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IGKC Gene

protein-coding   GIFtS: 51
GCID: GC02M089156

Immunoglobulin Kappa Constant

  See IGKC-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immunoglobulin Kappa Constant1 2
IGKCD2 5
HCAK12
Km2

External Ids:    HGNC: 57161   Entrez Gene: 35142   Ensembl: ENSG000002115927   OMIM: 1472005   UniProtKB: P018343   

Export aliases for IGKC gene to outside databases

Previous GC identifers: GC02M088711 GC02U900019 GC02M089043 GC02M089058 GC02M089060 GC02M088995 GC02M089010 GC02M088937


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IGKC Gene:
IGKC (immunoglobulin kappa constant) is a protein-coding gene. Diseases associated with IGKC include recurrent infections associated with rare immunoglobulin isotypes deficiency, and light chain deposition disease. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGLL5.

Gene Wiki entry for IGKC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for IGKC
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for IGKC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGKC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

IGKC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGKC gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M089156:  view genomic region     (about GC identifiers)

Start:
89,156,674 bp from pter      End:
89,157,196 bp from pter
Size:
523 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IGKC_HUMAN, P01834 (See protein sequence)
Recommended Name: Ig kappa chain C region  
Size: 106 amino acids; 11609 Da
Miscellaneous: The EU sequence has the INV (3) allotypic marker, Ala-45 and Val-83. The ROY sequence has the INV
(1,2) allotypic marker, Ala-45 and Leu-83
Selected PDB 3D structures from and Proteopedia for IGKC (see all 53):
1A4J (3D)        1A4K (3D)        1D5B (3D)        1D5I (3D)        1D6V (3D)        1DFB (3D)    

Explore the universe of human proteins at neXtProt for IGKC: NX_P01834

Explore proteomics data for IGKC at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus (IGKC)

  • See IGKC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000374777  
    Reactome Protein details: P01834

    IGKC Human Recombinant Protein Products:

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    Novus Biologicals IGKC Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for IGKC 

     
    antibodies-online proteins for IGKC (3 products) 

     
    Search antibodies-online for peptides for IGKC

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    Abcam antibodies for IGKC (Q0KKI6, Q7Z473, P01834)
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    ThermoFisher Antibody for IGKC
    antibodies-online antibodies for IGKC (12 products) 

    IGKC Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for IGKC 
    antibodies-online kits for IGKC 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGK: Immunoglobulins / IGK locus

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P01834

    ProtoNet protein and cluster: P01834

    1 Blocks protein domain: IPB003597 Immunoglobulin C-type

    UniProtKB/Swiss-Prot: IGKC_HUMAN, P01834
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


    Find genes that share domains with IGKC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for IGKC:
    immunoglobulin,kappa,constant chain (Km marker)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding NAS6779204
    GO:0005515protein binding ----
         
    Find genes that share ontologies with IGKC           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Igkc):
     hematopoietic system  immune system  no phenotypic analysis 

    Find genes that share phenotypes with IGKC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IGKC: Igkctm1Jkbv Igkctm1Bgmn Igkctm1Cgn Igkctm1Schz

       genOway: Develop your customized and physiologically relevant rodent model for IGKC

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IGKC

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane4
    cytosol1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0005886plasma membrane TAS--
    GO:0070062extracellular vesicular exosome IDA19199708
    GO:0072562blood microparticle IDA--

    Find genes that share ontologies with IGKC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IGKC About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Creation of C4 and C2 activators
    Creation of C4 and C2 activators0.85
    FCGR activation0.54
    Initial triggering of complement0.85
    Role of phospholipids in phagocytosis0.53
    Classical antibody-mediated complement activation0.82
    FCERI mediated NF-kB activation0.32
    Complement cascade0.68
    2Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
    FCERI mediated Ca+2 mobilization0.47
    FCERI mediated MAPK activation0.45
    Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.47
    3Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    4PI-3K cascade
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    Fc epsilon receptor (FCERI) signaling0.64
    5Binding and Uptake of Ligands by Scavenger Receptors
    Binding and Uptake of Ligands by Scavenger Receptors0.53
    Scavenging of Heme from Plasma0.53


    Find genes that share SuperPaths with IGKC           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for IGKC (see all 7)
        Immune response IL-4 signaling pathway
    Immune response Fc epsilon RI pathway
    Immune response CD16 signaling in NK cells
    Immune response Classical complement pathway
    Immune response BCR pathway

    Selected Reactome Pathways for IGKC (see all 13)
        FCERI mediated MAPK activation
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    FCERI mediated NF-kB activation
    FCGR activation
    Scavenging of heme from plasma


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGKC
    Interactions:

        Search GeneGlobe Interaction Network for IGKC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IGKC (P018342, 3 ENSP000003747774) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGHG4P018612, 3, ENSP000003749854MINT-25060 I2D: score=1 STRING: ENSP00000374985
    IGHG1P018572, 3, ENSP000003749904MINT-24896 MINT-25051 I2D: score=3 STRING: ENSP00000374990
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    IGHG2P018593, ENSP000003749874I2D: score=1 STRING: ENSP00000374987
    APOA1P026473I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001895retina homeostasis IEP--
    GO:0006955immune response NAS6779204
    GO:0006956complement activation TAS--
    GO:0006958complement activation, classical pathway TAS--
    GO:0038095Fc-epsilon receptor signaling pathway TAS--

    Find genes that share ontologies with IGKC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGKC

    Selected DrugBank Compounds for IGKC (see all 14)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL-- --target--10592235
    (2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE-- --target--10592235
    (4Z)-2,8:7,12:11,15:14,18:17,22-PENTAANHYDRO-4,5,6,9,10,13,19,20,21-NONADEOXY-D-ARABINO-D-ALLO-D-ALLO-DOCOSA-4,9,20-TRIENITOL-- --target--10592235
    3-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACID-- --target--10592235
    4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID-- --target--10592235
    4-{4-[2-(1A,7A-DIMETHYL-4-OXY-OCTAHYDRO-1-OXA-4-AZA-CYCLOPROPA[A]NAPHTHALEN-4-YL) -ACETYLAMINO]-PHENYLCARBAMOYL}-BUTYRIC ACID-- --target--10592235
    5-BETA-ANDROSTANE-3,17-DIONE-- --target--10592235
    ECGONINE METHYL ESTER-- --target--10592235
    METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER-- --target--10592235
    N-(PARA-GLUTARAMIDOPHENYL-ETHYL)-PIPERIDINIUM-N-OXIDE-- --target--10592235

    2 Novoseek inferred chemical compound relationships for IGKC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    valine 24 1 8120118 (1)
    cysteine 0 1 1902379 (1)



    Find genes that share compounds with IGKC           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    Unigene Cluster for IGKC:

    Immunoglobulin kappa constant
    Hs.449609  [show with all ESTs]
    Unigene Representative Sequence: AK128524
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000390237(uc002sti.1)
    miRNA
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    Additional mRNA sequence: 

    AB004304.1 AB006842.1 AB006843.1 AB006844.1 AB006845.1 AB006846.1 AB006847.1 AB006848.1 
    AB006849.1 AB012910.1 AB022651.1 AB022653.1 AB022654.1 AB027434.1 AB027436.1 AB027438.1 
    AB027440.1 AB027442.1 AB027444.1 AB027446.1 AB027767.1 AB030640.1 AB063928.1 AB063929.1 
    AB063930.1 AB063931.1 AB063932.1 AB063934.1 AB063935.1 AB063936.1 AB063937.1 AB063938.1 
    AB063939.1 AB063940.1 AB063941.1 AB063942.1 AB063943.1 AB063944.1 AB063949.1 AB063950.1 
    AB063951.1 AB063952.1 AB063953.1 AB063954.1 AB063955.1 AB063956.1 AB063958.1 AB063959.1 
    AB063960.1 AB063961.1 AB063962.1 AB063963.1 AB063965.1 AB063966.1 AB063967.1 AB063968.1 
    AB064042.1 AB064043.1 AB064044.1 AB064045.1 AB064047.1 AB064048.1 AB064050.1 AB064051.1 
    AB064052.1 AB064053.1 AB064054.1 AB064055.1 AB064056.1 AB064057.1 AB064058.1 AB064059.1 
    AB064060.1 AB064061.1 AB064062.1 AB064063.1 AB064064.1 AB064065.1 AB064066.1 AB064067.1 
    AB064068.1 AB064069.1 AB064070.1 AB064071.1 AB064072.1 AB064073.1 AB064074.1 AB064075.1 
    AB064076.1 AB064077.1 AB064078.1 AB064079.1 AB064080.1 AB064081.1 AB064082.1 AB064083.1 
    AB064084.1 AB064085.1 AB064086.1 AB064087.1 AB064088.1 AB064089.1 AB064090.1 AB064091.1 
    AB064092.1 AB064093.1 AB064094.1 AB064095.1 AB064096.1 AB064097.1 AB064098.1 AB064099.1 
    AB064100.1 AB064101.1 AB064102.1 AB064103.1 AB064104.1 AB064105.1 AB064106.1 AB064107.1 
    AB064108.1 AB064109.1 AB064110.1 AB064111.1 AB064112.1 AB064113.1 AB064114.1 AB064115.1 
    AB064116.1 AB064117.1 AB064118.1 AB064119.1 AB064120.1 AB064121.1 AB064122.1 AB064123.1 
    AB064124.1 AB064125.1 AB064126.1 AB064127.1 AB064128.1 AB064129.1 AB064130.1 AB064131.1 
    AB064132.1 AB064133.1 AB064134.1 AB064135.1 AB064136.1 AB064137.1 AB064138.1 AB064139.1 
    AB064140.1 AB095273.1 AB095279.1 AB095280.1 AB095281.1 AB095282.1 AB095283.1 AB095284.1 
    AB095285.1 AB095286.1 AB095287.1 AB095289.1 AB095290.1 AB095291.1 AB110647.1 AB114464.1 
    AB114469.1 AB159729.1 AB245096.1 AB266093.1 AB266511.1 AB274405.1 AB274407.1 AB274409.1 
    AB274411.1 AB288083.1 AB289328.1 AB289329.1 AB289330.1 AB355875.1 AB363242.1 AB363244.1 
    AB363245.1 AB363248.1 AB363250.1 AB363251.1 AB363253.1 AB363256.1 AB363257.1 AB363263.1 
    AB363264.1 AB363267.1 AB363271.1 AB363272.1 AB363273.1 AB363274.1 AB363276.1 AB363277.1 
    AB363278.1 AB363279.1 AB363281.1 AB363282.1 AB363283.1 AB363284.1 AB363285.1 AB363286.1 
    AB363287.1 AB363288.1 AB363289.1 AB363290.1 AB363291.1 AB363292.1 AB363294.1 AB363295.1 
    AB363296.1 AB363297.1 AB363298.1 AB363299.1 AB363300.1 AB363301.1 AB363302.1 AB363303.1 
    AB363304.1 AB363305.1 AB363306.1 AB363307.1 AB363308.1 AB363310.1 AB363311.1 AB363312.1 
    AB363313.1 AB363314.1 AB363315.1 AB363316.1 AB363317.1 AB363318.1 AB363319.1 AB363320.1 
    AB363321.1 AB363322.1 AB363324.1 AB363325.1 AB363326.1 AB363327.1 AB363328.1 AB363329.1 
    AB363330.1 AB363331.1 AB363332.1 AB363333.1 AB363334.1 AB363335.1 AB363336.1 AB363337.1 
    AB363338.1 AB373033.1 AB373034.1 AB373035.1 AB373036.1 AB373037.1 AB373038.1 AB373039.1 
    AB373040.1 AB373041.1 AB373042.1 AB373043.1 AB373044.1 AB373045.1 AB373046.1 AB373047.1 
    AB373048.1 AB373049.1 AB373050.1 AB373051.1 AB373052.1 AB453234.1 AB453235.1 AB453236.1 
    AB453237.1 AB586000.1 AB586001.1 AB608260.1 AB608261.1 AB608262.1 AB729121.1 AF007572.1 
    AF026381.1 AF026927.1 AF026933.1 AF027158.2 AF029334.1 AF029335.1 AF029336.1 AF029341.1 
    AF029989.1 AF032357.1 AF032359.1 AF035028.1 AF035029.1 AF035031.1 AF035033.1 AF035036.1 
    AF035037.1 AF039298.1 AF051099.1 AF052532.1 AF052535.1 AF052618.1 AF078944.1 AF078947.1 
    AF078948.1 AF082202.1 AF082203.1 AF082204.1 AF082205.1 AF082206.1 AF082207.1 AF082208.1 
    AF086900.1 AF086902.1 AF090354.1 AF090357.1 AF092499.1 AF092501.1 AF097601.1 AF097602.1 
    AF097603.1 AF098361.1 AF098363.1 AF098365.1 AF098367.1 AF099193.1 AF103373.1 AF103374.1 
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    L43119.1 L48238.1 L48240.1 L48242.1 M11937.1 M26437.1 M26438.1 M27025.1 
    M27026.1 M27028.1 M27029.1 M27030.1 M27031.1 M27032.1 M29469.1 M33060.1 
    M63438.1 M74019.1 M74470.1 M74471.1 M80920.1 M87269.1 M87478.1 M88314.1 
    M88317.1 M88319.1 M88499.1 M95721.1 M95722.1 M95723.1 M97805.1 M97806.1 
    M99596.1 M99597.1 M99599.1 M99603.1 M99608.1 S46248.1 S56182.1 S56199.1 
    S56913.1 S56915.1 S64995.1 S65199.1 S66101.1 S67059.1 S67060.1 S67061.1 
    S67637.1 S68699.1 S68704.1 S68705.1 S73509.1 S73911.1 S73966.1 S74681.1 
    S79919.1 S83559.1 U03401.1 U03481.1 U03482.1 U03483.1 U03484.1 U04372.1 
    U04373.1 U04374.1 U04375.1 U04376.1 U04378.1 U07426.1 U07429.1 U07430.1 
    U07431.1 U07432.1 U07433.1 U07434.1 U07435.1 U07436.1 U07437.1 U07438.1 
    U07440.1 U07442.1 U07443.1 U07444.1 U07445.1 U07446.1 U07448.1 U07449.1 
    U07453.1 U07454.1 U07456.1 U07457.1 U07458.1 U07459.1 U07460.1 U07461.1 
    U07462.1 U07463.1 U07464.1 U07465.1 U07466.1 U07467.1 U07468.1 U07469.1 
    U07471.1 U07472.1 U07473.1 U07475.1 U07476.1 U07480.1 U07481.1 U07482.1 
    U07483.1 U07484.1 U07485.1 U07489.1 U07491.1 U07492.1 U07493.1 U07494.1 
    U07495.1 U07496.1 U07497.1 U07498.1 U07500.1 U07501.1 U07502.1 U07503.1 
    U07504.1 U07505.1 U07507.1 U07508.1 U07509.1 U07510.1 U07511.1 U07512.1 
    U07513.1 U07514.1 U07515.1 U07516.1 U07517.1 U07518.1 U07519.1 U07520.1 
    U07521.1 U07522.1 U07523.1 U07524.1 U07525.1 U07526.1 U07527.1 U07528.1 
    U07529.1 U07530.1 U07531.1 U07532.1 U07533.1 U07534.1 U07535.1 U07536.1 
    U07537.1 U07538.1 U07541.1 U07542.1 U07543.1 U07544.1 U07545.1 U07546.1 
    U07989.1 U07990.1 U09071.1 U09075.1 U09076.1 U19884.1 U21248.1 U37724.1 
    U43764.1 U43765.1 U43766.1 U43768.1 U43770.1 U43771.1 U43773.1 U44792.1 
    U44794.1 U50342.1 U50343.1 U66190.1 U76682.1 U79586.1 U79587.1 U79589.1 
    U79590.1 U79763.1 U82258.1 U82770.1 U82772.1 U86792.1 U86794.1 U89902.1 
    U91942.1 U94422.1 U95242.1 U95243.1 U95244.1 U96290.1 U96291.1 U96294.1 
    U96390.1 U96396.1 U96397.1 U97249.1 U97250.1 X06763.1 X06764.1 X13075.1 
    X13076.1 X13077.1 X13078.1 X15987.1 X54821.1 X54822.1 X54824.1 X54825.1 
    X54826.1 X54827.1 X54828.1 X54829.1 X54830.1 X54831.1 X54832.1 X54833.1 
    X54834.1 X54835.1 X54836.1 X54837.1 X54838.1 X54839.1 X54840.1 X54841.1 
    X56594.1 X58081.1 X58082.1 X58083.1 X58086.1 X58087.1 X58088.1 X58089.1 
    X58090.1 X58091.1 X58092.1 X58093.1 X58094.1 X58095.1 X58096.1 X58097.1 
    X58098.1 X59705.1 X61642.1 X64133.1 X64162.1 X64164.1 X64168.1 X67322.1 
    X67904.1 X72423.1 X72424.1 X72425.1 X72426.1 X72427.1 X72428.1 X72429.1 
    X72430.1 X72432.1 X72433.1 X72435.1 X72436.1 X72437.1 X72438.1 X72439.1 
    X72441.1 X72442.1 X72444.1 X72445.1 X72446.1 X72447.1 X72449.1 X72451.1 
    X72452.1 X72453.1 X72454.1 X72455.1 X72456.1 X72460.1 X72461.1 X72464.1 
    X72466.1 X72467.1 X72468.1 X72469.1 X72470.1 X72471.1 X72473.1 X72477.1 
    X72478.1 X72480.1 X72481.1 X72485.1 X72487.1 X72489.1 X72490.1 X73852.1 
    X73855.1 X73858.1 X73860.1 X73863.1 X73864.1 X73866.1 X75387.1 X77945.1 
    X77948.1 X79272.1 X79784.1 X79786.1 X82934.1 X84341.1 X84342.1 X84343.1 
    X84344.1 X84346.1 X85143.1 X85146.1 X85150.1 X85151.1 X85154.1 X85155.1 
    X85156.1 X85157.1 X85159.1 X85160.1 X85161.1 X85162.1 X85164.1 X85165.1 
    X85751.1 X85996.1 X85997.1 X87441.1 X87443.1 X87445.1 X87448.1 X87450.1 
    X87454.1 X87460.1 X87898.1 X89054.1 X89056.1 X92991.1 X92993.1 X92994.1 
    X92996.1 X93005.1 X93008.1 X93695.1 X93696.1 X93697.1 X93698.1 X93699.1 
    X93700.1 X93702.1 X93706.1 X93707.1 X93708.1 X93710.1 X93712.1 X93713.1 
    X93715.1 X93716.1 X93718.1 X93720.1 X93721.1 X93722.1 X93723.1 X93724.1 
    X93725.1 X93726.1 X93727.1 X93728.1 X93729.1 X93730.1 X93731.1 X93732.1 
    X93733.1 X93734.1 X93735.1 X93736.1 X93737.1 X93738.1 X93739.1 X93740.1 
    X93741.1 X93742.1 X93743.1 X93744.1 X93745.1 X93746.1 X93747.1 X93748.1 
    X93749.1 X93750.1 X93751.1 X93752.1 X93753.1 X93754.1 X93755.1 X93756.1 
    X93757.1 X93758.1 X93759.1 X93760.1 X93761.1 X93762.1 X93763.1 X93764.1 
    X93765.1 X93766.1 X93767.1 X93768.1 X93769.1 X93770.1 X93771.1 X93772.1 
    X93773.1 X93774.1 X93775.1 X93776.1 X93777.1 X93778.1 X93779.1 X93780.1 
    X93781.1 X93782.1 X93783.1 X93784.1 X93785.1 X93786.1 X93787.1 X93788.1 
    X93789.1 X93790.1 X93792.1 X93793.1 X93794.1 X93796.1 X93797.1 X93798.1 
    X93799.1 X93800.1 X93801.1 X93802.1 X93803.1 X93804.1 X93805.1 X93806.1 
    X93807.1 X93809.1 X93810.1 X94431.1 X96754.1 X97481.1 X97482.1 X97551.1 
    X97555.1 X98216.1 X98218.1 X98894.1 X98965.1 X98966.1 X98967.1 X98968.1 
    X98969.1 X98970.1 X98971.1 X98972.1 X98973.1 X98974.1 X98975.1 X98977.1 
    X98979.1 X98980.1 X98981.1 X98982.1 X98983.1 X98984.1 X98985.1 X98986.1 
    X98987.1 X98988.1 X98989.1 X98990.1 Y08148.1 Y08191.1 Y08193.1 Y08195.1 
    Y08196.1 Y08197.1 Y08199.1 Y08248.1 Y08249.1 Y08251.1 Y08594.1 Y11899.1 
    Y12697.1 Y12698.1 Y14736.1 Y14864.1 Y14868.1 Y14869.1 Y14871.1 Y17771.1 
    Y17773.1 Y17786.1 Y17787.1 Y17788.1 Y17935.1 Y17936.1 Y17937.1 Y17938.1 
    Y17939.1 Y17951.1 Y17953.1 Y17954.1 Y17955.1 Z11890.1 Z11891.1 Z11892.1 
    Z11893.1 Z11894.1 Z11895.1 Z11903.1 Z14247.1 Z15073.1 Z15074.1 Z15075.1 
    Z15077.1 Z15078.1 Z15080.1 Z15081.1 Z18326.1 Z18327.1 Z18330.1 Z18838.1 
    Z18840.1 Z18842.1 Z18845.1 Z26596.1 Z26597.1 Z26598.1 Z26599.1 Z26600.1 
    Z26601.1 Z26602.1 Z26603.1 Z26604.1 Z26606.1 Z26607.1 Z26608.1 Z26609.1 
    Z26610.1 Z26611.1 Z26612.1 Z26613.1 Z26614.1 Z26615.1 Z26616.1 Z26617.1 
    Z26618.1 Z26619.1 Z26620.1 Z26621.1 Z26622.1 Z26623.1 Z26624.1 Z27170.1 
    Z27171.1 Z27172.1 Z27173.1 Z27175.1 Z27176.1 Z27177.1 Z27178.1 Z30564.1 
    Z30565.1 Z30566.1 Z30567.1 Z30568.1 Z34890.1 Z34911.1 Z34964.1 Z34965.1 
    Z34966.1 Z35083.1 Z35084.1 Z46309.1 Z46310.1 Z46311.1 Z46345.1 Z46620.1 
    Z46624.1 Z46628.1 Z46634.1 Z46854.1 Z46860.1 Z49137.1 Z49142.1 Z68925.1 
    Z68927.1 Z68929.1 Z68930.1 Z68931.1 Z68932.1 Z68933.1 Z68936.1 Z68938.1 
    Z68939.1 Z68940.1 Z68941.1 Z68944.1 Z68947.1 Z68948.1 Z68949.1 Z68950.1 
    Z68952.1 Z68953.1 Z68955.1 Z68956.1 Z68957.1 Z68958.1 Z68960.1 Z68961.1 
    Z68962.1 Z68963.1 Z68964.1 Z68965.1 Z68967.1 Z68968.1 Z68971.1 Z68973.1 
    Z68976.1 Z68977.1 Z68979.1 Z68980.1 Z68981.1 Z68983.1 Z68985.1 Z68987.1 
    Z68988.1 Z68989.1 Z68990.1 Z68991.1 Z68995.1 Z68996.1 Z68997.1 Z68998.1 
    Z69001.1 Z69002.1 Z69007.1 Z69008.1 Z69009.1 Z69012.1 Z69015.1 Z69018.1 
    Z69019.1 Z69020.1 Z69021.1 Z69022.1 Z69023.1 Z69024.1 Z69027.1 Z70253.1 
    Z70259.1 Z70260.1 Z74667.1 Z74692.1 Z82141.1 Z82143.1 Z82144.1 Z82145.1 
    Z82146.1 Z82147.1 Z82148.1 Z82149.1 Z82150.1 Z82151.1 Z82152.1 Z82153.1 
    Z82154.1 Z82155.1 Z82156.1 Z82157.1 Z82158.1 Z82159.1 Z82160.1 Z82161.1 
    Z82162.1 Z82163.1 Z82164.1 Z82165.1 Z82166.1 Z82167.1 Z84392.1 Z84393.1 
    Z84394.1 

    Selected DOTS entries (see all 302):

    DT.95204200  DT.95339737  DT.98083038  DT.95261924  DT.100061049  DT.92019906  DT.92004244  DT.95243711 
    DT.95195310  DT.91733902  DT.120984208  DT.305209  DT.91705797  DT.95322415  DT.92419960  DT.97759703 
    DT.87007699  DT.99944076  DT.95212079  DT.100850810  DT.92475934  DT.95244004  DT.91970838  DT.95243766 

    Selected AceView cDNA sequences (see all 2867):

    AI610862 BE842625 AA327295 AI431270 H61190 AI285798 AI439499 BE842558 
    AI434136 AI627906 AI678434 AA419307 AI718132 AW337530 AW167631 AI833300 
    AI146646 AI073922 AW514398 AW337791 AI510769 AI569991 AI697172 H26314 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    IGKC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAACCCCAG
    IGKC Expression
    About this image


    IGKC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Mature B-Cells Peripheral Blood
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
    IGKC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGKC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.449609
        Custom PCR Arrays for IGKC
    Primer
    Products:
    Browse OriGene qPCR
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IGKC
    QuantiTect SYBR Green Assays in human, mouse, rat IGKC
    QuantiFast Probe-based Assays in human, mouse, rat IGKC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGKC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for IGKC gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igkc5 immunoglobulin kappa constant   --   6 (32.04 cM) 70726435 
    lizard
    (Anolis carolinensis)
    Reptilia IGKC6
    immunoglobulin kappa constant
    10(a)
    1 ↔ 1
    GL343252.1(78072-83161)
    zebrafish
    (Danio rerio)
    Actinopterygii IGKC6
    immunoglobulin kappa constant
    24(a)
    1 ↔ 1
    3(59548098-59551371) ENSDARG00000091281


    ENSEMBL Gene Tree for IGKC (if available)
    TreeFam Gene Tree for IGKC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for IGKC gene
    IGLL52  IGLC12  IGLC32  IGLL12  IGLC72  IGLC22  
    Selected SIMAP similar genes for IGKC using alignment to 1 protein entry:     IGKC_HUMAN(see all similar genes):
    IGK@    IGLC6    DKFZp667J0810    IGLC2    IgLC-rG    IGL@
    IGHG2    IGLC3    IGLC7    IGLL1    C1 segment    DKFZp686C15213
    DKFZp686I04196    DKFZp686I15212    DKFZp781M0386    FLJ00385    IGHG3    IGLC1

    Find genes that share paralogs with IGKC           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    2 SNPs for IGKC    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0664034
    Immunoglobulin kappa light chain deficiency (IGKCD)4--see VAR_0664032 W R mis40--------
    VAR_0038974
    ----see VAR_0038972 V L mis40--------

    HapMap Linkage Disequilibrium report for IGKC (89156674 - 89157196 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IGKC: --
    Locus Specific Mutation Databases (LSDB): IGKC

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IGKC
    DNA2.0 Custom Variant and Variant Library Synthesis for IGKC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 147200   
    OMIM disorders: 614102  
    UniProtKB/Swiss-Prot: IGKC_HUMAN, P01834
  • Immunoglobulin kappa light chain deficiency (IGKCD) [MIM:614102]: A disease characterized by the complete
    absence of immunoglobulin kappa chains. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 3 diseases for IGKC:    
    About MalaCards
    recurrent infections associated with rare immunoglobulin isotypes deficiency    light chain deposition disease    extramedullary plasmacytoma


    Find genes that share disorders with IGKC           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IGKC gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amyloidosis 55.7 2 18084704 (1), 10392240 (1)
    amyloid deposition 50 1 11172308 (1)
    lymphoma b-cell 48.2 1 15085149 (1)
    plasmacytoma 46.1 1 11172308 (1)
    lymphoma 45.7 4 10613459 (1), 8245027 (1), 15122457 (1), 10364369 (1)
    malt lymphoma 43.7 1 15122457 (1)
    somatic mutations 42.3 2 7635977 (2)
    myeloma 40.1 1 2147229 (1)
    rheumatoid arthritis 16.2 6 9632065 (2), 7635977 (1), 1642656 (1), 9186688 (1) (see all 5)
    nasopharyngeal carcinoma 15.1 1 11913778 (1)

    Genetic Association Database (GAD): IGKC
    Human Genome Epidemiology (HuGE) Navigator: IGKC (4 documents)

    Export disorders for IGKC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for IGKC gene, integrated from 10 sources (see all 155):
    (articles sorted by number of sources associating them with IGKC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Single nucleotide polymorphism of interleukin-1beta associated with Helicobacter pylori infection in immune thrombocytopenic purpura. (PubMed id 19317746)1, 4 Satoh T....Kuwana M. (Tissue Antigens 2009)
    2. Immunoglobulin gene polymorphisms are susceptibility factors in clinical and autoantibody subgroups of the idiopathic inflammatory myopathies. (PubMed id 18821675)1, 4 O'Hanlon T.P....Miller F.W. (Arthritis Rheum. 2008)
    3. Immunoglobulin kappa light chain gene alleles are not associated with primary SjAPgren's syndrome. (PubMed id 12215905)1, 4 Downie-Doyle S....Pile K. (Genes Immun. 2002)
    4. TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis. (PubMed id 12039524)1, 4 Pandey J.P. and Frederick M. (Hum. Immunol. 2002)
    5. Identification of a novel substitution in the constant region of a gene coding for an amyloidogenic kappa1 light chain. (PubMed id 10354514)1, 3 Wally J....Comenzo R.L. (Biochim. Biophys. Acta 1999)
    6. Extended analysis of AL-amyloid protein from abdominal wall subcutaneous fat biopsy: kappa IV immunoglobulin light chain. (PubMed id 9588180)1, 2 Olsen K.E.... Westermark P. (Biochem. Biophys. Res. Commun. 1998)
    7. Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments. (PubMed id 6775818)1, 2 Hieter P.A.... Leder P. (Cell 1980)
    8. Rule of antibody structure. The primary structure of a monoclonal immunoglobulin L-chain of kappa-type, subgroup 3 (Bence-Jones protein Ti). IV. The complete amino acid sequence and its significance for the mechanism of antibody production. (PubMed id 5027703)1, 2 Suter L.... Hilschmann N. (Hoppe-Seyler's Z. Physiol. Chem. 1972)
    9. The covalent structure of a human gamma G-immunoglobulin. VI. Amino acid sequence of the light chain. (PubMed id 5489770)1, 2 Gottlieb P.D.... Edelman G.M. (Biochemistry 1970)
    10. Macroglobulin structure: variable sequence of light and heavy chains. (PubMed id 5447531)1, 2 Kohler H.... Putnam F.W. (Science 1970)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3514 HGNC: 5716 AceView: IGK_ Ensembl:ENSG00000211592 euGenes: HUgn3514
    ECgene: IGKC H-InvDB: IGKC

    (According to HUGE)
    About This Section

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IGKC Pharmacogenomics, SNPs, Pathways
    IMGT entry for IGKC The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
    IMGT/GENE-DBhttp://www.imgt.org/IMGT_GENE-DB/GENElect?query=2+IGKC&species=Homo+sapiens

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGKC gene:
    Search GeneIP for patents involving IGKC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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