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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGKV1D-42 Gene

protein-coding   GIFtS: 20
GCID: GC02P090230

immunoglobulin kappa variable 1D-42 (non-functional)

(Previous name: immunoglobulin kappa variable 1D-42 )
 Explore 1 disease affiliated with
IGKV1D-42 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGKV1D-42    

Aliases
for IGKV1D-42 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immunoglobulin Kappa Variable 1D-42 (Non-Functional)1 2
Immunoglobulin Kappa Variable 1D-421
IGKV1D422
L222

External Ids:    HGNC: 57571   Entrez Gene: 288922   Ensembl: ENSG000002116337   UniProtKB: A2NXD24   

Export aliases for IGKV1D-42 gene to outside databases

Previous GC identifers: GC02U990170 GC02P089970 GC02P089987 GC02P089924 GC02P089868


Summaries
for IGKV1D-42 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for IGKV1D-42 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGKV1D-42
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGKV1D-42

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGKV1D-42


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

IGKV1D-42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGKV1D-42 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P090230:  view genomic region     (about GC identifiers)

Start:
 90,229,045 bp from pter      End:
 90,229,531 bp from pter
Size:
 487 bases      Orientation:
 plus strand

Proteins
for IGKV1D-42 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/TrEMBL: A2NXD2 (See protein sequence)
Recommended Name: Immunolglobulin kappa light chain variable region L22 precursor  
Size: 117 amino acids; 13026 Da

IGKV1D-42 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).


ENSEMBL proteins: 
 ENSP00000374813  
Reactome Protein details: A2NXD2
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Protein Domains /
Families
for IGKV1D-42 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
IGKV1D-42 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR007110 Ig-like_dom
 IPR003596 Ig_V-set_subgr
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry A2NXD2

ProtoNet protein and cluster: A2NXD2


Function
for IGKV1D-42 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
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Inhib. RNA
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Gene Editing
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Clone
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In Situ Assay
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Pathways & Interactions
for IGKV1D-42 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Pathway sources
See GeneCards unified pathways
Show all pathways


5/21        Reactome Pathways for IGKV1D-42 (see all 21)
    Role of myosins in phagosome formation
FCGR activation
Cleavage of Alpha-1-Microglobulin
Sequestering and phosphorylation Fc gamma receptors in the lipid rafts
Role of phospholipids in phagocytosis



IGKV1D-42 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGKV1D-42

Drugs & Compounds
for IGKV1D-42 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGKV1D-42
Search CenterWatch for drugs/clinical trials and news about IGKV1D-42 

Transcripts
for IGKV1D-42 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390278

miRNA
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Inhib. RNA
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Browse OriGene siRNA
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Clone
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Primer
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  Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGKV1D-42

1 AceView cDNA sequence:

BM820007 

GeneLoc Exon Structure


Expression
for IGKV1D-42 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGKV1D-42 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image
See IGKV1D-42 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for IGKV1D-42
Primer
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In Situ
Assay Products: 
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Orthologs
for IGKV1D-42 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for IGKV1D-42 gene from 1/3 species (see all 3)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
zebrafish
(Danio rerio)		 Actinopterygii CR391995.26
 --
 32(a)
 1 → many
 24(34453726-34454034)


ENSEMBL Gene Tree for IGKV1D-42 (if available)
TreeFam Gene Tree for IGKV1D-42 (if available) 

Paralogs
for IGKV1D-42 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGKV1D-42 gene
IGKV1D-372  IGKV1D-82  IGKV3D-112  IGKV1D-332  IGKV4-12  IGKV1-62  IGKV3-112  IGKV1D-122  
IGKV2-402  IGKV3D-72  IGKV3-202  IGKV1-162  IGKV1-82  IGKV1-172  IGKV1-272  IGKV2D-262  
IGKV1-392  IGKV1-52  IGKV6D-212  IGKV1-372  IGKV1D-172  IGKV1-332  IGKV2-302  ENSG000002283252  
IGKV2D-302  IGKV1D-132  IGKV1D-392  IGKV2-282  IGKV1-122  IGKV5-22  IGKV3D-202  IGKV3-72  
IGKV2D-282  IGKV1D-432  IGKV3D-152  IGKV3-152  IGKV1-92  IGKV1D-162  IGKV6-212  IGKV2D-242  
IGKV2-242  IGKV2D-292  IGKV6D-412  IGKV2D-402  

IGKV1D-42 for paralogs           About GeneDecksing



Genomic Variants
for IGKV1D-42 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGKV1D-42
DNA2.0 Custom Variant and Variant Library Synthesis for IGKV1D-42

Disorders / Diseases
for IGKV1D-42 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
IGKV1D-42 for disorders           About GeneDecksing

1 disease for IGKV1D-42:    About MalaCards
poems syndrome

1 disease from the University of Copenhagen DISEASES database for IGKV1D-42:
POEMS syndrome

Export disorders for IGKV1D-42 gene to outside databases

Publications
for IGKV1D-42 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGKV1D-42 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGKV1D-42)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Evolutionary dynamics of the human immunoglobulin kappa locus and the germline repertoire of the Vkappa genes. (PubMed id 11298326)1 Kawasaki K....Shimizu N. (2001)
  2. The V kappa genes of the L regions and the repertoire of V kappa gene sequences in the human germ line. (PubMed id 8223863)1 Huber C.... Zachau H.G. (1993)

External Searches for IGKV1D-42 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGKV1D-42 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28892 HGNC: 5757 AceView: IGKV1D-42andIGKV1D-8 Ensembl:ENSG00000211633 euGenes: HUgn28892
ECgene: IGKV1D-42 H-InvDB: IGKV1D-42

Other Databases showing IGKV1D-42 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGKV1D-42 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGKV1D-42 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGKV1D-42 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGKV1D-42 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGKV1D-42 gene:
Search GeneIP for patents involving IGKV1D-42

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
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About This Section

 
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