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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGKV5-2 Gene

protein-coding   GIFtS: 20
GCID: GC02P089254

Immunoglobulin Kappa Variable 5-2

  Search for IGKV5-2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Immunoglobulin Kappa Variable 5-21 2
B22
IGKV522

External Ids:    HGNC: 58351   Entrez Gene: 289072   Ensembl: ENSG000002115997   UniProtKB: P063153   

Export aliases for IGKV5-2 gene to outside databases

Previous GC identifers: GC02U990185 GC02P089082 GC02P089098 GC02P089036 GC02P089197 GC02P089198 GC02P089245


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IGKV5-2 Gene: 
IGKV5-2 (immunoglobulin kappa variable 5-2) is a protein-coding gene. An important paralog of this gene is IGKV1D-37.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGKV5-2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGKV5-2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGKV5-2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

IGKV5-2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGKV5-2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P089254:  view genomic region     (about GC identifiers)

Start:
89,196,748 bp from pter      End:
89,197,300 bp from pter
Size:
553 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: KV501_HUMAN, P06315 (See protein sequence)
Recommended Name: Ig kappa chain V region EV15 precursor  
Size: 115 amino acids; 12728 Da
Miscellaneous: This sequence does not belong to any of the previously described V-kappa subgroups. Although the
gene is located in the same region as other V-kappa genes, it appears to be the only one of its type
Miscellaneous: The gene was found to be aberrantly rearranged in an individual who does not synthesize any kappa
light chains. It has not been shown to be expressed

Explore the universe of human proteins at neXtProt for IGKV5-2: NX_P06315

Explore proteomics data for IGKV5-2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P06315

  • IGKV5-2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IGKV5-2 Protein Expression

    ENSEMBL proteins: 
     ENSP00000374779  
    Reactome Protein details: P06315
    Human Recombinant Protein Products for IGKV5-2: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005886plasma membrane ----

    IGKV5-2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGK: Immunoglobulins / IGK locus

    4 InterPro protein domains:
     IPR003596 Ig_V-set_subgr
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry P06315

    ProtoNet protein and cluster: P06315

    2 Blocks protein domains:
    IPB003596 Immunoglobulin V-type
    IPB013106 Immunoglobulin V-set



    IGKV5-2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding ----
    GO:0005515protein binding ----
         
    IGKV5-2 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    Pathways by sourceSee SuperPaths
    Show all pathways


    5/21        Reactome Pathways for IGKV5-2 (see all 21)
        FCERI mediated MAPK activation
    FCERI mediated NF-kB activation
    FCGR activation
    Role of phospholipids in phagocytosis
    Binding and Uptake of Ligands by Scavenger Receptors



    IGKV5-2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGKV5-2

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response ----
    GO:0006956complement activation ----
    GO:0006958complement activation, classical pathway ----
    GO:0038095Fc-epsilon receptor signaling pathway ----
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis ----

    IGKV5-2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for IGKV5-2 (KV501)

    Search CenterWatch for drugs/clinical trials and news about IGKV5-2 / KV501

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000390244
    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGKV5-2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IGKV5-2 Expression
    About this image


    See IGKV5-2 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for IGKV5-2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGKV5-2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IGKV5-2 gene from 2/3 species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    --
    (see all 29)
    Uncharacterized protein
    (see all 29)
    50(a)
    49(a)
    (see all 29)
    possible ortholog
    possible ortholog
    (see all 29)
    1(715486847-715487443)
    1(715687704-715688312)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 8)
    Uncharacterized protein
    (see all 8)
    37(a)
    36(a)
    (see all 8)
    possible ortholog
    possible ortholog
    (see all 8)
    6(59840548-59840910)
    6(59851072-59852268)


    ENSEMBL Gene Tree for IGKV5-2 (if available)
    TreeFam Gene Tree for IGKV5-2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGKV5-2 gene
    IGKV1D-372  IGKV3D-112  IGKV1D-82  IGKV1D-332  IGKV4-12  IGKV1-62  IGKV3-112  IGKV1D-122  
    IGKV3D-72  IGKV2-402  IGKV3OR2-2682  IGKV3-202  ENSG000002709992  IGKV1OR2-1082  IGKV1-162  IGKV1-172  
    IGKV1-82  IGKV1-272  IGKV2D-262  IGKV1-392  IGKV6D-212  IGKV1-52  IGKV1-372  IGKV1-332  
    IGKV1D-172  IGKV2-302  ENSG000002283252  IGKV2D-302  IGKV1D-132  IGKV1D-392  IGKV2-282  IGKV1-122  
    IGKV3-72  IGKV3D-202  IGKV2D-282  IGKV1D-432  IGKV3-152  IGKV3D-152  IGKV1-92  IGKV1D-162  
    IGKV1D-422  IGKV6-212  IGKV2D-242  IGKV2-242  IGKV2D-292  IGKV2D-402  IGKV6D-412  

    IGKV5-2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IGKV5-2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGKV5-2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with IGKV5-2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Aberrant recombination events in B cell lines derived from a kappa- deficient human. (PubMed id 3925437)1, 2 Stavnezer J.... Zegers B.J.M. (1985)
    2. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)2 Liu T.... Smith R.D. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28907 HGNC: 5835 Ensembl:ENSG00000211599 euGenes: HUgn28907 ECgene: IGKV5-2
    H-InvDB: IGKV5-2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGKV5-2 Pharmacogenomics, SNPs, Pathways
    IMGT entry for IGKV5-2 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IGKV5-2 gene:
    Search GeneIP for patents involving IGKV5-2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
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     Search LifeMap BioReagents cell lines for IGKV5-2
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGKV5-2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for IGKV5-2
     Browse SwitchGear Promoter luciferase reporter plasmids for IGKV5-2
     Search ThermoFisher Antibodies for IGKV5-2
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGKV5-2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for IGKV5-2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGKV5-2
    Customized:
     lentivirus for stable overexpression of IGKV5-2
     lentivirus expression plasmids for stable overexpression of IGKV5-2
     adenovirus for overexpression of IGKV5-2
     Search LSBio for Antibodies for IGKV5-2
    Customized transgenic rodents for:
     Humanization
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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