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IGK Gene

protein-coding   GIFtS: 23
GCID: GC02P090039

Immunoglobulin Kappa Locus


(Previous symbol: IGK@)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immunoglobulin Kappa Locus1 2
IGK@1 2
AOS35
IGKJRB15
RBPJ5
RBPSUH5

External Ids:    HGNC: 57151   Entrez Gene: 508022   OMIM: 1471835   

Export aliases for IGK gene to outside databases

Previous GC identifer: GC02P089931


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IGK Gene:
IGK (immunoglobulin kappa locus) is a protein-coding gene. Diseases associated with IGK include cd8 deficiency, familial, and glomerulonephritis.

Gene Wiki entry for IGK (IGK@) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for IGK
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGK promoter sequence
   Search Chromatin IP Primers for IGK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   HGNC cytogenetic band: 2p11.2

IGK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGK gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P090039:  view genomic region     (about GC identifiers)

Start:
89,890,568 bp from pter      End:
90,274,235 bp from pter
Size:
383,668 bases      Orientation:
plus strand
IGK has overlapping exons with:
IGKV2D-24

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB: --
Post-translational modifications: 
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGK: Immunoglobulins / IGK locus

      --

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IGK About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    Immune response BCR pathway0.43
    2Complement Pathway
    Immune response Classic complement pathway0.56
    3Immune response NFAT in immune response
    Immune response NFAT in immune response0.55
    4Development Angiotensin activation of ERK
    Signal transduction IP3 signaling0.43
    5Development IGF 1 receptor signaling
    Immune response IL 4 signaling pathway0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IGK
        Notch Signaling
    Molecular Mechanisms of Cancer
    Presenilin-Mediated Signaling

    Selected GeneGo (Thomson Reuters) Pathways for IGK (see all 7)
        Immune response IL-4 signaling pathway
    Immune response Fc epsilon RI pathway
    Immune response CD16 signaling in NK cells
    Immune response Classical complement pathway
    Immune response BCR pathway


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    Interactions:

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for IGK



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    miRNA
    Products:
         
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    SwitchGear 3'UTR luciferase reporter plasmidIGK 3' UTR sequence
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IGK Expression
    About this image


    IGK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Tonsil (Hematopoietic System)
    IGK Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
        Custom PCR Arrays for IGK
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IGK
    DNA2.0 Custom Variant and Variant Library Synthesis for IGK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147183   
    OMIM disorders: 614814  
    13 diseases for IGK:    
    About MalaCards
    cd8 deficiency, familial    glomerulonephritis    non-hodgkin lymphoma    b-cell lymphomas
    nasopharyngitis    hodgkin's lymphoma    inflammatory bowel disease    chronic lymphocytic leukemia
    multiple sclerosis    multiple myeloma    myeloma    leukemia
    breast cancer


    IGK for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for IGK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia lymphocytic chronic 65.1 2 16076869 (1), 16622520 (1)
    minimal residual disease 62.2 1 12970784 (1)


    Export disorders for IGK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGK gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with IGK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of expressed and non-expressed IGK locus rearrangements in chronic lymphocytic leukemia. (PubMed id 16622520)1, 9 Belessi C....Laoutaris N. (Mol. Med. 2005)
    2. Free light chain monomer-dimer patterns in the diagnosis of multiple sclerosis. (PubMed id 23376556)1 Kaplan B....Livneh A. (J. Immunol. Methods 2013)
    3. IGKV3 proteins as candidate &quot;off-the-shelf&quot; vaccines for kappa-light chain-restricted B-cell non-Hodgkin lymphomas. (PubMed id 22705988)1 Martorelli D....Dolcetti R. (Clin. Cancer Res. 2012)
    4. Molecular analysis of the t(2;8)/MYC-IGK translocation in high-grade lymphoma/leukemia by long-distance inverse PCR. (PubMed id 22120970)1 Kroenlein H....Burmeister T. (amp 2012)
    5. EBV-encoded LMP1 upregulates IgI_ 3'enhancer activity and IgI_ expression in nasopharyngeal cancer cells by activating the Ets-1 through ERKs signaling. (PubMed id 22396784)1 Liu H....Cao Y. (PLoS ONE 2012)
    6. Combined analysis using extended renal reference range of serum free light chain ratio and serum protein electrophoresis improves the diagnostic accuracy of multiple myeloma in renal insufficiency. (PubMed id 22503879)1 Park J.W....Kim S.W. (Clin. Biochem. 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Ig-free light chains play a crucial role in murine mast cell-dependent colitis and are associated with human inflammatory bowel diseases. (PubMed id 20505143)1 Rijnierse A....Kraneveld A.D. (J. Immunol. 2010)
    9. The polymorphisms on Igkappa gene are related to susceptibility of breast cancer and gastric cancer. (PubMed id 19072568)1 Hu D....Ya C. (Genet. Test. 2008)
    10. Analysis of immunoglobulin variable kappa gene mutations in cutaneous B-cell lymphoma. (PubMed id 17600686)1 Bortoletto G....Alaibac M. (J. Dermatol. Sci. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50802 HGNC: 5715 euGenes: HUgn50802 ECgene: IGK H-InvDB: IGK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IGK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGK gene:
    Search GeneIP for patents involving IGK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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