IGKV2D-29 Gene
protein-coding GIFtS : 17 GCID: GC02 P090019
immunoglobulin kappa variable 2D-29
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Aliasesfor IGKV2D-29 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Immunoglobulin Kappa Variable 2D-29 1 2 A2a2 A2c2 IGKV2D292
Export aliases for IGKV2D-29 gene to outside databases Previous GC identifers: GC02U990160 GC02P089727 GC02P089744 GC02P089682 GC02P089623 GC02P089988 GC02P089989 GC02P089993 GC02P089995 GC02P089997
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Summariesfor IGKV2D-29 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section
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Genomic Viewsfor IGKV2D-29 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for IGKV2D-29 Other transcription factors Search SABiosciences Chromatin IP Primers for IGKV2D-29 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGKV2D-29
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2p12 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2 IGKV2D-29 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02P090019: view genomic region
(about GC identifiers )
Start: 89,986,322 bp from pter End:
89,987,081 bp from pter
Size: 760 bases Orientation:
plus strand
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Proteinsfor IGKV2D-29 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB: --IGKV2D-29 Protein expression data from MOPED and PaxDb : About this image ENSEMBL proteins: ENSP00000417637 Human Recombinant Protein Products for IGKV2D-29: Antibody Products for IGKV2D-29: Assay Products for IGKV2D-29:
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Protein
Domains /for IGKV2D-29 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
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Functionfor IGKV2D-29 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Animal Models:
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Pathways & Interactionsfor IGKV2D-29 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IGKV2D-29 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for IGKV2D-29 (ENSP00000417637 4 via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor IGKV2D-29 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for IGKV2D-29 10/18 Novoseek chemical compound relationships for IGKV2D-29 gene (see all 18 ) About this table IGKV2D-29
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Transcriptsfor IGKV2D-29 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000491977 24/139 AceView cDNA sequences (see all 139 ):
BV176263 BV179551 BV175962 BV193631 BV175944 X67904 CB988631 AF408723 BF173131 AY062349 AF103382 AF103376 AF408727 AJ698330 M80914 AF408732 AF408729 AF332145 AA464313 AF049690 AJ272080 AW405071 AW407873 AF035034 GeneLoc Exon Structure
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Expression for IGKV2D-29 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section IGKV2D-29 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: -- About this image See IGKV2D-29 Protein Expression from SPIRE MOPED and PaxDB SABiosciences Custom PCR Arrays for IGKV2D-29
Primer Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat IGKV2D-29 Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGKV2D-29 Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGKV2D-29
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Orthologsfor IGKV2D-29 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for IGKV2D-29 gene from 1/3 species (see all 3 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
zebrafish Actinopterygii CR391995.26
--
35(a)
1 → many
24(34453726-34454034)
ENSEMBL Gene Tree for IGKV2D-29 (if available)TreeFam Gene Tree for IGKV2D-29 (if available)
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Paralogsfor IGKV2D-29 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for IGKV2D-29 gene IGKV1D-37 2 IGKV1D-8 2 IGKV3D-11 2 IGKV1D-33 2 IGKV4-1 2 IGKV1-6 2 IGKV3-11 2 IGKV1D-12 2 IGKV2-40 2 IGKV3D-7 2 IGKV3-20 2 IGKV1-16 2 IGKV1-8 2 IGKV1-17 2 IGKV1-27 2 IGKV2D-26 2 IGKV1-39 2 IGKV1-5 2 IGKV6D-21 2 IGKV1-37 2 IGKV1D-17 2 IGKV1-33 2 IGKV2-30 2 ENSG00000228325 2 IGKV2D-30 2 IGKV1D-13 2 IGKV1D-39 2 IGKV2-28 2 IGKV1-12 2 IGKV5-2 2 IGKV3D-20 2 IGKV3-7 2 IGKV2D-28 2 IGKV1D-43 2 IGKV3D-15 2 IGKV3-15 2 IGKV1-9 2 IGKV1D-16 2 IGKV6-21 2 IGKV1D-42 2 IGKV2D-24 2 IGKV2-24 2 IGKV6D-41 2 IGKV2D-40 2 About GeneDecksing 5/10 Pseudogenes.org Pseudogenes for IGKV2D-29 (see all 10 )PGOHUM00000246208 PGOHUM00000240158 PGOHUM00000240161 PGOHUM00000250438 PGOHUM00000240169
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Genomic Variantsfor IGKV2D-29 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor IGKV2D-29 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing 12 : About MalaCards haemophilus influenzae panic disorder gestational diabetes tremor rheumatoid arthritis influenza parkinson's disease gingivitis arthritis asthma hypoxia neuronitis 2 Novoseek disease relationships for IGKV2D-29 gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
tumors
5.55
2
18292929 (1), 15748700 (1)
necrosis
0
2
19790066 (1), 15748700 (1)
Export disorders for IGKV2D-29 gene to outside databases
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Publicationsfor IGKV2D-29 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for IGKV2D-29 gene, integrated from 9 sources (see all 71 ):(articles sorted by number of sources associating them with IGKV2D-29) Utopia : connect your pdf to the dynamic
The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor. (PubMed id 16339847) 1 (2006) Evolutionary dynamics of the human immunoglobulin kappa locus and the germline repertoire of the Vkappa genes. (PubMed id 11298326) 1 (2001) Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. III. A single VKII gene and one of several JK genes are joined by an invariant arginine to form the most common L chain V region. (PubMed id 2512350) 1 (1989) Evidence for co-expression and desensitization of A2a and A2b adenosine receptors in NG108-15 cells. (PubMed id 9515570) 9 Mundell S.J. and Kelly E. (1998) Normalization of A2A and A3 adenosine receptor up-reg ulation in rheumatoid arthritis patients by treatment with anti-tumor necrosis factor alpha but not methotrexate. (PubMed id 19790066) 9 Varani K....Borea P.A. (2009) Adenosine A2a blockade prevents synergy between mu-opiate and cannabinoid CB1 receptors and eliminates heroin-seeking behavior in addicted rats. (PubMed id 16684876) 9 Yao L....Diamond I. (2006) Pharmacological characterization of a novel, potent adenosine A1 and A2A receptor dual antagonist, 5-[5-amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine- 2(1H)-one (ASP5854), in models of Parkinson's disease and cognition. (PubMed id 17684118) 9 Mihara T....Matsuoka N. (2007) Synthesis and biological activity of new potential ag onists for the human adenosine A2A receptor. (PubMed id 15267242) 9 Bosch M.P....Guerrero A. (2004) 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin -6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. (PubMed id 16250647) 9 Minetti P....Tarzia G. (2005) Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes. (PubMed id 15539641) 9 Torvinen M....Fuxe K. (2005)
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External Searches for IGKV2D-29 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing IGKV2D-29 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing IGKV2D-29 gene
(According to HUGE )
About This Section --
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Specialized Databases showing IGKV2D-29 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for IGKV2D-29 Pharmacogenomics, SNPs, Pathways IMGT entry for IGKV2D-29The international I mM unoG eneT ics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
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About This Section Patent Information for IGKV2D-29 gene: IGKV2D-29 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor IGKV2D-29 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGKV2D-29 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGKV2D-29 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGKV2D-29 Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGKV2D-29 Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGKV2D-29 Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGKV2D-29
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGKV2D-29
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Browse Tocris compounds for 
