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Aliases for IGL Gene

Aliases for IGL Gene

  • Immunoglobulin Lambda Locus 2 3
  • Immunoglobulin Lambda Gene Cluster 3
  • Ig Lambda-6 Chain C Region 3
  • VPREB2 6
  • IGLC6 3
  • IGLL1 6
  • AGM2 6
  • IGL5 6
  • IGL@ 3
  • IGO 6

External Ids for IGL Gene

Previous HGNC Symbols for IGL Gene

  • IGL@

Previous GeneCards Identifiers for IGL Gene

  • GC22P022407
  • GC22P022421

Summaries for IGL Gene

Entrez Gene Summary for IGL Gene

  • Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to other species. [provided by RefSeq, Jul 2008]

GeneCards Summary for IGL Gene

IGL (Immunoglobulin Lambda Locus) is a Protein Coding gene. Diseases associated with IGL include mantle cell lymphoma. Among its related pathways are PI-3K cascade and PI-3K cascade.

Gene Wiki entry for IGL Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGL Gene

Genomics for IGL Gene

Genomic Location for IGL Gene

Start:
22,026,076 bp from pter
End:
22,922,913 bp from pter
Size:
896,838 bases
Orientation:
Plus strand

Genomic View for IGL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGL Gene

No data available for Regulatory Elements for IGL Gene

Proteins for IGL Gene

Post-translational modifications for IGL Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGL Gene

Domains for IGL Gene

Gene Families for IGL Gene

HGNC:
  • IGL :Immunoglobulins / IGL locus

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGL: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGL Gene

Function for IGL Gene

Phenotypes for IGL Gene

MGI mutant phenotypes for IGL:
inferred from 5 alleles
GenomeRNAi human phenotypes for IGL:
genes like me logo Genes that share phenotypes with IGL: view

Animal Models for IGL Gene

MGI Knock Outs for IGL:

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for IGL Gene

Localization for IGL Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for IGL Gene

Pathways for IGL Gene

genes like me logo Genes that share pathways with IGL: view

Interacting Proteins for IGL Gene

Gene Ontology (GO) - Biological Process for IGL Gene

None

Transcripts for IGL Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGL Gene

No ASD Table

Relevant External Links for IGL Gene

GeneLoc Exon Structure for
IGL
ECgene alternative splicing isoforms for
IGL

No data available for mRNA/cDNA for IGL Gene

Expression for IGL Gene

mRNA expression in normal human tissues for IGL Gene

genes like me logo Genes that share expressions with IGL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for IGL Gene

Orthologs for IGL Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for IGL Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Igl 16
Species with no ortholog for IGL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

No data available for Evolution for IGL Gene

Paralogs for IGL Gene

No data available for Paralogs for IGL Gene

Variants for IGL Gene

Relevant External Links for IGL Gene

HapMap Linkage Disequilibrium report
IGL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for IGL Gene

Disorders for IGL Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for IGL Gene including...

Search for IGL Gene in MalaCards »

(1) OMIM Diseases for IGL Gene (146770)

genes like me logo Genes that share disorders with IGL: view

No data available for UniProtKB/Swiss-Prot for IGL Gene

Publications for IGL Gene

  1. Assignment of the genes for human lambda immunoglobulin chains to chromosome 22. (PMID: 6795508) Erikson J. … Croce C.M. (Nature 1981) 2 3
  2. Structure and expression of the human immunoglobulin lambda genes. (PMID: 2115572) Vasicek T.J. … Leder P. (J. Exp. Med. 1990) 3 23
  3. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K. … Shimizu N. (Genome Res. 1997) 3 23
  4. The lambda gene immunoglobulin repertoire of human neonatal B cells. (PMID: 17675156) Richl P. … Girschick H.J. (Mol. Immunol. 2008) 3 23
  5. Chromosomal orientation of the lambda light chain locus: V lambda is proximal to C lambda in 22q11. (PMID: 3923432) Emanuel B.S. … Croce C.M. (Nucleic Acids Res. 1985) 2 3

Products for IGL Gene

Sources for IGL Gene

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