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Aliases for IGKV2-29 Gene

Aliases for IGKV2-29 Gene

  • Immunoglobulin Kappa Variable 2-29 (Gene/Pseudogene) 2 3 5
  • Anti-Hib Capsular Polysaccharide Immunoglobulin Light Chain Variable Region 3
  • Immunoglobulin Light Chain Variable Region 3
  • Immunoglobulin Kappa Variable 2-29 2
  • IGVK A18b 3
  • IGVK-A18 3
  • IGKV229 3
  • IGKV 3
  • A18b 3
  • A18 3

External Ids for IGKV2-29 Gene

Previous GeneCards Identifiers for IGKV2-29 Gene

  • GC02U990198
  • GC02M089418
  • GC02M089435
  • GC02M089374
  • GC02M089316
  • GC02M089534
  • GC02M089579
  • GC02M089750
  • GC02M089965
  • GC02M090140
  • GC02M089261
  • GC02M089341
  • GC02M089358
  • GC02M089405
  • GC02M089445

Summaries for IGKV2-29 Gene

GeneCards Summary for IGKV2-29 Gene

IGKV2-29 (Immunoglobulin Kappa Variable 2-29 (Gene/Pseudogene)) is a Pseudogene.

UniProtKB/Swiss-Prot for IGKV2-29 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV2-29 Gene

Genomics for IGKV2-29 Gene

Genomic Location for IGKV2-29 Gene

Chromosome:
2
Start:
89,234,174 bp from pter
End:
89,234,912 bp from pter
Size:
739 bases
Orientation:
Minus strand

Genomic View for IGKV2-29 Gene

Genes around IGKV2-29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGKV2-29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGKV2-29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKV2-29 Gene

No data available for Regulatory Elements for IGKV2-29 Gene

Proteins for IGKV2-29 Gene

  • Protein details for IGKV2-29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2NJV5-KV229_HUMAN
    Recommended name:
    Immunoglobulin kappa variable 2-29
    Protein Accession:
    A2NJV5

    Protein attributes for IGKV2-29 Gene

    Size:
    120 amino acids
    Molecular mass:
    13085 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
    SequenceCaution:
    • Sequence=AAB17518.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for IGKV2-29 Gene

Post-translational modifications for IGKV2-29 Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGKV2-29 Gene

Domains & Families for IGKV2-29 Gene

Gene Families for IGKV2-29 Gene

Protein Domains for IGKV2-29 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGKV2-29: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGKV2-29 Gene

Function for IGKV2-29 Gene

Molecular function for IGKV2-29 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGKV2-29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGKV2-29: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKV2-29 Gene

Localization for IGKV2-29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGKV2-29 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGKV2-29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with IGKV2-29: view

No data available for Subcellular locations from COMPARTMENTS for IGKV2-29 Gene

Pathways & Interactions for IGKV2-29 Gene

SuperPathways for IGKV2-29 Gene

No Data Available

Interacting Proteins for IGKV2-29 Gene

Gene Ontology (GO) - Biological Process for IGKV2-29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
GO:0030449 regulation of complement activation TAS --
genes like me logo Genes that share ontologies with IGKV2-29: view

No data available for Pathways by source and SIGNOR curated interactions for IGKV2-29 Gene

Drugs & Compounds for IGKV2-29 Gene

No Compound Related Data Available

Transcripts for IGKV2-29 Gene

mRNA/cDNA for IGKV2-29 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV2-29 Gene

No ASD Table

Relevant External Links for IGKV2-29 Gene

GeneLoc Exon Structure for
IGKV2-29
ECgene alternative splicing isoforms for
IGKV2-29

Expression for IGKV2-29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGKV2-29 Gene

mRNA differential expression in normal tissues according to GTEx for IGKV2-29 Gene

This gene is overexpressed in Spleen (x19.9) and Colon - Transverse (x9.0).
genes like me logo Genes that share expression patterns with IGKV2-29: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGKV2-29 Gene

Orthologs for IGKV2-29 Gene

Evolution for IGKV2-29 Gene

ENSEMBL:
Gene Tree for IGKV2-29 (if available)
TreeFam:
Gene Tree for IGKV2-29 (if available)

No data available for Orthologs for IGKV2-29 Gene

Paralogs for IGKV2-29 Gene

No data available for Paralogs for IGKV2-29 Gene

Variants for IGKV2-29 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGKV2-29 Gene

KV229_HUMAN-A2NJV5
There are several alleles. The sequence shown is that of the functional IMGT allele IGKV2-29*02 that is not represented on the reference genome assembly (GRCh38/hg38). The sequence of the reference genome assembly (GRCh38/hg38) is that of IMGT allele IGKV2-29*01 that is a pseudogene due to a stop codon polymorphism at position 113.

Relevant External Links for IGKV2-29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGKV2-29

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKV2-29 Gene

Disorders for IGKV2-29 Gene

Relevant External Links for IGKV2-29

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGKV2-29

No disorders were found for IGKV2-29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGKV2-29 Gene

Publications for IGKV2-29 Gene

  1. New alleles of IGKV genes A2 and A18 suggest significant human IGKV locus polymorphism. (PMID: 8662073) Atkinson M.J. … Feeney A.J. (Immunogenetics 1996) 3 4 64
  2. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  3. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  4. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  5. Lambda light chain revision in the human intestinal IgA response. (PMID: 18606680) Su W. … Spencer J. (J. Immunol. 2008) 3 64

Products for IGKV2-29 Gene

Sources for IGKV2-29 Gene

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