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Aliases for IGKV5-2 Gene

Aliases for IGKV5-2 Gene

  • Immunoglobulin Kappa Variable 5-2 2 3 5
  • Ig Kappa Chain V Region EV15 3 4
  • IGKV52 3
  • B2 3

External Ids for IGKV5-2 Gene

Previous GeneCards Identifiers for IGKV5-2 Gene

  • GC02U990185
  • GC02P089082
  • GC02P089098
  • GC02P089036
  • GC02P089197
  • GC02P089198
  • GC02P089245
  • GC02P089254
  • GC02P089264

Summaries for IGKV5-2 Gene

GeneCards Summary for IGKV5-2 Gene

IGKV5-2 (Immunoglobulin Kappa Variable 5-2) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Role of phospholipids in phagocytosis. GO annotations related to this gene include antigen binding.

UniProtKB/Swiss-Prot for IGKV5-2 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV5-2 Gene

Genomics for IGKV5-2 Gene

Genomic Location for IGKV5-2 Gene

Chromosome:
2
Start:
88,897,232 bp from pter
End:
88,897,784 bp from pter
Size:
553 bases
Orientation:
Plus strand

Genomic View for IGKV5-2 Gene

Genes around IGKV5-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGKV5-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGKV5-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKV5-2 Gene

No data available for Regulatory Elements for IGKV5-2 Gene

Proteins for IGKV5-2 Gene

  • Protein details for IGKV5-2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06315-KV502_HUMAN
    Recommended name:
    Immunoglobulin kappa variable 5-2
    Protein Accession:
    P06315

    Protein attributes for IGKV5-2 Gene

    Size:
    115 amino acids
    Molecular mass:
    12728 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGKV5-2 Gene

Post-translational modifications for IGKV5-2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGKV5-2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGKV5-2 Gene

Domains & Families for IGKV5-2 Gene

Gene Families for IGKV5-2 Gene

Protein Domains for IGKV5-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGKV5-2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGKV5-2 Gene

Function for IGKV5-2 Gene

Molecular function for IGKV5-2 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGKV5-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 3925437
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGKV5-2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKV5-2 Gene

Localization for IGKV5-2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGKV5-2 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGKV5-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGKV5-2: view

No data available for Subcellular locations from COMPARTMENTS for IGKV5-2 Gene

Pathways & Interactions for IGKV5-2 Gene

genes like me logo Genes that share pathways with IGKV5-2: view

Interacting Proteins for IGKV5-2 Gene

Gene Ontology (GO) - Biological Process for IGKV5-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 3925437
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGKV5-2: view

No data available for SIGNOR curated interactions for IGKV5-2 Gene

Transcripts for IGKV5-2 Gene

mRNA/cDNA for IGKV5-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV5-2 Gene

No ASD Table

Relevant External Links for IGKV5-2 Gene

GeneLoc Exon Structure for
IGKV5-2
ECgene alternative splicing isoforms for
IGKV5-2

Expression for IGKV5-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGKV5-2 Gene

mRNA differential expression in normal tissues according to GTEx for IGKV5-2 Gene

This gene is overexpressed in Spleen (x9.4), Colon - Transverse (x6.4), and Whole Blood (x5.8).

Protein differential expression in normal tissues from HIPED for IGKV5-2 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGKV5-2 Gene



Protein tissue co-expression partners for IGKV5-2 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGKV5-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGKV5-2 Gene

Orthologs for IGKV5-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGKV5-2 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 47 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
-- 35
  • 34 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia IGKV5-2 35
  • 43 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 19 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 32 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU570684.1 35
  • 30 (a)
ManyToMany
CU570684.2 35
  • 30 (a)
ManyToMany
CU570684.3 35
  • 30 (a)
ManyToMany
Species where no ortholog for IGKV5-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGKV5-2 Gene

ENSEMBL:
Gene Tree for IGKV5-2 (if available)
TreeFam:
Gene Tree for IGKV5-2 (if available)

Paralogs for IGKV5-2 Gene

No data available for Paralogs for IGKV5-2 Gene

Variants for IGKV5-2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGKV5-2 Gene

KV502_HUMAN-P06315
There are several alleles. The sequence shown is that of IMGT allele IGKV5-2*01.

Relevant External Links for IGKV5-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGKV5-2

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKV5-2 Gene

Disorders for IGKV5-2 Gene

No disorders were found for IGKV5-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGKV5-2 Gene

Publications for IGKV5-2 Gene

  1. Aberrant recombination events in B cell lines derived from a kappa- deficient human. (PMID: 3925437) Stavnezer J. … Zegers B.J.M. (Nucleic Acids Res. 1985) 3 4 64
  2. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  3. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  4. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V. … Han D.K. (Sci. Signal. 2009) 4 64

Products for IGKV5-2 Gene

Sources for IGKV5-2 Gene

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