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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGL Gene

protein-coding   GIFtS: 23
GCID: GC22P022407

Immunoglobulin Lambda Locus


(Previous symbol: IGL@)
  Search for IGL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Immunoglobulin Lambda Locus1 2
IGL@1 2
IGLC62
Ig Lambda-6 Chain C Region2
Immunoglobulin Lambda Gene Cluster2
P5

External Ids:    HGNC: 58531   Entrez Gene: 35352   OMIM: 6059475   

Export aliases for IGL gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IGL Gene:
Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement
system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There
are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda
light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell
development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is
later joined by splicing at the RNA level. Recombination of many different V segments with several J segments
provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting
from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation,
which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are
known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several
non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or
homology to other species. (provided by RefSeq, Jul 2008)

GeneCards Summary for IGL Gene: 
IGL (immunoglobulin lambda locus) is a protein-coding gene. Among its related super-pathways are Immune response Lectin induced complement pathway and Immune response Role of DAP12 receptors in NK cells.

Gene Wiki entry for IGL (IGL@) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGL
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   HGNC cytogenetic band: 22q11.2

IGL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGL gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P022407:  view genomic region     (about GC identifiers)

Start:
22,380,474 bp from pter      End:
23,265,085 bp from pter
Size:
884,612 bases      Orientation:
plus strand
IGL has overlapping exons with:
IGLV4-60 BMS1P20 IGLV7-43 IGLV1-62 IGLV4-69 IGLVI-56 LOC100419915

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --
Post-translational modifications:
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_

  • IGL Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGL: Immunoglobulins / IGL locus

      --

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for IGL:
     Increased G2M DNA content 

         3 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Igl):
     cellular  hematopoietic system  immune system 

    IGL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IGL: Igltm2.1Bgmn Igltm1.1Bgmn

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IGL About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune response Lectin induced complement pathway
    Immune response Classic complement pathway0.53
    Immune response Classical complement pathway0.52
    2Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.45
    Immune response IL-4 signaling pathway0.38
    Immune response BCR pathway0.45
    Immune response CD16 signaling in NK cells0.32
    3Signal transduction IP3 signaling
    Signal transduction IP3 signaling0.92
    4Immune response NFAT in immune response
    Immune response NFAT in immune response0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 EMD Millipore Pathways for IGL (see all 7)
        Immune response Classic complement pathway
    Immune response BCR pathway
    Immune response CD16 signaling in NK cells
    Signal transduction IP3 signaling
    Immune response IL-4 signaling pathway


    5/7 GeneGo (Thomson Reuters) Pathways for IGL (see all 7)
        Immune response IL-4 signaling pathway
    Immune response Fc epsilon RI pathway
    Immune response CD16 signaling in NK cells
    Immune response Classical complement pathway
    Immune response BCR pathway



    IGL for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGL

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Search CenterWatch for drugs/clinical trials and news about IGL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IGL Expression
    About this image


    Genevestigator expression for IGL
        SABiosciences Custom PCR Arrays for IGL
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for IGL gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igl5 immunoglobulin lambda chain complex   --   16 -

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IGL
    DNA2.0 Custom Variant and Variant Library Synthesis for IGL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IGL for disorders           About MalaCards
    OMIM gene information: 605947    OMIM disorders: --


    IGL for disorders           About GeneDecksing


    Export disorders for IGL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGL gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with IGL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal orientation of the lambda light chain locus: V lambda is proximal to C lambda in 22q11. (PubMed id 3923432)1, 3 Emanuel B.S....Croce C.M. (1985)
    2. Assignment of the genes for human lambda immunoglobul in chains to chromosome 22. (PubMed id 6795508)1, 3 Erikson J....Croce C.M. (1981)
    3. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1, 9 Kawasaki K....Shimizu N. (1997)
    4. The lambda gene immunoglobulin repertoire of human neonatal B cells. (PubMed id 17675156)1, 9 Richl P....Girschick H.J. (2008)
    5. Structure and expression of the human immunoglobulin lambda genes. (PubMed id 2115572)1, 9 Vasicek T.J. and Leder P. (1990)
    6. High-affinity IgG antibodies develop naturally in Ig-k nockout rats carrying germline human IgH/Igk/Igl loci bearing the rat CH region. (PubMed id 23303672)1 Osborn M.J....Bruggemann M. (2013)
    7. Free light chain monomer-dimer patterns in the diagnos is of multiple sclerosis. (PubMed id 23376556)1 Kaplan B....Livneh A. (2013)
    8. The origin of deletion 22q11 in chronic lymphocytic le ukemia is related to the rearrangement of immunoglobulin lambda light chain locu s. (PubMed id 23608880)1 Mraz M....Pospisilova S. (2013)
    9. Combined analysis using extended renal reference range of serum free light chain ratio and serum protein electrophoresis improves the diagnostic accuracy of multiple myeloma in renal insufficiency. (PubMed id 22503879)1 Park J.W....Kim S.W. (2012)
    10. Higher serum levels of free kk plus l immunoglobulin l ight chains ameliorate survival of hemodialysis patients. (PubMed id 21646814)1 Thilo F....Tepel M. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3535 HGNC: 5853 euGenes: HUgn3535 ECgene: IGL H-InvDB: IGL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IGL gene:
    Search GeneIP for patents involving IGL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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