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Aliases for IGKC Gene

Aliases for IGKC Gene

  • Immunoglobulin Kappa Constant 2 3 5
  • Immunoglobulin Kappa (Invariant Region) 3
  • Immunoglobulin Kappa Light Chain (VJ) 3
  • Immunoglobulin Kappa Constant Region 3
  • HCAK1 3
  • IGKCD 3
  • Km 3

External Ids for IGKC Gene

Previous GeneCards Identifiers for IGKC Gene

  • GC02M088711
  • GC02U900019
  • GC02M089043
  • GC02M089058
  • GC02M089060
  • GC02M088995
  • GC02M089010
  • GC02M088937
  • GC02M089156
  • GC02M088860
  • GC02M088871

Summaries for IGKC Gene

GeneCards Summary for IGKC Gene

IGKC (Immunoglobulin Kappa Constant) is a Protein Coding gene. Diseases associated with IGKC include kappa light chain deficiency and recurrent infections associated with rare immunoglobulin isotypes deficiency. Among its related pathways are Immune System and FCERI mediated Ca+2 mobilization. GO annotations related to this gene include antigen binding. An important paralog of this gene is IGKV2D-24.

Gene Wiki entry for IGKC Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKC Gene

Genomics for IGKC Gene

Genomic Location for IGKC Gene

88,857,161 bp from pter
89,046,465 bp from pter
189,305 bases
Minus strand

Genomic View for IGKC Gene

Genes around IGKC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGKC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGKC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKC Gene

No data available for Regulatory Elements for IGKC Gene

Proteins for IGKC Gene

  • Protein details for IGKC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ig kappa chain C region
    Protein Accession:

    Protein attributes for IGKC Gene

    106 amino acids
    Molecular mass:
    11609 Da
    Quaternary structure:
    No Data Available
    • The EU sequence has the INV (3) allotypic marker, Ala-45 and Val-83. The ROY sequence has the INV (1,2) allotypic marker, Ala-45 and Leu-83.

    Three dimensional structures from OCA and Proteopedia for IGKC Gene

neXtProt entry for IGKC Gene

Proteomics data for IGKC Gene at MOPED

Post-translational modifications for IGKC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGKC Gene

No data available for DME Specific Peptides for IGKC Gene

Domains & Families for IGKC Gene

Gene Families for IGKC Gene

Protein Domains for IGKC Gene

Suggested Antigen Peptide Sequences for IGKC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGKC: view

Function for IGKC Gene

Molecular function for IGKC Gene

GENATLAS Biochemistry:
immunoglobulin,kappa,constant chain (Km marker)

Human Phenotype Ontology for IGKC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKC Gene

Localization for IGKC Gene

Gene Ontology (GO) - Cellular Components for IGKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IBA --
genes like me logo Genes that share ontologies with IGKC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for IGKC Gene

Pathways & Interactions for IGKC Gene

genes like me logo Genes that share pathways with IGKC: view

Interacting Proteins for IGKC Gene

Gene Ontology (GO) - Biological Process for IGKC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS --
GO:0006955 immune response NAS 5489770
GO:0006956 complement activation TAS --
GO:0045087 innate immune response IBA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with IGKC: view

No data available for SIGNOR curated interactions for IGKC Gene

Drugs & Compounds for IGKC Gene

(16) Drugs for IGKC Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL Experimental Pharma Target 0
(2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE Experimental Pharma Target 0
(4Z)-2,8:7,12:11,15:14,18:17,22-PENTAANHYDRO-4,5,6,9,10,13,19,20,21-NONADEOXY-D-ARABINO-D-ALLO-D-ALLO-DOCOSA-4,9,20-TRIENITOL Experimental Pharma Target 0
genes like me logo Genes that share compounds with IGKC: view

Transcripts for IGKC Gene

Unigene Clusters for IGKC Gene

Immunoglobulin kappa constant:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGKC Gene

No ASD Table

Relevant External Links for IGKC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGKC Gene

mRNA expression in normal human tissues for IGKC Gene

Protein differential expression in normal tissues from HIPED for IGKC Gene

This gene is overexpressed in Pancreatic juice (8.7) and Urine (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGKC Gene

SOURCE GeneReport for Unigene cluster for IGKC Gene Hs.449609

genes like me logo Genes that share expression patterns with IGKC: view

Protein tissue co-expression partners for IGKC Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IGKC Gene

Orthologs for IGKC Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGKC Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Igkc 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia IGKC 36
  • 55 (a)
(Anolis carolinensis)
Reptilia IGKC 36
  • 10 (a)
(Danio rerio)
Actinopterygii IGKC 36
  • 24 (a)
Species with no ortholog for IGKC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGKC Gene

Gene Tree for IGKC (if available)
Gene Tree for IGKC (if available)

Paralogs for IGKC Gene

genes like me logo Genes that share paralogs with IGKC: view

Variants for IGKC Gene

Sequence variations from dbSNP and Humsavar for IGKC Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_066403 Immunoglobulin kappa light chain deficiency (IGKCD)
VAR_003897 -

Relevant External Links for IGKC Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKC Gene

Disorders for IGKC Gene

MalaCards: The human disease database

(5) MalaCards diseases for IGKC Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
kappa light chain deficiency
  • kappa-chain deficiency
recurrent infections associated with rare immunoglobulin isotypes deficiency
  • igg subclass deficiency with iga subclass deficiency
light chain deposition disease
  • light-chain deposition disease
b cell prolymphocytic leukemia
  • leukemia, b cell prolymphocytic
lymphoma, malt, somatic
  • malt lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search IGKC in MalaCards View complete list of genes associated with diseases


  • Immunoglobulin kappa light chain deficiency (IGKCD) [MIM:614102]: A disease characterized by the complete absence of immunoglobulin kappa chains. {ECO:0000269 PubMed:3931219}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IGKC

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IGKC: view

No data available for Genatlas for IGKC Gene

Publications for IGKC Gene

  1. Single nucleotide polymorphism of interleukin-1beta associated with Helicobacter pylori infection in immune thrombocytopenic purpura. (PMID: 19317746) Satoh T. … Kuwana M. (Tissue Antigens 2009) 3 48 67
  2. Identification of a novel substitution in the constant region of a gene coding for an amyloidogenic kappa1 light chain. (PMID: 10354514) Wally J. … Comenzo R.L. (Biochim. Biophys. Acta 1999) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. Genetic variants of immunoglobulin I^ and I_ chains influence humoral immunity to the cancer-testis antigen XAGE-1b (GAGED2a) in patients with non-small cell lung cancer. (PMID: 24304136) Pandey J.P. … Nakayama E. (Clin. Exp. Immunol. 2014) 3

Products for IGKC Gene

Sources for IGKC Gene