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Aliases for IGKV1-5 Gene

Aliases for IGKV1-5 Gene

  • Immunoglobulin Kappa Variable 1-5 2 3 5
  • Ig Kappa Chain V-I Region HK102 4
  • Ig Kappa Chain V-I Region CAR 4
  • Ig Kappa Chain V-I Region Kue 4
  • Ig Kappa Chain V-I Region EU 4
  • Ig Kappa Chain V-Region 3
  • IGKV15 3
  • IGKV 3
  • L12a 3
  • L12 3
  • V1 3

External Ids for IGKV1-5 Gene

Previous GeneCards Identifiers for IGKV1-5 Gene

  • GC02U990138
  • GC02M089044
  • GC02M089059
  • GC02M088998
  • GC02M089086
  • GC02M088938
  • GC02M089246

Summaries for IGKV1-5 Gene

GeneCards Summary for IGKV1-5 Gene

IGKV1-5 (Immunoglobulin Kappa Variable 1-5) is a Protein Coding gene. Diseases associated with IGKV1-5 include Light Chain Deposition Disease. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGKV1D-13.

UniProtKB/Swiss-Prot for IGKV1-5 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV1-5 Gene

Genomics for IGKV1-5 Gene

Genomic Location for IGKV1-5 Gene

Chromosome:
2
Start:
88,947,301 bp from pter
End:
88,947,957 bp from pter
Size:
657 bases
Orientation:
Minus strand

Genomic View for IGKV1-5 Gene

Genes around IGKV1-5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGKV1-5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGKV1-5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKV1-5 Gene

No data available for Regulatory Elements for IGKV1-5 Gene

Proteins for IGKV1-5 Gene

  • Protein details for IGKV1-5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01602-KV105_HUMAN
    Recommended name:
    Immunoglobulin kappa variable 1-5
    Protein Accession:
    P01602
    Secondary Accessions:
    • A0A075B6S8
    • P01596
    • P01598
    • P01604

    Protein attributes for IGKV1-5 Gene

    Size:
    117 amino acids
    Molecular mass:
    12782 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains, linked by disulfide bonds.

neXtProt entry for IGKV1-5 Gene

Post-translational modifications for IGKV1-5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGKV1-5 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGKV1-5 Gene

Domains & Families for IGKV1-5 Gene

Gene Families for IGKV1-5 Gene

Protein Domains for IGKV1-5 Gene

Suggested Antigen Peptide Sequences for IGKV1-5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01602

UniProtKB/Swiss-Prot:

KV105_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGKV1-5: view

Function for IGKV1-5 Gene

Molecular function for IGKV1-5 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGKV1-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 112021
GO:0004252 serine-type endopeptidase activity TAS --
genes like me logo Genes that share ontologies with IGKV1-5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKV1-5 Gene

Localization for IGKV1-5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGKV1-5 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGKV1-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS,TAS --
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with IGKV1-5: view

No data available for Subcellular locations from COMPARTMENTS for IGKV1-5 Gene

Pathways & Interactions for IGKV1-5 Gene

SuperPathways for IGKV1-5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGKV1-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002377 immunoglobulin production IBA --
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS,IBA 112021
genes like me logo Genes that share ontologies with IGKV1-5: view

No data available for Pathways by source and SIGNOR curated interactions for IGKV1-5 Gene

Transcripts for IGKV1-5 Gene

mRNA/cDNA for IGKV1-5 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV1-5 Gene

No ASD Table

Relevant External Links for IGKV1-5 Gene

GeneLoc Exon Structure for
IGKV1-5
ECgene alternative splicing isoforms for
IGKV1-5

Expression for IGKV1-5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGKV1-5 Gene

mRNA differential expression in normal tissues according to GTEx for IGKV1-5 Gene

This gene is overexpressed in Spleen (x13.7), Colon - Transverse (x6.8), and Small Intestine - Terminal Ileum (x4.2).

Protein differential expression in normal tissues from HIPED for IGKV1-5 Gene

This gene is overexpressed in Vitreous humor (23.2), Urine (12.1), and Synovial fluid (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGKV1-5 Gene



Protein tissue co-expression partners for IGKV1-5 Gene

genes like me logo Genes that share expression patterns with IGKV1-5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IGKV1-5 Gene

Orthologs for IGKV1-5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGKV1-5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGKV1-5 35
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 57 (a)
OneToMany
Species where no ortholog for IGKV1-5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGKV1-5 Gene

ENSEMBL:
Gene Tree for IGKV1-5 (if available)
TreeFam:
Gene Tree for IGKV1-5 (if available)

Paralogs for IGKV1-5 Gene

genes like me logo Genes that share paralogs with IGKV1-5: view

Variants for IGKV1-5 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGKV1-5 Gene

KV105_HUMAN-P01602
There are several alleles. The sequence shown is that of IMGT allele IGKV1-5*03.

Sequence variations from dbSNP and Humsavar for IGKV1-5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_073349 --

Relevant External Links for IGKV1-5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGKV1-5

No data available for Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKV1-5 Gene

Disorders for IGKV1-5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGKV1-5 Gene - From: GeneCards

Disorder Aliases PubMed IDs
light chain deposition disease
  • light-chain deposition disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IGKV1-5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGKV1-5
genes like me logo Genes that share disorders with IGKV1-5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGKV1-5 Gene

Publications for IGKV1-5 Gene

  1. Composite human VK genes and a model of their evolution. (PMID: 6087279) Jaenichen H.R. … Zachau H.G. (Nucleic Acids Res. 1984) 3 4 64
  2. Human immunoglobulin variable region genes -- DNA sequences of two V kappa genes and a pseudogene. (PMID: 6779204) Bentley D.L. … Rabbitts T.H. (Nature 1980) 3 4 64
  3. The primary structure of the Bence-Jones protein Kue. The amino acid sequence of the variable part of a human L-chain of the kappa-type. (PMID: 112021) Eulitz M. … Zeitler H.-J. (Hoppe-Seyler's Z. Physiol. Chem. 1979) 3 4 64
  4. Primary structure of kappa light chain from a human myeloma protein. (PMID: 4216454) Milstein C.P. … Deverson E.V. (Eur. J. Biochem. 1974) 3 4 64
  5. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3 64

Products for IGKV1-5 Gene

Sources for IGKV1-5 Gene

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