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Aliases for IGKV3-20 Gene

Aliases for IGKV3-20 Gene

  • Immunoglobulin Kappa Variable 3-20 2 3
  • Immunoglobulin Light Chain Variable Region 3
  • Ig Kappa Chain V-III Region HIC 3
  • Anti-FactorVIII ScFv 3
  • Anti-(ED-B) ScFV 3
  • Anti-IFN-G ScFv 3
  • Anti-TeTox ScFv 3
  • Anti-HCS ScFv 3
  • IGKV320 3
  • 13K18 3
  • A27 3

External Ids for IGKV3-20 Gene

Previous GeneCards Identifiers for IGKV3-20 Gene

  • GC02U990190
  • GC02M089327
  • GC02M089345
  • GC02M089346
  • GC02M089281
  • GC02M089443
  • GC02M089537
  • GC02M089741
  • GC02M089951
  • GC02M090126

Summaries for IGKV3-20 Gene

GeneCards Summary for IGKV3-20 Gene

IGKV3-20 (Immunoglobulin Kappa Variable 3-20) is a Protein Coding gene. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGKV3D-15.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV3-20 Gene

Genomics for IGKV3-20 Gene

Genomic Location for IGKV3-20 Gene

Start:
89,142,574 bp from pter
End:
89,143,160 bp from pter
Size:
587 bases
Orientation:
Minus strand

Genomic View for IGKV3-20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGKV3-20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKV3-20 Gene

No data available for Regulatory Elements for IGKV3-20 Gene

Proteins for IGKV3-20 Gene

  • Protein details for IGKV3-20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18136-KV313_HUMAN
    Recommended name:
    Ig kappa chain V-III region HIC
    Protein Accession:
    P18136
    Secondary Accessions:

    Protein attributes for IGKV3-20 Gene

    Size:
    129 amino acids
    Molecular mass:
    14089 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • One of the surface immunoglobulin M autoantibodies expressed in patients with chronic lymphocytic leukemia

    Three dimensional structures from OCA and Proteopedia for IGKV3-20 Gene

neXtProt entry for IGKV3-20 Gene

Proteomics data for IGKV3-20 Gene at MOPED

Post-translational modifications for IGKV3-20 Gene

No Post-translational modifications

Other Protein References for IGKV3-20 Gene

ENSEMBL proteins:
Reactome Protein details:

No data available for DME Specific Peptides for IGKV3-20 Gene

Domains for IGKV3-20 Gene

Gene Families for IGKV3-20 Gene

HGNC:
  • IGK :Immunoglobulins / IGK locus

Protein Domains for IGKV3-20 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGKV3-20: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGKV3-20 Gene

Function for IGKV3-20 Gene

Gene Ontology (GO) - Molecular Function for IGKV3-20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 3127527
GO:0005515 protein binding --
GO:0034987 contributes_to immunoglobulin receptor binding IDA 23250751
genes like me logo Genes that share ontologies with IGKV3-20: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IGKV3-20 Gene

Localization for IGKV3-20 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGKV3-20 Gene COMPARTMENTS Subcellular localization image for IGKV3-20 gene
Compartment Confidence
extracellular 5
plasma membrane 4
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for IGKV3-20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 23398317
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 19199708
GO:0071748 monomeric IgA immunoglobulin complex IDA 23250751
genes like me logo Genes that share ontologies with IGKV3-20: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IGKV3-20 Gene

Pathways for IGKV3-20 Gene

genes like me logo Genes that share pathways with IGKV3-20: view

Interacting Proteins for IGKV3-20 Gene

Gene Ontology (GO) - Biological Process for IGKV3-20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003094 glomerular filtration IMP 23398317
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 3127527
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
genes like me logo Genes that share ontologies with IGKV3-20: view

Transcripts for IGKV3-20 Gene

mRNA/cDNA for IGKV3-20 Gene

(316) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV3-20 Gene

No ASD Table

Relevant External Links for IGKV3-20 Gene

GeneLoc Exon Structure for
IGKV3-20
ECgene alternative splicing isoforms for
IGKV3-20

Expression for IGKV3-20 Gene

mRNA expression in normal human tissues for IGKV3-20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGKV3-20 Gene

This gene is overexpressed in Spleen (15.7), Colon - Transverse (7.0), Small Intestine - Terminal Ileum (4.6), and Minor Salivary Gland (4.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IGKV3-20 Gene

genes like me logo Genes that share expressions with IGKV3-20: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IGKV3-20 Gene

Orthologs for IGKV3-20 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGKV3-20 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 36
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
Species with no ortholog for IGKV3-20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGKV3-20 Gene

ENSEMBL:
Gene Tree for IGKV3-20 (if available)
TreeFam:
Gene Tree for IGKV3-20 (if available)

Paralogs for IGKV3-20 Gene

genes like me logo Genes that share paralogs with IGKV3-20: view

Variants for IGKV3-20 Gene

Relevant External Links for IGKV3-20 Gene

HapMap Linkage Disequilibrium report
IGKV3-20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for IGKV3-20 Gene

Disorders for IGKV3-20 Gene

No disorders were found for IGKV3-20 Gene.

No data available for UniProtKB/Swiss-Prot for IGKV3-20 Gene

Publications for IGKV3-20 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  2. Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy. (PMID: 3127527) Kipps T.J. … Carson D.A. (J. Exp. Med. 1988) 3 4
  3. The human VK locus. Characterization of a duplicated region encoding 28 different immunoglobulin genes. (PMID: 3351922) Straubinger B. … Zachau H.G. (J. Mol. Biol. 1988) 3
  4. Myosin-reactive autoantibodies in rheumatic carditis and normal fetus. (PMID: 9614934) Wu X. … Young D.C. (Clin. Immunol. Immunopathol. 1998) 3
  5. Design and use of a phage display library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel. (PMID: 9705314) Pini A. … Neri D. (J. Biol. Chem. 1998) 3

Products for IGKV3-20 Gene

Sources for IGKV3-20 Gene

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