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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGKC Gene

protein-coding   GIFtS: 52
GCID: GC02M089156

Immunoglobulin Kappa Constant

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Immunoglobulin Kappa Constant1 2
HCAK12
IGKCD2
Km2

External Ids:    HGNC: 57161   Entrez Gene: 35142   Ensembl: ENSG000002115927   OMIM: 1472005   UniProtKB: P018343   

Export aliases for IGKC gene to outside databases

Previous GC identifers: GC02M088711 GC02U900019 GC02M089043 GC02M089058 GC02M089060 GC02M088995 GC02M089010 GC02M088937


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IGKC Gene: 
IGKC (immunoglobulin kappa constant) is a protein-coding gene. Diseases associated with IGKC include light chain deposition disease, and b cell prolymphocytic leukemia, and among its related super-pathways are Immune response Lectin induced complement pathway and Classical antibody-mediated complement activation. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLL5.

Gene Wiki entry for IGKC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGKC
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGKC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGKC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

IGKC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGKC gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M089156:  view genomic region     (about GC identifiers)

Start:
89,156,674 bp from pter      End:
89,157,196 bp from pter
Size:
523 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IGKC_HUMAN, P01834 (See protein sequence)
Recommended Name: Ig kappa chain C region  
Size: 106 amino acids; 11609 Da
Miscellaneous: The EU sequence has the INV (3) allotypic marker, Ala-45 and Val-83. The ROY sequence has the INV
(1,2) allotypic marker, Ala-45 and Leu-83
6/43 PDB 3D structures from and Proteopedia for IGKC (see all 43):
1A4J (3D)        1A4K (3D)        1D5B (3D)        1D5I (3D)        1D6V (3D)        1DFB (3D)    

Explore the universe of human proteins at neXtProt for IGKC: NX_P01834

Explore proteomics data for IGKC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus (IGKC)
  • View neXtProt modification sites for NX_P01834

  • IGKC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IGKC Protein Expression

    ENSEMBL proteins: 
     ENSP00000374777  
    Reactome Protein details: P01834
    Human Recombinant Protein Products for IGKC: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for IGKC
    GenScript Custom Purified and Recombinant Proteins Services for IGKC
    Novus Biologicals IGKC Protein
    Novus Biologicals IGKC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005886plasma membrane TAS--

    IGKC for ontologies           About GeneDecksing



    IGKC Antibody Products: 
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    Novus Biologicals IGKC Antibodies
    Abcam antibodies for IGKC
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for IGKC
    LSBio Antibodies in human, mouse, rat for IGKC 

    Assay Products for IGKC: 
    EMD Millipore Kits and Assays for the Analysis of IGKC
    OriGene Custom Assay Services for IGKC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IGKC
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGK: Immunoglobulins / IGK locus

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P01834

    ProtoNet protein and cluster: P01834

    1 Blocks protein domain: IPB003597 Immunoglobulin C-type

    UniProtKB/Swiss-Prot: IGKC_HUMAN, P01834
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


    IGKC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for IGKC:
    immunoglobulin,kappa,constant chain (Km marker)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding NAS6779204
    GO:0005515protein binding ----
         
    IGKC for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Igkc):
     cellular  hematopoietic system  immune system  no phenotypic analysis 

    IGKC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IGKC: Igkctm1Jkbv Igkctm1Bgmn Igkctm1Cgn Igkctm1Schz

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IGKC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGKC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGKC 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGKC 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGKC
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IGKC
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene RNAi
    Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGKC

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of IGKC

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for IGKC
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGKC
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGKC
    Sirion Biotech Customized lentivirus for stable overexpression of IGKC 
                         Customized lentivirus expression plasmids for stable overexpression of IGKC 

    Cell Line
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    Search LifeMap BioReagents cell lines for IGKC
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGKC


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IGKC About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Lectin induced complement pathway
    Immune response Classic complement pathway0.53
    Immune response Classical complement pathway0.52
    2Classical antibody-mediated complement activation
    Classical antibody-mediated complement activation0.88
    FCGR activation0.70
    Creation of C4 and C2 activators0.88
    Role of phospholipids in phagocytosis0.65
    Initial triggering of complement0.86
    FCERI mediated NF-kB activation0.47
    Complement cascade0.76
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30
    3Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.45
    Immune response IL-4 signaling pathway0.38
    Immune response BCR pathway0.45
    Immune response CD16 signaling in NK cells0.32
    4FCERI mediated Ca+2 mobilization
    FCERI mediated Ca+2 mobilization0.60
    Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.31
    FCERI mediated MAPK activation0.60
    5Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 EMD Millipore Pathways for IGKC (see all 7)
        Immune response Classic complement pathway
    Immune response BCR pathway
    Immune response CD16 signaling in NK cells
    Signal transduction IP3 signaling
    Immune response IL-4 signaling pathway


    5/7 GeneGo (Thomson Reuters) Pathways for IGKC (see all 7)
        Immune response IL-4 signaling pathway
    Immune response Fc epsilon RI pathway
    Immune response CD16 signaling in NK cells
    Immune response Classical complement pathway
    Immune response BCR pathway

    5/21        Reactome Pathways for IGKC (see all 21)
        FCERI mediated MAPK activation
    FCERI mediated NF-kB activation
    FCGR activation
    Role of phospholipids in phagocytosis
    Binding and Uptake of Ligands by Scavenger Receptors



    IGKC for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGKC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/60 Interacting proteins for IGKC (P018342, 3 ENSP000003747774) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGHG4P018612, 3, ENSP000003749854MINT-25060 I2D: score=1 STRING: ENSP00000374985
    IGHG1P018572, 3, ENSP000003749904MINT-24896 MINT-25051 I2D: score=3 STRING: ENSP00000374990
    IGHG2P018593, ENSP000003749874I2D: score=1 STRING: ENSP00000374987
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    APOA1P026473I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS6779204
    GO:0006956complement activation TAS--
    GO:0006958complement activation, classical pathway TAS--
    GO:0038095Fc-epsilon receptor signaling pathway TAS--
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--

    IGKC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IGKC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGKC

    10/14 DrugBank Compounds for IGKC (see all 14)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL-- --target--10592235
    (2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE-- --target--10592235
    (4Z)-2,8:7,12:11,15:14,18:17,22-PENTAANHYDRO-4,5,6,9,10,13,19,20,21-NONADEOXY-D-ARABINO-D-ALLO-D-ALLO-DOCOSA-4,9,20-TRIENITOL-- --target--10592235
    3-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACID-- --target--10592235
    4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID-- --target--10592235
    4-{4-[2-(1A,7A-DIMETHYL-4-OXY-OCTAHYDRO-1-OXA-4-AZA-CYCLOPROPA[A]NAPHTHALEN-4-YL) -ACETYLAMINO]-PHENYLCARBAMOYL}-BUTYRIC ACID-- --target--10592235
    5-BETA-ANDROSTANE-3,17-DIONE-- --target--10592235
    ECGONINE METHYL ESTER-- --target--10592235
    METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER-- --target--10592235
    N-(PARA-GLUTARAMIDOPHENYL-ETHYL)-PIPERIDINIUM-N-OXIDE-- --target--10592235

    2 Novoseek inferred chemical compound relationships for IGKC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    valine 24 1 8120118 (1)
    cysteine 0 1 1902379 (1)

    Search CenterWatch for drugs/clinical trials and news about IGKC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    Unigene Cluster for IGKC:

    Immunoglobulin kappa constant
    Hs.449609  [show with all ESTs]
    Unigene Representative Sequence: AK128524
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000390237(uc002sti.1)
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGKC
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IGKC
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene RNAi
    Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGKC
    Clone
    Products:
         
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for IGKC
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGKC
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                         Customized lentivirus expression plasmids for stable overexpression of IGKC 
    Primer
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      Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGKC
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    Additional mRNA sequence: 

    AB004304.1 AB006842.1 AB006843.1 AB006844.1 AB006845.1 AB006846.1 AB006847.1 AB006848.1 
    AB006849.1 AB012910.1 AB022651.1 AB022653.1 AB022654.1 AB027434.1 AB027436.1 AB027438.1 
    AB027440.1 AB027442.1 AB027444.1 AB027446.1 AB027767.1 AB030640.1 AB063928.1 AB063929.1 
    AB063930.1 AB063931.1 AB063932.1 AB063934.1 AB063935.1 AB063936.1 AB063937.1 AB063938.1 
    AB063939.1 AB063940.1 AB063941.1 AB063942.1 AB063943.1 AB063944.1 AB063949.1 AB063950.1 
    AB063951.1 AB063952.1 AB063953.1 AB063954.1 AB063955.1 AB063956.1 AB063958.1 AB063959.1 
    AB063960.1 AB063961.1 AB063962.1 AB063963.1 AB063965.1 AB063966.1 AB063967.1 AB063968.1 
    AB064042.1 AB064043.1 AB064044.1 AB064045.1 AB064047.1 AB064048.1 AB064050.1 AB064051.1 
    AB064052.1 AB064053.1 AB064054.1 AB064055.1 AB064056.1 AB064057.1 AB064058.1 AB064059.1 
    AB064060.1 AB064061.1 AB064062.1 AB064063.1 AB064064.1 AB064065.1 AB064066.1 AB064067.1 
    AB064068.1 AB064069.1 AB064070.1 AB064071.1 AB064072.1 AB064073.1 AB064074.1 AB064075.1 
    AB064076.1 AB064077.1 AB064078.1 AB064079.1 AB064080.1 AB064081.1 AB064082.1 AB064083.1 
    AB064084.1 AB064085.1 AB064086.1 AB064087.1 AB064088.1 AB064089.1 AB064090.1 AB064091.1 
    AB064092.1 AB064093.1 AB064094.1 AB064095.1 AB064096.1 AB064097.1 AB064098.1 AB064099.1 
    AB064100.1 AB064101.1 AB064102.1 AB064103.1 AB064104.1 AB064105.1 AB064106.1 AB064107.1 
    AB064108.1 AB064109.1 AB064110.1 AB064111.1 AB064112.1 AB064113.1 AB064114.1 AB064115.1 
    AB064116.1 AB064117.1 AB064118.1 AB064119.1 AB064120.1 AB064121.1 AB064122.1 AB064123.1 
    AB064124.1 AB064125.1 AB064126.1 AB064127.1 AB064128.1 AB064129.1 AB064130.1 AB064131.1 
    AB064132.1 AB064133.1 AB064134.1 AB064135.1 AB064136.1 AB064137.1 AB064138.1 AB064139.1 
    AB064140.1 AB095273.1 AB095279.1 AB095280.1 AB095281.1 AB095282.1 AB095283.1 AB095284.1 
    AB095285.1 AB095286.1 AB095287.1 AB095289.1 AB095290.1 AB095291.1 AB110647.1 AB114464.1 
    AB114469.1 AB159729.1 AB245096.1 AB266093.1 AB266511.1 AB274405.1 AB274407.1 AB274409.1 
    AB274411.1 AB288083.1 AB289328.1 AB289329.1 AB289330.1 AB355875.1 AB363242.1 AB363244.1 
    AB363245.1 AB363248.1 AB363250.1 AB363251.1 AB363253.1 AB363256.1 AB363257.1 AB363263.1 
    AB363264.1 AB363267.1 AB363271.1 AB363272.1 AB363273.1 AB363274.1 AB363276.1 AB363277.1 
    AB363278.1 AB363279.1 AB363281.1 AB363282.1 AB363283.1 AB363284.1 AB363285.1 AB363286.1 
    AB363287.1 AB363288.1 AB363289.1 AB363290.1 AB363291.1 AB363292.1 AB363294.1 AB363295.1 
    AB363296.1 AB363297.1 AB363298.1 AB363299.1 AB363300.1 AB363301.1 AB363302.1 AB363303.1 
    AB363304.1 AB363305.1 AB363306.1 AB363307.1 AB363308.1 AB363310.1 AB363311.1 AB363312.1 
    AB363313.1 AB363314.1 AB363315.1 AB363316.1 AB363317.1 AB363318.1 AB363319.1 AB363320.1 
    AB363321.1 AB363322.1 AB363324.1 AB363325.1 AB363326.1 AB363327.1 AB363328.1 AB363329.1 
    AB363330.1 AB363331.1 AB363332.1 AB363333.1 AB363334.1 AB363335.1 AB363336.1 AB363337.1 
    AB363338.1 AB373033.1 AB373034.1 AB373035.1 AB373036.1 AB373037.1 AB373038.1 AB373039.1 
    AB373040.1 AB373041.1 AB373042.1 AB373043.1 AB373044.1 AB373045.1 AB373046.1 AB373047.1 
    AB373048.1 AB373049.1 AB373050.1 AB373051.1 AB373052.1 AB453234.1 AB453235.1 AB453236.1 
    AB453237.1 AB586000.1 AB586001.1 AB608260.1 AB608261.1 AB608262.1 AB729121.1 AF007572.1 
    AF026381.1 AF026927.1 AF026933.1 AF027158.2 AF029334.1 AF029335.1 AF029336.1 AF029341.1 
    AF029989.1 AF032357.1 AF032359.1 AF035028.1 AF035029.1 AF035031.1 AF035033.1 AF035036.1 
    AF035037.1 AF039298.1 AF051099.1 AF052532.1 AF052535.1 AF052618.1 AF078944.1 AF078947.1 
    AF078948.1 AF082202.1 AF082203.1 AF082204.1 AF082205.1 AF082206.1 AF082207.1 AF082208.1 
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    L40715.1 L40716.1 L40717.1 L40718.1 L40719.1 L40720.1 L40721.1 L40722.1 
    L40723.1 L40726.1 L40727.1 L40730.1 L40732.1 L40733.1 L40734.1 L40735.1 
    L40736.1 L40737.1 L40738.1 L40739.1 L40740.1 L41174.1 L43086.2 L43118.1 
    L43119.1 L48238.1 L48240.1 L48242.1 M11937.1 M26437.1 M26438.1 M27025.1 
    M27026.1 M27028.1 M27029.1 M27030.1 M27031.1 M27032.1 M29469.1 M33060.1 
    M63438.1 M74019.1 M74470.1 M74471.1 M80920.1 M87269.1 M87478.1 M88314.1 
    M88317.1 M88319.1 M88499.1 M95721.1 M95722.1 M95723.1 M97805.1 M97806.1 
    M99596.1 M99597.1 M99599.1 M99603.1 M99608.1 S46248.1 S56182.1 S56199.1 
    S56913.1 S56915.1 S64995.1 S65199.1 S66101.1 S67059.1 S67060.1 S67061.1 
    S67637.1 S68699.1 S68704.1 S68705.1 S73509.1 S73911.1 S73966.1 S74681.1 
    S79919.1 S83559.1 U03401.1 U03481.1 U03482.1 U03483.1 U03484.1 U04372.1 
    U04373.1 U04374.1 U04375.1 U04376.1 U04378.1 U07426.1 U07429.1 U07430.1 
    U07431.1 U07432.1 U07433.1 U07434.1 U07435.1 U07436.1 U07437.1 U07438.1 
    U07440.1 U07442.1 U07443.1 U07444.1 U07445.1 U07446.1 U07448.1 U07449.1 
    U07453.1 U07454.1 U07456.1 U07457.1 U07458.1 U07459.1 U07460.1 U07461.1 
    U07462.1 U07463.1 U07464.1 U07465.1 U07466.1 U07467.1 U07468.1 U07469.1 
    U07471.1 U07472.1 U07473.1 U07475.1 U07476.1 U07480.1 U07481.1 U07482.1 
    U07483.1 U07484.1 U07485.1 U07489.1 U07491.1 U07492.1 U07493.1 U07494.1 
    U07495.1 U07496.1 U07497.1 U07498.1 U07500.1 U07501.1 U07502.1 U07503.1 
    U07504.1 U07505.1 U07507.1 U07508.1 U07509.1 U07510.1 U07511.1 U07512.1 
    U07513.1 U07514.1 U07515.1 U07516.1 U07517.1 U07518.1 U07519.1 U07520.1 
    U07521.1 U07522.1 U07523.1 U07524.1 U07525.1 U07526.1 U07527.1 U07528.1 
    U07529.1 U07530.1 U07531.1 U07532.1 U07533.1 U07534.1 U07535.1 U07536.1 
    U07537.1 U07538.1 U07541.1 U07542.1 U07543.1 U07544.1 U07545.1 U07546.1 
    U07989.1 U07990.1 U09071.1 U09075.1 U09076.1 U19884.1 U21248.1 U37724.1 
    U43764.1 U43765.1 U43766.1 U43768.1 U43770.1 U43771.1 U43773.1 U44792.1 
    U44794.1 U50342.1 U50343.1 U66190.1 U76682.1 U79586.1 U79587.1 U79589.1 
    U79590.1 U79763.1 U82258.1 U82770.1 U82772.1 U86792.1 U86794.1 U89902.1 
    U91942.1 U94422.1 U95242.1 U95243.1 U95244.1 U96290.1 U96291.1 U96294.1 
    U96390.1 U96396.1 U96397.1 U97249.1 U97250.1 X06763.1 X06764.1 X13075.1 
    X13076.1 X13077.1 X13078.1 X15987.1 X54821.1 X54822.1 X54824.1 X54825.1 
    X54826.1 X54827.1 X54828.1 X54829.1 X54830.1 X54831.1 X54832.1 X54833.1 
    X54834.1 X54835.1 X54836.1 X54837.1 X54838.1 X54839.1 X54840.1 X54841.1 
    X56594.1 X58081.1 X58082.1 X58083.1 X58086.1 X58087.1 X58088.1 X58089.1 
    X58090.1 X58091.1 X58092.1 X58093.1 X58094.1 X58095.1 X58096.1 X58097.1 
    X58098.1 X59705.1 X61642.1 X64133.1 X64162.1 X64164.1 X64168.1 X67322.1 
    X67904.1 X72423.1 X72424.1 X72425.1 X72426.1 X72427.1 X72428.1 X72429.1 
    X72430.1 X72432.1 X72433.1 X72435.1 X72436.1 X72437.1 X72438.1 X72439.1 
    X72441.1 X72442.1 X72444.1 X72445.1 X72446.1 X72447.1 X72449.1 X72451.1 
    X72452.1 X72453.1 X72454.1 X72455.1 X72456.1 X72460.1 X72461.1 X72464.1 
    X72466.1 X72467.1 X72468.1 X72469.1 X72470.1 X72471.1 X72473.1 X72477.1 
    X72478.1 X72480.1 X72481.1 X72485.1 X72487.1 X72489.1 X72490.1 X73852.1 
    X73855.1 X73858.1 X73860.1 X73863.1 X73864.1 X73866.1 X75387.1 X77945.1 
    X77948.1 X79272.1 X79784.1 X79786.1 X82934.1 X84341.1 X84342.1 X84343.1 
    X84344.1 X84346.1 X85143.1 X85146.1 X85150.1 X85151.1 X85154.1 X85155.1 
    X85156.1 X85157.1 X85159.1 X85160.1 X85161.1 X85162.1 X85164.1 X85165.1 
    X85751.1 X85996.1 X85997.1 X87441.1 X87443.1 X87445.1 X87448.1 X87450.1 
    X87454.1 X87460.1 X87898.1 X89054.1 X89056.1 X92991.1 X92993.1 X92994.1 
    X92996.1 X93005.1 X93008.1 X93695.1 X93696.1 X93697.1 X93698.1 X93699.1 
    X93700.1 X93702.1 X93706.1 X93707.1 X93708.1 X93710.1 X93712.1 X93713.1 
    X93715.1 X93716.1 X93718.1 X93720.1 X93721.1 X93722.1 X93723.1 X93724.1 
    X93725.1 X93726.1 X93727.1 X93728.1 X93729.1 X93730.1 X93731.1 X93732.1 
    X93733.1 X93734.1 X93735.1 X93736.1 X93737.1 X93738.1 X93739.1 X93740.1 
    X93741.1 X93742.1 X93743.1 X93744.1 X93745.1 X93746.1 X93747.1 X93748.1 
    X93749.1 X93750.1 X93751.1 X93752.1 X93753.1 X93754.1 X93755.1 X93756.1 
    X93757.1 X93758.1 X93759.1 X93760.1 X93761.1 X93762.1 X93763.1 X93764.1 
    X93765.1 X93766.1 X93767.1 X93768.1 X93769.1 X93770.1 X93771.1 X93772.1 
    X93773.1 X93774.1 X93775.1 X93776.1 X93777.1 X93778.1 X93779.1 X93780.1 
    X93781.1 X93782.1 X93783.1 X93784.1 X93785.1 X93786.1 X93787.1 X93788.1 
    X93789.1 X93790.1 X93792.1 X93793.1 X93794.1 X93796.1 X93797.1 X93798.1 
    X93799.1 X93800.1 X93801.1 X93802.1 X93803.1 X93804.1 X93805.1 X93806.1 
    X93807.1 X93809.1 X93810.1 X94431.1 X96754.1 X97481.1 X97482.1 X97551.1 
    X97555.1 X98216.1 X98218.1 X98894.1 X98965.1 X98966.1 X98967.1 X98968.1 
    X98969.1 X98970.1 X98971.1 X98972.1 X98973.1 X98974.1 X98975.1 X98977.1 
    X98979.1 X98980.1 X98981.1 X98982.1 X98983.1 X98984.1 X98985.1 X98986.1 
    X98987.1 X98988.1 X98989.1 X98990.1 Y08148.1 Y08191.1 Y08193.1 Y08195.1 
    Y08196.1 Y08197.1 Y08199.1 Y08248.1 Y08249.1 Y08251.1 Y08594.1 Y11899.1 
    Y12697.1 Y12698.1 Y14736.1 Y14864.1 Y14868.1 Y14869.1 Y14871.1 Y17771.1 
    Y17773.1 Y17786.1 Y17787.1 Y17788.1 Y17935.1 Y17936.1 Y17937.1 Y17938.1 
    Y17939.1 Y17951.1 Y17953.1 Y17954.1 Y17955.1 Z11890.1 Z11891.1 Z11892.1 
    Z11893.1 Z11894.1 Z11895.1 Z11903.1 Z14247.1 Z15073.1 Z15074.1 Z15075.1 
    Z15077.1 Z15078.1 Z15080.1 Z15081.1 Z18326.1 Z18327.1 Z18330.1 Z18838.1 
    Z18840.1 Z18842.1 Z18845.1 Z26596.1 Z26597.1 Z26598.1 Z26599.1 Z26600.1 
    Z26601.1 Z26602.1 Z26603.1 Z26604.1 Z26606.1 Z26607.1 Z26608.1 Z26609.1 
    Z26610.1 Z26611.1 Z26612.1 Z26613.1 Z26614.1 Z26615.1 Z26616.1 Z26617.1 
    Z26618.1 Z26619.1 Z26620.1 Z26621.1 Z26622.1 Z26623.1 Z26624.1 Z27170.1 
    Z27171.1 Z27172.1 Z27173.1 Z27175.1 Z27176.1 Z27177.1 Z27178.1 Z30564.1 
    Z30565.1 Z30566.1 Z30567.1 Z30568.1 Z34890.1 Z34911.1 Z34964.1 Z34965.1 
    Z34966.1 Z35083.1 Z35084.1 Z46309.1 Z46310.1 Z46311.1 Z46345.1 Z46620.1 
    Z46624.1 Z46628.1 Z46634.1 Z46854.1 Z46860.1 Z49137.1 Z49142.1 Z68925.1 
    Z68927.1 Z68929.1 Z68930.1 Z68931.1 Z68932.1 Z68933.1 Z68936.1 Z68938.1 
    Z68939.1 Z68940.1 Z68941.1 Z68944.1 Z68947.1 Z68948.1 Z68949.1 Z68950.1 
    Z68952.1 Z68953.1 Z68955.1 Z68956.1 Z68957.1 Z68958.1 Z68960.1 Z68961.1 
    Z68962.1 Z68963.1 Z68964.1 Z68965.1 Z68967.1 Z68968.1 Z68971.1 Z68973.1 
    Z68976.1 Z68977.1 Z68979.1 Z68980.1 Z68981.1 Z68983.1 Z68985.1 Z68987.1 
    Z68988.1 Z68989.1 Z68990.1 Z68991.1 Z68995.1 Z68996.1 Z68997.1 Z68998.1 
    Z69001.1 Z69002.1 Z69007.1 Z69008.1 Z69009.1 Z69012.1 Z69015.1 Z69018.1 
    Z69019.1 Z69020.1 Z69021.1 Z69022.1 Z69023.1 Z69024.1 Z69027.1 Z70253.1 
    Z70259.1 Z70260.1 Z74667.1 Z74692.1 Z82141.1 Z82143.1 Z82144.1 Z82145.1 
    Z82146.1 Z82147.1 Z82148.1 Z82149.1 Z82150.1 Z82151.1 Z82152.1 Z82153.1 
    Z82154.1 Z82155.1 Z82156.1 Z82157.1 Z82158.1 Z82159.1 Z82160.1 Z82161.1 
    Z82162.1 Z82163.1 Z82164.1 Z82165.1 Z82166.1 Z82167.1 Z84392.1 Z84393.1 
    Z84394.1 

    24/302 DOTS entries (see all 302):

    DT.95204200  DT.95339737  DT.98083038  DT.95261924  DT.100061049  DT.92019906  DT.92004244  DT.95243711 
    DT.95195310  DT.91733902  DT.120984208  DT.305209  DT.91705797  DT.95322415  DT.92419960  DT.97759703 
    DT.87007699  DT.99944076  DT.95212079  DT.100850810  DT.92475934  DT.95244004  DT.91970838  DT.95243766 

    24/2867 AceView cDNA sequences (see all 2867):

    BU733277 BQ787721 CA412619 BE171296 AA318551 AW515123 H26314 AI708113 
    AI523487 AA345574 BE465297 H25288 BM512311 AW514398 AW337530 AI275730 
    T94612 AW275915 BG272757 AI679335 AI523515 AI832680 AA487988 AI073928 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGKC expression in normal human tissues (normalized intensities)      IGKC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAACCCCAG
    IGKC Expression
    About this image


    IGKC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 2 entries
             TONGUE   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Colon (Gastrointestinal Tract)
             Appendix   
     
     Thymus (Hematopoietic System)
             Thymus   
     
     Bone (Muscoskeletal System)
             Bone Marrow

    See IGKC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGKC

    SOURCE GeneReport for Unigene cluster: Hs.449609
        SABiosciences Custom PCR Arrays for IGKC
    Primer
    Products:
    Browse OriGene qPCR
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IGKC
    Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGKC
    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGKC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGKC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IGKC gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igkc5 immunoglobulin kappa constant   --   6 (32.04 cM) 70726435 
    lizard
    (Anolis carolinensis)
    Reptilia IGKC6
    immunoglobulin kappa constant
    22(a)
    1 ↔ 1
    6(59759402-59771538)
    zebrafish
    (Danio rerio)
    Actinopterygii igic1s16
    igl3v56
    (see all 5)
    immunoglobulin light 3 variable 5
    (see all 5)
    28(a)
    27(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    24(39697150-39700054)
    24(39705312-39708147)


    ENSEMBL Gene Tree for IGKC (if available)
    TreeFam Gene Tree for IGKC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGKC gene
    IGLL52  IGLC12  IGLC32  IGLL12  IGLC72  IGLC22  
    18/53 SIMAP similar genes for IGKC using alignment to 1 protein entry:     IGKC_HUMAN(see all similar genes):
    IGK@    IGLC6    DKFZp667J0810    IGLC2    IgLC-rG    IGL@
    IGHG2    IGLC3    IGLC7    IGLL1    C1 segment    DKFZp686C15213
    DKFZp686I04196    DKFZp686I15212    DKFZp781M0386    FLJ00385    IGHG3    IGLC1

    IGKC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in IGKC are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0664034
    Immunoglobulin kappa light chain deficiency (IGKCD)4--see VAR_0664032 W R mis40--------
    VAR_0038974
    ----see VAR_0038972 V L mis40--------

    HapMap Linkage Disequilibrium report for IGKC (89156674 - 89157196 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IGKC: --

    Locus Specific Mutation Databases (LSDB): IGKC
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IGKC
    DNA2.0 Custom Variant and Variant Library Synthesis for IGKC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147200    OMIM disorders: --

    UniProtKB/Swiss-Prot: IGKC_HUMAN, P01834
  • Immunoglobulin kappa light chain deficiency (IGKCD) [MIM:614102]: A disease characterized by the complete
    absence of immunoglobulin kappa chains. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 20/41 diseases for IGKC (see all 41):    About MalaCards
    light chain deposition disease    b cell prolymphocytic leukemia    extramedullary plasmacytoma    plasmacytoma
    prolymphocytic leukemia    t-cell prolymphocytic leukemia    malt lymphoma    guillain-barre syndrome
    amyloidosis    alopecia areata    juvenile rheumatoid arthritis    biliary atresia
    severe acute respiratory syndrome    nasopharyngitis    alopecia    histiocytosis
    mantle cell lymphoma    kawasaki disease    rheumatoid arthritis    abdominal aortic aneurysm


    IGKC for disorders           About GeneDecksing

    10/13 Novoseek inferred disease relationships for IGKC gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amyloidosis 55.7 2 18084704 (1), 10392240 (1)
    amyloid deposition 50 1 11172308 (1)
    lymphoma b-cell 48.2 1 15085149 (1)
    plasmacytoma 46.1 1 11172308 (1)
    lymphoma 45.7 4 10613459 (1), 8245027 (1), 15122457 (1), 10364369 (1)
    malt lymphoma 43.7 1 15122457 (1)
    somatic mutations 42.3 2 7635977 (2)
    myeloma 40.1 1 2147229 (1)
    rheumatoid arthritis 16.2 6 9632065 (2), 7635977 (1), 1642656 (1), 9186688 (1) (see all 5)
    nasopharyngeal carcinoma 15.1 1 11913778 (1)

    Genetic Association Database (GAD): IGKC
    Human Genome Epidemiology (HuGE) Navigator: IGKC (4 documents)

    Export disorders for IGKC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGKC gene, integrated from 9 sources (see all 153):
    (articles sorted by number of sources associating them with IGKC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Single nucleotide polymorphism of interleukin-1beta associated with Helicobacter pylori infection in immune thrombocytopenic purpura. (PubMed id 19317746)1, 4 Satoh T....Kuwana M. (2009)
    2. Immunoglobulin gene polymorphisms are susceptibility factors in clinical and autoantibody subgroups of the idiopathic inflammatory myopathies. (PubMed id 18821675)1, 4 O'Hanlon T.P....Miller F.W. (2008)
    3. Immunoglobulin kappa light chain gene alleles are not associated with primary Sjogren's syndrome. (PubMed id 12215905)1, 4 Downie-Doyle S....Pile K. (2002)
    4. TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis. (PubMed id 12039524)1, 4 Pandey J.P. and Frederick M. (2002)
    5. Identification of a novel substitution in the constant region of a gene coding for an amyloidogenic kappa1 light chain. (PubMed id 10354514)1, 3 Wally J....Comenzo R.L. (1999)
    6. Extended analysis of AL-amyloid protein from abdominal wall subcutaneous fat biopsy: kappa IV immunoglobulin light chain. (PubMed id 9588180)1, 2 Olsen K.E.... Westermark P. (1998)
    7. Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments. (PubMed id 6775818)1, 2 Hieter P.A.... Leder P. (1980)
    8. Rule of antibody structure. The primary structure of a monoclonal immunoglobulin L-chain of kappa-type, subgroup 3 (Bence-Jones protein Ti). IV. The complete amino acid sequence and its significance for the mechanism of antibody production. (PubMed id 5027703)1, 2 Suter L.... Hilschmann N. (1972)
    9. The covalent structure of a human gamma G-immunoglobulin. VI. Amino acid sequence of the light chain. (PubMed id 5489770)1, 2 Gottlieb P.D.... Edelman G.M. (1970)
    10. Macroglobulin structure: variable sequence of light and heavy chains. (PubMed id 5447531)1, 2 Kohler H.... Putnam F.W. (1970)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3514 HGNC: 5716 AceView: IGK_ Ensembl:ENSG00000211592 euGenes: HUgn3514
    ECgene: IGKC H-InvDB: IGKC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGKC Pharmacogenomics, SNPs, Pathways
    IMGT entry for IGKC The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
    IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGKC&species=Homo+sapiens

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IGKC gene:
    Search GeneIP for patents involving IGKC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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