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Aliases for IGKV4-1 Gene

Aliases for IGKV4-1 Gene

  • Immunoglobulin Kappa Variable 4-1 2 3 5
  • IGKV41 3
  • B3 3

External Ids for IGKV4-1 Gene

Previous GeneCards Identifiers for IGKV4-1 Gene

  • GC02P088739
  • GC02M089478
  • GC02P089070
  • GC02P089087
  • GC02P089024
  • GC02P089184

Summaries for IGKV4-1 Gene

GeneCards Summary for IGKV4-1 Gene

IGKV4-1 (Immunoglobulin Kappa Variable 4-1) is a Protein Coding gene. Among its related pathways are Immune System and Regulation of actin dynamics for phagocytic cup formation. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGKV2D-24.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV4-1 Gene

Genomics for IGKV4-1 Gene

Regulatory Elements for IGKV4-1 Gene

Promoters for IGKV4-1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IGKV4-1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGKV4-1 Gene

Chromosome:
2
Start:
88,885,397 bp from pter
End:
88,886,153 bp from pter
Size:
757 bases
Orientation:
Plus strand

Genomic View for IGKV4-1 Gene

Genes around IGKV4-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGKV4-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGKV4-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKV4-1 Gene

Proteins for IGKV4-1 Gene

  • Protein details for IGKV4-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06312-KV401_HUMAN
    Recommended name:
    Ig kappa chain V-IV region
    Protein Accession:
    P06312

    Protein attributes for IGKV4-1 Gene

    Size:
    121 amino acids
    Molecular mass:
    13380 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • There is only one Ig kappa V-IV gene.
    SequenceCaution:
    • Sequence=CAA77318.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for IGKV4-1 Gene

Proteomics data for IGKV4-1 Gene at MOPED

Post-translational modifications for IGKV4-1 Gene

No Post-translational modifications

Other Protein References for IGKV4-1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGKV4-1 Gene

Domains & Families for IGKV4-1 Gene

Gene Families for IGKV4-1 Gene

Protein Domains for IGKV4-1 Gene

Suggested Antigen Peptide Sequences for IGKV4-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGKV4-1: view

No data available for UniProtKB/Swiss-Prot for IGKV4-1 Gene

Function for IGKV4-1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKV4-1 Gene

Localization for IGKV4-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for IGKV4-1 Gene

Pathways & Interactions for IGKV4-1 Gene

genes like me logo Genes that share pathways with IGKV4-1: view

Interacting Proteins for IGKV4-1 Gene

Selected Interacting proteins: P06312-KV401_HUMAN for IGKV4-1 Gene via I2D

Symbol External ID(s) Details
USP45

Gene Ontology (GO) - Biological Process for IGKV4-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002377 immunoglobulin production IBA --
GO:0006956 complement activation TAS --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with IGKV4-1: view

No data available for SIGNOR curated interactions for IGKV4-1 Gene

Drugs & Compounds for IGKV4-1 Gene

No Compound Related Data Available

Transcripts for IGKV4-1 Gene

mRNA/cDNA for IGKV4-1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV4-1 Gene

No ASD Table

Relevant External Links for IGKV4-1 Gene

GeneLoc Exon Structure for
IGKV4-1
ECgene alternative splicing isoforms for
IGKV4-1

Expression for IGKV4-1 Gene

mRNA expression in normal human tissues for IGKV4-1 Gene

mRNA differential expression in normal tissues according to GTEx for IGKV4-1 Gene

This gene is overexpressed in Spleen (x14.6), Colon - Transverse (x7.4), Minor Salivary Gland (x4.8), and Small Intestine - Terminal Ileum (x4.7).

Protein differential expression in normal tissues from HIPED for IGKV4-1 Gene

This gene is overexpressed in Urine (27.4), Pancreatic juice (16.4), Serum (6.7), and Skin (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGKV4-1 Gene



genes like me logo Genes that share expression patterns with IGKV4-1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IGKV4-1 Gene

Orthologs for IGKV4-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGKV4-1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia IGKV4-1 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 53 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
Species with no ortholog for IGKV4-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGKV4-1 Gene

ENSEMBL:
Gene Tree for IGKV4-1 (if available)
TreeFam:
Gene Tree for IGKV4-1 (if available)

Paralogs for IGKV4-1 Gene

genes like me logo Genes that share paralogs with IGKV4-1: view

Variants for IGKV4-1 Gene

Relevant External Links for IGKV4-1 Gene

HapMap Linkage Disequilibrium report
IGKV4-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKV4-1 Gene

Disorders for IGKV4-1 Gene

No disorders were found for IGKV4-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGKV4-1 Gene

Publications for IGKV4-1 Gene

  1. Subgroup IV of human immunoglobulin K light chains is encoded by a single germline gene. (PMID: 2997712) Klobeck H.G. … Zachau H.G. (Nucleic Acids Res. 1985) 3 4 67
  2. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. (PMID: 22516433) Bastos-Amador P. … Falcon-Perez J.M. (J Proteomics 2012) 3
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  4. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3
  5. Recognition of immunoglobulins by Fcgamma receptors. (PMID: 11955599) Radaev S. … Sun P. (Mol. Immunol. 2002) 3

Products for IGKV4-1 Gene

Sources for IGKV4-1 Gene

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