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Aliases for IGKJ1 Gene

Aliases for IGKJ1 Gene

  • Immunoglobulin Kappa Joining 1 2 3 5
  • J1 3

External Ids for IGKJ1 Gene

Previous GeneCards Identifiers for IGKJ1 Gene

  • GC02U990226
  • GC02M089049
  • GC02M089064
  • GC02M089069
  • GC02M089000
  • GC02M088942
  • GC02M089169
  • GC02M089175
  • GC02M089188
  • GC02M089193
  • GC02M089202
  • GC02M089208
  • GC02M089234
  • GC02M089716
  • GC02M089920
  • GC02M090103
  • GC02M088866
  • GC02M088869
  • GC02M088877
  • GC02M088885
  • GC02M088891

Summaries for IGKJ1 Gene

GeneCards Summary for IGKJ1 Gene

IGKJ1 (Immunoglobulin Kappa Joining 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IGKJ1 Gene

  • J region of the variable domain of immunoglobulin kappa light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKJ1 Gene

Genomics for IGKJ1 Gene

Regulatory Elements for IGKJ1 Gene

Enhancers for IGKJ1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G088865 0.9 Ensembl ENCODE dbSUPER 0.7 -4.4 -4378 1.8 POLR2A SPI1 IGKJ1 IGKV4-1
GH02G088879 1.2 Ensembl ENCODE dbSUPER 0.4 -18.5 -18537 1.0 CTCF ZNF654 HLF RAD21 RELA POLR2A SMC3 ZNF143 ZNF24 SPI1 RPIA IGKV4-1 IGKJ1
GH02G088863 0.4 dbSUPER 0.7 -1.8 -1811 1.0 POLR2A IGKJ1 IGKV4-1
GH02G088868 0.5 dbSUPER 0.4 -7.7 -7703 1.9 ZNF366 ZNF512 CEBPB PRDM1 IGKV1-9 IGKJ1 IGKV4-1
GH02G088870 0.4 dbSUPER 0.4 -9.3 -9310 1.2 ZNF512 IGKV1-9 IGKJ1 IGKV4-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGKJ1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGKJ1 Gene

Chromosome:
2
Start:
88,861,886 bp from pter
End:
88,861,923 bp from pter
Size:
38 bases
Orientation:
Minus strand

Genomic View for IGKJ1 Gene

Genes around IGKJ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGKJ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGKJ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKJ1 Gene

Proteins for IGKJ1 Gene

  • Protein details for IGKJ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A0A0MT89-KJ01_HUMAN
    Recommended name:
    Immunoglobulin kappa joining 1
    Protein Accession:
    A0A0A0MT89

    Protein attributes for IGKJ1 Gene

    Size:
    13 amino acids
    Molecular mass:
    1505 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGKJ1 Gene

Post-translational modifications for IGKJ1 Gene

No Post-translational modifications

Other Protein References for IGKJ1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGKJ1 Gene

Domains & Families for IGKJ1 Gene

Gene Families for IGKJ1 Gene

Protein Domains for IGKJ1 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGKJ1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGKJ1 Gene

Function for IGKJ1 Gene

Molecular function for IGKJ1 Gene

UniProtKB/Swiss-Prot Function:
J region of the variable domain of immunoglobulin kappa light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKJ1 Gene

Localization for IGKJ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGKJ1 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGKJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with IGKJ1: view

No data available for Subcellular locations from COMPARTMENTS for IGKJ1 Gene

Pathways & Interactions for IGKJ1 Gene

SuperPathways for IGKJ1 Gene

No Data Available

Interacting Proteins for IGKJ1 Gene

Gene Ontology (GO) - Biological Process for IGKJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
genes like me logo Genes that share ontologies with IGKJ1: view

No data available for Pathways by source and SIGNOR curated interactions for IGKJ1 Gene

Drugs & Compounds for IGKJ1 Gene

No Compound Related Data Available

Transcripts for IGKJ1 Gene

mRNA/cDNA for IGKJ1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGKJ1 Gene

No ASD Table

Relevant External Links for IGKJ1 Gene

GeneLoc Exon Structure for
IGKJ1
ECgene alternative splicing isoforms for
IGKJ1

Expression for IGKJ1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IGKJ1 Gene:

IGKJ1
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGKJ1 Gene

Orthologs for IGKJ1 Gene

Evolution for IGKJ1 Gene

ENSEMBL:
Gene Tree for IGKJ1 (if available)
TreeFam:
Gene Tree for IGKJ1 (if available)

No data available for Orthologs for IGKJ1 Gene

Paralogs for IGKJ1 Gene

No data available for Paralogs for IGKJ1 Gene

Variants for IGKJ1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGKJ1 Gene

KJ01_HUMAN-A0A0A0MT89
The sequence shown is that of IMGT allele IGKJ1*01.

Relevant External Links for IGKJ1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGKJ1

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKJ1 Gene

Disorders for IGKJ1 Gene

No disorders were found for IGKJ1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGKJ1 Gene

Publications for IGKJ1 Gene

  1. Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc M.P. (Front. Immunol. 2014) 4 64
  2. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M. … McHeyzer-Williams L. (Nat. Rev. Immunol. 2012) 4 64
  3. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder H.W. Jr. … Cavacini L. (J. Allergy Clin. Immunol. 2010) 4 64
  4. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G. … Papavasiliou F.N. (Annu. Rev. Genet. 2007) 4 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64

Products for IGKJ1 Gene

Sources for IGKJ1 Gene

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