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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGKV3-15 Gene

protein-coding   GIFtS: 17
GCID: GC02M089736

immunoglobulin kappa variable 3-15
  Search for IGKV3-15
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGKV3-15    

Aliases
for IGKV3-15 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Immunoglobulin Kappa Variable 3-151 2
IGKV3152
L22

External Ids:    HGNC: 58161   Entrez Gene: 289132   Ensembl: ENSG000002444377   
ORGUL members:         
NONCODE:n335976 n336781 n335837 n336196 n335833 see all 9    

Export aliases for IGKV3-15 gene to outside databases

Previous GC identifers: GC02U990191 GC02M089269 GC02M089286 GC02M089223 GC02M089166 GC02M089385 GC02M089430


Summaries
for IGKV3-15 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for IGKV3-15 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGKV3-15
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGKV3-15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGKV3-15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

IGKV3-15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGKV3-15 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M089736:  view genomic region     (about GC identifiers)

Start:
 89,384,673 bp from pter      End:
 89,385,283 bp from pter
Size:
 611 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

  • n335840
  • n335837
  • n335833
  • n336774
  • n336196
  • n335963
  • n336682
  • n335976
  • n336781
89157145 89271177 89385208 chr2

Proteins
for IGKV3-15 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB: --
IGKV3-15 Protein expression data from MOPED and PaxDb:    About this image 
Estimated protein expression log10 (pmol).


ENSEMBL proteins: 
 ENSP00000374787  

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Protein Domains /
Families
for IGKV3-15 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
   --

Function
for IGKV3-15 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
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Inhib. RNA
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Gene Editing
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Clone
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In Situ Assay
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Pathways & Interactions
for IGKV3-15 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGKV3-15

Drugs & Compounds
for IGKV3-15 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGKV3-15
Search CenterWatch for drugs/clinical trials and news about IGKV3-15 

Transcripts
for IGKV3-15 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390252

miRNA
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Inhib. RNA
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Browse OriGene siRNA
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Clone
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Primer
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24/207 AceView cDNA sequences (see all 207):

AW407700 U07430 U07526 BF724717 U07527 AA464451 AA485616 AA482641 
AA383914 AA430565 L33042 CD687967 AA295311 L40706 AI299994 CD707464 
AA464647 U07525 L39959 Y17937 BU787743 AF103398 U07517 U07518 

GeneLoc Exon Structure


Expression
for IGKV3-15 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGKV3-15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image
See IGKV3-15 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for IGKV3-15
Primer
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In Situ
Assay Products: 
 		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGKV3-15

Orthologs
for IGKV3-15 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for IGKV3-15 gene from 1/3 species (see all 3)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
zebrafish
(Danio rerio)		 Actinopterygii CR391995.26
 --
 36(a)
 1 → many
 24(34453726-34454034)


ENSEMBL Gene Tree for IGKV3-15 (if available)
TreeFam Gene Tree for IGKV3-15 (if available) 

Paralogs
for IGKV3-15 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGKV3-15 gene
IGKV1D-372  IGKV1D-82  IGKV3D-112  IGKV1D-332  IGKV4-12  IGKV1-62  IGKV3-112  IGKV1D-122  
IGKV2-402  IGKV3D-72  IGKV3-202  IGKV1-162  IGKV1-82  IGKV1-172  IGKV1-272  IGKV2D-262  
IGKV1-392  IGKV1-52  IGKV6D-212  IGKV1-372  IGKV1D-172  IGKV1-332  IGKV2-302  ENSG000002283252  
IGKV2D-302  IGKV1D-132  IGKV1D-392  IGKV2-282  IGKV1-122  IGKV5-22  IGKV3D-202  IGKV3-72  
IGKV2D-282  IGKV1D-432  IGKV3D-152  IGKV1-92  IGKV1D-162  IGKV6-212  IGKV1D-422  IGKV2D-242  
IGKV2-242  IGKV2D-292  IGKV6D-412  IGKV2D-402  

IGKV3-15 for paralogs           About GeneDecksing


3 Pseudogenes.org Pseudogenes for IGKV3-15
PGOHUM00000240162 PGOHUM00000240736 PGOHUM00000257043


Genomic Variants
for IGKV3-15 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGKV3-15
DNA2.0 Custom Variant and Variant Library Synthesis for IGKV3-15

Disorders / Diseases
for IGKV3-15 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
IGKV3-15 for disorders           About MalaCards

IGKV3-15 for disorders           About GeneDecksing

1 disease from the University of Copenhagen DISEASES database for IGKV3-15:
Splenic marginal zone lymphoma

Export disorders for IGKV3-15 gene to outside databases

Publications
for IGKV3-15 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed article for IGKV3-15 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGKV3-15)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of four homologous L chain variable region genes that are related to 6B6.6 idiotype positive human rheumatoid factor L chains. (PubMed id 2492051)1 Liu M.F....Chen P.P. (1989)

External Searches for IGKV3-15 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGKV3-15 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28913 HGNC: 5816 AceView: IGKV3-15 Ensembl:ENSG00000244437 euGenes: HUgn28913
ECgene: IGKV3-15 H-InvDB: IGKV3-15

Other Databases showing IGKV3-15 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGKV3-15 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGKV3-15 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGKV3-15 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGKV3-15 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGKV3-15 gene:
Search GeneIP for patents involving IGKV3-15

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for IGKV3-15 gene

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About This Section

 
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