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Aliases for IGKV@ Gene

Aliases for IGKV@ Gene

  • Immunoglobulin Kappa Variable Cluster 3
  • Immunoglobulin Kappa Variable Region 3
  • Immunoglobulin Kappa Variable Group 3
  • IGKV1@ 3
  • IGKV2@ 3
  • IGKV3@ 3
  • IGKV1 3
  • IGKV2 3
  • IGKV3 3
  • IGKV 3

External Ids for IGKV@ Gene

Summaries for IGKV@ Gene

Entrez Gene Summary for IGKV@ Gene

  • Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains (see MIM 147100) and 2 identical light chains, either kappa or lambda (see MIM 147220), joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. The kappa and lambda light chains have no apparent functional differences. Each Ig kappa light chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by a C region gene (IGKC; MIM 147200), that provides signaling functions. The kappa light chain V region is encoded by 2 types of genes: V genes and joining (J) genes (see MIM 146970). Random selection of just 1 gene of each type to assemble a V region accounts for the great diversity of V regions among Ig molecules. The kappa light chain locus on chromosome 2 contains approximately 40 functional V genes, followed by approximately 5 functional J genes. Due to polymorphism, the numbers of functional V and J genes differ among individuals (Janeway et al., 2005).[supplied by OMIM, Apr 2008]

GeneCards Summary for IGKV@ Gene

IGKV@ (Immunoglobulin Kappa Variable Cluster) is a Gene Cluster gene. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Immune response NFAT in immune response.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV@ Gene

Genomics for IGKV@ Gene

Genomic Location for IGKV@ Gene

Unknown strand

Genomic View for IGKV@ Gene

Cytogenetic band:

No data available for RefSeq DNA sequence and Regulatory Elements for IGKV@ Gene

Proteins for IGKV@ Gene

Post-translational modifications for IGKV@ Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGKV@ Gene

Domains for IGKV@ Gene

No data available for Gene Families , Protein Domains and UniProtKB/Swiss-Prot for IGKV@ Gene

Function for IGKV@ Gene

Molecular function for IGKV@ Gene

GENATLAS Biochemistry: immunoglobulin,kappa,variable region (32 genes,25 pseudogenes,16 sequences with minor defects,3 undetermined),in two groups called Lp (proximal) and Ld (distal)

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IGKV@ Gene

Localization for IGKV@ Gene

No data available for Gene Ontology (GO) - Cellular Components for IGKV@ Gene

Transcripts for IGKV@ Gene

mRNA/cDNA for IGKV@ Gene

(6) Additional mRNA sequences :

Unigene Clusters for IGKV@ Gene

Immunoglobulin kappa variable cluster:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV@ Gene

No ASD Table

Expression for IGKV@ Gene

SOURCE GeneReport for Unigene cluster for IGKV@ Gene Hs.535669

No Expression Related Data Available

Orthologs for IGKV@ Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for IGKV@ Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Igk-V 16
Species with no ortholog for IGKV@:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

No data available for Evolution for IGKV@ Gene

Paralogs for IGKV@ Gene

No data available for Paralogs for IGKV@ Gene

Variants for IGKV@ Gene

Relevant External Links for IGKV@ Gene

Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for IGKV@ Gene

Disorders for IGKV@ Gene

Relevant External Links for IGKV@

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IGKV@: view

No data available for UniProtKB/Swiss-Prot for IGKV@ Gene

Publications for IGKV@ Gene

  1. Distribution of human kappa locus IGKV2-29 and IGKV2D-29 alleles in Swedish Caucasians and Hong Kong Chinese. (PMID: 11261927) Padyukov L. … Hanson L.A. (Immunogenetics 2001) 3 49
  2. Immunoglobulin light chain variable (V) region genes influence clinical presentation and outcome in light chain-associated amyloidosis (AL). (PMID: 12515719) Abraham R.S. … Fonseca R. (Blood 2003) 3 49
  3. Biased immunoglobulin light chain use in the Chlamydophila psittaci negative ocular adnexal marginal zone lymphomas. (PMID: 23418012) Zhu D. … Lossos I.S. (Am. J. Hematol. 2013) 3
  4. A new apparently functional IGVK gene (VkLa) present in some individuals only. (PMID: 9601942) Juul L. … Barington T. (Immunogenetics 1998) 23
  5. The human immunoglobulin kappa variable (IGKV) genes and joining (IGKJ) segments. (PMID: 9813414) BarbiAc V. … Lefranc M.P. (Exp. Clin. Immunogenet. 1998) 23

Products for IGKV@ Gene

Sources for IGKV@ Gene

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