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IGL Gene

protein-coding   GIFtS: 24
GCID: GC22P022421

Immunoglobulin Lambda Locus


(Previous symbol: IGL@)
  See IGL-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immunoglobulin Lambda Locus1 2     AGM25
IGL@1 2     IGL55
IGLC62     IGLL15
Ig Lambda-6 Chain C Region2     IGO5
Immunoglobulin Lambda Gene Cluster2     VPREB25

External Ids:    HGNC: 58531   Entrez Gene: 35352   OMIM: 1467705   

Export aliases for IGL gene to outside databases

Previous GC identifer: GC22P022407


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IGL Gene:
Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement
system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There
are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda
light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell
development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is
later joined by splicing at the RNA level. Recombination of many different V segments with several J segments
provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting
from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation,
which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are
known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several
non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or
homology to other species. (provided by RefSeq, Jul 2008)

GeneCards Summary for IGL Gene:
IGL (immunoglobulin lambda locus) is a protein-coding gene. Diseases associated with IGL include mantle cell lymphoma, and hodgkin's lymphoma.

Gene Wiki entry for IGL (IGL@) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for IGL
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGL promoter sequence
   Search Chromatin IP Primers for IGL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   HGNC cytogenetic band: 22q11.2

IGL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGL gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P022421:  view genomic region     (about GC identifiers)

Start:
22,380,474 bp from pter      End:
23,265,085 bp from pter
Size:
884,612 bases      Orientation:
plus strand
IGL has overlapping exons with:
IGLV4-60 ENSG00000236118 ENSG00000227710 ENSG00000225741

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB: --
Post-translational modifications: 
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGL: Immunoglobulins / IGL locus

      --

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for IGL:
     Increased G2M DNA content 

         2 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Igl):
     hematopoietic system  immune system 

    Find genes that share phenotypes with IGL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IGL: Igltm2.1Bgmn Igltm1.1Bgmn

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IGL About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    Immune response BCR pathway0.43
    2Complement Pathway
    Immune response Classic complement pathway0.56
    3Immune response NFAT in immune response
    Immune response NFAT in immune response0.55
    4Development Angiotensin activation of ERK
    Signal transduction IP3 signaling0.43
    5Development IGF 1 receptor signaling
    Immune response IL 4 signaling pathway0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for IGL (see all 7)
        Immune response IL-4 signaling pathway
    Immune response Fc epsilon RI pathway
    Immune response CD16 signaling in NK cells
    Immune response Classical complement pathway
    Immune response BCR pathway


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    Interactions:

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for IGL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IGL Expression
    About this image

    IGL Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for IGL gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igl5 immunoglobulin lambda chain complex   --   16 -

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IGL
    DNA2.0 Custom Variant and Variant Library Synthesis for IGL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 146770   
    OMIM disorders: 613500  
    3 diseases for IGL:    
    About MalaCards
    mantle cell lymphoma    hodgkin's lymphoma    multiple myeloma


    Find genes that share disorders with IGL           About GenesLikeMe


    Export disorders for IGL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGL gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with IGL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal orientation of the lambda light chain locus: V lambda is proximal to C lambda in 22q11. (PubMed id 3923432)1, 3 Emanuel B.S....Croce C.M. (Nucleic Acids Res. 1985)
    2. Assignment of the genes for human lambda immunoglobulin chains to chromosome 22. (PubMed id 6795508)1, 3 Erikson J....Croce C.M. (Nature 1981)
    3. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1, 9 Kawasaki K.... Shimizu N. (Genome Res. 1997)
    4. The lambda gene immunoglobulin repertoire of human neonatal B cells. (PubMed id 17675156)1, 9 Richl P....Girschick H.J. (Mol. Immunol. 2008)
    5. Structure and expression of the human immunoglobulin lambda genes. (PubMed id 2115572)1, 9 Vasicek T.J. and Leder P. (J. Exp. Med. 1990)
    6. High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/IgI_/IgI> loci bearing the rat CH region. (PubMed id 23303672)1 Osborn M.J....BrA1ggemann M. (J. Immunol. 2013)
    7. Free light chain monomer-dimer patterns in the diagnosis of multiple sclerosis. (PubMed id 23376556)1 Kaplan B....Livneh A. (J. Immunol. Methods 2013)
    8. Mutational and genetic determinants of I>6 light chain amyloidogenesis. (PubMed id 24107228)1 GonzA!lez-Andrade M....del Pozo-Yauner L. (FEBS J. 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. The origin of deletion 22q11 in chronic lymphocytic leukemia is related to the rearrangement of immunoglobulin lambda light chain locus. (PubMed id 23608880)1 Mraz M....Pospisilova S. (Leuk. Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3535 HGNC: 5853 euGenes: HUgn3535 ECgene: IGL H-InvDB: IGL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IGL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGL gene:
    Search GeneIP for patents involving IGL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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