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Aliases for IGL Gene

Aliases for IGL Gene

  • Immunoglobulin Lambda Locus 2 3
  • Immunoglobulin Lambda Gene Cluster 3
  • Ig Lambda-6 Chain C Region 3
  • IGLC6 3
  • IGL@ 3

External Ids for IGL Gene

Previous HGNC Symbols for IGL Gene

  • IGL@

Previous GeneCards Identifiers for IGL Gene

  • GC22P022407
  • GC22P022421

Summaries for IGL Gene

Entrez Gene Summary for IGL Gene

  • Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to other species. [provided by RefSeq, Jul 2008]

GeneCards Summary for IGL Gene

IGL (Immunoglobulin Lambda Locus) is a Protein Coding gene. Among its related pathways are Development Angiotensin activation of ERK and Development IGF-1 receptor signaling.

Gene Wiki entry for IGL Gene

Additional gene information for IGL Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGL Gene

Genomics for IGL Gene

Regulatory Elements for IGL Gene

Enhancers for IGL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H022029 1.1 Ensembl ENCODE 0.7 +4.3 4286 2.4 HDGF PKNOX1 RB1 SIN3A YBX1 ZNF2 RAD21 ZNF766 ZNF143 RUNX3 TOP3B IGLV5-52 ENSG00000234630 PPIL2 ENSG00000272779 PPM1F IGL IGLVI-70 IGLV4-69
GH22H022025 0.8 ENCODE 0.7 0.0 -39 2 TBP ZNF207 ATF7 RUNX3 CREM IKZF2 SMARCA5 SMAD5 CBFB JUNB ENSG00000272779 IGLVI-70 IGLV5-52 ENSG00000234630 PPIL2 TOP3B GC22P022024 IGL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGL on UCSC Golden Path with GeneCards custom track

Genomic Locations for IGL Gene

Genomic Locations for IGL Gene
896,838 bases
Plus strand

Genomic View for IGL Gene

Genes around IGL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGL Gene

Proteins for IGL Gene

Post-translational modifications for IGL Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGL Gene

Domains & Families for IGL Gene

Gene Families for IGL Gene

Suggested Antigen Peptide Sequences for IGL Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGL: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for IGL Gene

Function for IGL Gene

Phenotypes From GWAS Catalog for IGL Gene

Phenotypes for IGL Gene

GenomeRNAi human phenotypes for IGL:
genes like me logo Genes that share phenotypes with IGL: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGL Gene

Localization for IGL Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for IGL Gene

Drugs & Compounds for IGL Gene

No Compound Related Data Available

Transcripts for IGL Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGL Gene

No ASD Table

Relevant External Links for IGL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

No data available for mRNA/cDNA for IGL Gene

Expression for IGL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGL Gene

NURSA nuclear receptor signaling pathways regulating expression of IGL Gene:

genes like me logo Genes that share expression patterns with IGL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGL Gene

Orthologs for IGL Gene

No data available for Orthologs and Evolution for IGL Gene

Paralogs for IGL Gene

No data available for Paralogs for IGL Gene

Variants for IGL Gene

Relevant External Links for IGL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGL Gene

Disorders for IGL Gene

Relevant External Links for IGL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IGL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGL Gene

Publications for IGL Gene

  1. The lambda gene immunoglobulin repertoire of human neonatal B cells. (PMID: 17675156) Richl P … Girschick HJ (Molecular immunology 2008) 3 22 60
  2. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K … Shimizu N (Genome research 1997) 3 22 60
  3. Structure and expression of the human immunoglobulin lambda genes. (PMID: 2115572) Vasicek TJ … Leder P (The Journal of experimental medicine 1990) 3 22 60
  4. Chromosomal orientation of the lambda light chain locus: V lambda is proximal to C lambda in 22q11. (PMID: 3923432) Emanuel BS … Croce CM (Nucleic acids research 1985) 2 3 60
  5. Assignment of the genes for human lambda immunoglobulin chains to chromosome 22. (PMID: 6795508) Erikson J … Croce CM (Nature 1981) 2 3 60

Products for IGL Gene

Sources for IGL Gene

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