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Aliases for IGKV1-5 Gene

Aliases for IGKV1-5 Gene

  • Immunoglobulin Kappa Variable 1-5 2 3 4
  • Ig Kappa Chain V-I Region HK102 4
  • Ig Kappa Chain V-Region 3
  • IGKV15 3
  • IGKV 3
  • L12a 3
  • L12 3
  • V1 3

External Ids for IGKV1-5 Gene

Previous GeneCards Identifiers for IGKV1-5 Gene

  • GC02U990138
  • GC02M089044
  • GC02M089059
  • GC02M088998
  • GC02M089086
  • GC02M088938
  • GC02M089246

Summaries for IGKV1-5 Gene

GeneCards Summary for IGKV1-5 Gene

IGKV1-5 (Immunoglobulin Kappa Variable 1-5) is a Protein Coding gene. Diseases associated with IGKV1-5 include light chain deposition disease. Among its related pathways are PI3K/AKT Signaling in Cancer and Immune System. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGKV3D-15.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV1-5 Gene

Genomics for IGKV1-5 Gene

Genomic Location for IGKV1-5 Gene

Chromosome:
2
Start:
88,947,301 bp from pter
End:
88,947,957 bp from pter
Size:
657 bases
Orientation:
Minus strand

Genomic View for IGKV1-5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for IGKV1-5 Gene

No data available for Regulatory Elements for IGKV1-5 Gene

Proteins for IGKV1-5 Gene

  • Protein details for IGKV1-5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01602-KV110_HUMAN
    Recommended name:
    Ig heavy chain V-I region 5
    Protein Accession:
    P01602
    Secondary Accessions:
    • A0A075B6S8

    Protein attributes for IGKV1-5 Gene

    Size:
    117 amino acids
    Molecular mass:
    12782 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGKV1-5 Gene

Proteomics data for IGKV1-5 Gene at MOPED

Post-translational modifications for IGKV1-5 Gene

No Post-translational modifications

Other Protein References for IGKV1-5 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGKV1-5 Gene

Domains & Families for IGKV1-5 Gene

Gene Families for IGKV1-5 Gene

Protein Domains for IGKV1-5 Gene

Suggested Antigen Peptide Sequences for IGKV1-5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGKV1-5: view

No data available for UniProtKB/Swiss-Prot for IGKV1-5 Gene

Function for IGKV1-5 Gene

Gene Ontology (GO) - Molecular Function for IGKV1-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 6325927
genes like me logo Genes that share ontologies with IGKV1-5: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKV1-5 Gene

Localization for IGKV1-5 Gene

Gene Ontology (GO) - Cellular Components for IGKV1-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 23376485
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with IGKV1-5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for IGKV1-5 Gene

Pathways & Interactions for IGKV1-5 Gene

genes like me logo Genes that share pathways with IGKV1-5: view

Interacting Proteins for IGKV1-5 Gene

Selected Interacting proteins: P01602-KV110_HUMAN for IGKV1-5 Gene via I2D

Gene Ontology (GO) - Biological Process for IGKV1-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 6325927
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
GO:0038095 Fc-epsilon receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with IGKV1-5: view

No data available for SIGNOR curated interactions for IGKV1-5 Gene

Drugs & Compounds for IGKV1-5 Gene

No Compound Related Data Available

Transcripts for IGKV1-5 Gene

mRNA/cDNA for IGKV1-5 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV1-5 Gene

No ASD Table

Relevant External Links for IGKV1-5 Gene

GeneLoc Exon Structure for
IGKV1-5
ECgene alternative splicing isoforms for
IGKV1-5

Expression for IGKV1-5 Gene

mRNA expression in normal human tissues for IGKV1-5 Gene

mRNA differential expression in normal tissues according to GTEx for IGKV1-5 Gene

This gene is overexpressed in Spleen (x13.7), Colon - Transverse (x6.8), and Small Intestine - Terminal Ileum (x4.2).

Protein differential expression in normal tissues from HIPED for IGKV1-5 Gene

This gene is overexpressed in Vitreous humor (23.2), Urine (12.1), and Synovial fluid (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGKV1-5 Gene



genes like me logo Genes that share expression patterns with IGKV1-5: view

Protein tissue co-expression partners for IGKV1-5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGKV1-5 Gene

Orthologs for IGKV1-5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGKV1-5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 57 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia IGKV1-5 36
  • 89 (a)
OneToOne
Species with no ortholog for IGKV1-5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGKV1-5 Gene

ENSEMBL:
Gene Tree for IGKV1-5 (if available)
TreeFam:
Gene Tree for IGKV1-5 (if available)

Paralogs for IGKV1-5 Gene

genes like me logo Genes that share paralogs with IGKV1-5: view

Variants for IGKV1-5 Gene

Sequence variations from dbSNP and Humsavar for IGKV1-5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_073349 -

Relevant External Links for IGKV1-5 Gene

HapMap Linkage Disequilibrium report
IGKV1-5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKV1-5 Gene

Disorders for IGKV1-5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGKV1-5 Gene - From: GeneCards

Disorder Aliases PubMed IDs
light chain deposition disease
  • light-chain deposition disease
- elite association

Relevant External Links for IGKV1-5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGKV1-5
genes like me logo Genes that share disorders with IGKV1-5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGKV1-5 Gene

Publications for IGKV1-5 Gene

  1. Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3. (PMID: 17675554) Widhopf G.F. … Kipps T.J. (Blood 2008) 23 67
  2. Immunoglobulin kappa gene repertoire and somatic hypermutation patterns in follicular lymphoma. (PMID: 18640859) Smilevska T. … Stamatopoulos K. (Blood Cells Mol. Dis. 2008) 23 67
  3. Immunoglobulin genes in multiple myeloma: expressed and non-expressed repertoires, heavy and light chain pairings and somatic mutation patterns in a series of 101 cases. (PMID: 16769580) Hadzidimitriou A. … Fassas A. (Haematologica 2006) 23 67
  4. Immunoglobulin heavy- and light-chain repertoire in splenic marginal zone lymphoma. (PMID: 15706403) Stamatopoulos K. … Anagnostopoulos A. (Mol. Med. 2004) 23 67
  5. Protein displays of the human immunoglobulin heavy, kappa and lambda variable and joining regions. (PMID: 10575277) Scaviner D. … Lefranc M.P. (Exp. Clin. Immunogenet. 1999) 23 67

Products for IGKV1-5 Gene

Sources for IGKV1-5 Gene

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