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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGK@ Cluster

gene cluster   GIFtS: 35
GCID: GC02P089891

immunoglobulin kappa locus
 Explore 8 diseases affiliated with
IGK@ via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGK@    

Aliases
for IGK@ gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Immunoglobulin Kappa Locus1 2
IGK1 2

External Ids:    HGNC: 57151   Entrez Gene: 508022   UniProtKB: Q6P5S84   UniProtKB: Q6PIL84   UniProtKB: Q6PJF24   

Export aliases for IGK@ gene to outside databases

Previous GC identifers: GC02U990232 GC02M089561 GC02M089890


Summaries
for IGK@ gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Gene Wiki entry for IGK@


Genomic Views
for IGK@ gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  NT_032994.6  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGK@
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGK@

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGK@


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   HGNC cytogenetic band: 2p11.2

IGK@ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGK@ gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P089891:  view genomic region     (about GC identifiers)

Start:
 89,890,568 bp from pter      End:
 90,274,235 bp from pter
Size:
 383,668 bases      Orientation:
 plus strand
IGK@ has overlapping exons with:
 IGKV2D-19 IGKV2D-36

Proteins
for IGK@ gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/TrEMBL: Q6P5S8 (See protein sequence)
Recommended Name: IGK@ protein  
Size: 236 amino acids; 25773 Da
4 PDB 3D structures from and Proteopedia for IGK@:
2NXY (3D)        2NY1 (3D)        2NY3 (3D)        2NY6 (3D)    

UniProtKB/TrEMBL: Q6PIL8 (See protein sequence)

Recommended Name: IGK@ protein  
Size: 236 amino acids; 25834 Da
1 PDB 3D structure from and Proteopedia for IGK@:
3DVN (3D)    

UniProtKB/TrEMBL: Q6PJF2 (See protein sequence)

Recommended Name: IGK@ protein  
Size: 235 amino acids; 25521 Da
1 PDB 3D structure from and Proteopedia for IGK@:
2AGJ (3D)    

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6PJF2

    • IGK@ Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).


    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for IGK@ 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn


    IGK@ Antibody Products: 
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    OriGene Custom Antibody Services for IGK@ 
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    Novus Biologicals IGK@ Antibody
    Search for Antibodies for IGK@ at Abcam  
    Browse Antibodies at Uscn
    Search ThermoFisher Antibodies for IGK@

    Assay Products for IGK@: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IGK@
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for IGK@ gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IGK@ for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR007110 Ig-like_dom
     IPR003596 Ig_V-set_subgr
     IPR013783 Ig-like_fold
     IPR003006 Ig/MHC_CS
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q6P5S8
    Graphical View of Domain Structure for InterPro Entry Q6PIL8
    Graphical View of Domain Structure for InterPro Entry Q6PJF2

    ProtoNet protein and cluster: Q6P5S8

    2 Blocks protein families:
    IPB003596 Immunoglobulin V-type
    IPB003599 Immunoglobulin subtype



    Function
    for IGK@ gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGK@
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IGK@
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene 29mer shRNA kits
    Browse OriGene siRNA
    Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGK@

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IGK@

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for IGK@
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGK@
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGK@ 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IGK@
    Search LifeMap BioReagents cell lines for IGK@

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGK@


    Pathways & Interactions
    for IGK@ gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune response_NFAT in immune response
    		Immune response_NFAT in immune response1.00
    		Immune response NFAT in immune response0.91
    2Signal transduction_IP3 signaling
    		Signal transduction_IP3 signaling1.00
    		Signal transduction IP3 signaling0.92
    3Immune response_Classical complement pathway
    		Immune response_Classical complement pathway1.00
    		Immune response Classic complement pathway0.98
    4Immune response_IL-4 signaling pathway
    		Immune response_IL-4 signaling pathway1.00
    		Immune response IL-4 signaling pathway0.98
    5Immune response CD16 signaling in NK cells
    		Immune response CD16 signaling in NK cells1.00
    		Immune response_CD16 signaling in NK cells0.99

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/7 EMD Millipore Pathways for IGK@ (see all 7)
        Immune response Classic complement pathway
    Immune response BCR pathway
    Immune response CD16 signaling in NK cells
    Signal transduction IP3 signaling
    Immune response IL-4 signaling pathway


    5/7 GeneGo (Thomson Reuters) Pathways for IGK@ (see all 7)
        Immune response IL-4 signaling pathway
    Immune response Fc epsilon RI pathway
    Immune response CD16 signaling in NK cells
    Immune response Classical complement pathway
    Immune response BCR pathway



    IGK@ for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGK@

    Drugs & Compounds
    for IGK@ gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGK@
    Search CenterWatch for drugs/clinical trials and news about IGK@ 

    Transcripts
    for IGK@ gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    Unigene Cluster for IGK@:

    Immunoglobulin kappa locus
    Hs.719895  [show with all ESTs]
    Unigene Representative Sequence: BQ706730

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGK@
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IGK@
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene 29mer shRNA kits
    Browse OriGene siRNA
    Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGK@
    Clone
    Products:             		Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for IGK@
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGK@
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGK@ 
    Primer
    Products:            		Browse OriGene genome-wide validated SYBR primer pairs
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat IGK@
      Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGK@
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGK@

    Additional cDNA sequence: 

    AB021519.1 AB021521.1 AB021523.1 AB021526.1 AB021530.1 AB021534.1 AB021536.1 AB021541.1 
    AB049915.1 AB063654.1 AB063664.1 AB063672.1 AB063675.1 AB063807.1 AB063824.1 AB063887.1 
    AB063890.1 AB063895.1 AB063896.1 AB066894.1 AB066973.1 AB066977.1 AB067077.1 AB067081.1 
    AB067095.1 AB067102.1 AB067124.1 AB067177.1 AB067240.1 AB067250.1 AB067252.1 AB067259.1 
    AB067260.1 AB067269.1 AB363117.1 AB363120.1 AB363129.1 AB374188.1 AB374189.1 AB374191.1 
    AF001424.1 AF004322.1 AF004323.1 AF004324.1 AF015123.1 AF015125.1 AF015126.1 AF015128.1 
    AF015130.1 AF015132.1 AF015133.1 AF015134.1 AF021986.1 AF022011.1 AF052520.1 AF052522.1 
    AF052524.1 AF062136.1 AF062167.1 AF062184.1 AF062191.1 AF062205.1 AF062251.1 AF062260.1 
    AF062270.1 AF062275.1 AF062276.1 AF062280.1 AF062289.1 AF062297.1 AF062298.1 AF062301.1 
    AF062304.1 AF062307.1 AF103115.1 AF103148.1 AF103150.1 AF103210.1 AF103273.1 AF103286.2 
    AF103290.1 AF103321.1 AF103328.1 AF103352.1 AF103353.1 AF103369.1 AF103371.1 AF115107.1 
    AF115108.1 AF115109.1 AF115110.1 AF123351.1 AF123354.1 AF123355.1 AF123356.1 AF123357.1 
    AF123358.1 AF123359.1 AF123360.1 AF123361.1 AF123363.1 AF123364.1 AF123365.1 AF123366.1 
    AF123367.1 AF123368.1 AF123369.1 AF123370.1 AF123371.1 AF123372.1 AF123373.1 AF123374.1 
    AF123375.1 AF123376.1 AF123377.1 AF123378.1 AF123379.1 AF174012.1 AF174017.1 AF174019.1 
    AF174024.1 AF174029.1 AF174038.1 AF174057.1 AF174067.1 AF174077.1 AF174083.1 AF174089.1 
    AF174098.1 AF174101.1 AF174103.1 AF174105.1 AF174111.1 AF231394.1 AF231395.1 AF231396.1 
    AF231397.1 AF231398.1 AF231399.1 AF231400.1 AF231402.1 AF231403.1 AF283793.1 AF283795.1 
    AF283796.1 AF283798.1 AF283799.1 AF283805.1 AF302822.1 AF394201.1 AF396468.1 AF396474.1 
    AF396476.1 AF417848.1 AF431049.1 AF455924.1 AF460666.1 AF460671.1 AF460672.1 AF460678.1 
    AF460687.1 AF460691.1 AF460699.1 AF460700.1 AF460800.1 AF460806.1 AF485437.1 AF485447.1 
    AJ006111.1 AJ006114.1 AJ006115.1 AJ006116.1 AJ006117.1 AJ006118.1 AJ006119.1 AJ006120.1 
    AJ008168.1 AJ008183.1 AJ008196.1 AJ008214.1 AJ008241.1 AJ008250.1 AJ010334.1 AJ132561.1 
    AJ132562.1 AJ132563.1 AJ233694.1 AJ239354.1 AJ239356.1 AJ239367.1 AJ241351.1 AJ243110.1 
    AJ245229.1 AJ249630.1 AJ271551.1 AJ271557.1 AJ272334.1 AJ276097.1 AJ298606.1 AJ298607.1 
    AJ298608.1 AJ298609.1 AJ298610.1 AJ298611.1 AJ300780.1 AJ300784.1 AJ300789.1 AJ300791.1 
    AJ300794.1 AJ308450.1 AJ313386.1 AJ389188.1 AJ508767.1 AJ519219.1 AJ519221.1 AJ519237.1 
    AJ519238.1 AJ519239.1 AJ519244.1 AJ519248.1 AJ519250.1 AJ519252.1 AJ519256.1 AJ519257.1 
    AJ519258.1 AJ519259.1 AJ519262.1 AJ519264.1 AJ519265.1 AJ519266.1 AJ519267.1 AJ519268.1 
    AJ519269.1 AJ519271.1 AJ519272.1 AJ519273.1 AJ519277.1 AJ519281.1 AJ519283.1 AJ519285.1 
    AJ519286.1 AJ519288.1 AJ519290.1 AJ519291.1 AJ519294.1 AJ519296.1 AJ519297.1 AJ519300.1 
    AJ519301.1 AJ519303.1 AJ519304.1 AJ519307.1 AJ519308.1 AJ519312.1 AJ519314.1 AJ519316.1 
    AJ519317.1 AJ519318.1 AJ519319.1 AJ519320.1 AJ519321.1 AJ519322.1 AJ519324.1 AJ519325.1 
    AJ519326.1 AJ519327.1 AJ519328.1 AJ519330.1 AJ519331.1 AJ519332.1 AJ519333.1 AJ519334.1 
    AJ519336.1 AJ519337.1 AJ519338.1 AJ519339.1 AJ555256.1 AJ555266.1 AJ579095.1 AJ579100.1 
    AJ579106.1 AJ579108.1 AJ579113.1 AJ579142.1 AJ579157.1 AJ579181.1 AJ579184.1 AJ579195.1 
    AJ579196.1 AJ579221.1 AJ579225.1 AJ579226.1 AJ579228.1 AJ579236.1 AJ579238.1 AJ579261.1 
    AJ579264.1 AJ579267.1 AJ579270.1 AJ579271.1 AJ579272.1 AJ579274.1 AJ579277.1 AJ579278.1 
    AJ579280.1 AJ579283.1 AJ617570.1 AJ627233.1 AJ627234.1 AJ627240.1 AJ627250.1 AM183988.1 
    AM183989.1 AM183991.1 AM259136.1 AM259140.1 AM279492.1 AM279605.1 AM279629.1 AY003715.1 
    AY003717.1 AY003725.1 AY003737.1 AY003738.1 AY003761.1 AY003766.1 AY003774.1 AY003778.1 
    AY003806.1 AY003815.1 AY003820.1 AY003827.1 AY003843.1 AY003847.1 AY003852.1 AY003856.1 
    AY003857.1 AY055484.1 AY099259.1 AY263417.1 AY263418.1 AY423163.1 AY423180.1 AY423185.1 
    AY506559.1 AY554179.1 AY554180.1 AY577295.1 AY686868.1 AY686918.1 AY781824.1 AY781826.1 
    AY781827.1 AY781828.1 AY781873.1 AY789123.1 AY789125.1 AY789442.1 AY866624.1 AY866718.1 
    AY866738.1 AY866766.1 AY866788.1 AY880990.1 AY885173.1 AY941888.1 AY941899.1 AY941927.1 
    AY941930.1 AY996337.1 D83687.1 D83693.1 DQ005273.1 DQ005292.1 DQ005303.1 DQ065632.1 
    DQ065672.1 DQ065678.1 DQ065685.1 DQ065693.1 DQ065707.1 DQ065721.1 DQ100710.1 DQ100713.1 
    DQ100717.1 DQ100794.1 DQ100810.1 DQ100817.1 DQ100838.1 DQ100842.1 DQ100843.1 DQ100851.1 
    DQ100859.1 DQ100860.1 DQ100890.1 DQ100915.1 DQ100922.1 DQ184510.1 DQ184512.1 DQ187555.1 
    DQ187556.1 DQ212496.1 DQ212498.1 DQ212499.1 DQ212500.1 DQ322923.1 DQ454401.1 DQ454481.1 
    DQ454508.1 DQ454518.1 DQ454562.1 DQ454618.1 DQ454687.1 DQ454750.1 DQ454767.1 DQ454786.1 
    DQ454789.1 DQ454876.1 DQ523884.1 DQ523922.1 DQ523923.1 DQ523924.1 DQ524028.1 DQ524115.1 
    DQ524170.1 DQ535280.1 DQ535283.1 DQ535297.1 DQ535299.1 DQ535312.1 DQ535317.1 DQ535318.1 
    DQ535341.1 DQ535376.1 DQ535380.1 DQ535400.1 DQ535446.1 DQ535463.1 DQ535471.1 DQ535481.1 
    EF175394.1 EF441760.1 EF624135.1 EF624145.1 EU099110.1 EU099172.1 EU099182.1 EU099195.1 
    EU099225.1 EU099228.1 EU099256.1 EU099264.1 EU146323.1 EU146326.1 EU146327.1 EU146329.1 
    EU146332.1 EU146335.1 EU146342.1 EU146374.1 EU146387.1 EU433871.1 EU433883.1 EU619960.1 
    EU814957.1 FJ385277.1 FJ385282.1 FJ385291.1 FJ385309.1 FJ385311.1 FJ385317.1 FJ385357.1 
    FJ385358.1 FJ385361.1 FJ385380.1 FJ385384.1 FJ385389.1 FJ481090.1 FJ492944.1 FJ840090.1 
    FJ840195.1 FJ840312.1 FJ840319.1 FJ840320.1 FJ840327.1 FJ873815.1 FJ873824.1 FJ873849.1 
    FJ873867.1 FJ873872.1 FJ873885.1 FJ873902.1 FJ873910.1 FJ873913.1 FJ873916.1 FJ873922.1 
    FJ873935.1 FJ873946.1 FJ873959.1 FJ873974.1 FJ873975.1 FJ873994.1 FJ874010.1 FJ874023.1 
    FJ874034.1 FJ874059.1 FJ874064.1 FJ874074.1 FN562944.1 FN562945.1 FN562946.1 FN562947.1 
    FN562948.1 FN562949.1 FN562950.1 FN562951.1 FN562952.1 FN562953.1 FN562954.1 FN562955.1 
    FN562956.1 FN562957.1 FN562958.1 FN562959.1 FN562960.1 FN562961.1 FN562962.1 FN562963.1 
    FN562964.1 FN562965.1 FN562966.1 FN562967.1 FN562968.1 FN563753.1 FN563754.1 FN563755.1 
    FN563756.1 FN563757.1 FN563758.1 FN563759.1 FN563761.1 FN563763.1 FN563764.1 FN563770.1 
    FN563773.1 FN563774.1 FN563775.1 FN563776.1 FN563777.1 FN563778.1 FN563782.1 FN563783.1 
    FN563787.1 FN563788.1 FN563790.1 FN563791.1 FN563792.1 FN563793.1 FN563794.1 FN563795.1 
    FN563796.1 FN563797.1 FN563799.1 FN563801.1 FN563808.1 FN563809.1 FN563815.1 FN563819.1 
    FN563820.1 FN563821.1 FN563822.1 FN563823.1 GQ504854.1 GQ504868.1 GQ504870.1 GQ504875.1 
    GQ504879.1 GQ504881.1 GQ504884.1 GQ504890.1 GQ504894.1 GQ504903.1 GQ504923.1 GQ504937.1 
    GQ504972.1 GQ504985.1 GU552694.1 GU552704.1 GU552707.1 GU552708.1 GU552710.1 GU552712.1 
    GU552718.1 GU552734.1 GU552741.1 GU552742.1 GU552746.1 GU552748.1 GU552752.1 GU552758.1 
    GU552759.1 GU570309.1 GU570311.1 GU570312.1 GU570316.1 GU570317.1 GU570318.1 GU570322.1 
    HM116131.1 HM152523.1 HM774098.1 HM774364.1 HM774385.1 HM774431.1 HM774459.1 HM774649.1 
    HM774689.1 HM774750.1 HM774775.1 HM774784.1 HM774890.1 HM774997.1 HM995048.1 HM995138.1 
    HM995165.1 HM995202.1 HM995230.1 HM995232.1 HM995233.1 HM995238.1 HM995242.1 HM995243.1 
    HM995256.1 HM995257.1 HM995259.1 HM995260.1 HM995261.1 HM995262.1 HM995263.1 HM995264.1 
    HM995266.1 HM995390.1 HM995391.1 HM995393.1 HM995422.1 HM995434.1 HM995435.1 HM995436.1 
    HM995437.1 HM995438.1 HM995439.1 HM995440.1 HM995451.1 HM995466.1 HM995568.1 HM995590.1 
    HM995620.1 HM995791.1 HM995796.1 HM995797.1 HM995800.1 HM995802.1 HM995807.1 HM995808.1 
    HM995809.1 HM995810.1 HM995811.1 HM995812.1 HM995813.1 HM995822.1 HM995894.1 HM995896.1 
    HM995931.1 HM995956.1 HM995959.1 HM996082.1 HM996159.1 HM996219.1 HM996232.1 HM996312.1 
    HM996533.1 HQ129860.1 HQ129862.1 HQ378370.1 HQ703997.1 HQ703998.1 HQ703999.1 HQ704017.1 
    HQ704042.1 JF966695.1 JN110538.1 JN110631.1 JN110650.1 JN110677.1 JN110699.1 JN376671.1 
    JN376672.1 JN376697.1 JQ301909.1 JX027421.1 JX027464.1 JX027472.1 JX027475.1 JX173306.1 
    JX173317.1 JX173319.1 JX173331.1 JX462752.1 L01276.1 L02256.1 L02262.1 L02264.1 
    L02266.1 L02268.1 L02269.1 L03816.1 L03817.1 L03818.1 L03819.1 L03830.1 
    L04342.1 L08083.1 L08088.1 L08090.1 L11699.1 L12188.1 L14821.1 L14822.1 
    L19914.1 L19915.1 L19916.1 L19917.1 L19919.1 L19920.1 L23931.1 L25292.1 
    L26907.1 L28052.1 L33031.1 L33035.1 L33039.1 L34164.1 L38433.1 L43083.1 
    L43085.1 L48237.1 M17746.1 M17747.1 M17748.1 M17749.1 M18513.1 M26994.1 
    M26995.1 M29470.1 M34024.1 M57940.1 M57941.1 M57942.1 M57943.1 M57944.1 
    M62731.1 M87268.1 M97920.1 M99595.1 S55094.1 S67717.1 S73957.1 U00491.1 
    U00495.1 U00509.1 U00510.1 U00521.1 U00525.1 U00536.1 U00537.1 U00541.1 
    U00549.1 U09064.1 U19885.1 U21259.1 U21262.1 U21272.1 U38588.1 U41571.1 
    U42468.1 U58144.1 U64467.1 U64476.1 U64486.1 U76685.1 U77373.1 U82257.1 
    U86798.1 U93176.1 U95237.1 U96043.1 U96286.1 U97242.1 X14584.1 X56526.1 
    X61018.1 X62955.1 X62956.1 X62957.1 X62962.1 X62963.1 X62964.1 X62971.1 
    X65895.1 X65900.1 X67909.1 X81726.1 X81731.1 X81742.1 X81746.1 X81748.1 
    X81755.1 X95661.1 X98751.1 X99363.1 X99365.1 Y09384.1 Y09386.1 Y09388.1 
    Y18120.1 Z11945.1 Z11946.1 Z14200.1 Z14201.1 Z14202.1 Z14205.1 Z18830.1 
    Z33900.1 Z33903.1 Z46382.1 Z47214.1 Z47217.1 Z47218.1 Z47226.1 Z47232.1 
    Z80849.1 Z96954.1 Z96955.1 Z96956.1 Z96957.1 Z96958.1 Z96967.1 Z98714.1 
    Z98715.1 Z98716.1 Z98720.1 Z98721.1 Z98723.1 

    24/517 DOTS entries (see all 517):

    DT.95368001  DT.95264941  DT.95248569  DT.121648692  DT.121649675  DT.95205462  DT.95261651  DT.97866935 
    DT.100646536  DT.121649642  DT.100684353  DT.100775361  DT.100848453  DT.100860026  DT.102844100  DT.121507730 
    DT.97865772  DT.121509019  DT.121509587  DT.121650050  DT.121650336  DT.100046823  DT.100651539  DT.100849605 

    GeneLoc Exon Structure


    Expression
    for IGK@ gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    Expression evidence for IGK@:none

    IGK@ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See IGK@ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGK@

    SOURCE GeneReport for Unigene cluster: Hs.719895
        SABiosciences Custom PCR Arrays for IGK@
    Primer
    Products:    		Browse OriGene genome-wide validated SYBR primer pairs
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat IGK@
    Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGK@
    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGK@
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGK@

    Orthologs
    for IGK@ gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    		   --

    Paralogs
    for IGK@ gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for IGK@ gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGK@
    DNA2.0 Custom Variant and Variant Library Synthesis for IGK@

    Disorders / Diseases
    for IGK@ gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IGK@ for disorders           About GeneDecksing

    8 diseases for IGK@:    About MalaCards
    b-cell lymphomas    chronic lymphocytic leukemia    lymphocytic leukemia    sjogren's syndrome
    glomerulonephritis    leukemia    gastric cancer    breast cancer

    2 Novoseek disease relationships for IGK@ gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia lymphocytic chronic 65.1 2 16076869 (1), 16622520 (1)
    minimal residual disease 62.2 1 12970784 (1)

    Genetic Association Database (GAD): IGK@
    Human Genome Epidemiology (HuGE) Navigator: IGK@ (2 documents)

    Export disorders for IGK@ gene to outside databases

    Publications
    for IGK@ gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGK@ gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with IGK@)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Immunoglobulin KM and GM gene polymorphisms modify the clinical presentation of primary Sjogren's syndrome. (PubMed id 15517630)1, 4 Pertovaara M....Pandey J.P. (2004)
    2. Analysis of expressed and non-expressed IGK locus rearrangements in chronic lymphocytic leukemia. (PubMed id 16622520)1, 9 Belessi C....Laoutaris N. (2005)
    3. IGKV3 proteins as candidate 'off-the-shelf' vaccines for kappa-light chain-restricted B-cell non-Hodgkin lymphomas. (PubMed id 22705988)1 Martorelli D....Dolcetti R. (2012)
    4. Molecular analysis of the t(2;8)/MYC-IGK translocation in high-grade lymphoma/leukemia by long-distance inverse PCR. (PubMed id 22120970)1 Kroenlein H....Burmeister T. (2012)
    5. EBV-encoded LMP1 upregulates Igk 3'enhancer activity a nd Igk expression in nasopharyngeal cancer cells by activating the Ets-1 through ERKs signaling. (PubMed id 22396784)1 Liu H....Cao Y. (2012)
    6. Combined analysis using extended renal reference range of serum free light chain ratio and serum protein electrophoresis improves the diagnostic accuracy of multiple myeloma in renal insufficiency. (PubMed id 22503879)1 Park J.W....Kim S.W. (2012)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Ig-free light chains play a crucial role in murine ma st cell-dependent colitis and are associated with human inflammatory bowel dise ases. (PubMed id 20505143)1 Rijnierse A....Kraneveld A.D. (2010)
    9. The polymorphisms on Igkappa gene are related to susceptibility of breast cancer and gastric cancer. (PubMed id 19072568)1 Hu D....Ya C. (2008)
    10. Analysis of immunoglobulin variable kappa gene mutations in cutaneous B-cell lymphoma. (PubMed id 17600686)1 Bortoletto G....Alaibac M. (2007)

    External Searches for IGK@ gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IGK@ gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50802 HGNC: 5715 euGenes: HUgn50802 ECgene: IGK@ H-InvDB: IGK@

    Other Databases showing IGK@ gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IGK@ gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGK@ Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IGK@ Genetics and Cytogenetics in Oncology and Haematology
    IMGT entry for IGK@ The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

    Intellectual Property
    for IGK@ gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IGK@ gene:
    Search GeneIP for patents involving IGK@

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for IGK@ gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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