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Aliases for IGKC Gene

Aliases for IGKC Gene

  • Immunoglobulin Kappa Constant 2 3
  • Immunoglobulin Kappa (Invariant Region) 3
  • Immunoglobulin Kappa Light Chain (VJ) 3
  • Immunoglobulin Kappa Constant Region 3
  • HCAK1 3
  • IGKCD 3
  • Km 3

External Ids for IGKC Gene

Previous GeneCards Identifiers for IGKC Gene

  • GC02M088711
  • GC02U900019
  • GC02M089043
  • GC02M089058
  • GC02M089060
  • GC02M088995
  • GC02M089010
  • GC02M088937
  • GC02M089156
  • GC02M088860

Summaries for IGKC Gene

GeneCards Summary for IGKC Gene

IGKC (Immunoglobulin Kappa Constant) is a Protein Coding gene. Diseases associated with IGKC include kappa light chain deficiency and light chain deposition disease. Among its related pathways are PI3K/AKT Signaling in Cancer and Immune System. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLC1.

Gene Wiki entry for IGKC Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKC Gene

Genomics for IGKC Gene

Genomic Location for IGKC Gene

Chromosome:
2
Start:
88,857,161 bp from pter
End:
89,245,596 bp from pter
Size:
388,436 bases
Orientation:
Minus strand

Genomic View for IGKC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for IGKC Gene

No data available for Regulatory Elements for IGKC Gene

Proteins for IGKC Gene

  • Protein details for IGKC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01834-IGKC_HUMAN
    Recommended name:
    Ig kappa chain C region
    Protein Accession:
    P01834

    Protein attributes for IGKC Gene

    Size:
    106 amino acids
    Molecular mass:
    11609 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The EU sequence has the INV (3) allotypic marker, Ala-45 and Val-83. The ROY sequence has the INV (1,2) allotypic marker, Ala-45 and Leu-83

    Three dimensional structures from OCA and Proteopedia for IGKC Gene

neXtProt entry for IGKC Gene

Proteomics data for IGKC Gene at MOPED

Post-translational modifications for IGKC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGKC Gene

No data available for DME Specific Peptides for IGKC Gene

Domains & Families for IGKC Gene

Gene Families for IGKC Gene

Protein Domains for IGKC Gene

Suggested Antigen Peptide Sequences for IGKC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01834

UniProtKB/Swiss-Prot:

IGKC_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGKC: view

Function for IGKC Gene

Molecular function for IGKC Gene

GENATLAS Biochemistry:
immunoglobulin,kappa,constant chain (Km marker)

Gene Ontology (GO) - Molecular Function for IGKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 5489770
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGKC: view
genes like me logo Genes that share phenotypes with IGKC: view

Animal Models for IGKC Gene

MGI Knock Outs for IGKC:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for IGKC Gene

Localization for IGKC Gene

Gene Ontology (GO) - Cellular Components for IGKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA --
GO:0042571 immunoglobulin complex, circulating IBA --
genes like me logo Genes that share ontologies with IGKC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for IGKC Gene

Pathways & Interactions for IGKC Gene

genes like me logo Genes that share pathways with IGKC: view

Interacting Proteins for IGKC Gene

Gene Ontology (GO) - Biological Process for IGKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006955 immune response NAS 5489770
genes like me logo Genes that share ontologies with IGKC: view

No data available for SIGNOR curated interactions for IGKC Gene

Drugs & Compounds for IGKC Gene

(16) Drugs for IGKC Gene - From: DrugBank and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL Experimental Pharma Target 0
(2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE Experimental Pharma Target 0
(4Z)-2,8:7,12:11,15:14,18:17,22-PENTAANHYDRO-4,5,6,9,10,13,19,20,21-NONADEOXY-D-ARABINO-D-ALLO-D-ALLO-DOCOSA-4,9,20-TRIENITOL Experimental Pharma Target 0
[4-(4-ACETYLAMINO-PHENYL)-3,5-DIOXO-4-AZA-TRICYCLO[5.2.2.0 2,6]UNDEC-1-YLCARBAMOYLOXY]-ACETIC ACID Experimental Pharma Target 0
3-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACID Experimental Pharma Target 0
genes like me logo Genes that share compounds with IGKC: view

Transcripts for IGKC Gene

Unigene Clusters for IGKC Gene

Immunoglobulin kappa constant:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGKC Gene

No ASD Table

Relevant External Links for IGKC Gene

GeneLoc Exon Structure for
IGKC
ECgene alternative splicing isoforms for
IGKC

Expression for IGKC Gene

mRNA expression in normal human tissues for IGKC Gene

Protein differential expression in normal tissues from HIPED for IGKC Gene

This gene is overexpressed in Pancreatic juice (8.7) and Urine (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGKC Gene



SOURCE GeneReport for Unigene cluster for IGKC Gene Hs.449609

genes like me logo Genes that share expression patterns with IGKC: view

Protein tissue co-expression partners for IGKC Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IGKC Gene

Orthologs for IGKC Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGKC Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Igkc 16
Igkc 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGKC 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGKC 36
  • 10 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii IGKC 36
  • 24 (a)
OneToOne
Species with no ortholog for IGKC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGKC Gene

ENSEMBL:
Gene Tree for IGKC (if available)
TreeFam:
Gene Tree for IGKC (if available)

Paralogs for IGKC Gene

Paralogs for IGKC Gene

genes like me logo Genes that share paralogs with IGKC: view

Variants for IGKC Gene

Sequence variations from dbSNP and Humsavar for IGKC Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_003897 -
VAR_066403 Immunoglobulin kappa light chain deficiency (IGKCD)

Relevant External Links for IGKC Gene

HapMap Linkage Disequilibrium report
IGKC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKC Gene

Disorders for IGKC Gene

MalaCards: The human disease database

(4) MalaCards diseases for IGKC Gene - From: OMIM, ClinVar, Swiss-Prot, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
kappa light chain deficiency
  • immunoglobulin kappa light chain deficiency
light chain deposition disease
  • light-chain deposition disease
b cell prolymphocytic leukemia
  • leukemia, b cell prolymphocytic
lymphoma, malt, somatic
  • malt lymphoma
- elite association
Search IGKC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IGKC_HUMAN
  • Immunoglobulin kappa light chain deficiency (IGKCD) [MIM:614102]: A disease characterized by the complete absence of immunoglobulin kappa chains. {ECO:0000269 PubMed:3931219}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IGKC

Genetic Association Database (GAD)
IGKC
Human Genome Epidemiology (HuGE) Navigator
IGKC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGKC
genes like me logo Genes that share disorders with IGKC: view

No data available for Genatlas for IGKC Gene

Publications for IGKC Gene

  1. Mass spectrometric detection of candidate protein biomarkers of cancer cachexia in human urine. (PMID: 20198343) Skipworth R.J. … Ross J.A. (Int. J. Oncol. 2010) 23 67
  2. Histochemical approach of cryobiopsy for glycogen distribution in living mouse livers under fasting and local circulation loss conditions. (PMID: 19949818) Saitoh Y. … Ohno S. (Histochem. Cell Biol. 2010) 23 67
  3. Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. (PMID: 19946273) Malin S. … Busslinger M. (Nat. Immunol. 2010) 23 67
  4. Large-scale chromatin remodeling at the immunoglobulin heavy chain locus: a paradigm for multigene regulation. (PMID: 19731801) Bolland D.J. … Corcoran A.E. (Adv. Exp. Med. Biol. 2009) 23 67
  5. TCDD-mediated suppression of the in vitro anti-sheep erythrocyte IgM antibody forming cell response is reversed by interferon-gamma. (PMID: 18948302) North C.M. … Kaminski N.E. (Toxicol. Sci. 2009) 23 67

Products for IGKC Gene

Sources for IGKC Gene

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