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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGKV2D-29 Gene

protein-coding   GIFtS: 19
GCID: GC02P090031

Immunoglobulin Kappa Variable 2D-29

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Immunoglobulin Kappa Variable 2D-291 2
A2a2
A2c2
IGKV2D292

External Ids:    HGNC: 58001   Entrez Gene: 288822   Ensembl: ENSG000002432647   

Export aliases for IGKV2D-29 gene to outside databases

Previous GC identifers: GC02U990160 GC02P089727 GC02P089744 GC02P089682 GC02P089623 GC02P089988 GC02P089989 GC02P089993 GC02P089995 GC02P089997 GC02P090019


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IGKV2D-29 Gene: 
IGKV2D-29 (immunoglobulin kappa variable 2D-29) is a protein-coding gene. Diseases associated with IGKV2D-29 include gestational diabetes, and panic disorder. An important paralog of this gene is IGKV1D-37.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGKV2D-29
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGKV2D-29

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGKV2D-29


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

IGKV2D-29 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGKV2D-29 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P090031:  view genomic region     (about GC identifiers)

Start:
89,986,322 bp from pter      End:
89,987,081 bp from pter
Size:
760 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --
Explore proteomics data for IGKV2D-29 at MOPED 

IGKV2D-29 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IGKV2D-29 Protein Expression

ENSEMBL proteins: 
 ENSP00000417637  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IGK: Immunoglobulins / IGK locus

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
IGKV2D-29 for ontologies           About GeneDecksing


Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IGKV2D-29

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for IGKV2D-29 (ENSP000004176374) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
UBCENSP000003448184STRING: ENSP00000344818
USP4ENSP000002655604STRING: ENSP00000265560
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IGKV2D-29 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGKV2D-29

10/18 Novoseek inferred chemical compound relationships for IGKV2D-29 gene (see all 18)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
cgs21680 90.3 8 16963274 (1), 12374781 (1), 7560091 (1), 7834835 (1) (see all 6)
8-(3-chlorostyryl)caffeine 88.4 5 9515570 (1), 12711634 (1), 15267242 (1)
mrs1191 83.3 1 16539849 (1)
heneca 81.8 2 12570757 (1)
dmpx 71.7 1 16539849 (1)
5'-n-ethylcarboxamidoadenosine 68.2 4 9515570 (2), 7560091 (1)
isoalloxazine 59.6 1 15267242 (1)
theophylline 49.6 1 16539849 (1)
nucleoside 48.9 2 7955150 (1), 15748700 (1)
adenylate 38.2 1 7560091 (1)

Search CenterWatch for drugs/clinical trials and news about IGKV2D-29

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000491977

miRNA
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Inhib. RNA
Products:
     
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Clone
Products:
     
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Primer
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  Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGKV2D-29

24/139 AceView cDNA sequences (see all 139):

BV179551 BV175962 BV193631 BV175944 BV176263 X67904 BF173131 AY062349 
AF408723 CB988631 AF103382 AF103376 AF408727 AJ698330 AF408732 AW405071 
AW407873 AF035034 AF455562 BQ083426 AF049701 AF490930 CD692917 AY043107 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGKV2D-29 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGKV2D-29 Expression
About this image


See IGKV2D-29 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for IGKV2D-29
Primer
Products:
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGKV2D-29

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of mammals.

Orthologs for IGKV2D-29 gene from 1/2 species (see all 2)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia --
--
(see all 18)
--
82(a)
82(a)
(see all 18)
possible ortholog
possible ortholog
(see all 18)
17(37707368-37829005)
17(37513136-37513420)


ENSEMBL Gene Tree for IGKV2D-29 (if available)
TreeFam Gene Tree for IGKV2D-29 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGKV2D-29 gene
IGKV1D-372  IGKV3D-112  IGKV1D-82  IGKV1D-332  IGKV4-12  IGKV1-62  IGKV3-112  IGKV1D-122  
IGKV3D-72  IGKV2-402  IGKV3OR2-2682  IGKV3-202  ENSG000002709992  IGKV1OR2-1082  IGKV1-162  IGKV1-172  
IGKV1-82  IGKV1-272  IGKV2D-262  IGKV1-392  IGKV6D-212  IGKV1-52  IGKV1-372  IGKV1-332  
IGKV1D-172  IGKV2-302  ENSG000002283252  IGKV2D-302  IGKV1D-132  IGKV1D-392  IGKV2-282  IGKV1-122  
IGKV5-22  IGKV3-72  IGKV3D-202  IGKV2D-282  IGKV1D-432  IGKV3-152  IGKV3D-152  IGKV1-92  
IGKV1D-162  IGKV1D-422  IGKV6-212  IGKV2D-242  IGKV2-242  IGKV2D-402  IGKV6D-412  

IGKV2D-29 for paralogs           About GeneDecksing


5/10 Pseudogenes.org Pseudogenes for IGKV2D-29 (see all 10)
PGOHUM00000246208 PGOHUM00000240158 PGOHUM00000240161 PGOHUM00000250438 PGOHUM00000240169


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing IGKV2D-29
DNA2.0 Custom Variant and Variant Library Synthesis for IGKV2D-29

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
12 diseases for IGKV2D-29:    About MalaCards
gestational diabetes    panic disorder    influenza    tremor
gingivitis    hypoxia    parkinson's disease    asthma
endotheliitis    rheumatoid arthritis    arthritis    neuronitis


IGKV2D-29 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

2 Novoseek inferred disease relationships for IGKV2D-29 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tumors 5.55 2 18292929 (1), 15748700 (1)
necrosis 0 2 19790066 (1), 15748700 (1)


Export disorders for IGKV2D-29 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGKV2D-29 gene, integrated from 9 sources (see all 71):
(articles sorted by number of sources associating them with IGKV2D-29)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor. (PubMed id 16339847)1 Milojevic T.... Nanoff C. (2006)
  2. Evolutionary dynamics of the human immunoglobulin kappa locus and the germline repertoire of the Vkappa genes. (PubMed id 11298326)1 Kawasaki K....Shimizu N. (2001)
  3. Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. III. A single VKII gene and one of several JK genes are joined by an invariant arginine to form the most common L chain V region. (PubMed id 2512350)1 Scott M.G....Nahm M.H. (1989)
  4. Evidence for co-expression and desensitization of A2a and A2b adenosine receptors in NG108-15 cells. (PubMed id 9515570)9 Mundell S.J. and Kelly E. (1998)
  5. Normalization of A2A and A3 adenosine receptor up-reg ulation in rheumatoid arthritis patients by treatment with anti-tumor necrosis factor alpha but not methotrexate. (PubMed id 19790066)9 Varani K....Borea P.A. (2009)
  6. Adenosine A2a blockade prevents synergy between mu-opiate and cannabinoid CB1 receptors and eliminates heroin-seeking behavior in addicted rats. (PubMed id 16684876)9 Yao L....Diamond I. (2006)
  7. Pharmacological characterization of a novel, potent adenosine A1 and A2A receptor dual antagonist, 5-[5-amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine- 2(1H)-one (ASP5854), in models of Parkinson's disease and cognition. (PubMed id 17684118)9 Mihara T....Matsuoka N. (2007)
  8. Synthesis and biological activity of new potential ag onists for the human adenosine A2A receptor. (PubMed id 15267242)9 Bosch M.P....Guerrero A. (2004)
  9. 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin -6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. (PubMed id 16250647)9 Minetti P....Tarzia G. (2005)
  10. Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes. (PubMed id 15539641)9 Torvinen M....Fuxe K. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28882 HGNC: 5800 AceView: IGKV2D_ Ensembl:ENSG00000243264 euGenes: HUgn28882
ECgene: IGKV2D-29 H-InvDB: IGKV2D-29

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGKV2D-29 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGKV2D-29 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGKV2D-29 gene:
Search GeneIP for patents involving IGKV2D-29

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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