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Aliases for IGKC Gene

Aliases for IGKC Gene

  • Immunoglobulin Kappa Constant 2 3
  • IGKCD 3 6
  • Immunoglobulin Kappa (Invariant Region) 3
  • Immunoglobulin Kappa Light Chain (VJ) 3
  • Immunoglobulin Kappa Constant Region 3
  • HCAK1 3
  • Km 3

External Ids for IGKC Gene

Summaries for IGKC Gene

GeneCards Summary for IGKC Gene

IGKC (Immunoglobulin Kappa Constant) is a Protein Coding gene. Diseases associated with IGKC include immunoglobulin kappa light chain deficiency and light chain deposition disease. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLC1.

Gene Wiki entry for IGKC Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKC Gene

Genomics for IGKC Gene

Genomic Location for IGKC Gene

Start:
88,857,161 bp from pter
End:
89,085,723 bp from pter
Size:
228,563 bases
Orientation:
Minus strand

Genomic View for IGKC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGKC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKC Gene

No data available for Regulatory Elements for IGKC Gene

Proteins for IGKC Gene

  • Protein details for IGKC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01834-IGKC_HUMAN
    Recommended name:
    Ig kappa chain C region
    Protein Accession:
    P01834
    Secondary Accessions:

    Protein attributes for IGKC Gene

    Size:
    106 amino acids
    Molecular mass:
    11609 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The EU sequence has the INV (3) allotypic marker, Ala-45 and Val-83. The ROY sequence has the INV (1,2) allotypic marker, Ala-45 and Leu-83

    Three dimensional structures from OCA and Proteopedia for IGKC Gene

neXtProt entry for IGKC Gene

Proteomics data for IGKC Gene at MOPED

Post-translational modifications for IGKC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGKC Gene

ENSEMBL proteins:
Reactome Protein details:

No data available for DME Specific Peptides for IGKC Gene

Domains for IGKC Gene

Gene Families for IGKC Gene

HGNC:
  • IGK :Immunoglobulins / IGK locus

Protein Domains for IGKC Gene

UniProtKB/Swiss-Prot:

IGKC_HUMAN
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.:
    • P01834
genes like me logo Genes that share domains with IGKC: view

Function for IGKC Gene

Molecular function for IGKC Gene

GENATLAS Biochemistry: immunoglobulin,kappa,constant chain (Km marker)

Gene Ontology (GO) - Molecular Function for IGKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 6779204
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IGKC: view
genes like me logo Genes that share phenotypes with IGKC: view

Animal Models for IGKC Gene

MGI Knock Outs for IGKC:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IGKC Gene

Localization for IGKC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGKC Gene COMPARTMENTS Subcellular localization image for IGKC gene
Compartment Confidence
extracellular 4
plasma membrane 4
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IGKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 23376485
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with IGKC: view

Pathways for IGKC Gene

genes like me logo Genes that share pathways with IGKC: view

Interacting Proteins for IGKC Gene

Gene Ontology (GO) - Biological Process for IGKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 6779204
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway TAS --
genes like me logo Genes that share ontologies with IGKC: view

Transcripts for IGKC Gene

Unigene Clusters for IGKC Gene

Immunoglobulin kappa constant:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGKC Gene

No ASD Table

Relevant External Links for IGKC Gene

GeneLoc Exon Structure for
IGKC
ECgene alternative splicing isoforms for
IGKC

Expression for IGKC Gene

mRNA expression in normal human tissues for IGKC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IGKC Gene

SOURCE GeneReport for Unigene cluster for IGKC Gene Hs.449609

genes like me logo Genes that share expressions with IGKC: view

Orthologs for IGKC Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGKC Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Igkc 16
Igkc 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGKC 37
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGKC 37
  • 10 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii IGKC 37
  • 24 (a)
OneToOne
Species with no ortholog for IGKC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGKC Gene

ENSEMBL:
Gene Tree for IGKC (if available)
TreeFam:
Gene Tree for IGKC (if available)

Paralogs for IGKC Gene

Paralogs for IGKC Gene

genes like me logo Genes that share paralogs with IGKC: view

Variants for IGKC Gene

Sequence variations from dbSNP and Humsavar for IGKC Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_003897 -
VAR_066403 Immunoglobulin kappa light chain deficiency (IGKCD)

Relevant External Links for IGKC Gene

HapMap Linkage Disequilibrium report
IGKC
Locus Specific Mutation Databases (LSDB)
IGKC

No data available for Structural Variations from Database of Genomic Variants (DGV) for IGKC Gene

Disorders for IGKC Gene

(1) OMIM Diseases for IGKC Gene (147200)

UniProtKB/Swiss-Prot

IGKC_HUMAN
  • Immunoglobulin kappa light chain deficiency (IGKCD) [MIM:614102]: A disease characterized by the complete absence of immunoglobulin kappa chains. {ECO:0000269 PubMed:3931219}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(13) Novoseek inferred disease relationships for IGKC Gene

Disease -log(P) Hits PubMed IDs
amyloidosis 55.7 2
amyloid deposition 50 1
lymphoma b-cell 48.2 1
plasmacytoma 46.1 1
lymphoma 45.7 4

Relevant External Links for IGKC

Genetic Association Database (GAD)
IGKC
Human Genome Epidemiology (HuGE) Navigator
IGKC
genes like me logo Genes that share disorders with IGKC: view

Publications for IGKC Gene

  1. The amino acid sequence of a kappa type Bence-Jones protein. 3. The complete sequence and the location of the disulfide bridges. (PMID: 4893682) Titani K. … Putnam F.W. (J. Biol. Chem. 1969) 3 4
  2. The covalent structure of a human gamma G-immunoglobulin. X. Intrachain disulfide bonds. (PMID: 4923144) Gall W.E. … Edelman G.M. (Biochemistry 1970) 3 4
  3. Rule of antibody structure. The primary structure of a monoclonal immunoglobulin L-chain of kappa-type, subgroup 3 (Bence-Jones protein Ti). IV. The complete amino acid sequence and its significance for the mechanism of antibody production. (PMID: 5027703) Suter L. … Hilschmann N. (Hoppe-Seyler's Z. Physiol. Chem. 1972) 3 4
  4. Macroglobulin structure: variable sequence of light and heavy chains. (PMID: 5447531) Kohler H. … Putnam F.W. (Science 1970) 3 4
  5. The covalent structure of a human gamma G-immunoglobulin. VI. Amino acid sequence of the light chain. (PMID: 5489770) Gottlieb P.D. … Edelman G.M. (Biochemistry 1970) 3 4

Products for IGKC Gene

Sources for IGKC Gene

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