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Aliases for IGKC Gene

Aliases for IGKC Gene

  • Immunoglobulin Kappa Constant 2 3 5
  • Immunoglobulin Kappa (Invariant Region) 3
  • Immunoglobulin Kappa Light Chain (VJ) 3
  • Immunoglobulin Kappa Constant Region 3
  • HCAK1 3
  • IGKCD 3
  • Km 3

External Ids for IGKC Gene

Previous GeneCards Identifiers for IGKC Gene

  • GC02M088711
  • GC02U900019
  • GC02M089043
  • GC02M089058
  • GC02M089060
  • GC02M088995
  • GC02M089010
  • GC02M088937
  • GC02M089156
  • GC02M088860
  • GC02M088871
  • GC02M088878
  • GC02M088886

Summaries for IGKC Gene

GeneCards Summary for IGKC Gene

IGKC (Immunoglobulin Kappa Constant) is a Protein Coding gene. Diseases associated with IGKC include Kappa Light Chain Deficiency and Light Chain Deposition Disease. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and RET signaling. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLC3.

Gene Wiki entry for IGKC Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKC Gene

Genomics for IGKC Gene

Regulatory Elements for IGKC Gene

Enhancers for IGKC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F088855 1.3 FANTOM5 Ensembl ENCODE 0.8 -1.4 -1425 7.8 CTCF RFX1 CHD1 GABPA NR2F2 RELA SMARCA4 POLR2A NR2F6 SPI1 IGKV1-13 THNSL2 RPIA IGKV4-1 EIF2AK3 GC02M088842 IGKC
GH02F088853 0.5 FANTOM5 0.8 +4.5 4514 0.3 POLR2A EGR2 ANKRD36BP2 EIF2AK3 IGKC IGKDEL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGKC on UCSC Golden Path with GeneCards custom track

Genomic Location for IGKC Gene

88,857,161 bp from pter
88,857,683 bp from pter
523 bases
Minus strand

Genomic View for IGKC Gene

Genes around IGKC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGKC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGKC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKC Gene

Proteins for IGKC Gene

  • Protein details for IGKC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ig kappa chain C region
    Protein Accession:

    Protein attributes for IGKC Gene

    106 amino acids
    Molecular mass:
    11609 Da
    Quaternary structure:
    No Data Available
    • The EU sequence has the INV (3) allotypic marker, Ala-45 and Val-83. The ROY sequence has the INV (1,2) allotypic marker, Ala-45 and Leu-83.

    Three dimensional structures from OCA and Proteopedia for IGKC Gene

neXtProt entry for IGKC Gene

Post-translational modifications for IGKC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGKC Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGKC Gene

Domains & Families for IGKC Gene

Gene Families for IGKC Gene

Protein Domains for IGKC Gene

Suggested Antigen Peptide Sequences for IGKC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGKC: view

Function for IGKC Gene

Molecular function for IGKC Gene

GENATLAS Biochemistry:
immunoglobulin,kappa,constant chain (Km marker)

Gene Ontology (GO) - Molecular Function for IGKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 5489770
GO:0004252 serine-type endopeptidase activity TAS --
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGKC: view

Human Phenotype Ontology for IGKC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKC Gene

Localization for IGKC Gene

Gene Ontology (GO) - Cellular Components for IGKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA --
GO:0042571 immunoglobulin complex, circulating IBA --
genes like me logo Genes that share ontologies with IGKC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for IGKC Gene

Pathways & Interactions for IGKC Gene

genes like me logo Genes that share pathways with IGKC: view

Interacting Proteins for IGKC Gene

Gene Ontology (GO) - Biological Process for IGKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
genes like me logo Genes that share ontologies with IGKC: view

No data available for SIGNOR curated interactions for IGKC Gene

Drugs & Compounds for IGKC Gene

(19) Drugs for IGKC Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL Experimental Pharma Target 0
(2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE Experimental Pharma Target 0
(4Z)-2,8:7,12:11,15:14,18:17,22-PENTAANHYDRO-4,5,6,9,10,13,19,20,21-NONADEOXY-D-ARABINO-D-ALLO-D-ALLO-DOCOSA-4,9,20-TRIENITOL Experimental Pharma Target 0
genes like me logo Genes that share compounds with IGKC: view

Transcripts for IGKC Gene

mRNA/cDNA for IGKC Gene

Unigene Clusters for IGKC Gene

Immunoglobulin kappa constant:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGKC Gene

No ASD Table

Relevant External Links for IGKC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGKC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGKC Gene

Protein differential expression in normal tissues from HIPED for IGKC Gene

This gene is overexpressed in Pancreatic juice (8.7) and Urine (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGKC Gene

Protein tissue co-expression partners for IGKC Gene

NURSA nuclear receptor signaling pathways regulating expression of IGKC Gene:


SOURCE GeneReport for Unigene cluster for IGKC Gene:

genes like me logo Genes that share expression patterns with IGKC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IGKC Gene

Orthologs for IGKC Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGKC Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Igkc 35
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia IGKC 35
  • 55 (a)
(Anolis carolinensis)
Reptilia IGKC 35
  • 10 (a)
(Danio rerio)
Actinopterygii IGKC 35
  • 24 (a)
Species where no ortholog for IGKC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGKC Gene

Gene Tree for IGKC (if available)
Gene Tree for IGKC (if available)

Paralogs for IGKC Gene

Variants for IGKC Gene

Sequence variations from dbSNP and Humsavar for IGKC Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_066403 Immunoglobulin kappa light chain deficiency (IGKCD) [MIM:614102]
VAR_003897 --

Relevant External Links for IGKC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKC Gene

Disorders for IGKC Gene

MalaCards: The human disease database

(4) MalaCards diseases for IGKC Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
kappa light chain deficiency
  • immunoglobulin kappa light chain deficiency
light chain deposition disease
  • light-chain deposition disease
b cell prolymphocytic leukemia
  • leukemia, b cell prolymphocytic
lymphoma, malt, somatic
  • lymphoma, mucosa-associated lymphoid type
- elite association - COSMIC cancer census association via MalaCards
Search IGKC in MalaCards View complete list of genes associated with diseases


  • Immunoglobulin kappa light chain deficiency (IGKCD) [MIM:614102]: A disease characterized by the complete absence of immunoglobulin kappa chains. {ECO:0000269 PubMed:3931219}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IGKC

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IGKC: view

No data available for Genatlas for IGKC Gene

Publications for IGKC Gene

  1. Single nucleotide polymorphism of interleukin-1beta associated with Helicobacter pylori infection in immune thrombocytopenic purpura. (PMID: 19317746) Satoh T. … Kuwana M. (Tissue Antigens 2009) 3 46 64
  2. Immunoglobulin gene polymorphisms are susceptibility factors in clinical and autoantibody subgroups of the idiopathic inflammatory myopathies. (PMID: 18821675) O'Hanlon T.P. … Miller F.W. (Arthritis Rheum. 2008) 3 46 64
  3. TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis. (PMID: 12039524) Pandey J.P. … Frederick M. (Hum. Immunol. 2002) 3 46 64
  4. Immunoglobulin kappa light chain gene alleles are not associated with primary SjAPgren's syndrome. (PMID: 12215905) Downie-Doyle S. … Pile K. (Genes Immun. 2002) 3 46 64
  5. Identification of a novel substitution in the constant region of a gene coding for an amyloidogenic kappa1 light chain. (PMID: 10354514) Wally J. … Comenzo R.L. (Biochim. Biophys. Acta 1999) 2 3 64

Products for IGKC Gene

Sources for IGKC Gene

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