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Aliases for IGKV@ Gene

Aliases for IGKV@ Gene

  • Immunoglobulin Kappa Variable Cluster 3
  • Immunoglobulin Kappa Variable Region 3
  • Immunoglobulin Kappa Variable Group 3
  • IGKV1@ 3
  • IGKV2@ 3
  • IGKV3@ 3
  • IGKV1 3
  • IGKV2 3
  • IGKV3 3
  • IGKV 3

External Ids for IGKV@ Gene

Summaries for IGKV@ Gene

Entrez Gene Summary for IGKV@ Gene

  • Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains (see MIM 147100) and 2 identical light chains, either kappa or lambda (see MIM 147220), joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. The kappa and lambda light chains have no apparent functional differences. Each Ig kappa light chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by a C region gene (IGKC; MIM 147200), that provides signaling functions. The kappa light chain V region is encoded by 2 types of genes: V genes and joining (J) genes (see MIM 146970). Random selection of just 1 gene of each type to assemble a V region accounts for the great diversity of V regions among Ig molecules. The kappa light chain locus on chromosome 2 contains approximately 40 functional V genes, followed by approximately 5 functional J genes. Due to polymorphism, the numbers of functional V and J genes differ among individuals (Janeway et al., 2005).[supplied by OMIM, Apr 2008]

GeneCards Summary for IGKV@ Gene

IGKV@ (Immunoglobulin Kappa Variable Cluster) is a Gene Cluster. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Immune response NFAT in immune response.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV@ Gene

Genomics for IGKV@ Gene

Genomic Location for IGKV@ Gene

Unknown strand

Genomic View for IGKV@ Gene

Cytogenetic band:
GeneLoc Logo Gene Density

No data available for Regulatory Elements and RefSeq DNA sequence for IGKV@ Gene

Proteins for IGKV@ Gene

Post-translational modifications for IGKV@ Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGKV@ Gene

Domains & Families for IGKV@ Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGKV@ Gene

Function for IGKV@ Gene

Molecular function for IGKV@ Gene

GENATLAS Biochemistry:
immunoglobulin,kappa,variable region (32 genes,25 pseudogenes,16 sequences with minor defects,3 undetermined),in two groups called Lp (proximal) and Ld (distal)

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKV@ Gene

Localization for IGKV@ Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for IGKV@ Gene

Drugs & Compounds for IGKV@ Gene

No Compound Related Data Available

Transcripts for IGKV@ Gene

mRNA/cDNA for IGKV@ Gene

(6) Additional mRNA sequences :

Unigene Clusters for IGKV@ Gene

Immunoglobulin kappa variable cluster:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV@ Gene

No ASD Table

Expression for IGKV@ Gene

SOURCE GeneReport for Unigene cluster for IGKV@ Gene Hs.535669

No Expression Related Data Available

Primer Products

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IGKV@ Gene

Orthologs for IGKV@ Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for IGKV@ Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Igk-V 16
Species with no ortholog for IGKV@:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

No data available for Evolution for IGKV@ Gene

Paralogs for IGKV@ Gene

No data available for Paralogs for IGKV@ Gene

Variants for IGKV@ Gene

Relevant External Links for IGKV@ Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKV@ Gene

Disorders for IGKV@ Gene

Relevant External Links for IGKV@

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IGKV@: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGKV@ Gene

Publications for IGKV@ Gene

  1. The reported germline repertoire of human immunoglobulin kappa chain genes is relatively complete and accurate. (PMID: 18712520) Collins A.M. … Sewell W.A. (Immunogenetics 2008) 23 67
  2. Immunoglobulin light-chain genes in the rhesus macaque II: lambda light-chain germline sequences for subgroups IGLV1, IGLV2, IGLV3, IGLV4 and IGLV5. (PMID: 16189671) Howard W.A. … Dunn-Walters D.K. (Immunogenetics 2005) 23 67
  3. The pre-immune variable kappa repertoire of swine is selectively generated from certain subfamilies of Vkappa2 and one Jkappa gene. (PMID: 16112743) Butler J.E. … Wells K. (Vet. Immunol. Immunopathol. 2005) 23 67
  4. Immunoglobulin light-chain genes in the rhesus macaque I: kappa light-chain germline sequences for subgroups IGKV1, IGKV and IGKV3. (PMID: 15900492) Howard W.A. … Dunn-Walters D.K. (Immunogenetics 2005) 23 67
  5. Nomenclature of the human immunoglobulin kappa (IGK) genes. (PMID: 11549845) Lefranc M.P. (Exp. Clin. Immunogenet. 2001) 23 67

Products for IGKV@ Gene

Sources for IGKV@ Gene

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