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Aliases for IGIP Gene

Aliases for IGIP Gene

  • IgA Inducing Protein 2 3 5
  • IgA-Inducing Protein Homolog (Bos Taurus) 2 3
  • C5orf53 3 4
  • Chromosome 5 Open Reading Frame 53 2
  • IgA-Inducing Protein Homolog 3

External Ids for IGIP Gene

Previous HGNC Symbols for IGIP Gene

  • C5orf53

Previous GeneCards Identifiers for IGIP Gene

  • GC05P139505

Summaries for IGIP Gene

GeneCards Summary for IGIP Gene

IGIP (IgA Inducing Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IGIP Gene

  • Enhances IgA secretion from B-cells stimulated via CD40.

Additional gene information for IGIP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGIP Gene

Genomics for IGIP Gene

Regulatory Elements for IGIP Gene

Enhancers for IGIP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H139517 1.8 FANTOM5 Ensembl ENCODE 22.9 -607.8 -607760 1 ZFP64 FEZF1 DMAP1 ZNF416 ZNF143 SP3 ZC3H11A MEF2D SSRP1 ZNF610 PURA ANKHD1 MALINC1 IGIP MATR3 DNAJC18 ENSG00000232174 SLC23A1 CTNNA1 PSD2
GH05H140239 1.5 Ensembl ENCODE dbSUPER 17.8 +117.8 117836 8 PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF121 GLIS2 PFDN1 IGIP MATR3 PCDHA6 DNAJC18 PCDHA5 PCDHA10 PCDHA2 PCDHAC2 PCDHB17P
GH05H140363 1.2 Ensembl ENCODE 17.8 +237.5 237520 0 HDGF ZFP64 ARID4B DMAP1 ZNF2 ZNF121 GLIS2 ZNF416 ZNF143 ATF7 IGIP PCDHA6 PCDHGB2 DNAJC18 PCDHA5 PCDHA10 HARS2 PCDHA2 PCDHAC2 PURA
GH05H140710 1.2 ENCODE 17.7 +585.0 585049 1 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF143 HARS2 PURA ANKHD1 HDAC3 WDR55 LOC102723915 PCDHB18P IK PCDHA4 HARS
GH05H140717 1.2 ENCODE 17.7 +593.2 593202 2 MLX ZNF416 ZNF143 SP3 PPARGC1A MEF2D GLIS1 RCOR2 NBN KDM1A ANKHD1 HARS2 PURA HDAC3 WDR55 PCDHB18P PCDHB19P TMCO6 PCDHB12 HARS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGIP on UCSC Golden Path with GeneCards custom track

Genomic Location for IGIP Gene

Chromosome:
5
Start:
140,125,935 bp from pter
End:
140,129,392 bp from pter
Size:
3,458 bases
Orientation:
Plus strand

Genomic View for IGIP Gene

Genes around IGIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGIP Gene

Proteins for IGIP Gene

  • Protein details for IGIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NJ69-IGIP_HUMAN
    Recommended name:
    IgA-inducing protein homolog
    Protein Accession:
    A6NJ69

    Protein attributes for IGIP Gene

    Size:
    53 amino acids
    Molecular mass:
    5937 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGIP Gene

Post-translational modifications for IGIP Gene

No Post-translational modifications

Other Protein References for IGIP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGIP Gene

Domains & Families for IGIP Gene

Gene Families for IGIP Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IGIP Gene

ProtoNet:

Suggested Antigen Peptide Sequences for IGIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGIP: view

No data available for UniProtKB/Swiss-Prot for IGIP Gene

Function for IGIP Gene

Molecular function for IGIP Gene

UniProtKB/Swiss-Prot Function:
Enhances IgA secretion from B-cells stimulated via CD40.

Phenotypes From GWAS Catalog for IGIP Gene

Phenotypes for IGIP Gene

genes like me logo Genes that share phenotypes with IGIP: view

Animal Model Products

CRISPR Products

miRNA for IGIP Gene

miRTarBase miRNAs that target IGIP

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IGIP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGIP Gene

Localization for IGIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGIP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGIP gene
Compartment Confidence
extracellular 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IGIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with IGIP: view

Pathways & Interactions for IGIP Gene

No Data Available

Interacting Proteins for IGIP Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000327344%0d%0a9606.ENSP00000330572%0d%0a
Selected Interacting proteins: A6NJ69-IGIP_HUMAN ENSP00000327344 for IGIP Gene via IID STRING

Gene Ontology (GO) - Biological Process for IGIP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IGIP Gene

Drugs & Compounds for IGIP Gene

No Compound Related Data Available

Transcripts for IGIP Gene

mRNA/cDNA for IGIP Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGIP Gene

IgA-inducing protein homolog (Bos taurus):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IGIP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IGIP Gene

No ASD Table

Relevant External Links for IGIP Gene

GeneLoc Exon Structure for
IGIP
ECgene alternative splicing isoforms for
IGIP

Expression for IGIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of IGIP Gene:

IGIP

SOURCE GeneReport for Unigene cluster for IGIP Gene:

Hs.696360

Evidence on tissue expression from TISSUES for IGIP Gene

  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with IGIP: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGIP Gene

Orthologs for IGIP Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGIP 33 34
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia IGIP 33
  • 96.23 (n)
mouse
(Mus musculus)
Mammalia Igip 33 16
  • 96.23 (n)
rat
(Rattus norvegicus)
Mammalia Igip 33
  • 94.34 (n)
cow
(Bos Taurus)
Mammalia IGIP 34
  • 94 (a)
OneToOne
Species where no ortholog for IGIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGIP Gene

ENSEMBL:
Gene Tree for IGIP (if available)
TreeFam:
Gene Tree for IGIP (if available)

Paralogs for IGIP Gene

No data available for Paralogs for IGIP Gene

Variants for IGIP Gene

Sequence variations from dbSNP and Humsavar for IGIP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1001398135 -- 140,127,274(+) TGGAC(A/T)CTTGT utr-variant-5-prime
rs1001703725 -- 140,126,738(+) TTGAT(C/T)ACCTG utr-variant-5-prime
rs1002617515 -- 140,128,249(+) TTCCA(A/G)AATGA utr-variant-5-prime
rs1004126275 -- 140,127,633(+) TTTTT(A/G)TGTAT utr-variant-5-prime
rs1004168819 -- 140,127,058(+) GTGGG(A/T)CTTCT utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for IGIP Gene

Variant ID Type Subtype PubMed ID
nsv819068 CNV loss 19587683

Variation tolerance for IGIP Gene

Residual Variation Intolerance Score: 73.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGIP Gene

Disorders for IGIP Gene

Relevant External Links for IGIP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGIP

No disorders were found for IGIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGIP Gene

Publications for IGIP Gene

  1. Regulation of IgA responses in cattle, humans and mice. (PMID: 21074276) Estes DM (Veterinary immunology and immunopathology 2010) 2 3 60
  2. Human IgA-inducing protein from dendritic cells induces IgA production by naive IgD+ B cells. (PMID: 19201837) Endsley MA … Estes DM (Journal of immunology (Baltimore, Md. : 1950) 2009) 2 3 60
  3. Identification and characterization of a novel regulatory factor: IgA-inducing protein. (PMID: 12874223) Austin AS … Estes DM (Journal of immunology (Baltimore, Md. : 1950) 2003) 2 3 60
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 60
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 60

Products for IGIP Gene

Sources for IGIP Gene

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