB/TrEMBL: Q6GMX3 (See protein sequence)

Recommended Name: IGL@ protein  
Size: 236 amino acids; 24700 Da

UniProtKB/TrEMBL: Q6GMX4 (See protein sequence)

Recommended Name: IGL@ protein  
Size: 236 amino acids; 24810 Da
1 PDB 3D structure from and Proteopedia for IGL@:
4D9L (3D)    

UniProtKB/TrEMBL: Q6IN99 (See protein sequence)

Recommended Name: IGL@ protein  
Size: 235 amino acids; 24888 Da

UniProtKB/TrEMBL: Q6IPQ0 (See protein sequence)

Recommended Name: IGL@ protein  
Size: 236 amino acids; 24824 Da

UniProtKB/TrEMBL: Q6NS95 (See protein sequence)

Recommended Name: IGL@ protein  
Size: 234 amino acids; 25148 Da

UniProtKB/TrEMBL: Q6PIK1 (See protein sequence)

Recommended Name: IGL@ protein  
Size: 235 amino acids; 24858 Da

UniProtKB/TrEMBL: Q6PIQ7 (See protein sequence)

Recommended Name: IGL@ protein  
Size: 236 amino acids; 25021 Da

UniProtKB/TrEMBL: Q6PJR7 (See protein sequence)

Recommended Name: IGL@ protein  
Size: 139 amino acids; 14678 Da

UniProtKB/TrEMBL: Q8N355 (See protein sequence)

Recommended Name: IGL@ protein  
Size: 234 amino acids; 24793 Da

UniProtKB/TrEMBL: Q8N5F4 (See protein sequence)

Recommended Name: IGL@ protein  
Size: 233 amino acids; 24961 Da

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N5F4

    • IGL@ Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).


    Human Recombinant Protein Products: 
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for IGL@ 
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    Novus Biologicals IGL@ Protein
    Novus Biologicals IGL@ Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn


    IGL@ Antibody Products: 
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    Novus Biologicals IGL@ Antibodies
    Search for Antibodies for IGL@ at Abcam  
    Browse Antibodies at Uscn
    Search ThermoFisher Antibodies for IGL@

    Assay Products for IGL@: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for IGL@
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for IGL@ gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IGL@ for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR007110 Ig-like_dom
     IPR003596 Ig_V-set_subgr
     IPR013783 Ig-like_fold
     IPR003006 Ig/MHC_CS
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q567P1
    Graphical View of Domain Structure for InterPro Entry Q5FWF9
    Graphical View of Domain Structure for InterPro Entry Q6GMW3
    Graphical View of Domain Structure for InterPro Entry Q6GMW4
    Graphical View of Domain Structure for InterPro Entry Q6GMX3
    Graphical View of Domain Structure for InterPro Entry Q6GMX4
    Graphical View of Domain Structure for InterPro Entry Q6IN99
    Graphical View of Domain Structure for InterPro Entry Q6IPQ0
    Graphical View of Domain Structure for InterPro Entry Q6NS95
    Graphical View of Domain Structure for InterPro Entry Q6PIK1
    Graphical View of Domain Structure for InterPro Entry Q6PIQ7
    Graphical View of Domain Structure for InterPro Entry Q6PJR7
    Graphical View of Domain Structure for InterPro Entry Q8N355
    Graphical View of Domain Structure for InterPro Entry Q8N5F4

    ProtoNet protein and cluster: Q567P1

    2 Blocks protein families:
    IPB003596 Immunoglobulin V-type
    IPB013106 Immunoglobulin V-set



    Function
    for IGL@ gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for IGL@:
    immunoglobulin lambda gene cluster (see,IGLC@,IGLV@)

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene 29mer shRNA kits
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    Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGL@

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IGL@

    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGL@
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    GenScript Custom all cDNA clones Services for IGL@
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGL@
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGL@ 

    Cell Line
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    Search LifeMap BioReagents cell lines for IGL@

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGL@

    1 GenomeRNAi human phenotype for IGL@:
     Increased G2M DNA content 

    Animal Models:
         Mouse knock-outs for IGL@: Igltm2.1Bgmn Igltm1.1Bgmn
         3 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Igl):
     cellular  hematopoietic system  immune system 

    IGL@ for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IGL@ gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune response_NFAT in immune response
    		Immune response_NFAT in immune response1.00
    		Immune response NFAT in immune response0.91
    2Signal transduction_IP3 signaling
    		Signal transduction_IP3 signaling1.00
    		Signal transduction IP3 signaling0.92
    3Immune response_Classical complement pathway
    		Immune response_Classical complement pathway1.00
    		Immune response Classic complement pathway0.98
    4Immune response_IL-4 signaling pathway
    		Immune response_IL-4 signaling pathway1.00
    		Immune response IL-4 signaling pathway0.98
    5Immune response CD16 signaling in NK cells
    		Immune response CD16 signaling in NK cells1.00
    		Immune response_CD16 signaling in NK cells0.99

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/7 EMD Millipore Pathways for IGL@ (see all 7)
        Immune response Classic complement pathway
    Immune response BCR pathway
    Immune response CD16 signaling in NK cells
    Signal transduction IP3 signaling
    Immune response IL-4 signaling pathway


    5/7 GeneGo (Thomson Reuters) Pathways for IGL@ (see all 7)
        Immune response IL-4 signaling pathway
    Immune response Fc epsilon RI pathway
    Immune response CD16 signaling in NK cells
    Immune response Classical complement pathway
    Immune response BCR pathway



    IGL@ for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGL@

    1 Interacting protein for IGL@ (Q8N3553) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --uniprotid: Q6GMX43I2D: score= 
    About this table

    Drugs & Compounds
    for IGL@ gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGL@
    Search CenterWatch for drugs/clinical trials and news about IGL@ 

    Transcripts
    for IGL@ gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGL@
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IGL@
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene 29mer shRNA kits
    Browse OriGene siRNA
    Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGL@
    Clone
    Products:             		 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGL@
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript Custom all cDNA clones Services for IGL@
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGL@
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGL@ 
    Primer
    Products:            		Browse OriGene genome-wide validated SYBR primer pairs
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat IGL@
      Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGL@
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGL@

    GeneLoc Exon Structure


    Expression
    for IGL@ gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGL@ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See IGL@ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGL@
        SABiosciences Custom PCR Arrays for IGL@
    Primer
    Products:    		Browse OriGene genome-wide validated SYBR primer pairs
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat IGL@
    Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGL@
    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGL@
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGL@

    Orthologs
    for IGL@ gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for IGL@ gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Igl5 immunoglobulin lambda chain complex   --   16 -

    Paralogs
    for IGL@ gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for IGL@ gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3243 NCBI SNPs in IGL@ are shown (see all 3243)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs72850561,2
    		C,F,H,--5335346(+) AAAGAG/AGAGAG 1 -- int16Minor allele frequency- A:0.01NS EA WA NA 650
    rs4110291,2
    		C,O,H,--5335723(+) TGTGGA/GTCACT 1 -- int15Minor allele frequency- G:0.03NS NA WA 380
    rs1124771131,2
    		C,--5335905(+) TAATCG/ATGTTA 1 -- int12Minor allele frequency- A:0.09WA 120
    rs615683601,2
    		C,--5336397(+) AGTCAT/CCCCGG 1 -- nc-transcript-variant2Minor allele frequency- C:0.15WA 120
    rs611205481,2
    		C,--5336422(+) GCTGTA/CTCTAG 1 -- nc-transcript-variant2Minor allele frequency- C:0.15WA 120
    rs605033661,2
    		C,--5336426(+) TATCTA/GGGGAG 1 -- nc-transcript-variant2Minor allele frequency- G:0.15WA 120
    rs110898571,2
    		C,F,A,--5336592(+) GGTCAC/TGGAGC 1 -- nc-transcript-variant6Minor allele frequency- T:0.23WA CSA NA 245
    rs733923481,2
    		C,F,--5336622(+) TGTGGG/AGTATG 1 -- nc-transcript-variant5Minor allele frequency- A:0.37WA CSA 125
    rs733923501,2
    		C,F,--5336673(+) CTGGGG/AAGGGT 1 -- nc-transcript-variant5Minor allele frequency- A:0.37WA CSA 125
    rs738797251,2
    		C,F,--5336947(+) GTCAGG/AAATGA 1 -- nc-transcript-variant4Minor allele frequency- A:0.15WA CSA 124

    HapMap Linkage Disequilibrium report for IGL@ (22380474 - 22630474 bp, first 250kb of IGL@)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IGL@: --

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGL@
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    Disorders / Diseases
    for IGL@ gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IGL@ for disorders           About GeneDecksing

    4 diseases for IGL@:    About MalaCards
    non-hodgkin lymphoma    mantle cell lymphoma    hodgkin's lymphoma    neuropathy


    Export disorders for IGL@ gene to outside databases

    Publications
    for IGL@ gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGL@ gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with IGL@)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal orientation of the lambda light chain locus: V lambda is proximal to C lambda in 22q11. (PubMed id 3923432)1, 3 Emanuel B.S....Croce C.M. (1985)
    2. Assignment of the genes for human lambda immunoglobul in chains to chromosome 22. (PubMed id 6795508)1, 3 Erikson J....Croce C.M. (1981)
    3. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1, 9 Kawasaki K....Shimizu N. (1997)
    4. The lambda gene immunoglobulin repertoire of human neonatal B cells. (PubMed id 17675156)1, 9 Richl P....Girschick H.J. (2008)
    5. Structure and expression of the human immunoglobulin lambda genes. (PubMed id 2115572)1, 9 Vasicek T.J. and Leder P. (1990)
    6. Combined analysis using extended renal reference range of serum free light chain ratio and serum protein electrophoresis improves the diagnostic accuracy of multiple myeloma in renal insufficiency. (PubMed id 22503879)1 Park J.W....Kim S.W. (2012)
    7. Higher serum levels of free kk plus l immunoglobulin l ight chains ameliorate survival of hemodialysis patients. (PubMed id 21646814)1 Thilo F....Tepel M. (2011)
    8. CD5-positive, cyclinD1-negative mantle cell lymphoma with a translocation involving the CCND2 gene and the IGL locus. (PubMed id 21504716)1 Shiller S.M....Saad R. (2011)
    9. Inhibition of pathologic immunoglobulin-free light ch ain production by small interfering RNA molecules. (PubMed id 20637260)1 Phipps J.E....Wall J.S. (2010)
    10. Immunoglobulin light chain gene translocations in non-Hodgkin's lymphoma as assessed by fluorescence in situ hybridisation. (PubMed id 18005388)1 Fujimoto Y....Taniwaki M. (2008)

    External Searches for IGL@ gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IGL@ gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3535 HGNC: 5853 euGenes: HUgn3535 ECgene: IGL@ H-InvDB: IGL@

    Other Databases showing IGL@ gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IGL@ gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGL@ Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IGL@ Genetics and Cytogenetics in Oncology and Haematology
    IMGT entry for IGL@ The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

    Intellectual Property
    for IGL@ gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IGL@ gene:
    Search GeneIP for patents involving IGL@

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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