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Aliases for IGKV6-21 Gene

Aliases for IGKV6-21 Gene

  • Immunoglobulin Kappa Variable 6-21 (Non-Functional) 2 3 5
  • Immunoglobulin Kappa Variable 6-21 2
  • IGKV621 3
  • A26 3

External Ids for IGKV6-21 Gene

Previous GeneCards Identifiers for IGKV6-21 Gene

  • GC02U990184
  • GC02M089344
  • GC02M089362
  • GC02M089363
  • GC02M089298
  • GC02M089240
  • GC02M089462
  • GC02M089547
  • GC02M089742
  • GC02M089952
  • GC02M090127
  • GC02M089263

Summaries for IGKV6-21 Gene

GeneCards Summary for IGKV6-21 Gene

IGKV6-21 (Immunoglobulin Kappa Variable 6-21 (Non-Functional)) is a Protein Coding gene. An important paralog of this gene is IGKV6D-21.

UniProtKB/Swiss-Prot for IGKV6-21 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV6-21 Gene

Genomics for IGKV6-21 Gene

Genomic Location for IGKV6-21 Gene

Chromosome:
2
Start:
89,159,751 bp from pter
End:
89,160,366 bp from pter
Size:
616 bases
Orientation:
Minus strand

Genomic View for IGKV6-21 Gene

Genes around IGKV6-21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGKV6-21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGKV6-21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKV6-21 Gene

No data available for Regulatory Elements for IGKV6-21 Gene

Proteins for IGKV6-21 Gene

  • Protein details for IGKV6-21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A0C4DH24-KV621_HUMAN
    Recommended name:
    Immunoglobulin kappa variable 6-21
    Protein Accession:
    A0A0C4DH24

    Protein attributes for IGKV6-21 Gene

    Size:
    114 amino acids
    Molecular mass:
    12430 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGKV6-21 Gene

Post-translational modifications for IGKV6-21 Gene

No Post-translational modifications

Other Protein References for IGKV6-21 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGKV6-21 Gene

Domains & Families for IGKV6-21 Gene

Gene Families for IGKV6-21 Gene

Protein Domains for IGKV6-21 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGKV6-21: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGKV6-21 Gene

Function for IGKV6-21 Gene

Molecular function for IGKV6-21 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGKV6-21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
genes like me logo Genes that share ontologies with IGKV6-21: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKV6-21 Gene

Localization for IGKV6-21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGKV6-21 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGKV6-21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGKV6-21: view

No data available for Subcellular locations from COMPARTMENTS for IGKV6-21 Gene

Pathways & Interactions for IGKV6-21 Gene

SuperPathways for IGKV6-21 Gene

No Data Available

Interacting Proteins for IGKV6-21 Gene

Gene Ontology (GO) - Biological Process for IGKV6-21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002377 immunoglobulin production IBA --
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with IGKV6-21: view

No data available for Pathways by source and SIGNOR curated interactions for IGKV6-21 Gene

Drugs & Compounds for IGKV6-21 Gene

No Compound Related Data Available

Transcripts for IGKV6-21 Gene

mRNA/cDNA for IGKV6-21 Gene

(316) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV6-21 Gene

No ASD Table

Relevant External Links for IGKV6-21 Gene

GeneLoc Exon Structure for
IGKV6-21
ECgene alternative splicing isoforms for
IGKV6-21

Expression for IGKV6-21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGKV6-21 Gene

mRNA differential expression in normal tissues according to GTEx for IGKV6-21 Gene

This gene is overexpressed in Spleen (x16.4), Small Intestine - Terminal Ileum (x7.9), Colon - Transverse (x7.6), and Minor Salivary Gland (x5.9).

Protein differential expression in normal tissues from HIPED for IGKV6-21 Gene

This gene is overexpressed in Skin (46.8) and Urine (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGKV6-21 Gene



Protein tissue co-expression partners for IGKV6-21 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGKV6-21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGKV6-21 Gene

Orthologs for IGKV6-21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGKV6-21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 60 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 56 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 39 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU570684.3 35
  • 40 (a)
ManyToMany
CU570684.2 35
  • 38 (a)
ManyToMany
CU570684.1 35
  • 35 (a)
ManyToMany
Species where no ortholog for IGKV6-21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGKV6-21 Gene

ENSEMBL:
Gene Tree for IGKV6-21 (if available)
TreeFam:
Gene Tree for IGKV6-21 (if available)

Paralogs for IGKV6-21 Gene

Variants for IGKV6-21 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGKV6-21 Gene

KV621_HUMAN-A0A0C4DH24
There are several alleles. The sequence shown is that of IMGT allele IGKV6-21*01.

Relevant External Links for IGKV6-21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGKV6-21

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKV6-21 Gene

Disorders for IGKV6-21 Gene

No disorders were found for IGKV6-21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGKV6-21 Gene

Publications for IGKV6-21 Gene

  1. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  2. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  3. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  4. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64

Products for IGKV6-21 Gene

Sources for IGKV6-21 Gene

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