Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IGKV3-20 Gene

Aliases for IGKV3-20 Gene

  • Immunoglobulin Kappa Variable 3-20 2 3 5
  • Ig Kappa Chain V-III Region HIC 3 4
  • Ig Kappa Chain V-III Region B6 3 4
  • Immunoglobulin Light Chain Variable Region 3
  • Ig Kappa Chain V-III Region IARC/BL41 4
  • Ig Kappa Chain V-III Region GOL 4
  • Ig Kappa Chain V-III Region HAH 4
  • Ig Kappa Chain V-III Region NG9 4
  • Ig Kappa Chain V-III Region SIE 4
  • Ig Kappa Chain V-III Region WOL 4
  • Ig Kappa Chain V-III Region Ti 4
  • Anti-FactorVIII ScFv 3
  • Anti-(ED-B) ScFV 3
  • Anti-IFN-G ScFv 3
  • Anti-TeTox ScFv 3
  • Anti-HCS ScFv 3
  • IGKV320 3
  • 13K18 3
  • A27 3

External Ids for IGKV3-20 Gene

Previous GeneCards Identifiers for IGKV3-20 Gene

  • GC02U990190
  • GC02M089327
  • GC02M089345
  • GC02M089346
  • GC02M089281
  • GC02M089443
  • GC02M089537
  • GC02M089741
  • GC02M089951
  • GC02M090126

Summaries for IGKV3-20 Gene

GeneCards Summary for IGKV3-20 Gene

IGKV3-20 (Immunoglobulin Kappa Variable 3-20) is a Protein Coding gene. GO annotations related to this gene include antigen binding and immunoglobulin receptor binding. An important paralog of this gene is IGKV3D-20.

UniProtKB/Swiss-Prot for IGKV3-20 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV3-20 Gene

Genomics for IGKV3-20 Gene

Genomic Location for IGKV3-20 Gene

Chromosome:
2
Start:
89,142,574 bp from pter
End:
89,143,160 bp from pter
Size:
587 bases
Orientation:
Minus strand

Genomic View for IGKV3-20 Gene

Genes around IGKV3-20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGKV3-20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGKV3-20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKV3-20 Gene

No data available for Regulatory Elements for IGKV3-20 Gene

Proteins for IGKV3-20 Gene

  • Protein details for IGKV3-20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01619-KV320_HUMAN
    Recommended name:
    Immunoglobulin kappa variable 3-20
    Protein Accession:
    P01619
    Secondary Accessions:
    • A0A0B4J1Z6
    • P01620
    • P01621
    • P01622
    • P01623
    • P04206
    • P06311
    • P18135
    • P18136

    Protein attributes for IGKV3-20 Gene

    Size:
    116 amino acids
    Molecular mass:
    12557 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
    SequenceCaution:
    • Sequence=CAA77316.1; Type=Miscellaneous discrepancy; Note=Chimeric DNA. A chimeric DNA corresponding to regions V and J of immunoglobulin kappa light chain.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGKV3-20 Gene

neXtProt entry for IGKV3-20 Gene

Post-translational modifications for IGKV3-20 Gene

No Post-translational modifications

Other Protein References for IGKV3-20 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGKV3-20 Gene

Domains & Families for IGKV3-20 Gene

Gene Families for IGKV3-20 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGKV3-20: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGKV3-20 Gene

Function for IGKV3-20 Gene

Molecular function for IGKV3-20 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGKV3-20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 2997711
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGKV3-20: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKV3-20 Gene

Localization for IGKV3-20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGKV3-20 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGKV3-20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 22664934
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with IGKV3-20: view

No data available for Subcellular locations from COMPARTMENTS for IGKV3-20 Gene

Pathways & Interactions for IGKV3-20 Gene

SuperPathways for IGKV3-20 Gene

No Data Available

Interacting Proteins for IGKV3-20 Gene

Gene Ontology (GO) - Biological Process for IGKV3-20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0003094 glomerular filtration IMP 23398317
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 2997711
genes like me logo Genes that share ontologies with IGKV3-20: view

No data available for Pathways by source and SIGNOR curated interactions for IGKV3-20 Gene

Drugs & Compounds for IGKV3-20 Gene

No Compound Related Data Available

Transcripts for IGKV3-20 Gene

mRNA/cDNA for IGKV3-20 Gene

(316) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV3-20 Gene

No ASD Table

Relevant External Links for IGKV3-20 Gene

GeneLoc Exon Structure for
IGKV3-20
ECgene alternative splicing isoforms for
IGKV3-20

Expression for IGKV3-20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGKV3-20 Gene

mRNA differential expression in normal tissues according to GTEx for IGKV3-20 Gene

This gene is overexpressed in Spleen (x15.7), Colon - Transverse (x7.0), Small Intestine - Terminal Ileum (x4.6), and Minor Salivary Gland (x4.5).

Protein differential expression in normal tissues from HIPED for IGKV3-20 Gene

This gene is overexpressed in Serum (47.4) and Urine (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGKV3-20 Gene



Protein tissue co-expression partners for IGKV3-20 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGKV3-20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGKV3-20 Gene

Orthologs for IGKV3-20 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGKV3-20 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 57 (a)
ManyToMany
-- 35
  • 57 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
Species where no ortholog for IGKV3-20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGKV3-20 Gene

ENSEMBL:
Gene Tree for IGKV3-20 (if available)
TreeFam:
Gene Tree for IGKV3-20 (if available)

Paralogs for IGKV3-20 Gene

Variants for IGKV3-20 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGKV3-20 Gene

KV320_HUMAN-P01619
There are several alleles. The sequence shown is that of IMGT allele IGKV3-20*01.

Relevant External Links for IGKV3-20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGKV3-20

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKV3-20 Gene

Disorders for IGKV3-20 Gene

Relevant External Links for IGKV3-20

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGKV3-20

No disorders were found for IGKV3-20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGKV3-20 Gene

Publications for IGKV3-20 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  2. Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy. (PMID: 3127527) Kipps T.J. … Carson D.A. (J. Exp. Med. 1988) 3 4 64
  3. Amino acid sequence of a light chain variable region of a human rheumatoid factor of the Wa idiotypic group, in part predicted by its reactivity with antipeptide antibodies. (PMID: 3086710) Newkirk M. … Capra J.D. (Mol. Immunol. 1986) 3 4 64
  4. Human immunoglobulin kappa light chain genes of subgroups II and III. (PMID: 2997711) Klobeck H.G. … Zachau H.G. (Nucleic Acids Res. 1985) 3 4 64
  5. Most kappa immunoglobulin mRNA in human lymphocytes is homologous to a small family of germ-line V genes. (PMID: 6419127) Bentley D.L. (Nature 1984) 3 4 64

Products for IGKV3-20 Gene

Sources for IGKV3-20 Gene

Content
Loading form....