IGHV@ Cluster
gene cluster GIFtS : 30 GCID: GC14 U900507
immunoglobulin heavy variable cluster immunoglobulin heavy variable group )IGHV )
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Aliasesfor IGHV@ gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Immunoglobulin Heavy Variable Cluster 1 2 IGHV1 2 Immunoglobulin Heavy Variable Group1
Export aliases for IGHV@ gene to outside databases Previous GC identifers: GC14M103760 GC14M100653 GC14M104664 GC14M104697 GC14M105088 GC16P031977 GC14M105253 GC14M105797 GC14M106725
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Summariesfor IGHV@ gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Gene Wiki entry for IGHV@
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Genomic Viewsfor IGHV@ gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for IGHV@ Other transcription factors Search SABiosciences Chromatin IP Primers for IGHV@ Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHV@
Genomic Location: Chromosome: 14 Entrez Gene cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32.33 GeneLoc information about chromosome 14
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Proteinsfor IGHV@ gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: HV303_HUMAN, P01764 See
protein sequence )Recommended Name: Size : 117 amino acids; 12582 Da4 PDB 3D structures from :1HOU (3D) 1OHQ (3D) 3BN9 (3D) 3UPC (3D) Explore the universe of human proteins at neXtProt for IGHV@: NX_P01764 IGHV@ Protein expression data from MOPED and PaxDb : About this image
Reactome Protein details: P01764 Human Recombinant Protein Products: IGHV@ Antibody Products: Assay Products for IGHV@:
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Protein
Domains /for IGHV@ gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P01764 ProtoNet protein and cluster: P01764
2 Blocks protein families : IPB003596 IPB013106 UniProtKB/Swiss-Prot: HV303_HUMAN, P01764 Similarity : Contains 1 Ig-like (immunoglobulin-like) domain
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Functionfor IGHV@ gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: Genatlas biochemistry entry for IGHV@ immunoglobulin,heavy chain variable cluster,87 genes and pseudogenes in 7 families (seeies see (IGHVS1 to IGHV7S)
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Pathways & Interactionsfor IGHV@ gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/7 super-pathways (see all 7 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Immune response_NFAT in immune response 2 Signal transduction_IP3 signaling 3 Immune response_Classical complement pathway 4 Immune response_IL-4 signaling pathway 5 Immune response CD16 signaling in NK cells
Pathway sources See GeneCards unified pathways Show all pathways 5/7 (see all 7 )5/7 (see all 7 )5/21 (see all 21 )About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGHV@ 2 Interacting proteins for IGHV@ (P01764 3 via UniProtKB, MINT, STRING, and/or I2D About this table
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Drugs & Compoundsfor IGHV@ gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for IGHV@ IGHV@
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Transcriptsfor IGHV@ gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section
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Expression for IGHV@ gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section Expression evidence for IGHV@:none See probesets specificity/sensitivity at GeneAnnot CGAP TAG: -- See IGHV@ Protein Expression from SPIRE MOPED and PaxDB SABiosciences Custom PCR Arrays for IGHV@
Primer Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat IGHV@ Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGHV@ Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGHV@
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Orthologsfor IGHV@ gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
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Paralogsfor IGHV@ gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section
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Genomic Variantsfor IGHV@ gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Locus Specific Mutation Databases (LSDB): IGHV@ SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor IGHV@ gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 147070
OMIM disorders : --9 : About MalaCards splenic marginal zone lymphoma diffuse large b-cell lymphoma b-cell lymphomas intraocular lymphoma mantle cell lymphoma lymphocytic leukemia chronic lymphocytic leukemia narcolepsy leukemia 2 diseases from the University of Copenhagen DISEASES database for IGHV@ :Chronic lymphocytic leukemia Lymphoma 3 Novoseek disease relationships for IGHV@ gene About this table
Genetic Association Database (GAD): IGHV@ Human Genome Epidemiology (HuGE) Navigator: IGHV@ (16 documents) Export disorders for IGHV@ gene to outside databases
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Publicationsfor IGHV@ gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for IGHV@ gene, integrated from 9 sources (see all 61 ):(articles sorted by number of sources associating them with IGHV@) Utopia : connect your pdf to the dynamic
The prognostic impact of autologous stem cell transplantation in patients with chronic lymphocytic leukemia: a risk-matched analysis based on the VH gene mutational status. (PubMed id 14670929) 1 , 4(2004) Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein. (PubMed id 7681398) 1 , 2 (1993) A deletion map of the human immunoglobulin heavy chain variable region. (PubMed id 1649888) 1 , 3(1991) Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements. (PubMed id 3141924) 1 , 3(1988) Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain. (PubMed id 3866244) 1 , 2 (1985) Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region. (PubMed id 6450418) 1 , 2 (1980) Rearrangement of only one human IGHV gene is sufficient to generate a wide repertoire of antigen specific antibody responses in transgenic mice. (PubMed id 16343622) 1 , 9(2006) IGHV gene mutational status and 17p deletion are indep endent molecular predictors in a comprehensive clinical-biological prognostic mo del for overall survival prediction in chronic lymphocytic leukemia. (PubMed id 22289136) 1 (2012) Molecular subsets of mantle cell lymphoma defined by t he IGHV mutational status and SOX11 expression have distinct biologic and clinic al features. (PubMed id 22915760) 1 (2012) T-cell independent, B-cell receptor-mediated induction of telomerase activity differs among IGHV mutation-based subgroups of chronic l ymphocytic leukemia patients. (PubMed id 22875913) 1 (2012)
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External Searches for IGHV@ gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing IGHV@ gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing IGHV@ gene
(According to HUGE )
About This Section --
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Specialized Databases showing IGHV@ gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for IGHV@ Pharmacogenomics, SNPs, Pathways IMGT entry for IGHV@The international I mM unoG eneT ics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
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About This Section Patent Information for IGHV@ gene: IGHV@ GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor IGHV@ gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGHV@ Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGHV@ QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGHV@ Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGHV@ Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGHV@ Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGHV@
Search Tocris compounds for IGHV@
IGHV@ Proteins, Antibodies, CLIAs, and ELISAs
Search ThermoFisher Antibodies for IGHV@
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IGHV@
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Genomic Views for IGHV@
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and Proteopedia 
for IGHV@:
Reactome Pathways for IGHV@ (
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