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Aliases for IGKV3D-11 Gene

Aliases for IGKV3D-11 Gene

  • Immunoglobulin Kappa Variable 3D-11 2 3 5
  • IGKV3D11 3
  • L20 3

External Ids for IGKV3D-11 Gene

Previous GeneCards Identifiers for IGKV3D-11 Gene

  • GC02U990154
  • GC02P089953
  • GC02P089971
  • GC02P089972
  • GC02P089907
  • GC02P089852
  • GC02P090212
  • GC02P090115
  • GC02P090118

Summaries for IGKV3D-11 Gene

GeneCards Summary for IGKV3D-11 Gene

IGKV3D-11 (Immunoglobulin Kappa Variable 3D-11) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Role of phospholipids in phagocytosis. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGKV3-11.

UniProtKB/Swiss-Prot for IGKV3D-11 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV3D-11 Gene

Genomics for IGKV3D-11 Gene

Genomic Location for IGKV3D-11 Gene

Chromosome:
2
Start:
90,172,802 bp from pter
End:
90,173,414 bp from pter
Size:
613 bases
Orientation:
Plus strand

Genomic View for IGKV3D-11 Gene

Genes around IGKV3D-11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGKV3D-11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGKV3D-11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKV3D-11 Gene

No data available for Regulatory Elements for IGKV3D-11 Gene

Proteins for IGKV3D-11 Gene

  • Protein details for IGKV3D-11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A0A0MRZ8-KVD11_HUMAN
    Recommended name:
    Immunoglobulin kappa variable 3D-11
    Protein Accession:
    A0A0A0MRZ8

    Protein attributes for IGKV3D-11 Gene

    Size:
    115 amino acids
    Molecular mass:
    12625 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGKV3D-11 Gene

Post-translational modifications for IGKV3D-11 Gene

No Post-translational modifications

Other Protein References for IGKV3D-11 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGKV3D-11 Gene

Domains & Families for IGKV3D-11 Gene

Gene Families for IGKV3D-11 Gene

Protein Domains for IGKV3D-11 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGKV3D-11: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGKV3D-11 Gene

Function for IGKV3D-11 Gene

Molecular function for IGKV3D-11 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGKV3D-11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS,IEA 6440122
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGKV3D-11: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKV3D-11 Gene

Localization for IGKV3D-11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGKV3D-11 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGKV3D-11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with IGKV3D-11: view

No data available for Subcellular locations from COMPARTMENTS for IGKV3D-11 Gene

Pathways & Interactions for IGKV3D-11 Gene

genes like me logo Genes that share pathways with IGKV3D-11: view

Interacting Proteins for IGKV3D-11 Gene

Gene Ontology (GO) - Biological Process for IGKV3D-11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002377 immunoglobulin production IBA --
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
genes like me logo Genes that share ontologies with IGKV3D-11: view

No data available for SIGNOR curated interactions for IGKV3D-11 Gene

Drugs & Compounds for IGKV3D-11 Gene

No Compound Related Data Available

Transcripts for IGKV3D-11 Gene

mRNA/cDNA for IGKV3D-11 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV3D-11 Gene

No ASD Table

Relevant External Links for IGKV3D-11 Gene

GeneLoc Exon Structure for
IGKV3D-11
ECgene alternative splicing isoforms for
IGKV3D-11

Expression for IGKV3D-11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGKV3D-11 Gene

mRNA differential expression in normal tissues according to GTEx for IGKV3D-11 Gene

This gene is overexpressed in Spleen (x13.2), Colon - Transverse (x5.9), and Minor Salivary Gland (x4.7).

Protein differential expression in normal tissues from HIPED for IGKV3D-11 Gene

This gene is overexpressed in Urine (44.5) and Serum (22.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGKV3D-11 Gene



Protein tissue co-expression partners for IGKV3D-11 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGKV3D-11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGKV3D-11 Gene

Orthologs for IGKV3D-11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGKV3D-11 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 77 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 58 (a)
ManyToMany
-- 35
  • 57 (a)
ManyToMany
-- 35
  • 57 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
Species where no ortholog for IGKV3D-11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGKV3D-11 Gene

ENSEMBL:
Gene Tree for IGKV3D-11 (if available)
TreeFam:
Gene Tree for IGKV3D-11 (if available)

Paralogs for IGKV3D-11 Gene

Variants for IGKV3D-11 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGKV3D-11 Gene

KVD11_HUMAN-A0A0A0MRZ8
There are several alleles. The sequence shown is that of IMGT allele IGKV3D-11*02.

Relevant External Links for IGKV3D-11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGKV3D-11

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKV3D-11 Gene

Disorders for IGKV3D-11 Gene

No disorders were found for IGKV3D-11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGKV3D-11 Gene

Publications for IGKV3D-11 Gene

  1. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 64
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3 64
  4. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. (PMID: 22516433) Bastos-Amador P. … Falcon-Perez J.M. (J Proteomics 2012) 3 64
  5. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64

Products for IGKV3D-11 Gene

Sources for IGKV3D-11 Gene

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