Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IGKV1-5 Gene

Aliases for IGKV1-5 Gene

  • Immunoglobulin Kappa Variable 1-5 2 3 4 5
  • Ig Kappa Chain V-I Region HK102 4
  • Ig Kappa Chain V-Region 3
  • IGKV15 3
  • IGKV 3
  • L12a 3
  • L12 3
  • V1 3

External Ids for IGKV1-5 Gene

Previous GeneCards Identifiers for IGKV1-5 Gene

  • GC02U990138
  • GC02M089044
  • GC02M089059
  • GC02M088998
  • GC02M089086
  • GC02M088938
  • GC02M089246

Summaries for IGKV1-5 Gene

GeneCards Summary for IGKV1-5 Gene

IGKV1-5 (Immunoglobulin Kappa Variable 1-5) is a Protein Coding gene. Diseases associated with IGKV1-5 include light chain deposition disease. Among its related pathways are Immune System and Regulation of actin dynamics for phagocytic cup formation. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGKV3D-15.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV1-5 Gene

Genomics for IGKV1-5 Gene

Genomic Location for IGKV1-5 Gene

Chromosome:
2
Start:
88,947,301 bp from pter
End:
88,947,957 bp from pter
Size:
657 bases
Orientation:
Minus strand

Genomic View for IGKV1-5 Gene

Genes around IGKV1-5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGKV1-5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGKV1-5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKV1-5 Gene

No data available for Regulatory Elements for IGKV1-5 Gene

Proteins for IGKV1-5 Gene

  • Protein details for IGKV1-5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01602-KV110_HUMAN
    Recommended name:
    Ig heavy chain V-I region 5
    Protein Accession:
    P01602
    Secondary Accessions:
    • A0A075B6S8

    Protein attributes for IGKV1-5 Gene

    Size:
    117 amino acids
    Molecular mass:
    12782 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGKV1-5 Gene

Proteomics data for IGKV1-5 Gene at MOPED

Post-translational modifications for IGKV1-5 Gene

No Post-translational modifications

Other Protein References for IGKV1-5 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGKV1-5 Gene

Domains & Families for IGKV1-5 Gene

Gene Families for IGKV1-5 Gene

Protein Domains for IGKV1-5 Gene

Suggested Antigen Peptide Sequences for IGKV1-5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGKV1-5: view

No data available for UniProtKB/Swiss-Prot for IGKV1-5 Gene

Function for IGKV1-5 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKV1-5 Gene

Localization for IGKV1-5 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for IGKV1-5 Gene

Pathways & Interactions for IGKV1-5 Gene

genes like me logo Genes that share pathways with IGKV1-5: view

Interacting Proteins for IGKV1-5 Gene

Selected Interacting proteins: P01602-KV110_HUMAN for IGKV1-5 Gene via I2D

Gene Ontology (GO) - Biological Process for IGKV1-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002377 immunoglobulin production IBA --
GO:0006956 complement activation TAS --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with IGKV1-5: view

No data available for SIGNOR curated interactions for IGKV1-5 Gene

Drugs & Compounds for IGKV1-5 Gene

No Compound Related Data Available

Transcripts for IGKV1-5 Gene

mRNA/cDNA for IGKV1-5 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV1-5 Gene

No ASD Table

Relevant External Links for IGKV1-5 Gene

GeneLoc Exon Structure for
IGKV1-5
ECgene alternative splicing isoforms for
IGKV1-5

Expression for IGKV1-5 Gene

mRNA expression in normal human tissues for IGKV1-5 Gene

mRNA differential expression in normal tissues according to GTEx for IGKV1-5 Gene

This gene is overexpressed in Spleen (x13.7), Colon - Transverse (x6.8), and Small Intestine - Terminal Ileum (x4.2).

Protein differential expression in normal tissues from HIPED for IGKV1-5 Gene

This gene is overexpressed in Vitreous humor (23.2), Urine (12.1), and Synovial fluid (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGKV1-5 Gene



genes like me logo Genes that share expression patterns with IGKV1-5: view

Protein tissue co-expression partners for IGKV1-5 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGKV1-5 Gene

Orthologs for IGKV1-5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGKV1-5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGKV1-5 36
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 57 (a)
OneToMany
Species with no ortholog for IGKV1-5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGKV1-5 Gene

ENSEMBL:
Gene Tree for IGKV1-5 (if available)
TreeFam:
Gene Tree for IGKV1-5 (if available)

Paralogs for IGKV1-5 Gene

genes like me logo Genes that share paralogs with IGKV1-5: view

Variants for IGKV1-5 Gene

Sequence variations from dbSNP and Humsavar for IGKV1-5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_073349 -

Relevant External Links for IGKV1-5 Gene

HapMap Linkage Disequilibrium report
IGKV1-5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKV1-5 Gene

Disorders for IGKV1-5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGKV1-5 Gene - From: GeneCards

Disorder Aliases PubMed IDs
light chain deposition disease
  • light-chain deposition disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IGKV1-5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGKV1-5
genes like me logo Genes that share disorders with IGKV1-5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGKV1-5 Gene

Publications for IGKV1-5 Gene

  1. Human immunoglobulin variable region genes -- DNA sequences of two V kappa genes and a pseudogene. (PMID: 6779204) Bentley D.L. … Rabbitts T.H. (Nature 1980) 3 4 67
  2. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. (PMID: 22516433) Bastos-Amador P. … Falcon-Perez J.M. (J Proteomics 2012) 3

Products for IGKV1-5 Gene

Sources for IGKV1-5 Gene

Back to Top

Content