IGIP Gene
protein-coding GIFtS: 33
GCID: GC05P139505
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IgA-inducing protein homolog (Bos taurus)(Previous name: chromosome 5 open reading frame 53 )
(Previous symbol: C5orf53)
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Aliases
for IGIP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| IgA-Inducing Protein Homolog (Bos Taurus)1 2 | | C5orf531 2 3 | | LOC4923111 | | Chromosome 5 Open Reading Frame 531 | | IgA-Inducing Protein (Bos Taurus)2 | | IgA-Inducing Protein Homolog2 |
Export aliases for IGIP gene to outside databases |
Summaries
for IGIP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: IGIP_HUMAN, A6NJ69Function: Enhances IgA secretion from B-cells stimulated via CD40 (By similarity)
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Genomic Views
for IGIP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for IGIP
Other transcription factors
Search SABiosciences Chromatin IP Primers for IGIP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGIP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q31IGIP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P139505: view genomic region
(about GC identifiers)
Start:
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139,505,521 bp from pter |
End:
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139,508,391 bp from pter |
Size:
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2,871 bases |
Orientation:
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plus strand |
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Proteins
for IGIP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IGIP_HUMAN, A6NJ69 (See
protein sequence)Recommended Name: IgA-inducing protein homolog precursor Size: 53 amino acids; 5937 Da
Subcellular location: Secreted (By similarity)
Caution: It is uncertain whether Met-1 or Met-7 is the initiatorExplore the universe of human proteins at neXtProt for IGIP: NX_A6NJ69
IGIP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001007190.1
ENSEMBL proteins: ENSP00000327344
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
IGIP for ontologies About GeneDecksing
IGIP Antibody Products:
Assay Products for IGIP: |
Protein
Domains /
Families
for IGIP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: A6NJ69 |
Function
for IGIP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IGIP_HUMAN, A6NJ69Function: Enhances IgA secretion from B-cells stimulated via CD40 (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGIP
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGIP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for IGIP | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IGIP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGIP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGIP |
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Pathways & Interactions
for IGIP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGIP
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for IGIP (ENSP000003273444) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for IGIP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IGIP
Search CenterWatch for drugs/clinical trials and news about IGIP
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Transcripts
for IGIP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IGIP gene: NM_001007189.1 Unigene Cluster for IGIP: IgA-inducing protein homolog (Bos taurus) Hs.696360 [show with all ESTs]Unigene Representative Sequence: NM_0010071891 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000333305(uc003lfb.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGIP
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGIP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for IGIP | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IGIP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGIP |
Additional cDNA sequence: AB073888.1 BC017422.1 BC041380.1 2 DOTS entries: DT.414635 DT.101978404
GeneLoc Exon Structure
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Expression
for IGIP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IGIP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGAAACCAA
About this image
See IGIP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGIP
SOURCE GeneReport for Unigene cluster: Hs.696360
SABiosciences Custom PCR Arrays for IGIP
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat IGIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGIP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGIP |
Orthologs
for IGIP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of human and mouse.
Orthologs for IGIP gene from 1/3 species (see all 3) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
6330403M23Rik5 |
RIKEN cDNA 6330403M23 gene |
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18 (19.46 cM) 36296950 |
ENSEMBL Gene Tree for IGIP (if available)
TreeFam Gene Tree for IGIP (if available) |
Paralogs
for IGIP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IGIP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IGIP (139505521 - 139508391 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IGIP: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGIP |
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Disorders
/ Diseases
for IGIP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for IGIP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IGIP gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGIP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human IgA-inducing protein from dendritic cells induces IgA production by naive IgD+ B cells. (PubMed id 19201837)1, 3 Endsley M.A....Estes D.M. (2009)
- Identification and characterization of a novel regula tory factor: IgA-inducing protein. (PubMed id 12874223)1, 3 Austin A.S....Estes D.M. (2003)
- Regulation of IgA responses in cattle, humans and mice . (PubMed id 21074276)1 Estes D.M. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for IGIP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing IGIP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing IGIP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IGIP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IGIP | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for IGIP gene:
Search GeneIP for patents involving IGIP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IGIP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IGIP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGIP | | Browse OriGene genome-wide validated SYBR primer pairs | | | OriGene Protein Over-expression Lysate for IGIP | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IGIP | | OriGene 3'-UTR Clone for IGIP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGIP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGIP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IGIP | | OriGene Custom Protein Services for IGIP | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGIP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGIP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGIP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGIP |
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| | | | Search Tocris compounds for IGIP |
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 | | | IGIP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGIP |
|  |  |  | | | | Search ThermoFisher Antibodies for IGIP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGIP |
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