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Aliases for IGKV2-40 Gene

Aliases for IGKV2-40 Gene

  • Immunoglobulin Kappa Variable 2-40 2 3 5
  • Ig Kappa Chain V-II 3
  • IGKV240 3
  • O11a 3
  • O11 3

External Ids for IGKV2-40 Gene

Previous GeneCards Identifiers for IGKV2-40 Gene

  • GC02U990194
  • GC02M089410
  • GC02M089630
  • GC02M089670
  • GC02M089779
  • GC02M089988
  • GC02M090170
  • GC02M089413
  • GC02M089487

Summaries for IGKV2-40 Gene

GeneCards Summary for IGKV2-40 Gene

IGKV2-40 (Immunoglobulin Kappa Variable 2-40) is a Protein Coding gene. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGKV2D-40.

UniProtKB/Swiss-Prot for IGKV2-40 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV2-40 Gene

Genomics for IGKV2-40 Gene

Genomic Location for IGKV2-40 Gene

Chromosome:
2
Start:
89,330,110 bp from pter
End:
89,330,430 bp from pter
Size:
321 bases
Orientation:
Minus strand

Genomic View for IGKV2-40 Gene

Genes around IGKV2-40 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGKV2-40 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGKV2-40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKV2-40 Gene

No data available for Regulatory Elements for IGKV2-40 Gene

Proteins for IGKV2-40 Gene

  • Protein details for IGKV2-40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A087WW87-KV240_HUMAN
    Recommended name:
    Immunoglobulin kappa variable 2-40
    Protein Accession:
    A0A087WW87

    Protein attributes for IGKV2-40 Gene

    Size:
    121 amino acids
    Molecular mass:
    13310 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGKV2-40 Gene

Post-translational modifications for IGKV2-40 Gene

No Post-translational modifications

Other Protein References for IGKV2-40 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGKV2-40 Gene

Domains & Families for IGKV2-40 Gene

Gene Families for IGKV2-40 Gene

Protein Domains for IGKV2-40 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGKV2-40: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGKV2-40 Gene

Function for IGKV2-40 Gene

Molecular function for IGKV2-40 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGKV2-40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS,IEA 5586923
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGKV2-40: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKV2-40 Gene

Localization for IGKV2-40 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGKV2-40 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGKV2-40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with IGKV2-40: view

No data available for Subcellular locations from COMPARTMENTS for IGKV2-40 Gene

Pathways & Interactions for IGKV2-40 Gene

SuperPathways for IGKV2-40 Gene

No Data Available

Interacting Proteins for IGKV2-40 Gene

Gene Ontology (GO) - Biological Process for IGKV2-40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 5586923
genes like me logo Genes that share ontologies with IGKV2-40: view

No data available for Pathways by source and SIGNOR curated interactions for IGKV2-40 Gene

Drugs & Compounds for IGKV2-40 Gene

No Compound Related Data Available

Transcripts for IGKV2-40 Gene

mRNA/cDNA for IGKV2-40 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV2-40 Gene

No ASD Table

Relevant External Links for IGKV2-40 Gene

GeneLoc Exon Structure for
IGKV2-40
ECgene alternative splicing isoforms for
IGKV2-40

Expression for IGKV2-40 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGKV2-40 Gene

mRNA differential expression in normal tissues according to GTEx for IGKV2-40 Gene

This gene is overexpressed in Spleen (x12.9).

Protein differential expression in normal tissues from HIPED for IGKV2-40 Gene

This gene is overexpressed in Skin (53.4) and Urine (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGKV2-40 Gene



Protein tissue co-expression partners for IGKV2-40 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGKV2-40: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGKV2-40 Gene

Orthologs for IGKV2-40 Gene

Evolution for IGKV2-40 Gene

ENSEMBL:
Gene Tree for IGKV2-40 (if available)
TreeFam:
Gene Tree for IGKV2-40 (if available)

No data available for Orthologs for IGKV2-40 Gene

Paralogs for IGKV2-40 Gene

genes like me logo Genes that share paralogs with IGKV2-40: view

Variants for IGKV2-40 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGKV2-40 Gene

KV240_HUMAN-A0A087WW87
There are several alleles. The sequence shown is that of IMGT allele IGKV2-40*01.

Relevant External Links for IGKV2-40 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGKV2-40

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKV2-40 Gene

Disorders for IGKV2-40 Gene

No disorders were found for IGKV2-40 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGKV2-40 Gene

Publications for IGKV2-40 Gene

  1. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  2. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PMID: 23398456) Bett J.S. … Hay R.T. (Biochem. J. 2013) 3 64
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3 64
  4. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. (PMID: 22516433) Bastos-Amador P. … Falcon-Perez J.M. (J Proteomics 2012) 3 64
  5. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64

Products for IGKV2-40 Gene

Sources for IGKV2-40 Gene

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