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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGKV4-1 Gene

protein-coding   GIFtS: 28
GCID: GC02P089184

Immunoglobulin Kappa Variable 4-1

  Search for IGKV4-1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Immunoglobulin Kappa Variable 4-11 2
B32
IGKV412

External Ids:    HGNC: 58341   Entrez Gene: 289082   Ensembl: ENSG000002115987   UniProtKB: P063123   

Export aliases for IGKV4-1 gene to outside databases

Previous GC identifers: GC02P088739 GC02M089478 GC02P089070 GC02P089087 GC02P089024


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IGKV4-1 Gene: 
IGKV4-1 (immunoglobulin kappa variable 4-1) is a protein-coding gene. Among its related super-pathways are Classical antibody-mediated complement activation and FCERI mediated MAPK activation. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGKV1D-37.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGKV4-1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGKV4-1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGKV4-1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

IGKV4-1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGKV4-1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P089184:  view genomic region     (about GC identifiers)

Start:
89,184,913 bp from pter      End:
89,185,669 bp from pter
Size:
757 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KV401_HUMAN, P06312 (See protein sequence)
Recommended Name: Ig kappa chain V-IV region precursor  
Size: 121 amino acids; 13380 Da
Miscellaneous: There is only one Ig kappa V-IV gene

Explore the universe of human proteins at neXtProt for IGKV4-1: NX_P06312

Explore proteomics data for IGKV4-1 at MOPED 

IGKV4-1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IGKV4-1 Protein Expression

ENSEMBL proteins: 
 ENSP00000374778  
Reactome Protein details: P06312
Human Recombinant Protein Products for IGKV4-1: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005886plasma membrane TAS--

IGKV4-1 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IGK: Immunoglobulins / IGK locus

4 InterPro protein domains:
 IPR003596 Ig_V-set_subgr
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set
 IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry P06312

ProtoNet protein and cluster: P06312

2 Blocks protein domains:
IPB003596 Immunoglobulin V-type
IPB013106 Immunoglobulin V-set



IGKV4-1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding NAS2997712
GO:0005515protein binding ----
     
IGKV4-1 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IGKV4-1 About   (see all 7)                                                                                              See pathways by source

SuperPathContained pathways About
1Classical antibody-mediated complement activation
Classical antibody-mediated complement activation0.88
FCGR activation0.70
Creation of C4 and C2 activators0.88
Role of phospholipids in phagocytosis0.65
Initial triggering of complement0.86
FCERI mediated NF-kB activation0.47
Complement cascade0.76
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30
2FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization0.60
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.31
FCERI mediated MAPK activation0.60
3Immune System
Immune System0.56
Innate Immune System0.50
Adaptive Immune System0.56
4Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation0.80
Fcgamma receptor (FCGR) dependent phagocytosis0.80
5Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling0.69
Role of LAT2/NTAL/LAB on calcium mobilization0.69

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


5/21        Reactome Pathways for IGKV4-1 (see all 21)
    FCERI mediated MAPK activation
FCERI mediated NF-kB activation
FCGR activation
Role of phospholipids in phagocytosis
Binding and Uptake of Ligands by Scavenger Receptors



IGKV4-1 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGKV4-1

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for IGKV4-1 (P063123 ENSP000003747784) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
USP45Q70EL23, ENSP000003333764I2D: score=1 STRING: ENSP00000333376
IGHG1ENSP000003749904STRING: ENSP00000374990
IGHV1-69ENSP000003750424STRING: ENSP00000375042
IGHV3-23ENSP000003750184STRING: ENSP00000375018
KNCNENSP000003796074STRING: ENSP00000379607
About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS2997712
GO:0006956complement activation TAS--
GO:0006958complement activation, classical pathway TAS--
GO:0038095Fc-epsilon receptor signaling pathway TAS--
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--

IGKV4-1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGKV4-1 (KV401)

Search CenterWatch for drugs/clinical trials and news about IGKV4-1 / KV401

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390243(uc021vku.1)
miRNA
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Inhib. RNA
Products:
     
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24/157 AceView cDNA sequences (see all 157):

S56916 AJ004955 S62210 AJ004956 AA300651 AA581006 L06022 AW139470 
AU076777 Z46347 Y17952 AF099194 AF455560 M26439 AW404598 AY271359 
AY204756 CD683812 S62695 AB063957 AF099195 Z18328 CD701031 BM769250 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGKV4-1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGKV4-1 Expression
About this image


See IGKV4-1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGKV4-1
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGKV4-1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of mammals.

Orthologs for IGKV4-1 gene from 1/2 species (see all 2)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia IGKV4-16
--
Uncharacterized protein
65(a)
62(a)
1 ↔ 1
possible ortholog
17(37557756-37558115)
17(37729129-37729735)


ENSEMBL Gene Tree for IGKV4-1 (if available)
TreeFam Gene Tree for IGKV4-1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGKV4-1 gene
IGKV1D-372  IGKV3D-112  IGKV1D-82  IGKV1D-332  IGKV1-62  IGKV3-112  IGKV1D-122  IGKV3D-72  
IGKV2-402  IGKV3OR2-2682  IGKV3-202  ENSG000002709992  IGKV1OR2-1082  IGKV1-162  IGKV1-172  IGKV1-82  
IGKV1-272  IGKV2D-262  IGKV1-392  IGKV6D-212  IGKV1-52  IGKV1-372  IGKV1-332  IGKV1D-172  
IGKV2-302  ENSG000002283252  IGKV2D-302  IGKV1D-132  IGKV1D-392  IGKV2-282  IGKV1-122  IGKV5-22  
IGKV3-72  IGKV3D-202  IGKV2D-282  IGKV1D-432  IGKV3-152  IGKV3D-152  IGKV1-92  IGKV1D-162  
IGKV1D-422  IGKV6-212  IGKV2D-242  IGKV2-242  IGKV2D-292  IGKV2D-402  IGKV6D-412  
18/71 SIMAP similar genes for IGKV4-1 using alignment to 1 protein entry:     KV401_HUMAN(see all similar genes):
V1    VKA17    VK3    A30    IGKV A18    IGKV1-5
SDNK1    scFv    IGK@    V3    VL3L    IGLV2-11
V1-2    V1-4    VL1    IGLV1-40    V1-18    IGLV1-36

IGKV4-1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGKV4-1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGKV4-1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Subgroup IV of human immunoglobulin K light chains is encoded by a single germline gene. (PubMed id 2997712)1, 2 Klobeck H.G....Zachau H.G. (1985)
  2. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
  3. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
  4. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (2002)
  5. Activation of C1r by proteolytic cleavage. (PubMed id 1249422)1 Ziccardi R.J. and Cooper N.R. (1976)
  6. Physicochemical and functional characterization of the C1r subunit of the first complement component. (PubMed id 814163)1 Ziccardi R.J. and Cooper N.R. (1976)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28908 HGNC: 5834 AceView: IGKV4-1 Ensembl:ENSG00000211598 euGenes: HUgn28908
ECgene: IGKV4-1 H-InvDB: IGKV4-1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGKV4-1 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGKV4-1 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGKV4-1&species=Homo+sapiens

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGKV4-1 gene:
Search GeneIP for patents involving IGKV4-1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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