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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGHV@ Cluster

gene cluster   GIFtS: 25
GCID: GC14U900507

Immunoglobulin Heavy Variable Cluster


Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section


Aliases
IGHV2
Immunoglobulin Heavy Variable Cluster2

External Ids:    Entrez Gene: 35092   OMIM: 1470705   UniProtKB: P017643   

Export aliases for IGHV@ gene to outside databases

Previous GC identifers: GC14M103760 GC14M100653 GC14M104664 GC14M104697 GC14M105088 GC16P031977 GC14M105253 GC14M105797 GC14M106725


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IGHV@ Gene: 
IGHV@ is a gene cluster. Diseases associated with IGHV@ include diffuse large b-cell lymphoma, and mantle cell lymphoma, and among its related super-pathways are Immune response Lectin induced complement pathway and Immune response Role of DAP12 receptors in NK cells.

Gene Wiki entry for IGHV@ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for IGHV@
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGHV@

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHV@


Genomic Location:
Chromosome:14   

Entrez Gene cytogenetic band: 14q32.33   

GeneLoc information about chromosome 14        


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HV303_HUMAN, P01764 (See protein sequence)
Recommended Name: Ig heavy chain V-III region VH26 precursor  
Size: 117 amino acids; 12582 Da
4 PDB 3D structures from and Proteopedia for IGHV@:
1HOU (3D)        1OHQ (3D)        3BN9 (3D)        3UPC (3D)    

Explore the universe of human proteins at neXtProt for IGHV@: NX_P01764

Explore proteomics data for IGHV@ at MOPED 

IGHV@ Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IGHV@ Protein Expression
Reactome Protein details: P01764
Human Recombinant Protein Products for IGHV@: 

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro protein domains:
 IPR007110 Ig-like_dom
 IPR003596 Ig_V-set_subgr
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry P01764

ProtoNet protein and cluster: P01764

2 Blocks protein domains:
IPB003596 Immunoglobulin V-type
IPB013106 Immunoglobulin V-set


UniProtKB/Swiss-Prot: HV303_HUMAN, P01764
Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


IGHV@ for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:
     Genatlas biochemistry entry for IGHV@:
immunoglobulin,heavy chain variable cluster,87 genes and pseudogenes in 7 families (seeies see (IGHVS1 to IGHV7S)

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IGHV@ About                                                                                                See pathways by source

SuperPathContained pathways About
1Immune response Lectin induced complement pathway
Immune response Classic complement pathway0.53
Immune response Classical complement pathway0.52
2Immune response Fc epsilon RI pathway
Immune response Fc epsilon RI pathway0.45
Immune response IL-4 signaling pathway0.38
Immune response BCR pathway0.45
Immune response CD16 signaling in NK cells0.32
3Signal transduction IP3 signaling
Signal transduction IP3 signaling0.92
4Immune response NFAT in immune response
Immune response NFAT in immune response0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

5/7 EMD Millipore Pathways for IGHV@ (see all 7)
    Immune response Classic complement pathway
Immune response BCR pathway
Immune response CD16 signaling in NK cells
Signal transduction IP3 signaling
Immune response IL-4 signaling pathway


5/7 GeneGo (Thomson Reuters) Pathways for IGHV@ (see all 7)
    Immune response IL-4 signaling pathway
Immune response Fc epsilon RI pathway
Immune response CD16 signaling in NK cells
Immune response Classical complement pathway
Immune response BCR pathway

5/21        Reactome Pathways for IGHV@ (see all 21)
    FCERI mediated MAPK activation
FCERI mediated NF-kB activation
FCGR activation
Role of phospholipids in phagocytosis
Binding and Uptake of Ligands by Scavenger Receptors



IGHV@ for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGHV@

2 Interacting proteins for IGHV@ (P017643) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IGHG1P018573I2D: score=1 
--P016003I2D: score=1 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGHV@ (HV303)

Search CenterWatch for drugs/clinical trials and news about IGHV@

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section


miRNA
Products:
     
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Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IGHV@
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
Browse OriGene RNAi
Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGHV@
Clone
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GenScript Custom all cDNA clones Services for IGHV@
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Sirion Biotech Customized lentivirus for stable overexpression of IGHV@ 
                     Customized lentivirus expression plasmids for stable overexpression of IGHV@ 
Primer
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  Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGHV@
  Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGHV@

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for IGHV@:none

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --


See IGHV@ Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for IGHV@
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGHV@

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Locus Specific Mutation Databases (LSDB): IGHV@
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing IGHV@
DNA2.0 Custom Variant and Variant Library Synthesis for IGHV@

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 147070    OMIM disorders: --

10 diseases for IGHV@:    About MalaCards
diffuse large b-cell lymphoma    mantle cell lymphoma    b-cell chronic lymphocytic leukemia    splenic marginal zone lymphoma
intraocular lymphoma    chronic lymphocytic leukemia    narcolepsy    b-cell lymphomas
leukemia    endotheliitis

2 diseases from the University of Copenhagen DISEASES database for IGHV@:
Leukemia     Lymphoma

IGHV@ for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

3 Novoseek inferred disease relationships for IGHV@ gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
lymphocytic leukemia chronic b-cell 88.6 3 18045969 (1), 18314442 (1), 17657217 (1)
leukemia lymphocytic chronic 80.1 4 18326815 (1), 16321853 (1), 18314442 (1), 19824994 (1)
somatic mutations 53.8 2 16616061 (1), 17760806 (1)

Genetic Association Database (GAD): IGHV@
Human Genome Epidemiology (HuGE) Navigator: IGHV@ (16 documents)

Export disorders for IGHV@ gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IGHV@ gene, integrated from 9 sources (see all 62):
(articles sorted by number of sources associating them with IGHV@)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Variant IRF4/MUM1 associates with CD38 status and tre atment-free survival in chronic lymphocytic leukaemia. (PubMed id 20090783)1, 4 Allan J.M....Allsup D.J. (2010)
  2. Prognostic factors identify 3 risk groups in the LRF CLL4 trial, independent of treatment allocation. (PubMed id 20511662)1, 4 Oscier D....Catovsky D. (2010)
  3. IGHV gene mutational status and LPL/ADAM29 gene expression as clinical outcome predictors in CLL patients in remission following treatment with oral fludarabine plus cyclophosphamide. (PubMed id 19340428)1, 4 Maloum K....Merle-BAcral H. (2009)
  4. Abnormal serum free light chain ratios are associated with poor survival and may reflect biological subgroups in patients with chronic lymphocytic leukaemia. (PubMed id 19016722)1, 4 Pratt G....Mead G. (2009)
  5. [Immunoglobulin variable heavy chain region genetic constitution and mutation status in Chinese patients with chronic lymphocytic leukemia.] (PubMed id 19350515)1, 4 Zhang Y....Li J. (2009)
  6. BCL6: somatic mutations and expression in early-stage chronic lymphocytic leukemia. (PubMed id 19367498)1, 4 Jantus Lewintre E....GarcA-a-Conde J. (2009)
  7. The prognostic impact of autologous stem cell transplantation in patients with chronic lymphocytic leukemia: a risk-matched analysis based on the VH gene mutational status. (PubMed id 14670929)1, 4 Dreger P....Dohner H. (2004)
  8. Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein. (PubMed id 7681398)1, 2 Mariette X.... Brouet J.C. (1993)
  9. Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain. (PubMed id 3866244)1, 2 Toyonaga B.... Mak T.W. (1985)
  10. Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region. (PubMed id 6450418)1, 2 Matthyssens G. and Rabbitts T.H. (1980)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3509 euGenes: HUgn3509

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IGHV@ Pharmacogenomics, SNPs, Pathways
IMGT entry for IGHV@ The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IGHV@ gene:
Search GeneIP for patents involving IGHV@

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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