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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGKV3-20 Gene

protein-coding   GIFtS: 26
GCID: GC02M089741

immunoglobulin kappa variable 3-20
 Explore 3 diseases affiliated with
IGKV3-20 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGKV3-20    

Aliases
for IGKV3-20 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immunoglobulin Kappa Variable 3-201 2
13K182
A272
IGKV3202

External Ids:    HGNC: 58171   Entrez Gene: 289122   Ensembl: ENSG000002399517   UniProtKB: P181363   

Export aliases for IGKV3-20 gene to outside databases

Previous GC identifers: GC02U990190 GC02M089327 GC02M089345 GC02M089346 GC02M089281 GC02M089224 GC02M089443 GC02M089537


Summaries
for IGKV3-20 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for IGKV3-20 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGKV3-20
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGKV3-20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGKV3-20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

IGKV3-20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGKV3-20 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M089741:  view genomic region     (about GC identifiers)

Start:
 89,442,057 bp from pter      End:
 89,442,643 bp from pter
Size:
 587 bases      Orientation:
 minus strand

Proteins
for IGKV3-20 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KV313_HUMAN, P18136 (See protein sequence)
Recommended Name: Ig kappa chain V-III region HIC precursor  
Size: 129 amino acids; 14089 Da
Miscellaneous: One of the surface immunoglobulin M autoantibodies expressed in patients with chronic lymphocytic
leukemia

Explore the universe of human proteins at neXtProt for IGKV3-20: NX_P18136

IGKV3-20 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).


ENSEMBL proteins: 
 ENSP00000418649  
Reactome Protein details: P18136
Human Recombinant Protein Products: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005886plasma membrane TAS--


IGKV3-20 for ontologies           About GeneDecksing



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Protein Domains /
Families
for IGKV3-20 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
IGKV3-20 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR007110 Ig-like_dom
 IPR003596 Ig_V-set_subgr
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry P18136

ProtoNet protein and cluster: P18136

2 Blocks protein families:
IPB003596 Immunoglobulin V-type
IPB013106 Immunoglobulin V-set



Function
for IGKV3-20 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
Products:    		Browse 3'-UTR reporter clones for miRNA target validation
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGKV3-20
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Inhib. RNA
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Gene Editing
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Clone
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Cell Line
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In Situ Assay
Products:   
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding NAS3127527


IGKV3-20 for ontologies           About GeneDecksing



Pathways & Interactions
for IGKV3-20 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Pathway sources
See GeneCards unified pathways
Show all pathways


5/21        Reactome Pathways for IGKV3-20 (see all 21)
    Role of myosins in phagosome formation
FCGR activation
Cleavage of Alpha-1-Microglobulin
Sequestering and phosphorylation Fc gamma receptors in the lipid rafts
Role of phospholipids in phagocytosis



IGKV3-20 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGKV3-20

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for IGKV3-20 (ENSP000004186494) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
F8ENSP000003533934STRING: ENSP00000353393
IGHA1ENSP000003749894STRING: ENSP00000374989
UBCENSP000003448184STRING: ENSP00000344818
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS3127527
GO:0006956complement activation TAS--
GO:0006958complement activation, classical pathway TAS--
GO:0045087innate immune response TAS--
GO:0050776regulation of immune response TAS--


IGKV3-20 for ontologies           About GeneDecksing



Drugs & Compounds
for IGKV3-20 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGKV3-20
Search CenterWatch for drugs/clinical trials and news about IGKV3-20 / KV313 

Transcripts
for IGKV3-20 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000492167

miRNA
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Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
Browse OriGene 29mer shRNA kits
Browse OriGene siRNA
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Clone
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Primer
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  Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGKV3-20

24/316 AceView cDNA sequences (see all 316):

S56915 AF301490 BV193459 M26438 M26437 AA883902 BV193652 U07512 
AA292250 AW407058 U07514 U07515 U07543 U07531 AF408718 U07469 
L37729 AW404465 AA292499 U07460 D84139 AY574938 Z35083 L40733 

GeneLoc Exon Structure


Expression
for IGKV3-20 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGKV3-20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image
See IGKV3-20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGKV3-20
    SABiosciences Custom PCR Arrays for IGKV3-20
Primer
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Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGKV3-20
In Situ
Assay Products: 
 		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGKV3-20

Orthologs
for IGKV3-20 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for IGKV3-20 gene from 1/3 species (see all 3)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
zebrafish
(Danio rerio)		 Actinopterygii CR391995.26
 --
 36(a)
 1 → many
 24(34453726-34454034)


ENSEMBL Gene Tree for IGKV3-20 (if available)
TreeFam Gene Tree for IGKV3-20 (if available) 

Paralogs
for IGKV3-20 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGKV3-20 gene
IGKV1D-372  IGKV1D-82  IGKV3D-112  IGKV1D-332  IGKV4-12  IGKV1-62  IGKV3-112  IGKV1D-122  
IGKV2-402  IGKV3D-72  IGKV1-162  IGKV1-82  IGKV1-172  IGKV1-272  IGKV2D-262  IGKV1-392  
IGKV1-52  IGKV6D-212  IGKV1-372  IGKV1D-172  IGKV1-332  IGKV2-302  ENSG000002283252  IGKV2D-302  
IGKV1D-132  IGKV1D-392  IGKV2-282  IGKV1-122  IGKV5-22  IGKV3D-202  IGKV3-72  IGKV2D-282  
IGKV1D-432  IGKV3D-152  IGKV3-152  IGKV1-92  IGKV1D-162  IGKV6-212  IGKV1D-422  IGKV2D-242  
IGKV2-242  IGKV2D-292  IGKV6D-412  IGKV2D-402  

IGKV3-20 for paralogs           About GeneDecksing



Genomic Variants
for IGKV3-20 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGKV3-20
DNA2.0 Custom Variant and Variant Library Synthesis for IGKV3-20

Disorders / Diseases
for IGKV3-20 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
IGKV3-20 for disorders           About GeneDecksing

3 diseases for IGKV3-20:    About MalaCards
chronic lymphocytic leukemia    lymphocytic leukemia    leukemia


Export disorders for IGKV3-20 gene to outside databases

Publications
for IGKV3-20 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGKV3-20 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGKV3-20)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
  2. Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy. (PubMed id 3127527)1, 2 Kipps T.J.... Carson D.A. (1988)
  3. Antigen receptor stereotypy across B-cell lymphoprolif erations: the case of IGHV4-59/IGKV3-20 receptors with rheumatoid factor activit y. (PubMed id 22051533)1 Kostareli E....Stamatopoulos K. (2012)
  4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
  5. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (2002)
  6. Design and use of a phage display library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel. (PubMed id 9705314)1 Pini A....Neri D. (1998)
  7. Myosin-reactive autoantibodies in rheumatic carditis and normal fetus. (PubMed id 9614934)1 Wu X....Young D.C. (1998)
  8. The human VK locus. Characterization of a duplicated region encoding 28 different immunoglobulin genes. (PubMed id 3351922)1 Straubinger B....Zachau H.G. (1988)

External Searches for IGKV3-20 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGKV3-20 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28912 HGNC: 5817 AceView: IGKV6-21andIGKV3-20 Ensembl:ENSG00000239951 euGenes: HUgn28912
ECgene: IGKV3-20 H-InvDB: IGKV3-20

Other Databases showing IGKV3-20 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGKV3-20 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGKV3-20 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGKV3-20 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGKV3-20 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGKV3-20 gene:
Search GeneIP for patents involving IGKV3-20

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for IGKV3-20 gene

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About This Section

 
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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VWF
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von Willebrand factor
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