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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGK Gene

protein-coding   GIFtS: 25
GCID: GC02P089931

Immunoglobulin Kappa Locus


(Previous symbol: IGK@)
  Search for IGK
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Immunoglobulin Kappa Locus1 2
IGK@1 2
CD8A5

External Ids:    HGNC: 57151   Entrez Gene: 508022   OMIM: 1869105   

Export aliases for IGK gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IGK Gene: 
IGK (immunoglobulin kappa locus) is a protein-coding gene. Among its related super-pathways are Immune response Lectin induced complement pathway and Immune response Role of DAP12 receptors in NK cells.

Gene Wiki entry for IGK (IGK@) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  NT_032994.6  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGK
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IGK promoter sequence
   Search SABiosciences Chromatin IP Primers for IGK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   HGNC cytogenetic band: 2p11.2

IGK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGK gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P089931:  view genomic region     (about GC identifiers)

Start:
89,890,568 bp from pter      End:
90,274,235 bp from pter
Size:
383,668 bases      Orientation:
plus strand
IGK has overlapping exons with:
ORGUL053629 IGKV1D-32 IGKV3D-31 ORGUL025897 ORGUL069066 IGKV2D-38 ORGUL069877 IGKV2D-30 GRB10

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --
Post-translational modifications:
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_

  • IGK Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

    Human Recombinant Protein Products for IGK: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for IGK
    GenScript Custom Purified and Recombinant Proteins Services for IGK
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Antibody Products for IGK: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IGK
    GenScript Custom Superior Antibodies Services for IGK
    Novus Biologicals IGK Antibodies
    Search for Antibodies for IGK at Abcam
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for IGK
    Search LSBio for Antibodies for IGK 

    Assay Products for IGK: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IGK
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IGK
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGK: Immunoglobulins / IGK locus

      --

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IGK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IGK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGK 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGK 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGK
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IGK
    SwitchGear 3'UTR luciferase reporter plasmidIGK 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene RNAi
    Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IGK

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for IGK
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGK

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IGK
    Search LifeMap BioReagents cell lines for IGK
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IGK About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune response Lectin induced complement pathway
    Immune response Classic complement pathway0.53
    Immune response Classical complement pathway0.52
    2Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.45
    Immune response IL-4 signaling pathway0.38
    Immune response BCR pathway0.45
    Immune response CD16 signaling in NK cells0.32
    3Signal transduction IP3 signaling
    Signal transduction IP3 signaling0.92
    4Immune response NFAT in immune response
    Immune response NFAT in immune response0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 EMD Millipore Pathways for IGK (see all 7)
        Immune response Classic complement pathway
    Immune response BCR pathway
    Immune response CD16 signaling in NK cells
    Signal transduction IP3 signaling
    Immune response IL-4 signaling pathway


    5/7 GeneGo (Thomson Reuters) Pathways for IGK (see all 7)
        Immune response IL-4 signaling pathway
    Immune response Fc epsilon RI pathway
    Immune response CD16 signaling in NK cells
    Immune response Classical complement pathway
    Immune response BCR pathway



    IGK for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGK

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGK

    Search CenterWatch for drugs/clinical trials and news about IGK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    Unigene Cluster for IGK:

    Immunoglobulin kappa locus
    Hs.719895  [show with all ESTs]
    Unigene Representative Sequence: BQ706730
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGK
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IGK
    SwitchGear 3'UTR luciferase reporter plasmidIGK 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene RNAi
    Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGK
    Clone
    Products:
         
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for IGK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGK
    Primer
    Products:
        
    Browse OriGene qPCR
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat IGK
      Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGK
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGK

    Additional mRNA sequence: 

    AB021519.1 AB021521.1 AB021523.1 AB021526.1 AB021530.1 AB021534.1 AB021536.1 AB021541.1 
    AB049915.1 AB063654.1 AB063664.1 AB063672.1 AB063675.1 AB063807.1 AB063824.1 AB063887.1 
    AB063890.1 AB063895.1 AB063896.1 AB066894.1 AB066973.1 AB066977.1 AB067077.1 AB067081.1 
    AB067095.1 AB067102.1 AB067124.1 AB067177.1 AB067240.1 AB067250.1 AB067252.1 AB067259.1 
    AB067260.1 AB067269.1 AB363117.1 AB363120.1 AB363129.1 AB374188.1 AB374189.1 AB374191.1 
    AB729124.1 AF001424.1 AF004322.1 AF004323.1 AF004324.1 AF015123.1 AF015125.1 AF015126.1 
    AF015128.1 AF015130.1 AF015132.1 AF015133.1 AF015134.1 AF021986.1 AF022011.1 AF052520.1 
    AF052522.1 AF052524.1 AF062136.1 AF062167.1 AF062184.1 AF062191.1 AF062205.1 AF062251.1 
    AF062260.1 AF062270.1 AF062275.1 AF062276.1 AF062280.1 AF062289.1 AF062297.1 AF062298.1 
    AF062301.1 AF062304.1 AF062307.1 AF103115.1 AF103148.1 AF103150.1 AF103210.1 AF103273.1 
    AF103286.2 AF103290.1 AF103321.1 AF103328.1 AF103352.1 AF103353.1 AF103369.1 AF103371.1 
    AF115107.1 AF115108.1 AF115109.1 AF115110.1 AF123351.1 AF123354.1 AF123355.1 AF123356.1 
    AF123357.1 AF123358.1 AF123359.1 AF123360.1 AF123361.1 AF123363.1 AF123364.1 AF123365.1 
    AF123366.1 AF123367.1 AF123368.1 AF123369.1 AF123370.1 AF123371.1 AF123372.1 AF123373.1 
    AF123374.1 AF123375.1 AF123376.1 AF123377.1 AF123378.1 AF123379.1 AF174012.1 AF174017.1 
    AF174019.1 AF174024.1 AF174029.1 AF174038.1 AF174057.1 AF174067.1 AF174077.1 AF174083.1 
    AF174089.1 AF174098.1 AF174101.1 AF174103.1 AF174105.1 AF174111.1 AF231394.1 AF231395.1 
    AF231396.1 AF231397.1 AF231398.1 AF231399.1 AF231400.1 AF231402.1 AF231403.1 AF283793.1 
    AF283795.1 AF283796.1 AF283798.1 AF283799.1 AF283805.1 AF302822.1 AF394201.1 AF396468.1 
    AF396474.1 AF396476.1 AF417848.1 AF431049.1 AF455924.1 AF460666.1 AF460671.1 AF460672.1 
    AF460678.1 AF460687.1 AF460691.1 AF460699.1 AF460700.1 AF460800.1 AF460806.1 AF485437.1 
    AF485447.1 AJ006111.1 AJ006114.1 AJ006115.1 AJ006116.1 AJ006117.1 AJ006118.1 AJ006119.1 
    AJ006120.1 AJ008168.1 AJ008183.1 AJ008196.1 AJ008214.1 AJ008241.1 AJ008250.1 AJ010334.1 
    AJ132561.1 AJ132562.1 AJ132563.1 AJ233694.1 AJ239354.1 AJ239356.1 AJ239367.1 AJ241351.1 
    AJ243110.1 AJ245229.1 AJ249630.1 AJ271551.1 AJ271557.1 AJ272334.1 AJ276097.1 AJ298606.1 
    AJ298607.1 AJ298608.1 AJ298609.1 AJ298610.1 AJ298611.1 AJ300780.1 AJ300784.1 AJ300789.1 
    AJ300791.1 AJ300794.1 AJ308450.1 AJ313386.1 AJ389188.1 AJ508767.1 AJ519219.1 AJ519221.1 
    AJ519237.1 AJ519238.1 AJ519239.1 AJ519244.1 AJ519248.1 AJ519250.1 AJ519252.1 AJ519256.1 
    AJ519257.1 AJ519258.1 AJ519259.1 AJ519262.1 AJ519264.1 AJ519265.1 AJ519266.1 AJ519267.1 
    AJ519268.1 AJ519269.1 AJ519271.1 AJ519272.1 AJ519273.1 AJ519277.1 AJ519281.1 AJ519283.1 
    AJ519285.1 AJ519286.1 AJ519288.1 AJ519290.1 AJ519291.1 AJ519294.1 AJ519296.1 AJ519297.1 
    AJ519300.1 AJ519301.1 AJ519303.1 AJ519304.1 AJ519307.1 AJ519308.1 AJ519312.1 AJ519314.1 
    AJ519316.1 AJ519317.1 AJ519318.1 AJ519319.1 AJ519320.1 AJ519321.1 AJ519322.1 AJ519324.1 
    AJ519325.1 AJ519326.1 AJ519327.1 AJ519328.1 AJ519330.1 AJ519331.1 AJ519332.1 AJ519333.1 
    AJ519334.1 AJ519336.1 AJ519337.1 AJ519338.1 AJ519339.1 AJ555256.1 AJ555266.1 AJ579095.1 
    AJ579100.1 AJ579106.1 AJ579108.1 AJ579113.1 AJ579142.1 AJ579157.1 AJ579181.1 AJ579184.1 
    AJ579195.1 AJ579196.1 AJ579221.1 AJ579225.1 AJ579226.1 AJ579228.1 AJ579236.1 AJ579238.1 
    AJ579261.1 AJ579264.1 AJ579267.1 AJ579270.1 AJ579271.1 AJ579272.1 AJ579274.1 AJ579277.1 
    AJ579278.1 AJ579280.1 AJ579283.1 AJ617570.1 AJ627233.1 AJ627234.1 AJ627240.1 AJ627250.1 
    AM183988.1 AM183989.1 AM183991.1 AM259136.1 AM259140.1 AM279492.1 AM279605.1 AM279629.1 
    AY003715.1 AY003717.1 AY003725.1 AY003737.1 AY003738.1 AY003761.1 AY003766.1 AY003774.1 
    AY003778.1 AY003806.1 AY003815.1 AY003820.1 AY003827.1 AY003843.1 AY003847.1 AY003852.1 
    AY003856.1 AY003857.1 AY055484.1 AY099259.1 AY263417.1 AY263418.1 AY423163.1 AY423180.1 
    AY423185.1 AY506559.1 AY554179.1 AY554180.1 AY577295.1 AY686868.1 AY686918.1 AY781824.1 
    AY781826.1 AY781827.1 AY781828.1 AY781873.1 AY789123.1 AY789125.1 AY789442.1 AY866624.1 
    AY866718.1 AY866738.1 AY866766.1 AY866788.1 AY880990.1 AY885173.1 AY941888.1 AY941899.1 
    AY941927.1 AY941930.1 AY996337.1 D83687.1 D83693.1 DQ005273.1 DQ005292.1 DQ005303.1 
    DQ065632.1 DQ065672.1 DQ065678.1 DQ065685.1 DQ065693.1 DQ065707.1 DQ065721.1 DQ100710.1 
    DQ100713.1 DQ100717.1 DQ100794.1 DQ100810.1 DQ100817.1 DQ100838.1 DQ100842.1 DQ100843.1 
    DQ100851.1 DQ100859.1 DQ100860.1 DQ100890.1 DQ100915.1 DQ100922.1 DQ184510.1 DQ184512.1 
    DQ187555.1 DQ187556.1 DQ212496.1 DQ212498.1 DQ212499.1 DQ212500.1 DQ322923.1 DQ454401.1 
    DQ454481.1 DQ454508.1 DQ454518.1 DQ454562.1 DQ454618.1 DQ454687.1 DQ454750.1 DQ454767.1 
    DQ454786.1 DQ454789.1 DQ454876.1 DQ523884.1 DQ523922.1 DQ523923.1 DQ523924.1 DQ524028.1 
    DQ524115.1 DQ524170.1 DQ535280.1 DQ535283.1 DQ535297.1 DQ535299.1 DQ535312.1 DQ535317.1 
    DQ535318.1 DQ535341.1 DQ535376.1 DQ535380.1 DQ535400.1 DQ535446.1 DQ535463.1 DQ535471.1 
    DQ535481.1 EF175394.1 EF441760.1 EF624135.1 EF624145.1 EU099110.1 EU099172.1 EU099182.1 
    EU099195.1 EU099225.1 EU099228.1 EU099256.1 EU099264.1 EU146323.1 EU146326.1 EU146327.1 
    EU146329.1 EU146332.1 EU146335.1 EU146342.1 EU146374.1 EU146387.1 EU433871.1 EU433883.1 
    EU619960.1 EU814957.1 FJ385277.1 FJ385282.1 FJ385291.1 FJ385309.1 FJ385311.1 FJ385317.1 
    FJ385357.1 FJ385358.1 FJ385361.1 FJ385380.1 FJ385384.1 FJ385389.1 FJ481090.1 FJ492944.1 
    FJ840090.1 FJ840195.1 FJ840312.1 FJ840319.1 FJ840320.1 FJ840327.1 FJ873815.1 FJ873824.1 
    FJ873849.1 FJ873867.1 FJ873872.1 FJ873885.1 FJ873902.1 FJ873910.1 FJ873913.1 FJ873916.1 
    FJ873922.1 FJ873935.1 FJ873946.1 FJ873959.1 FJ873974.1 FJ873975.1 FJ873994.1 FJ874010.1 
    FJ874023.1 FJ874034.1 FJ874059.1 FJ874064.1 FJ874074.1 FN562944.1 FN562945.1 FN562946.1 
    FN562947.1 FN562948.1 FN562949.1 FN562950.1 FN562951.1 FN562952.1 FN562953.1 FN562954.1 
    FN562955.1 FN562956.1 FN562957.1 FN562958.1 FN562959.1 FN562960.1 FN562961.1 FN562962.1 
    FN562963.1 FN562964.1 FN562965.1 FN562966.1 FN562967.1 FN562968.1 FN563753.1 FN563754.1 
    FN563755.1 FN563756.1 FN563757.1 FN563758.1 FN563759.1 FN563761.1 FN563763.1 FN563764.1 
    FN563770.1 FN563773.1 FN563774.1 FN563775.1 FN563776.1 FN563777.1 FN563778.1 FN563782.1 
    FN563783.1 FN563787.1 FN563788.1 FN563790.1 FN563791.1 FN563792.1 FN563793.1 FN563794.1 
    FN563795.1 FN563796.1 FN563797.1 FN563799.1 FN563801.1 FN563808.1 FN563809.1 FN563815.1 
    FN563819.1 FN563820.1 FN563821.1 FN563822.1 FN563823.1 GQ504854.1 GQ504868.1 GQ504870.1 
    GQ504875.1 GQ504879.1 GQ504881.1 GQ504884.1 GQ504890.1 GQ504894.1 GQ504903.1 GQ504923.1 
    GQ504937.1 GQ504972.1 GQ504985.1 GU552694.1 GU552704.1 GU552707.1 GU552708.1 GU552710.1 
    GU552712.1 GU552718.1 GU552734.1 GU552741.1 GU552742.1 GU552746.1 GU552748.1 GU552752.1 
    GU552758.1 GU552759.1 GU570309.1 GU570311.1 GU570312.1 GU570316.1 GU570317.1 GU570318.1 
    GU570322.1 HM116131.1 HM152523.1 HM774098.1 HM774364.1 HM774385.1 HM774431.1 HM774459.1 
    HM774649.1 HM774689.1 HM774750.1 HM774775.1 HM774784.1 HM774890.1 HM774997.1 HM995048.1 
    HM995138.1 HM995165.1 HM995202.1 HM995230.1 HM995232.1 HM995233.1 HM995238.1 HM995242.1 
    HM995243.1 HM995256.1 HM995257.1 HM995259.1 HM995260.1 HM995261.1 HM995262.1 HM995263.1 
    HM995264.1 HM995266.1 HM995390.1 HM995391.1 HM995393.1 HM995422.1 HM995434.1 HM995435.1 
    HM995436.1 HM995437.1 HM995438.1 HM995439.1 HM995440.1 HM995451.1 HM995466.1 HM995568.1 
    HM995590.1 HM995620.1 HM995791.1 HM995796.1 HM995797.1 HM995800.1 HM995802.1 HM995807.1 
    HM995808.1 HM995809.1 HM995810.1 HM995811.1 HM995812.1 HM995813.1 HM995822.1 HM995894.1 
    HM995896.1 HM995931.1 HM995956.1 HM995959.1 HM996082.1 HM996159.1 HM996219.1 HM996232.1 
    HM996312.1 HM996533.1 HQ129860.1 HQ129862.1 HQ378370.1 HQ703997.1 HQ703998.1 HQ703999.1 
    HQ704017.1 HQ704042.1 JF966695.1 JN110538.1 JN110631.1 JN110650.1 JN110677.1 JN110699.1 
    JN376671.1 JN376672.1 JN376697.1 JQ301909.1 JX027421.1 JX027464.1 JX027472.1 JX027475.1 
    JX088507.1 JX173306.1 JX173317.1 JX173319.1 JX173331.1 JX462752.1 KC417399.1 KC417407.1 
    KC417408.1 KC417409.1 L01276.1 L02256.1 L02262.1 L02264.1 L02266.1 L02268.1 
    L02269.1 L03816.1 L03817.1 L03818.1 L03819.1 L03830.1 L04342.1 L08083.1 
    L08088.1 L08090.1 L11699.1 L12188.1 L14821.1 L14822.1 L19914.1 L19915.1 
    L19916.1 L19917.1 L19919.1 L19920.1 L23931.1 L25292.1 L26907.1 L28052.1 
    L33031.1 L33035.1 L33039.1 L34164.1 L38433.1 L43083.1 L43085.1 L48237.1 
    M17746.1 M17747.1 M17748.1 M17749.1 M18513.1 M26994.1 M26995.1 M29470.1 
    M34024.1 M57940.1 M57941.1 M57942.1 M57943.1 M57944.1 M62731.1 M87268.1 
    M97920.1 M99595.1 S55094.1 S67717.1 S73957.1 U00491.1 U00495.1 U00509.1 
    U00510.1 U00521.1 U00525.1 U00536.1 U00537.1 U00541.1 U00549.1 U09064.1 
    U19885.1 U21259.1 U21262.1 U21272.1 U38588.1 U41571.1 U42468.1 U58144.1 
    U64467.1 U64476.1 U64486.1 U76685.1 U77373.1 U82257.1 U86798.1 U93176.1 
    U95237.1 U96043.1 U96286.1 U97242.1 X14584.1 X56526.1 X61018.1 X62955.1 
    X62956.1 X62957.1 X62962.1 X62963.1 X62964.1 X62971.1 X65895.1 X65900.1 
    X67909.1 X81726.1 X81731.1 X81742.1 X81746.1 X81748.1 X81755.1 X95661.1 
    X98751.1 X99363.1 X99365.1 Y09384.1 Y09386.1 Y09388.1 Y18120.1 Z11945.1 
    Z11946.1 Z14200.1 Z14201.1 Z14202.1 Z14205.1 Z18830.1 Z33900.1 Z33903.1 
    Z46382.1 Z47214.1 Z47217.1 Z47218.1 Z47226.1 Z47232.1 Z80849.1 Z96954.1 
    Z96955.1 Z96956.1 Z96957.1 Z96958.1 Z96967.1 Z98714.1 Z98715.1 Z98716.1 
    Z98720.1 Z98721.1 Z98723.1 

    24/517 DOTS entries (see all 517):

    DT.95368001  DT.95264941  DT.95248569  DT.121648692  DT.121649675  DT.95205462  DT.95261651  DT.97866935 
    DT.100646536  DT.121649642  DT.100684353  DT.100775361  DT.100848453  DT.100860026  DT.102844100  DT.121507730 
    DT.97865772  DT.121509019  DT.121509587  DT.121650050  DT.121650336  DT.100046823  DT.100651539  DT.100849605 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGK expression in normal human tissues (normalized intensities)      IGK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IGK Expression
    About this image


    IGK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Colon (Gastrointestinal Tract)
             Appendix   
     
     Thymus (Hematopoietic System)
             Thymus   
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Oral Cavity (Gastrointestinal Tract)
             Salivary gland   

    Genevestigator expression for IGK

    SOURCE GeneReport for Unigene cluster: Hs.719895
        SABiosciences Custom PCR Arrays for IGK
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IGK
    DNA2.0 Custom Variant and Variant Library Synthesis for IGK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IGK for disorders           About MalaCards
    OMIM gene information: 186910   
    OMIM disorders: 608957  

    IGK for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for IGK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia lymphocytic chronic 65.1 2 16076869 (1), 16622520 (1)
    minimal residual disease 62.2 1 12970784 (1)


    Export disorders for IGK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGK gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with IGK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of expressed and non-expressed IGK locus rearrangements in chronic lymphocytic leukemia. (PubMed id 16622520)1, 9 Belessi C....Laoutaris N. (2005)
    2. Free light chain monomer-dimer patterns in the diagnos is of multiple sclerosis. (PubMed id 23376556)1 Kaplan B....Livneh A. (2013)
    3. IGKV3 proteins as candidate 'off-the-shelf' vaccines for kappa-light chain-restricted B-cell non-Hodgkin lymphomas. (PubMed id 22705988)1 Martorelli D....Dolcetti R. (2012)
    4. Molecular analysis of the t(2;8)/MYC-IGK translocation in high-grade lymphoma/leukemia by long-distance inverse PCR. (PubMed id 22120970)1 Kroenlein H....Burmeister T. (2012)
    5. EBV-encoded LMP1 upregulates Igk 3'enhancer activity a nd Igk expression in nasopharyngeal cancer cells by activating the Ets-1 through ERKs signaling. (PubMed id 22396784)1 Liu H....Cao Y. (2012)
    6. Combined analysis using extended renal reference range of serum free light chain ratio and serum protein electrophoresis improves the diagnostic accuracy of multiple myeloma in renal insufficiency. (PubMed id 22503879)1 Park J.W....Kim S.W. (2012)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Ig-free light chains play a crucial role in murine ma st cell-dependent colitis and are associated with human inflammatory bowel dise ases. (PubMed id 20505143)1 Rijnierse A....Kraneveld A.D. (2010)
    9. The polymorphisms on Igkappa gene are related to susceptibility of breast cancer and gastric cancer. (PubMed id 19072568)1 Hu D....Ya C. (2008)
    10. Analysis of immunoglobulin variable kappa gene mutations in cutaneous B-cell lymphoma. (PubMed id 17600686)1 Bortoletto G....Alaibac M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50802 HGNC: 5715 euGenes: HUgn50802 ECgene: IGK H-InvDB: IGK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IGK gene:
    Search GeneIP for patents involving IGK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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