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Aliases for IGKV5-2 Gene

Aliases for IGKV5-2 Gene

  • Immunoglobulin Kappa Variable 5-2 2 3
  • IGKV52 3
  • B2 3

External Ids for IGKV5-2 Gene

Summaries for IGKV5-2 Gene

GeneCards Summary for IGKV5-2 Gene

IGKV5-2 (Immunoglobulin Kappa Variable 5-2) is a Protein Coding gene. An important paralog of this gene is IGKV3D-15.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV5-2 Gene

Genomics for IGKV5-2 Gene

Genomic Location for IGKV5-2 Gene

Start:
88,897,232 bp from pter
End:
88,897,784 bp from pter
Size:
553 bases
Orientation:
Plus strand

Genomic View for IGKV5-2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGKV5-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKV5-2 Gene

No data available for Regulatory Elements for IGKV5-2 Gene

Proteins for IGKV5-2 Gene

  • Protein details for IGKV5-2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06315-KV501_HUMAN
    Recommended name:
    Ig kappa chain V region EV15
    Protein Accession:
    P06315
    Secondary Accessions:

    Protein attributes for IGKV5-2 Gene

    Size:
    115 amino acids
    Molecular mass:
    12728 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene was found to be aberrantly rearranged in an individual who does not synthesize any kappa light chains. It has not been shown to be expressed
    • This sequence does not belong to any of the previously described V-kappa subgroups. Although the gene is located in the same region as other V-kappa genes, it appears to be the only one of its type

neXtProt entry for IGKV5-2 Gene

Proteomics data for IGKV5-2 Gene at MOPED

Post-translational modifications for IGKV5-2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGKV5-2 Gene

ENSEMBL proteins:
Reactome Protein details:

No data available for DME Specific Peptides for IGKV5-2 Gene

Domains for IGKV5-2 Gene

Gene Families for IGKV5-2 Gene

HGNC:
  • IGK :Immunoglobulins / IGK locus

Protein Domains for IGKV5-2 Gene

genes like me logo Genes that share domains with IGKV5-2: view

No data available for UniProtKB/Swiss-Prot for IGKV5-2 Gene

Function for IGKV5-2 Gene

Gene Ontology (GO) - Molecular Function for IGKV5-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IGKV5-2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IGKV5-2 Gene

Localization for IGKV5-2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGKV5-2 Gene COMPARTMENTS Subcellular localization image for IGKV5-2 gene
Compartment Confidence
extracellular 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for IGKV5-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005886 plasma membrane --
genes like me logo Genes that share ontologies with IGKV5-2: view

Pathways for IGKV5-2 Gene

SuperPathways for IGKV5-2 Gene

No Data Available

Interacting Proteins for IGKV5-2 Gene

Gene Ontology (GO) - Biological Process for IGKV5-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response --
GO:0006956 complement activation --
GO:0006958 complement activation, classical pathway --
GO:0038095 Fc-epsilon receptor signaling pathway --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis --
genes like me logo Genes that share ontologies with IGKV5-2: view

No data available for Pathways by source for IGKV5-2 Gene

Transcripts for IGKV5-2 Gene

mRNA/cDNA for IGKV5-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV5-2 Gene

No ASD Table

Relevant External Links for IGKV5-2 Gene

GeneLoc Exon Structure for
IGKV5-2
ECgene alternative splicing isoforms for
IGKV5-2

Expression for IGKV5-2 Gene

mRNA expression in normal human tissues for IGKV5-2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGKV5-2 Gene

This gene is overexpressed in Spleen (9.4), Colon - Transverse (6.4), and Whole Blood (5.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IGKV5-2 Gene

genes like me logo Genes that share expressions with IGKV5-2: view

Orthologs for IGKV5-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGKV5-2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 37
  • 19 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia IGKV5-2 37
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 47 (a)
OneToMany
-- 37
  • 41 (a)
OneToMany
-- 37
  • 34 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 32 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU570684.1 37
  • 30 (a)
ManyToMany
CU570684.2 37
  • 30 (a)
ManyToMany
CU570684.3 37
  • 30 (a)
ManyToMany
Species with no ortholog for IGKV5-2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGKV5-2 Gene

ENSEMBL:
Gene Tree for IGKV5-2 (if available)
TreeFam:
Gene Tree for IGKV5-2 (if available)

Paralogs for IGKV5-2 Gene

genes like me logo Genes that share paralogs with IGKV5-2: view

Variants for IGKV5-2 Gene

Relevant External Links for IGKV5-2 Gene

HapMap Linkage Disequilibrium report
IGKV5-2

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for IGKV5-2 Gene

Disorders for IGKV5-2 Gene

No disorders were found for IGKV5-2 Gene.

No data available for UniProtKB/Swiss-Prot for IGKV5-2 Gene

Publications for IGKV5-2 Gene

  1. Aberrant recombination events in B cell lines derived from a kappa- deficient human. (PMID: 3925437) Stavnezer J. … Zegers B.J.M. (Nucleic Acids Res. 1985) 3 4
  2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 4
  3. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V. … Han D.K. (Sci. Signal. 2009) 4

Products for IGKV5-2 Gene

Sources for IGKV5-2 Gene

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