Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IGKV1D-33 Gene

Aliases for IGKV1D-33 Gene

  • Immunoglobulin Kappa Variable 1D-33 2 3 5
  • Ig Kappa Chain V-I Region AG 3 4
  • Ig Kappa Chain V-I Region Lay 4
  • Ig Kappa Chain V-I Region Rei 4
  • Ig Kappa Chain V-I Region Roy 4
  • Ig Kappa Chain V-I Region Scw 4
  • Ig Kappa Chain V-I Region WAT 4
  • Ig Kappa Chain V-I Region Bi 4
  • Ig Kappa Chain V-I Region Ni 4
  • IGKV1D33 3
  • O8 3

External Ids for IGKV1D-33 Gene

Previous GeneCards Identifiers for IGKV1D-33 Gene

  • GC02U990174
  • GC02P089711
  • GC02P089712
  • GC02P089648
  • GC02P089589
  • GC02P089954
  • GC02P089962
  • GC02P090055

Summaries for IGKV1D-33 Gene

GeneCards Summary for IGKV1D-33 Gene

IGKV1D-33 (Immunoglobulin Kappa Variable 1D-33) is a Protein Coding gene. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGKV1-33.

UniProtKB/Swiss-Prot for IGKV1D-33 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV1D-33 Gene

Genomics for IGKV1D-33 Gene

Regulatory Elements for IGKV1D-33 Gene

Enhancers for IGKV1D-33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F089909 0.6 Ensembl 0.8 -4.4 -4382 0.8 SRF CTCF ZNF654 SMC3 RAD21 IGKV1D-33 IGKV3D-34
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGKV1D-33 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGKV1D-33 Gene

Chromosome:
2
Start:
89,913,982 bp from pter
End:
89,916,052 bp from pter
Size:
2,071 bases
Orientation:
Plus strand

Genomic View for IGKV1D-33 Gene

Genes around IGKV1D-33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGKV1D-33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGKV1D-33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKV1D-33 Gene

Proteins for IGKV1D-33 Gene

  • Protein details for IGKV1D-33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01593-KVD33_HUMAN
    Recommended name:
    Immunoglobulin kappa variable 1D-33
    Protein Accession:
    P01593
    Secondary Accessions:
    • A0A0B4J1U0
    • P01595
    • P01605
    • P01607
    • P01608
    • P01609
    • P01613
    • P80362

    Protein attributes for IGKV1D-33 Gene

    Size:
    117 amino acids
    Molecular mass:
    12848 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains, linked by disulfide bonds.

    Three dimensional structures from OCA and Proteopedia for IGKV1D-33 Gene

neXtProt entry for IGKV1D-33 Gene

Post-translational modifications for IGKV1D-33 Gene

No Post-translational modifications

Other Protein References for IGKV1D-33 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGKV1D-33 Gene

Domains & Families for IGKV1D-33 Gene

Gene Families for IGKV1D-33 Gene

Protein Domains for IGKV1D-33 Gene

Graphical View of Domain Structure for InterPro Entry

P01593

UniProtKB/Swiss-Prot:

KVD33_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGKV1D-33: view

No data available for Suggested Antigen Peptide Sequences for IGKV1D-33 Gene

Function for IGKV1D-33 Gene

Molecular function for IGKV1D-33 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGKV1D-33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 818073
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGKV1D-33: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKV1D-33 Gene

Localization for IGKV1D-33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGKV1D-33 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGKV1D-33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS,TAS --
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 23376485
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with IGKV1D-33: view

No data available for Subcellular locations from COMPARTMENTS for IGKV1D-33 Gene

Pathways & Interactions for IGKV1D-33 Gene

SuperPathways for IGKV1D-33 Gene

No Data Available

Interacting Proteins for IGKV1D-33 Gene

Selected Interacting proteins: P01593-KVD33_HUMAN for IGKV1D-33 Gene via IID

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-DRB1
BTLA
BTN2A2

Gene Ontology (GO) - Biological Process for IGKV1D-33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 818073
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
genes like me logo Genes that share ontologies with IGKV1D-33: view

No data available for Pathways by source and SIGNOR curated interactions for IGKV1D-33 Gene

Transcripts for IGKV1D-33 Gene

mRNA/cDNA for IGKV1D-33 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV1D-33 Gene

No ASD Table

Relevant External Links for IGKV1D-33 Gene

GeneLoc Exon Structure for
IGKV1D-33
ECgene alternative splicing isoforms for
IGKV1D-33

Expression for IGKV1D-33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGKV1D-33 Gene

mRNA differential expression in normal tissues according to GTEx for IGKV1D-33 Gene

This gene is overexpressed in Spleen (x14.2), Colon - Transverse (x6.7), Minor Salivary Gland (x5.8), and Small Intestine - Terminal Ileum (x4.2).

Protein differential expression in normal tissues from HIPED for IGKV1D-33 Gene

This gene is overexpressed in Urine (38.4), Skin (23.9), and Serum (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGKV1D-33 Gene



Protein tissue co-expression partners for IGKV1D-33 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGKV1D-33: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGKV1D-33 Gene

Orthologs for IGKV1D-33 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGKV1D-33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 58 (a)
OneToMany
Species where no ortholog for IGKV1D-33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGKV1D-33 Gene

ENSEMBL:
Gene Tree for IGKV1D-33 (if available)
TreeFam:
Gene Tree for IGKV1D-33 (if available)

Paralogs for IGKV1D-33 Gene

Variants for IGKV1D-33 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGKV1D-33 Gene

KVD33_HUMAN-P01593
There are several alleles. The sequence shown is that of IMGT allele IGKV1D-33*01.

Relevant External Links for IGKV1D-33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGKV1D-33

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKV1D-33 Gene

Disorders for IGKV1D-33 Gene

No disorders were found for IGKV1D-33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGKV1D-33 Gene

Publications for IGKV1D-33 Gene

  1. Principle of antibody structure. The primary structure of a monoclonal kappa I-type immunoglobulin L-chain (Bence Jones protein Bi). 3. The complete amino acid sequence and the genetic significance of the variability principles for the mechanism of antibody formation. (PMID: 4563064) Braun M. … Hilschmann N. (Hoppe-Seyler's Z. Physiol. Chem. 1972) 3 4 64
  2. The amino acid sequence of a kappa type Bence-Jones protein. 3. The complete sequence and the location of the disulfide bridges. (PMID: 4893682) Titani K. … Putnam F.W. (J. Biol. Chem. 1969) 3 4 64
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 64
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3 64
  5. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. (PMID: 22516433) Bastos-Amador P. … Falcon-Perez J.M. (J Proteomics 2012) 3 64

Products for IGKV1D-33 Gene

Sources for IGKV1D-33 Gene

Content
Loading form....