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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGJ Gene

protein-coding   GIFtS: 48
GCID: GC04M071478

immunoglobulin J polypeptide, linker protein for immunoglobulin...
 Explore 13 diseases affiliated with
IGJ via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGJ    

Aliases
for IGJ gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immunoglobulin J Polypeptide, Linker Protein For Immunoglobulin Alpha And Mu
Polypeptides1 2
IGCJ1 2 3
JCH1 2
IgJ Chain2
Immunoglobulin J Chain2

External Ids:    HGNC: 57131   Entrez Gene: 35122   Ensembl: ENSG000001324657   OMIM: 1477905   UniProtKB: P015913   

Export aliases for IGJ gene to outside databases

Previous GC identifers: GC04M071761 GC04M071922 GC04M071987 GC04M071886 GC04M067325


Summaries
for IGJ gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: IGJ_HUMAN, P01591
Function: Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a
nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these
immunoglobulins to secretory component

Gene Wiki entry for IGJ


Genomic Views
for IGJ gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IGJ gene promoter:
         Oct-B1   oct-B2   AML1a   FOXJ2 (long isoform)   Lmo2   FOXJ2   XBP-1   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IGJ promoter sequence
   Search SABiosciences Chromatin IP Primers for IGJ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGJ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q21

IGJ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGJ gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M071478:  view genomic region     (about GC identifiers)

Start:
 71,521,258 bp from pter      End:
 71,547,534 bp from pter
Size:
 26,277 bases      Orientation:
 minus strand

Proteins
for IGJ gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IGJ_HUMAN, P01591 (See protein sequence)
Recommended Name: Immunoglobulin J chain precursor  
Size: 159 amino acids; 18099 Da
Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for IGJ: NX_P01591

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P01591

    • IGJ Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_653247.1  
    ENSEMBL proteins: 
     ENSP00000254801   ENSP00000426687   ENSP00000427112   ENSP00000426045   ENSP00000417560  
     ENSP00000440066  

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    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574


    IGJ for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for IGJ gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IGJ for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR024110 Ig_J

    Graphical View of Domain Structure for InterPro Entry P01591

    ProtoNet protein and cluster: P01591


    Function
    for IGJ gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IGJ_HUMAN, P01591
    Function: Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a
    nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these
    immunoglobulins to secretory component

         Genatlas biochemistry entry for IGJ:
    immunoglobulin,J linker for alpha and mu chains

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate IGJ (see all 13):
    hsa-miR-607 hsa-miR-586 hsa-miR-128 hsa-miR-4306 hsa-miR-3681* hsa-miR-944 hsa-miR-138-2* hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmid: IGJ 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding NAS2984306


    IGJ for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for IGJ: Igjtm1Jse Igjtm3Tl
         7 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Igj):
     digestive/alimentary  endocrine/exocrine gland  hematopoietic system  immune system  integument 
     liver/biliary system  mortality/aging 

    IGJ for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IGJ gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGJ

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for IGJ (P015913 ENSP000002548014) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD79AP119123, ENSP000002219724I2D: score=2 STRING: ENSP00000221972
    IGHMP018713I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    --ENSP000004002554STRING: ENSP00000400255
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS2984306


    IGJ for ontologies           About GeneDecksing



    Drugs & Compounds
    for IGJ gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGJ
    Search CenterWatch for drugs/clinical trials and news about IGJ 

    Transcripts
    for IGJ gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IGJ gene: 
    NM_144646.3  

    Unigene Cluster for IGJ:

    Immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
    Hs.643431  [show with all ESTs]
    Unigene Representative Sequence: BX648421
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254801(uc003hfn.4 uc010ihz.3) ENST00000510437 ENST00000510614
    ENST00000391614 ENST00000470866 ENST00000543780

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGJ
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate IGJ (see all 13):
    hsa-miR-607 hsa-miR-586 hsa-miR-128 hsa-miR-4306 hsa-miR-3681* hsa-miR-944 hsa-miR-138-2* hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmid: IGJ 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: IGJ
    OriGene siRNA: IGJ
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK312014.1 BC038982.1 BX648421.1 DQ884395.1 

    16 DOTS entries:

    DT.416100  DT.92065006  DT.100798803  DT.100798802  DT.100798805  DT.91693727  DT.91778639  DT.99936961 
    DT.95178305  DT.91778629  DT.121262686  DT.121262694  DT.100681864  DT.121262700  DT.121262709  DT.95178304 

    24/561 AceView cDNA sequences (see all 561):

    AA376887 BM783010 AA295062 BF173394 AA377376 AA376837 AW969604 BF174197 
    BM790003 AI572688 BM769597 BG563491 BF173145 AW337662 D25969 BP340239 
    BP338316 AI749954 AI950514 BF913853 BM849900 AI285557 AI285631 AI434182 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IGJ    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:        -     -           -                                 
    SP2:                                                            
    SP3:                          -                                 


    ECgene alternative splicing isoforms for IGJ

    Expression
    for IGJ gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGJ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTACGTATTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IGJ expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    AdiposeBody Subcutaneous White AdiposeAdipose
    AdiposeThoracic Perivascular AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IGJ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGJ

    SOURCE GeneReport for Unigene cluster: Hs.643431
        SABiosciences Custom PCR Arrays for IGJ
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    In Situ
    Assay Products:     
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    Orthologs
    for IGJ gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IGJ gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Igj1 , 5 immunoglobulin joining chain1, 5 82.49(n)1
    76.58(a)1    		   5 (43.70 cM)5
    160691  NM_152839.31  NP_690052.21 
     885205125 
    chicken
    (Gallus gallus)    		 Aves IGJ1 immunoglobulin J polypeptide, linker protein for immunoglobulin more 63.76(n)
    57.05(a)    		   374117  NM_204263.1  NP_989594.1 
    lizard
    (Anolis carolinensis)    		 Reptilia IGJ6
    		 --
    		 44(a)
    		 1 ↔ 1
    		 5(147078665-147083571)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.2612 Xenopus laevis immunoglobulin-associated J chain mRNA, more 77.71(n)    AF036547.1 


    ENSEMBL Gene Tree for IGJ (if available)
    TreeFam Gene Tree for IGJ (if available) 

    Paralogs
    for IGJ gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGJ gene

    IGJ for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IGJ
    PGOHUM00000249416


    Genomic Variants
    for IGJ gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGJ
    DNA2.0 Custom Variant and Variant Library Synthesis for IGJ

    Disorders / Diseases
    for IGJ gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IGJ for disorders           About GeneDecksing

    OMIM gene information: 147790    OMIM disorders: --

    13 diseases for IGJ:    About MalaCards
    fibromuscular dysplasia    renal artery obstruction    systemic lupus erythematosus    lupus erythematosus
    atopic dermatitis    keratopathy    dermatitis    tonsillitis
    hepatitis b    duodenitis    nephropathy    myeloma
    hepatitis

    Human Genome Epidemiology (HuGE) Navigator: IGJ (2 documents)

    Export disorders for IGJ gene to outside databases

    Publications
    for IGJ gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGJ gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with IGJ)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human J chain gene. Structure and expression in B lymphoid cells. (PubMed id 2984306)1, 2, 3 Max E.E. and Korsmeyer S.J. (1985)
    2. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    4. A proteomic analysis of human bile. (PubMed id 15084671)1, 2 Kristiansen T.Z.... Pandey A. (2004)
    5. Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M. (PubMed id 1472500)1, 2 Frutiger S.... Jaton J.-C. (1992)
    6. Human J chain gene: chromosomal localization and associated restriction fragment length polymorphisms. (PubMed id 3016707)1, 3 Max E.E....Robinson M.A. (1986)
    7. Primary structure of human J chain: alignment of peptides from chemical and enzymatic hydrolyses. (PubMed id 407930)1, 2 Mole J.E.... Bennett J.C. (1977)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells. (PubMed id 20947433)1 Liang Y....Ganley-Leal L.M. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    External Searches for IGJ gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IGJ gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3512 HGNC: 5713 AceView: IGJ Ensembl:ENSG00000132465 euGenes: HUgn3512
    ECgene: IGJ H-InvDB: IGJ

    Other Databases showing IGJ gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IGJ gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGJ Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IGJ gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IGJ gene:
    Search GeneIP for patents involving IGJ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for IGJ gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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     OriGene Antibodies for IGJ   OriGene shRNA RFP for IGJ  
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGJ
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     GenScript Custom Purified and Recombinant Proteins Services for IGJ GenScript cDNA clones with any tag delivered in your preferred vector for IGJ
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     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for IGJ
     SwitchGear 3'UTR luciferase reporter plasmids for IGJ
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
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    von Willebrand factor
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