Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IGKV1-8 Gene

Aliases for IGKV1-8 Gene

  • Immunoglobulin Kappa Variable 1-8 2 3 5
  • IGKV18 3
  • L9 3

External Ids for IGKV1-8 Gene

Previous GeneCards Identifiers for IGKV1-8 Gene

  • GC02U990220
  • GC02M089177
  • GC02M089195
  • GC02M089196
  • GC02M089131
  • GC02M089292
  • GC02M089349
  • GC02M089727
  • GC02M089934
  • GC02M090115
  • GC02M088858
  • GC02M088870
  • GC02M088875

Summaries for IGKV1-8 Gene

GeneCards Summary for IGKV1-8 Gene

IGKV1-8 (Immunoglobulin Kappa Variable 1-8) is a Protein Coding gene. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGKV1D-8.

UniProtKB/Swiss-Prot for IGKV1-8 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Additional gene information for IGKV1-8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV1-8 Gene

Genomics for IGKV1-8 Gene

Genomic Location for IGKV1-8 Gene

Chromosome:
2
Start:
88,992,409 bp from pter
End:
88,992,931 bp from pter
Size:
523 bases
Orientation:
Minus strand

Genomic View for IGKV1-8 Gene

Genes around IGKV1-8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGKV1-8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGKV1-8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKV1-8 Gene

No data available for Regulatory Elements for IGKV1-8 Gene

Proteins for IGKV1-8 Gene

  • Protein details for IGKV1-8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A0C4DH67-KV108_HUMAN
    Recommended name:
    Immunoglobulin kappa variable 1-8
    Protein Accession:
    A0A0C4DH67

    Protein attributes for IGKV1-8 Gene

    Size:
    115 amino acids
    Molecular mass:
    12537 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGKV1-8 Gene

Post-translational modifications for IGKV1-8 Gene

No Post-translational modifications

Other Protein References for IGKV1-8 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGKV1-8 Gene

Domains & Families for IGKV1-8 Gene

Gene Families for IGKV1-8 Gene

Protein Domains for IGKV1-8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGKV1-8: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGKV1-8 Gene

Function for IGKV1-8 Gene

Molecular function for IGKV1-8 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGKV1-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
genes like me logo Genes that share ontologies with IGKV1-8: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for IGKV1-8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKV1-8 Gene

Localization for IGKV1-8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGKV1-8 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGKV1-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGKV1-8: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGKV1-8 Gene

Pathways & Interactions for IGKV1-8 Gene

SuperPathways for IGKV1-8 Gene

No Data Available

Interacting Proteins for IGKV1-8 Gene

Gene Ontology (GO) - Biological Process for IGKV1-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with IGKV1-8: view

No data available for Pathways by source and SIGNOR curated interactions for IGKV1-8 Gene

Drugs & Compounds for IGKV1-8 Gene

No Compound Related Data Available

Transcripts for IGKV1-8 Gene

mRNA/cDNA for IGKV1-8 Gene

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for IGKV1-8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV1-8 Gene

No ASD Table

Relevant External Links for IGKV1-8 Gene

GeneLoc Exon Structure for
IGKV1-8
ECgene alternative splicing isoforms for
IGKV1-8

Expression for IGKV1-8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGKV1-8 Gene

mRNA differential expression in normal tissues according to GTEx for IGKV1-8 Gene

This gene is overexpressed in Spleen (x15.6), Whole Blood (x6.5), and Colon - Transverse (x4.9).

Protein differential expression in normal tissues from HIPED for IGKV1-8 Gene

This gene is overexpressed in Pancreatic juice (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGKV1-8 Gene



Protein tissue co-expression partners for IGKV1-8 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGKV1-8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGKV1-8 Gene

Orthologs for IGKV1-8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGKV1-8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 34
  • 56 (a)
OneToMany
Species where no ortholog for IGKV1-8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGKV1-8 Gene

ENSEMBL:
Gene Tree for IGKV1-8 (if available)
TreeFam:
Gene Tree for IGKV1-8 (if available)

Paralogs for IGKV1-8 Gene

Variants for IGKV1-8 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGKV1-8 Gene

KV108_HUMAN-A0A0C4DH67
There are several alleles. The sequence shown is that of IMGT allele IGKV1-8*01.

Relevant External Links for IGKV1-8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGKV1-8

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKV1-8 Gene

Disorders for IGKV1-8 Gene

No disorders were found for IGKV1-8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGKV1-8 Gene

Publications for IGKV1-8 Gene

  1. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4 60
  2. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M … McHeyzer-Williams L (Nature reviews. Immunology 2011) 4 60
  3. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder HW … Cavacini L (The Journal of allergy and clinical immunology 2010) 4 60
  4. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G … Papavasiliou FN (Annual review of genetics 2007) 4 60
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 60

Products for IGKV1-8 Gene

Sources for IGKV1-8 Gene

Content
Loading form....