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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGKV1D-33 Gene

protein-coding   GIFtS: 17
GCID: GC02P089954

immunoglobulin kappa variable 1D-33
 Explore 2 diseases affiliated with
IGKV1D-33 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGKV1D-33    

Aliases
for IGKV1D-33 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immunoglobulin Kappa Variable 1D-331 2
IGKV1D332
O82

External Ids:    HGNC: 57531   Entrez Gene: 288962   Ensembl: ENSG000002399757   

Export aliases for IGKV1D-33 gene to outside databases

Previous GC identifers: GC02U990174 GC02P089711 GC02P089712 GC02P089648 GC02P089589


Summaries
for IGKV1D-33 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for IGKV1D-33 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGKV1D-33
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGKV1D-33

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGKV1D-33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

IGKV1D-33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGKV1D-33 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P089954:  view genomic region     (about GC identifiers)

Start:
 89,952,792 bp from pter      End:
 89,953,355 bp from pter
Size:
 564 bases      Orientation:
 plus strand

Proteins
for IGKV1D-33 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB: --
IGKV1D-33 Protein expression data from MOPED and PaxDb:    About this image 
Estimated protein expression log10 (pmol).


ENSEMBL proteins: 
 ENSP00000374800  

Human Recombinant Protein Products: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005886plasma membrane TAS--


IGKV1D-33 for ontologies           About GeneDecksing



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Protein Domains /
Families
for IGKV1D-33 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
   --

Function
for IGKV1D-33 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
miRNA
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In Situ Assay
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding NAS5028201


IGKV1D-33 for ontologies           About GeneDecksing



Pathways & Interactions
for IGKV1D-33 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGKV1D-33

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS5028201
GO:0006956complement activation TAS--
GO:0006958complement activation, classical pathway TAS--
GO:0045087innate immune response TAS--
GO:0050776regulation of immune response TAS--


IGKV1D-33 for ontologies           About GeneDecksing



Drugs & Compounds
for IGKV1D-33 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGKV1D-33
Search CenterWatch for drugs/clinical trials and news about IGKV1D-33 

Transcripts
for IGKV1D-33 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390265

miRNA
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Inhib. RNA
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Browse OriGene siRNA
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Clone
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Primer
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  Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGKV1D-33

24/27 AceView cDNA sequences (see all 27):

AY043104 AY247662 AY043146 AJ697905 AJ697902 AY043102 AF103395 AJ698329 
AW406247 U93511 AY247658 AY247657 L03140 AF103499 AF124196 S67987 
AW408194 CD709894 AF054662 BF174305 AW404283 AF320835 CD694862 AY569449 

GeneLoc Exon Structure


Expression
for IGKV1D-33 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGKV1D-33 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image
See IGKV1D-33 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for IGKV1D-33
Primer
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In Situ
Assay Products: 
 		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGKV1D-33

Orthologs
for IGKV1D-33 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for IGKV1D-33 gene from 1/3 species (see all 3)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
zebrafish
(Danio rerio)		 Actinopterygii CR391995.26
 --
 37(a)
 1 → many
 24(34453726-34454034)


ENSEMBL Gene Tree for IGKV1D-33 (if available)
TreeFam Gene Tree for IGKV1D-33 (if available) 

Paralogs
for IGKV1D-33 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGKV1D-33 gene
IGKV1D-372  IGKV1D-82  IGKV3D-112  IGKV4-12  IGKV1-62  IGKV3-112  IGKV1D-122  IGKV2-402  
IGKV3D-72  IGKV3-202  IGKV1-162  IGKV1-82  IGKV1-172  IGKV1-272  IGKV2D-262  IGKV1-392  
IGKV1-52  IGKV6D-212  IGKV1-372  IGKV1D-172  IGKV1-332  IGKV2-302  ENSG000002283252  IGKV2D-302  
IGKV1D-132  IGKV1D-392  IGKV2-282  IGKV1-122  IGKV5-22  IGKV3D-202  IGKV3-72  IGKV2D-282  
IGKV1D-432  IGKV3D-152  IGKV3-152  IGKV1-92  IGKV1D-162  IGKV6-212  IGKV1D-422  IGKV2D-242  
IGKV2-242  IGKV2D-292  IGKV6D-412  IGKV2D-402  

IGKV1D-33 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for IGKV1D-33
PGOHUM00000250437 PGOHUM00000240741


Genomic Variants
for IGKV1D-33 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGKV1D-33
DNA2.0 Custom Variant and Variant Library Synthesis for IGKV1D-33

Disorders / Diseases
for IGKV1D-33 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
IGKV1D-33 for disorders           About GeneDecksing

2 diseases for IGKV1D-33:    About MalaCards
haemophilus influenzae    influenza


Export disorders for IGKV1D-33 gene to outside databases

Publications
for IGKV1D-33 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGKV1D-33 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGKV1D-33)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (2002)
  2. Evolutionary dynamics of the human immunoglobulin kappa locus and the germline repertoire of the Vkappa genes. (PubMed id 11298326)1 Kawasaki K....Shimizu N. (2001)
  3. Clonal characterization of the human IgG antibody rep ertoire to Haemophilus influenzae type b polysaccharide. IV. The less frequentl y expressed VL are heterogeneous. (PubMed id 1940382)1 Scott M.G....Nahm M.H. (1991)
  4. N segment insertion and region-directed somatic hypermutation in a kappa gene of a t(2;8) chromosomal translocation. (PubMed id 3110741)1 Klobeck H.G.... Zachau H.G. (1987)
  5. Activation of C1r by proteolytic cleavage. (PubMed id 1249422)1 Ziccardi R.J. and Cooper N.R. (1976)
  6. The structure determination of the variable portion of the Bence- Jones protein Au. (PubMed id 1234024)1 Fehlhammer H.... Schramm H.J. (1975)
  7. Rule of antibody structure. The primary structure of a monoclonal immunoglobulin L-chain of the kappa-type, subgroup I (Bence-Jones protein Au). (PubMed id 5028201)1 Schiechl H. and Hilschmann N. (1972)

External Searches for IGKV1D-33 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGKV1D-33 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28896 HGNC: 5753 AceView: IGKV1D-33 Ensembl:ENSG00000239975 euGenes: HUgn28896
ECgene: IGKV1D-33 H-InvDB: IGKV1D-33

Other Databases showing IGKV1D-33 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGKV1D-33 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGKV1D-33 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGKV1D-33 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGKV1D-33 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGKV1D-33 gene:
Search GeneIP for patents involving IGKV1D-33

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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