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Aliases for IGKV2-28 Gene

Aliases for IGKV2-28 Gene

  • Immunoglobulin Kappa Variable 2-28 2 3 5
  • IGKV228 3
  • A19 3

External Ids for IGKV2-28 Gene

Previous GeneCards Identifiers for IGKV2-28 Gene

  • GC02U990199
  • GC02M089406
  • GC02M089423
  • GC02M089360
  • GC02M089305
  • GC02M089524
  • GC02M089578
  • GC02M089749
  • GC02M089964
  • GC02M090139
  • GC02M089260
  • GC02M089338
  • GC02M089354
  • GC02M089409

Summaries for IGKV2-28 Gene

GeneCards Summary for IGKV2-28 Gene

IGKV2-28 (Immunoglobulin Kappa Variable 2-28) is a Protein Coding gene. An important paralog of this gene is IGKV2D-28.

UniProtKB/Swiss-Prot for IGKV2-28 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV2-28 Gene

Genomics for IGKV2-28 Gene

Genomic Location for IGKV2-28 Gene

Chromosome:
2
Start:
89,221,698 bp from pter
End:
89,222,461 bp from pter
Size:
764 bases
Orientation:
Minus strand

Genomic View for IGKV2-28 Gene

Genes around IGKV2-28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGKV2-28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGKV2-28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKV2-28 Gene

No data available for Regulatory Elements for IGKV2-28 Gene

Proteins for IGKV2-28 Gene

  • Protein details for IGKV2-28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A075B6P5-KV228_HUMAN
    Recommended name:
    Immunoglobulin kappa variable 2-28
    Protein Accession:
    A0A075B6P5

    Protein attributes for IGKV2-28 Gene

    Size:
    120 amino acids
    Molecular mass:
    12957 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains, linked by disulfide bonds.

neXtProt entry for IGKV2-28 Gene

Post-translational modifications for IGKV2-28 Gene

No Post-translational modifications

Other Protein References for IGKV2-28 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGKV2-28 Gene

Domains & Families for IGKV2-28 Gene

Gene Families for IGKV2-28 Gene

Protein Domains for IGKV2-28 Gene

Graphical View of Domain Structure for InterPro Entry

A0A075B6P5

UniProtKB/Swiss-Prot:

KV228_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGKV2-28: view

No data available for Suggested Antigen Peptide Sequences for IGKV2-28 Gene

Function for IGKV2-28 Gene

Molecular function for IGKV2-28 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGKV2-28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
genes like me logo Genes that share ontologies with IGKV2-28: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKV2-28 Gene

Localization for IGKV2-28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGKV2-28 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGKV2-28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with IGKV2-28: view

No data available for Subcellular locations from COMPARTMENTS for IGKV2-28 Gene

Pathways & Interactions for IGKV2-28 Gene

SuperPathways for IGKV2-28 Gene

No Data Available

Interacting Proteins for IGKV2-28 Gene

Gene Ontology (GO) - Biological Process for IGKV2-28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
genes like me logo Genes that share ontologies with IGKV2-28: view

No data available for Pathways by source and SIGNOR curated interactions for IGKV2-28 Gene

Transcripts for IGKV2-28 Gene

mRNA/cDNA for IGKV2-28 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV2-28 Gene

No ASD Table

Relevant External Links for IGKV2-28 Gene

GeneLoc Exon Structure for
IGKV2-28
ECgene alternative splicing isoforms for
IGKV2-28

Expression for IGKV2-28 Gene

mRNA expression in normal human tissues for IGKV2-28 Gene

mRNA differential expression in normal tissues according to GTEx for IGKV2-28 Gene

This gene is overexpressed in Spleen (x16.7), Colon - Transverse (x6.5), Small Intestine - Terminal Ileum (x6.1), and Minor Salivary Gland (x6.0).

Protein differential expression in normal tissues from HIPED for IGKV2-28 Gene

This gene is overexpressed in Skin (29.7), Urine (14.9), and Saliva (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGKV2-28 Gene



Protein tissue co-expression partners for IGKV2-28 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGKV2-28: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGKV2-28 Gene

Orthologs for IGKV2-28 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGKV2-28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 69 (a)
OneToMany
Species where no ortholog for IGKV2-28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGKV2-28 Gene

ENSEMBL:
Gene Tree for IGKV2-28 (if available)
TreeFam:
Gene Tree for IGKV2-28 (if available)

Paralogs for IGKV2-28 Gene

genes like me logo Genes that share paralogs with IGKV2-28: view

Variants for IGKV2-28 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGKV2-28 Gene

KV228_HUMAN-A0A075B6P5
There are several alleles. The sequence shown is that of IMGT allele IGKV2-28*01.

Relevant External Links for IGKV2-28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGKV2-28

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKV2-28 Gene

Disorders for IGKV2-28 Gene

No disorders were found for IGKV2-28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGKV2-28 Gene

Publications for IGKV2-28 Gene

  1. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  2. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  3. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64
  5. Nomenclature of the human immunoglobulin kappa (IGK) genes. (PMID: 11549845) Lefranc M.P. (Exp. Clin. Immunogenet. 2001) 4 64

Products for IGKV2-28 Gene

Sources for IGKV2-28 Gene

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