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Aliases for IGKV3-15 Gene

Aliases for IGKV3-15 Gene

  • Immunoglobulin Kappa Variable 3-15 2 3 5
  • Ig Kappa Chain V-III Region POM 3 4
  • Ig Kappa Chain V-III Region CLL 4
  • IGKV315 3
  • L2 3

External Ids for IGKV3-15 Gene

Previous GeneCards Identifiers for IGKV3-15 Gene

  • GC02U990191
  • GC02M089269
  • GC02M089286
  • GC02M089223
  • GC02M089385
  • GC02M089430
  • GC02M089736
  • GC02M089943
  • GC02M090123

Summaries for IGKV3-15 Gene

GeneCards Summary for IGKV3-15 Gene

IGKV3-15 (Immunoglobulin Kappa Variable 3-15) is a Protein Coding gene. An important paralog of this gene is IGKV3D-15.

UniProtKB/Swiss-Prot for IGKV3-15 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV3-15 Gene

Genomics for IGKV3-15 Gene

Genomic Location for IGKV3-15 Gene

Chromosome:
2
Start:
89,085,177 bp from pter
End:
89,085,787 bp from pter
Size:
611 bases
Orientation:
Minus strand

Genomic View for IGKV3-15 Gene

Genes around IGKV3-15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGKV3-15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGKV3-15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKV3-15 Gene

No data available for Regulatory Elements for IGKV3-15 Gene

Proteins for IGKV3-15 Gene

  • Protein details for IGKV3-15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01624-KV315_HUMAN
    Recommended name:
    Immunoglobulin kappa variable 3-15
    Protein Accession:
    P01624
    Secondary Accessions:
    • A0A0B4J1T9
    • P04207

    Protein attributes for IGKV3-15 Gene

    Size:
    115 amino acids
    Molecular mass:
    12496 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains, linked by disulfide bonds.
    SequenceCaution:
    • Sequence=AAA58992.1; Type=Miscellaneous discrepancy; Note=Chimeric DNA corresponding to regions V and J of immunoglobulin kappa light chain.; Evidence={ECO:0000305};

neXtProt entry for IGKV3-15 Gene

Post-translational modifications for IGKV3-15 Gene

No Post-translational modifications

Other Protein References for IGKV3-15 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGKV3-15 Gene

Domains & Families for IGKV3-15 Gene

Gene Families for IGKV3-15 Gene

Protein Domains for IGKV3-15 Gene

Graphical View of Domain Structure for InterPro Entry

P01624

UniProtKB/Swiss-Prot:

KV315_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGKV3-15: view

No data available for Suggested Antigen Peptide Sequences for IGKV3-15 Gene

Function for IGKV3-15 Gene

Molecular function for IGKV3-15 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGKV3-15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 60899
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGKV3-15: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKV3-15 Gene

Localization for IGKV3-15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGKV3-15 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGKV3-15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS,TAS --
GO:0005886 plasma membrane TAS --
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with IGKV3-15: view

No data available for Subcellular locations from COMPARTMENTS for IGKV3-15 Gene

Pathways & Interactions for IGKV3-15 Gene

SuperPathways for IGKV3-15 Gene

No Data Available

Interacting Proteins for IGKV3-15 Gene

Gene Ontology (GO) - Biological Process for IGKV3-15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 60899
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
genes like me logo Genes that share ontologies with IGKV3-15: view

No data available for Pathways by source and SIGNOR curated interactions for IGKV3-15 Gene

Transcripts for IGKV3-15 Gene

mRNA/cDNA for IGKV3-15 Gene

(207) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV3-15 Gene

No ASD Table

Relevant External Links for IGKV3-15 Gene

GeneLoc Exon Structure for
IGKV3-15
ECgene alternative splicing isoforms for
IGKV3-15

Expression for IGKV3-15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGKV3-15 Gene

mRNA differential expression in normal tissues according to GTEx for IGKV3-15 Gene

This gene is overexpressed in Spleen (x13.1) and Colon - Transverse (x4.4).

Protein differential expression in normal tissues from HIPED for IGKV3-15 Gene

This gene is overexpressed in Urine (51.5) and Serum (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGKV3-15 Gene



Protein tissue co-expression partners for IGKV3-15 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGKV3-15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGKV3-15 Gene

Orthologs for IGKV3-15 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGKV3-15 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 77 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 56 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
Species where no ortholog for IGKV3-15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGKV3-15 Gene

ENSEMBL:
Gene Tree for IGKV3-15 (if available)
TreeFam:
Gene Tree for IGKV3-15 (if available)

Paralogs for IGKV3-15 Gene

Variants for IGKV3-15 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGKV3-15 Gene

KV315_HUMAN-P01624
There are several alleles. The sequence shown is that of IMGT allele IGKV3-15*01.

Relevant External Links for IGKV3-15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGKV3-15

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKV3-15 Gene

Disorders for IGKV3-15 Gene

No disorders were found for IGKV3-15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGKV3-15 Gene

Publications for IGKV3-15 Gene

  1. The amino acid sequence of the variable regions of the light chains from two idiotypically cross reactive IgM anti-gamma globulins. (PMID: 60899) Klapper D.G. … Capra J.D. (Ann. Immunol. (Paris) 1976) 3 4 64
  2. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. (PMID: 22516433) Bastos-Amador P. … Falcon-Perez J.M. (J Proteomics 2012) 3 64
  3. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  4. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  5. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64

Products for IGKV3-15 Gene

Sources for IGKV3-15 Gene

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