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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGKV1-6 Gene

protein-coding   GIFtS: 16
GCID: GC02M089723

immunoglobulin kappa variable 1-6
 Explore 2 diseases affiliated with
IGKV1-6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGKV1-6    

Aliases
for IGKV1-6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immunoglobulin Kappa Variable 1-61 2
IGKV162
L112

External Ids:    HGNC: 57421   Entrez Gene: 289432   Ensembl: ENSG000002398557   

Export aliases for IGKV1-6 gene to outside databases

Previous GC identifers: GC02U990221 GC02M089152 GC02M089167 GC02M089105 GC02M089050 GC02M089266 GC02M089282


Summaries
for IGKV1-6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for IGKV1-6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGKV1-6
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGKV1-6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGKV1-6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

IGKV1-6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGKV1-6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M089723:  view genomic region     (about GC identifiers)

Start:
 89,265,781 bp from pter      End:
 89,266,286 bp from pter
Size:
 506 bases      Orientation:
 minus strand

Proteins
for IGKV1-6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB: --
IGKV1-6 Protein expression data from MOPED and PaxDb:    About this image 
IGKV1-6 Protein Expression

ENSEMBL proteins: 
 ENSP00000420361  

Human Recombinant Protein Products for IGKV1-6: 
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Protein Domains /
Families
for IGKV1-6 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
   --

Function
for IGKV1-6 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Animal Models:
   inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IGKV1-6 

miRNA
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Inhib. RNA
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Gene Editing
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In Situ Assay
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Pathways & Interactions
for IGKV1-6 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGKV1-6

Drugs & Compounds
for IGKV1-6 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGKV1-6
Search CenterWatch for drugs/clinical trials and news about IGKV1-6 

Transcripts
for IGKV1-6 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000464162

miRNA
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Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
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Browse OriGene siRNA
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Clone
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Primer
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  Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGKV1-6

24/105 AceView cDNA sequences (see all 105):

U79763 AW630271 AB063948 CD685364 AY043112 AW405904 S56182 AF039298 
CD708383 AW405289 AW407298 L39957 AW407313 AJ697904 L03555 CD697374 
L33030 CD697975 CD705591 AF396469 AY423220 CD708479 AF103418 CD697559 

GeneLoc Exon Structure


Expression
for IGKV1-6 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGKV1-6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
IGKV1-6 Expression
About this image
See IGKV1-6 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for IGKV1-6

Primer
Products:		Browse OriGene genome-wide validated SYBR primer pairs
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Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGKV1-6
In Situ
Assay Products: 
 		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGKV1-6

Orthologs
for IGKV1-6 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for IGKV1-6 gene from 1/2 species (see all 2)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
zebrafish
(Danio rerio)		 Actinopterygii CR391995.26
 --
 39(a)
 1 → many
 24(34453726-34454034)


ENSEMBL Gene Tree for IGKV1-6 (if available)
TreeFam Gene Tree for IGKV1-6 (if available) 

Paralogs
for IGKV1-6 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IGKV1-6 gene
IGKV1D-372  IGKV1D-82  IGKV3D-112  IGKV1D-332  IGKV4-12  IGKV3-112  IGKV1D-122  IGKV2-402  
IGKV3D-72  IGKV3-202  IGKV1-162  IGKV1-82  IGKV1-172  IGKV1-272  IGKV2D-262  IGKV1-392  
IGKV1-52  IGKV6D-212  IGKV1-372  IGKV1D-172  IGKV1-332  IGKV2-302  ENSG000002283252  IGKV2D-302  
IGKV1D-132  IGKV1D-392  IGKV2-282  IGKV1-122  IGKV5-22  IGKV3D-202  IGKV3-72  IGKV2D-282  
IGKV1D-432  IGKV3D-152  IGKV3-152  IGKV1-92  IGKV1D-162  IGKV6-212  IGKV1D-422  IGKV2D-242  
IGKV2-242  IGKV2D-292  IGKV2D-402  IGKV6D-412  

IGKV1-6 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for IGKV1-6
PGOHUM00000240871


Genomic Variants
for IGKV1-6 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGKV1-6
DNA2.0 Custom Variant and Variant Library Synthesis for IGKV1-6

Disorders / Diseases
for IGKV1-6 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
IGKV1-6 for disorders           About GeneDecksing

2 diseases for IGKV1-6:    About MalaCards
haemophilus influenzae    influenza


Export disorders for IGKV1-6 gene to outside databases

Publications
for IGKV1-6 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed article for IGKV1-6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGKV1-6)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Clonal characterization of the human IgG antibody rep ertoire to Haemophilus influenzae type b polysaccharide. IV. The less frequentl y expressed VL are heterogeneous. (PubMed id 1940382)1 Scott M.G....Nahm M.H. (1991)

External Searches for IGKV1-6 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing IGKV1-6 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 28943 HGNC: 5742 AceView: IGKV1-5andIGKV1-6 Ensembl:ENSG00000239855 euGenes: HUgn28943
ECgene: IGKV1-6 H-InvDB: IGKV1-6

Other Databases showing IGKV1-6 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing IGKV1-6 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGKV1-6 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGKV1-6 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Intellectual Property
for IGKV1-6 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGKV1-6 gene:
Search GeneIP for patents involving IGKV1-6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for IGKV1-6 gene

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About This Section

 
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