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IGKV1-5 Gene

protein-coding   GIFtS: 32
GCID: GC02M089246

Immunoglobulin Kappa Variable 1-5

  See IGKV1-5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immunoglobulin Kappa Variable 1-51 2
IGKV2
IGKV152
L122
L12a2
V12

External Ids:    HGNC: 57411   Entrez Gene: 282992   Ensembl: ENSG000002434667   UniProtKB: P016023   

Export aliases for IGKV1-5 gene to outside databases

Previous GC identifers: GC02U990138 GC02M089044 GC02M089059 GC02M088998 GC02M089086 GC02M088938 GC02M089027


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IGKV1-5 Gene:
IGKV1-5 (immunoglobulin kappa variable 1-5) is a protein-coding gene. Diseases associated with IGKV1-5 include light chain deposition disease, and follicular lymphoma. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGKV1D-37.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for IGKV1-5
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGKV1-5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

IGKV1-5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGKV1-5 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M089246:  view genomic region     (about GC identifiers)

Start:
89,246,819 bp from pter      End:
89,247,475 bp from pter
Size:
657 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KV110_HUMAN, P01602 (See protein sequence)
Recommended Name: Ig kappa chain V-I region HK102 precursor  
Size: 117 amino acids; 12768 Da

Explore the universe of human proteins at neXtProt for IGKV1-5: NX_P01602

Explore proteomics data for IGKV1-5 at MOPED


See IGKV1-5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000420436  
Reactome Protein details: P01602

IGKV1-5 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
IGK: Immunoglobulins / IGK locus

4 InterPro protein domains:
 IPR003596 Ig_V-set_subgr
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set
 IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry P01602

ProtoNet protein and cluster: P01602

2 Blocks protein domains:
IPB003596 Immunoglobulin V-type
IPB013106 Immunoglobulin V-set



Find genes that share domains with IGKV1-5           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003823antigen binding NAS6779204
GO:0005515protein binding ----
     
Find genes that share ontologies with IGKV1-5           About GenesLikeMe


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
plasma membrane4
cytosol1
peroxisome1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005886plasma membrane TAS--
GO:0072562blood microparticle IDA--

Find genes that share ontologies with IGKV1-5           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IGKV1-5 About   (see all 8)  
See pathways by source

SuperPathContained pathways About
1Creation of C4 and C2 activators
Creation of C4 and C2 activators0.85
FCGR activation0.54
Initial triggering of complement0.85
Role of phospholipids in phagocytosis0.53
Classical antibody-mediated complement activation0.82
FCERI mediated NF-kB activation0.32
Complement cascade0.68
2Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
FCERI mediated Ca+2 mobilization0.47
FCERI mediated MAPK activation0.45
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.47
3Fcgamma receptor (FCGR) dependent phagocytosis
Regulation of actin dynamics for phagocytic cup formation0.77
Fcgamma receptor (FCGR) dependent phagocytosis0.77
4PI-3K cascade
Role of LAT2/NTAL/LAB on calcium mobilization0.80
Fc epsilon receptor (FCERI) signaling0.64
5Binding and Uptake of Ligands by Scavenger Receptors
Binding and Uptake of Ligands by Scavenger Receptors0.53
Scavenging of Heme from Plasma0.53


Find genes that share SuperPaths with IGKV1-5           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


Selected Reactome Pathways for IGKV1-5 (see all 13)
    FCERI mediated MAPK activation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
FCERI mediated NF-kB activation
FCGR activation
Scavenging of heme from plasma


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGKV1-5
Interactions:

    GeneGlobe Interaction Network for IGKV1-5

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for IGKV1-5 (P016023 ENSP000004204364) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
ATG5Q9H1Y03, ENSP000003433134I2D: score=1 STRING: ENSP00000343313
GABARAPL1Q9H0R83I2D: score=1 
About this table

Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006955immune response NAS6779204
GO:0006956complement activation TAS--
GO:0006958complement activation, classical pathway TAS--
GO:0038095Fc-epsilon receptor signaling pathway TAS--
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--

Find genes that share ontologies with IGKV1-5           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for IGKV1-5 (KV110)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000496168
miRNA
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Selected AceView cDNA sequences (see all 105):

U79763 CD685364 AY043112 AW630271 AW405904 AB063948 AJ697904 L39957 
S56182 AW407298 AF039298 AW405289 AW407313 L03555 CD708383 AF103418 
CD705591 CD708479 AF396469 CD697975 CD697559 CD697374 AF103553 AY423220 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IGKV1-5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IGKV1-5 Expression
About this image


IGKV1-5 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Blood (Hematopoietic System)
         Mature B-Cells Peripheral Blood
IGKV1-5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IGKV1-5 Protein Expression
    Custom PCR Arrays for IGKV1-5
Primer
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of mammals.

Orthologs for IGKV1-5 gene from Selected species (see all 2)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
cow
(Bos taurus)
Mammalia --
Uncharacterized protein
57(a)
1 → many
11(47126233-47137844)


ENSEMBL Gene Tree for IGKV1-5 (if available)
TreeFam Gene Tree for IGKV1-5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IGKV1-5 gene
IGKV1D-372  IGKV3D-112  IGKV1D-82  IGKV1D-332  IGKV4-12  IGKV1-62  IGKV3-112  IGKV1D-122  
IGKV3D-72  IGKV2-402  IGKV3OR2-2682  IGKV3-202  ENSG000002709992  IGKV1OR2-1082  IGKV1-162  IGKV1-172  
IGKV1-82  IGKV1-272  IGKV2D-262  IGKV1-392  IGKV6D-212  IGKV1-372  IGKV1-332  IGKV1D-172  
IGKV2-302  ENSG000002283252  IGKV2D-302  IGKV1D-132  IGKV1D-392  IGKV2-282  IGKV1-122  IGKV5-22  
IGKV3-72  IGKV3D-202  IGKV2D-282  IGKV1D-432  IGKV3-152  IGKV3D-152  IGKV1-92  IGKV1D-162  
IGKV1D-422  IGKV6-212  IGKV2D-242  IGKV2-242  IGKV2D-292  IGKV2D-402  IGKV6D-412  
Selected SIMAP similar genes for IGKV1-5 using alignment to 1 protein entry:     KV110_HUMAN(see all similar genes):
V1    SDNK1    A30    scFv    V3    VK3
IGK@    IGKV A18    HuC4lambda Vlambda    IGKV4-1    IGLV    V1-2
VKA17    IGLV2-23    V1-4    IGLV2-11    IGLV2-18    IGLV3-19

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing IGKV1-5
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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3 diseases for IGKV1-5:    
About MalaCards
light chain deposition disease    follicular lymphoma    multiple myeloma


Find genes that share disorders with IGKV1-5           About GenesLikeMe

1 Novoseek inferred disease relationship for IGKV1-5 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
somatic mutations 70.1 1 10595931 (1)


Export disorders for IGKV1-5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IGKV1-5 gene, integrated from 10 sources (see all 15):
(articles sorted by number of sources associating them with IGKV1-5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human immunoglobulin variable region genes -- DNA sequences of two V kappa genes and a pseudogene. (PubMed id 6779204)1, 2 Bentley D.L. and Rabbitts T.H. (Nature 1980)
  2. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PubMed id 17620599)1 Xiao K....Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 2007)
  3. Recognition of immunoglobulins by Fcgamma receptors. (PubMed id 11955599)1 Radaev S. and Sun P. (Mol. Immunol. 2002)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  5. Composite human VK genes and a model of their evolution. (PubMed id 6087279)1 Jaenichen H.R....Zachau H.G. (Nucleic Acids Res. 1984)
  6. Contribution of human V kappa II germ-line genes to light-chain diversity. (PubMed id 6325927)1 Klobeck H.G.... Zachau H.G. (Nature 1984)
  7. Activation of C1r by proteolytic cleavage. (PubMed id 1249422)1 Ziccardi R.J. and Cooper N.R. (J. Immunol. 1976)
  8. Physicochemical and functional characterization of the C1r subunit of the first complement component. (PubMed id 814163)1 Ziccardi R.J. and Cooper N.R. (J. Immunol. 1976)
  9. New alleles of IGKV genes A2 and A18 suggest significant human IGKV locus polymorphism. (PubMed id 8662073)9 Atkinson M.J.... Feeney A.J. (Immunogenetics 1996)
  10. Somatic mutations of the L12a gene in V-kappa(1) light chain deposition disease: potential effects on aberrant protein conformation and deposition. (PubMed id 10595931)9 Vidal R....Gallo G. (Am. J. Pathol. 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 28299 HGNC: 5741 AceView: IGKV1-5andIGKV1-6 Ensembl:ENSG00000243466 euGenes: HUgn28299
ECgene: IGKV1-5 H-InvDB: IGKV1-5

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IGKV1-5 Pharmacogenomics, SNPs, Pathways
IMGT entry for IGKV1-5 The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGKV1-5&species=Homo+sapiens

(Patent information from GeneIP,
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Patent Information for IGKV1-5 gene:
Search GeneIP for patents involving IGKV1-5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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 OriGene Custom Antibody Services for IGKV1-5   OriGene Custom Protein Services for IGKV1-5  

 
 
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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