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Aliases for IGKV2D-28 Gene

Aliases for IGKV2D-28 Gene

  • Immunoglobulin Kappa Variable 2D-28 2 3 5
  • Ig Kappa Chain V-II Region FR 3 4
  • Ig Kappa Chain V-II Region GM607 4
  • Ig Kappa Chain V-II Region MIL 4
  • Ig Kappa Chain V-II Region TEW 4
  • IGKV2D28 3
  • A3 3

External Ids for IGKV2D-28 Gene

Previous GeneCards Identifiers for IGKV2D-28 Gene

  • GC02U990161
  • GC02P089740
  • GC02P089757
  • GC02P089695
  • GC02P089636
  • GC02P089999
  • GC02P090005
  • GC02P090021
  • GC02P090033
  • GC02P090066
  • GC02P089964
  • GC02P089965
  • GC02P090104
  • GC02P090105
  • GC02P090145

Summaries for IGKV2D-28 Gene

GeneCards Summary for IGKV2D-28 Gene

IGKV2D-28 (Immunoglobulin Kappa Variable 2D-28) is a Protein Coding gene. An important paralog of this gene is IGKV2-28.

UniProtKB/Swiss-Prot for IGKV2D-28 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV2D-28 Gene

Genomics for IGKV2D-28 Gene

Genomic Location for IGKV2D-28 Gene

Chromosome:
2
Start:
89,959,979 bp from pter
End:
89,960,754 bp from pter
Size:
776 bases
Orientation:
Plus strand

Genomic View for IGKV2D-28 Gene

Genes around IGKV2D-28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGKV2D-28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGKV2D-28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKV2D-28 Gene

No data available for Regulatory Elements for IGKV2D-28 Gene

Proteins for IGKV2D-28 Gene

  • Protein details for IGKV2D-28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01615-KVD28_HUMAN
    Recommended name:
    Immunoglobulin kappa variable 2D-28
    Protein Accession:
    P01615
    Secondary Accessions:
    • A0A0A0MTQ6
    • P01616
    • P01617
    • P06309

    Protein attributes for IGKV2D-28 Gene

    Size:
    120 amino acids
    Molecular mass:
    12957 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for IGKV2D-28 Gene

neXtProt entry for IGKV2D-28 Gene

Post-translational modifications for IGKV2D-28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGKV2D-28 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGKV2D-28 Gene

Domains & Families for IGKV2D-28 Gene

Gene Families for IGKV2D-28 Gene

Protein Domains for IGKV2D-28 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGKV2D-28: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGKV2D-28 Gene

Function for IGKV2D-28 Gene

Molecular function for IGKV2D-28 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGKV2D-28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 821524
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGKV2D-28: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKV2D-28 Gene

Localization for IGKV2D-28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGKV2D-28 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGKV2D-28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with IGKV2D-28: view

No data available for Subcellular locations from COMPARTMENTS for IGKV2D-28 Gene

Pathways & Interactions for IGKV2D-28 Gene

SuperPathways for IGKV2D-28 Gene

No Data Available

Interacting Proteins for IGKV2D-28 Gene

Gene Ontology (GO) - Biological Process for IGKV2D-28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 821524
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGKV2D-28: view

No data available for Pathways by source and SIGNOR curated interactions for IGKV2D-28 Gene

Drugs & Compounds for IGKV2D-28 Gene

No Compound Related Data Available

Transcripts for IGKV2D-28 Gene

mRNA/cDNA for IGKV2D-28 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV2D-28 Gene

No ASD Table

Relevant External Links for IGKV2D-28 Gene

GeneLoc Exon Structure for
IGKV2D-28
ECgene alternative splicing isoforms for
IGKV2D-28

Expression for IGKV2D-28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGKV2D-28 Gene

mRNA differential expression in normal tissues according to GTEx for IGKV2D-28 Gene

This gene is overexpressed in Spleen (x15.0), Small Intestine - Terminal Ileum (x7.0), Colon - Transverse (x6.3), Lung (x6.2), and Whole Blood (x5.2).

Protein differential expression in normal tissues from HIPED for IGKV2D-28 Gene

This gene is overexpressed in Skin (31.4), Urine (15.8), and Saliva (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGKV2D-28 Gene



Protein tissue co-expression partners for IGKV2D-28 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGKV2D-28: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGKV2D-28 Gene

Orthologs for IGKV2D-28 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGKV2D-28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 69 (a)
OneToMany
Species where no ortholog for IGKV2D-28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGKV2D-28 Gene

ENSEMBL:
Gene Tree for IGKV2D-28 (if available)
TreeFam:
Gene Tree for IGKV2D-28 (if available)

Paralogs for IGKV2D-28 Gene

Variants for IGKV2D-28 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGKV2D-28 Gene

KVD28_HUMAN-P01615
There are several alleles. The sequence shown is that of IMGT allele IGKV2D-28*01.

Relevant External Links for IGKV2D-28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGKV2D-28

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKV2D-28 Gene

Disorders for IGKV2D-28 Gene

No disorders were found for IGKV2D-28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGKV2D-28 Gene

Publications for IGKV2D-28 Gene

  1. Contribution of human V kappa II germ-line genes to light-chain diversity. (PMID: 6325927) Klobeck H.G. … Zachau H.G. (Nature 1984) 3 4 64
  2. Variable region sequence of the light chain from a Waldenstroms IgM with specificity for phosphorylcholine. (PMID: 821524) Riesen W.F. … Jaton J.-C. (Biochemistry 1976) 3 4 64
  3. Amino acid sequence of a kappa Bence Jones protein from a case of primary amyloidosis. (PMID: 4596149) Putnam F.W. … Davidson J.N. (Biochemistry 1973) 3 4 64
  4. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 64

Products for IGKV2D-28 Gene

Sources for IGKV2D-28 Gene

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