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Aliases for IGKC Gene

Aliases for IGKC Gene

  • Immunoglobulin Kappa Constant 2 3 5
  • Immunoglobulin Kappa (Invariant Region) 3
  • Immunoglobulin Kappa Light Chain (VJ) 3
  • Immunoglobulin Kappa Constant Region 3
  • Ig Kappa Chain C Region CUM 4
  • Ig Kappa Chain C Region ROY 4
  • Ig Kappa Chain C Region AG 4
  • Ig Kappa Chain C Region EU 4
  • Ig Kappa Chain C Region OU 4
  • Ig Kappa Chain C Region TI 4
  • Ig Kappa Chain C Region 4
  • HCAK1 3
  • IGKCD 3
  • Km 3

External Ids for IGKC Gene

Previous GeneCards Identifiers for IGKC Gene

  • GC02M088711
  • GC02U900019
  • GC02M089043
  • GC02M089058
  • GC02M089060
  • GC02M088995
  • GC02M089010
  • GC02M088937
  • GC02M089156
  • GC02M088860
  • GC02M088871
  • GC02M088878
  • GC02M088886
  • GC02M088893
  • GC02M088900

Summaries for IGKC Gene

GeneCards Summary for IGKC Gene

IGKC (Immunoglobulin Kappa Constant) is a Protein Coding gene. Diseases associated with IGKC include Kappa Light Chain Deficiency and Extramedullary Plasmacytoma. Among its related pathways are Development Angiotensin activation of ERK and Development IGF-1 receptor signaling. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLC3.

UniProtKB/Swiss-Prot for IGKC Gene

  • Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Wiki entry for IGKC Gene

Additional gene information for IGKC Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKC Gene

Genomics for IGKC Gene

Regulatory Elements for IGKC Gene

Enhancers for IGKC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H088855 1.5 FANTOM5 Ensembl ENCODE dbSUPER 0.7 -1.4 -1425 7 CHD1 NR2F2 RELA GABPA NFIC POLR2A SPI1 NR2C2 IGKV1-13 THNSL2 RPIA IGKV4-1 EIF2AK3 GC02M088842 IGKC
GH02H088853 0.8 FANTOM5 dbSUPER 0.7 +4.5 4514 0 NFIC POLR2A NFIB EGR2 ANKRD36BP2 EIF2AK3 IGKC IGKDEL
GH02H088835 1.2 FANTOM5 ENCODE dbSUPER 0.4 +15.1 15091 14 FOXA2 HLF CEBPB ATF2 RELA POLR2A IKZF1 NBN CREB1 FOXP1 EIF2AK3 ANKRD36BP2 IGKV1-13 RPIA LOC101928403 IGKDEL IGKC
GH02H088834 0.6 dbSUPER 0.3 +22.9 22905 0 ZNF316 POLR2A HLF MAFG EMSY MAFK ANKRD36BP2 IGKV1-13 IGKDEL IGKC
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGKC on UCSC Golden Path with GeneCards custom track

Genomic Location for IGKC Gene

Chromosome:
2
Start:
88,857,161 bp from pter
End:
88,857,683 bp from pter
Size:
523 bases
Orientation:
Minus strand

Genomic View for IGKC Gene

Genes around IGKC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGKC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGKC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKC Gene

Proteins for IGKC Gene

  • Protein details for IGKC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01834-IGKC_HUMAN
    Recommended name:
    Immunoglobulin kappa constant
    Protein Accession:
    P01834
    Secondary Accessions:
    • A0A075B6H6
    • A0A087X130

    Protein attributes for IGKC Gene

    Size:
    107 amino acids
    Molecular mass:
    11765 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
    SequenceCaution:
    • Sequence=AAA58989.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGKC Gene

neXtProt entry for IGKC Gene

Post-translational modifications for IGKC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGKC Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGKC Gene

Domains & Families for IGKC Gene

Gene Families for IGKC Gene

Protein Domains for IGKC Gene

Suggested Antigen Peptide Sequences for IGKC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGKC: view

No data available for UniProtKB/Swiss-Prot for IGKC Gene

Function for IGKC Gene

Molecular function for IGKC Gene

GENATLAS Biochemistry:
immunoglobulin,kappa,constant chain (Km marker)
UniProtKB/Swiss-Prot Function:
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 5489770
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005515 protein binding IPI 11183784
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGKC: view

Human Phenotype Ontology for IGKC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for IGKC
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKC Gene

Localization for IGKC Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGKC Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA --
GO:0042571 immunoglobulin complex, circulating IBA --
genes like me logo Genes that share ontologies with IGKC: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGKC Gene

Pathways & Interactions for IGKC Gene

genes like me logo Genes that share pathways with IGKC: view

Interacting Proteins for IGKC Gene

Gene Ontology (GO) - Biological Process for IGKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0002377 immunoglobulin production IBA --
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006910 phagocytosis, recognition IBA --
genes like me logo Genes that share ontologies with IGKC: view

No data available for SIGNOR curated interactions for IGKC Gene

Drugs & Compounds for IGKC Gene

(19) Drugs for IGKC Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL Experimental Pharma Target 0
(2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE Experimental Pharma Target 0
(4Z)-2,8:7,12:11,15:14,18:17,22-PENTAANHYDRO-4,5,6,9,10,13,19,20,21-NONADEOXY-D-ARABINO-D-ALLO-D-ALLO-DOCOSA-4,9,20-TRIENITOL Experimental Pharma Target 0
[4-(4-ACETYLAMINO-PHENYL)-3,5-DIOXO-4-AZA-TRICYCLO[5.2.2.0 2,6]UNDEC-1-YLCARBAMOYLOXY]-ACETIC ACID Experimental Pharma Target 0
3-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACID Experimental Pharma Target 0
genes like me logo Genes that share compounds with IGKC: view

Drug Products

Transcripts for IGKC Gene

mRNA/cDNA for IGKC Gene

Unigene Clusters for IGKC Gene

Immunoglobulin kappa constant:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for IGKC
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IGKC Gene

No ASD Table

Relevant External Links for IGKC Gene

GeneLoc Exon Structure for
IGKC
ECgene alternative splicing isoforms for
IGKC

Expression for IGKC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGKC Gene

Protein differential expression in normal tissues from HIPED for IGKC Gene

This gene is overexpressed in Pancreatic juice (8.7) and Urine (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGKC Gene



Protein tissue co-expression partners for IGKC Gene

NURSA nuclear receptor signaling pathways regulating expression of IGKC Gene:

IGKC

SOURCE GeneReport for Unigene cluster for IGKC Gene:

Hs.449609

Phenotype-based relationships between genes and organs from Gene ORGANizer for IGKC Gene

Germ Layers:
  • mesoderm
Systems:
  • immune
Organs:
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with IGKC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for IGKC Gene

Orthologs for IGKC Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGKC Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Igkc 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGKC 34
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGKC 34
  • 10 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii IGKC 34
  • 24 (a)
OneToOne
Species where no ortholog for IGKC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGKC Gene

ENSEMBL:
Gene Tree for IGKC (if available)
TreeFam:
Gene Tree for IGKC (if available)

Paralogs for IGKC Gene

Variants for IGKC Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGKC Gene

IGKC_HUMAN-P01834
There are several alleles. The sequence shown is that of IMGT allele IGKC*01.

Sequence variations from dbSNP and Humsavar for IGKC Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_066403 Immunoglobulin kappa light chain deficiency (IGKCD) [MIM:614102]
VAR_003897 --

Relevant External Links for IGKC Gene

Human Gene Mutation Database (HGMD)
IGKC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGKC

No data available for Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKC Gene

Disorders for IGKC Gene

MalaCards: The human disease database

(6) MalaCards diseases for IGKC Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
kappa light chain deficiency
  • kappa chain deficiency
extramedullary plasmacytoma
  • extraosseous plasmacytoma
b cell prolymphocytic leukemia
  • leukemia, b cell prolymphocytic
plasmacytoma
  • myeloma - solitary
light chain deposition disease
  • light-chain deposition disease
- elite association - COSMIC cancer census association via MalaCards
Search IGKC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IGKC_HUMAN
  • Immunoglobulin kappa light chain deficiency (IGKCD) [MIM:614102]: A disease characterized by the complete absence of immunoglobulin kappa chains. {ECO:0000269 PubMed:3931219}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IGKC

Genetic Association Database (GAD)
IGKC
Human Genome Epidemiology (HuGE) Navigator
IGKC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGKC
genes like me logo Genes that share disorders with IGKC: view

No data available for Genatlas for IGKC Gene

Publications for IGKC Gene

  1. Single nucleotide polymorphism of interleukin-1beta associated with Helicobacter pylori infection in immune thrombocytopenic purpura. (PMID: 19317746) Satoh T … Kuwana M (Tissue antigens 2009) 3 45 60
  2. Immunoglobulin gene polymorphisms are susceptibility factors in clinical and autoantibody subgroups of the idiopathic inflammatory myopathies. (PMID: 18821675) O'Hanlon TP … Miller FW (Arthritis and rheumatism 2008) 3 45 60
  3. TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis. (PMID: 12039524) Pandey JP … ACCESS Research Group. A Case Control Etiologic Study of Sarcoidosis (Human immunology 2002) 3 45 60
  4. Immunoglobulin kappa light chain gene alleles are not associated with primary Sjögren's syndrome. (PMID: 12215905) Downie-Doyle S … Pile K (Genes and immunity 2002) 3 45 60
  5. Identification of a novel substitution in the constant region of a gene coding for an amyloidogenic kappa1 light chain. (PMID: 10354514) Wally J … Comenzo RL (Biochimica et biophysica acta 1999) 2 3 60

Products for IGKC Gene

Sources for IGKC Gene

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