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Aliases for IGKV4-1 Gene

Aliases for IGKV4-1 Gene

  • Immunoglobulin Kappa Variable 4-1 2 3
  • IGKV41 3
  • B3 3

External Ids for IGKV4-1 Gene

Previous GeneCards Identifiers for IGKV4-1 Gene

  • GC02P088739
  • GC02M089478
  • GC02P089070
  • GC02P089087
  • GC02P089024
  • GC02P089184

Summaries for IGKV4-1 Gene

GeneCards Summary for IGKV4-1 Gene

IGKV4-1 (Immunoglobulin Kappa Variable 4-1) is a Protein Coding gene. Among its related pathways are PI3K/AKT Signaling in Cancer and Immune System. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGKV3D-15.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV4-1 Gene

Genomics for IGKV4-1 Gene

Genomic Location for IGKV4-1 Gene

Chromosome:
2
Start:
88,885,397 bp from pter
End:
88,886,153 bp from pter
Size:
757 bases
Orientation:
Plus strand

Genomic View for IGKV4-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for IGKV4-1 Gene

No data available for Regulatory Elements for IGKV4-1 Gene

Proteins for IGKV4-1 Gene

  • Protein details for IGKV4-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06312-KV401_HUMAN
    Recommended name:
    Ig kappa chain V-IV region
    Protein Accession:
    P06312

    Protein attributes for IGKV4-1 Gene

    Size:
    121 amino acids
    Molecular mass:
    13380 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • There is only one Ig kappa V-IV gene
    SequenceCaution:
    • Sequence=CAA77318.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for IGKV4-1 Gene

Proteomics data for IGKV4-1 Gene at MOPED

Post-translational modifications for IGKV4-1 Gene

No Post-translational modifications

Other Protein References for IGKV4-1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGKV4-1 Gene

Domains & Families for IGKV4-1 Gene

Gene Families for IGKV4-1 Gene

Protein Domains for IGKV4-1 Gene

Suggested Antigen Peptide Sequences for IGKV4-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGKV4-1: view

No data available for UniProtKB/Swiss-Prot for IGKV4-1 Gene

Function for IGKV4-1 Gene

Gene Ontology (GO) - Molecular Function for IGKV4-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 2997712
genes like me logo Genes that share ontologies with IGKV4-1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKV4-1 Gene

Localization for IGKV4-1 Gene

Gene Ontology (GO) - Cellular Components for IGKV4-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with IGKV4-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for IGKV4-1 Gene

Pathways & Interactions for IGKV4-1 Gene

genes like me logo Genes that share pathways with IGKV4-1: view

Interacting Proteins for IGKV4-1 Gene

Selected Interacting proteins: P06312-KV401_HUMAN for IGKV4-1 Gene via I2D

Symbol External ID(s) Details
USP45

Gene Ontology (GO) - Biological Process for IGKV4-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002377 immunoglobulin production IBA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 2997712
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
genes like me logo Genes that share ontologies with IGKV4-1: view

No data available for SIGNOR curated interactions for IGKV4-1 Gene

Drugs & Compounds for IGKV4-1 Gene

No Compound Related Data Available

Transcripts for IGKV4-1 Gene

mRNA/cDNA for IGKV4-1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV4-1 Gene

No ASD Table

Relevant External Links for IGKV4-1 Gene

GeneLoc Exon Structure for
IGKV4-1
ECgene alternative splicing isoforms for
IGKV4-1

Expression for IGKV4-1 Gene

mRNA expression in normal human tissues for IGKV4-1 Gene

mRNA differential expression in normal tissues according to GTEx for IGKV4-1 Gene

This gene is overexpressed in Spleen (x14.6), Colon - Transverse (x7.4), Minor Salivary Gland (x4.8), and Small Intestine - Terminal Ileum (x4.7).

Protein differential expression in normal tissues from HIPED for IGKV4-1 Gene

This gene is overexpressed in Urine (27.4), Pancreatic juice (16.4), Serum (6.7), and Skin (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGKV4-1 Gene



genes like me logo Genes that share expression patterns with IGKV4-1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IGKV4-1 Gene

Orthologs for IGKV4-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGKV4-1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia IGKV4-1 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 53 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
Species with no ortholog for IGKV4-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGKV4-1 Gene

ENSEMBL:
Gene Tree for IGKV4-1 (if available)
TreeFam:
Gene Tree for IGKV4-1 (if available)

Paralogs for IGKV4-1 Gene

genes like me logo Genes that share paralogs with IGKV4-1: view

Variants for IGKV4-1 Gene

Relevant External Links for IGKV4-1 Gene

HapMap Linkage Disequilibrium report
IGKV4-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKV4-1 Gene

Disorders for IGKV4-1 Gene

genes like me logo Genes that share disorders with IGKV4-1: view

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGKV4-1 Gene

Publications for IGKV4-1 Gene

  1. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. (PMID: 22516433) Bastos-Amador P. … Falcon-Perez J.M. (J Proteomics 2012) 67
  2. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 67
  3. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 67
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 67
  5. Recognition of immunoglobulins by Fcgamma receptors. (PMID: 11955599) Radaev S. … Sun P. (Mol. Immunol. 2002) 67

Products for IGKV4-1 Gene

Sources for IGKV4-1 Gene

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